ก#$%&'(%) *+,-.

#$&/0,1$2 3
Conc = mass / volume
a x ⋅ a y = a x+ y
∞ 1
∫ 0
e − kt =
k
( a x ) y = a xy
ax
= a x− y
ay

C = C o e − k e t ; k e t = ln Co
C
ln(ab) = ln a + ln b
ln( ab ) = ln a − ln b
X = X o e − k et
ln a x = x ln a
T1 / 2 = ln 2 / k e ln( 1a ) x = − x ln a
Cl = k eV d dx n = nx n −1dx
Dose = Css ⋅ CL n 1 n +1
∫x = n +1
x + const
R

:
X = B o e − k et + (1 − e − k e t ) de x = e x dx
ke
∫ e dx = e + const
x x

T1 / 2 = ln 2 / k e ~ 0 . 693 / k e
de ax = e ax dax = aeax dx
Ro − ket − 12 k *InfusionTime
Cinf = (1 − e )≈ Dose
e 1 ax
k eVd V
∫e dx =
e + const
ax

a
1 − e − nkQ da x = (ln a )a x dx
Cn = C1
1 − e − kQ ∫ a dx = (
x 1
ln a )a x + const
1 1
Css = C1 kQ
≈ kQ1 + 0.5 + 12
1 − e −kQ 1− e − kQ

(Laurent approximation for kQ < 2)

C peak − Ctrough **
( Bolus) : Cavg = ≈ (C peak + 2Ctrough ) / 3* ≈ C peak Ctrough
C
ln peak
Ctrough
* err < 10%,* * err > 10%
1 C peak
Q= ln
k Ctrough
Dose
= keCavgVd = Cavg CL
Q
AUC = Dose
Cl

*+,-*'()'ก*0+ ≈ %,$-./2%$ก(0).#$&/0 1234'5)$'6')%)$-789-+7:&,+ 1/2,)92(0)9-1$2-2/'2