Git Meds

Blocks H2 recpetors (parietal cells

prevents gthe release of gastrin hormone that causes release histamine-blocks
productiion of HCl

Cimetedine, Ranitidine, Famotidine - oral and parental forms

1. Cimetedine
Tablet/IV

Adverse Reaction
GI Effect
Diarrhea, Constipation

CNS effect
may cause mental confusion, agitation, anxiety and disorientation

Gynecomastia, impotence (prolonged use)

Nursing Responsibilties

>taken on an empty stomach

>administered 1 hour apart from antacids
>Metablosim - mainly in the liver
> Excreted in the urine cross, placenta and milk

2. Ranitidine (zantac)
Tablet / Iv

Indications
> Treatment of duodenal and benign gastric ulcers, GERD
>prophylaxis of stress ulcers
>relief symptoms of heart brun indidgestion sour stomach

Adverse reaction
Side effcts are uncommon and does not cross vlood-brain barrier

Nursing Resp
Longer Acting
More pietent than cimetidine
Metablized the liver excreted in the urine
crossess the placenta
not affected by food
reduce with geriaitic patients

3.Famotidine

Indication
Treatment of duodenal and benign gastric ulcers, GERD
>prophylaxis of stress ulcers
>relief symptoms of heart brun indidgestion sour stomach

Nursing Resp
redcue dose with geriatric patients with renal impairment

II. Antacids

neutrilize stomach acids

inactive pepsin and enhance mucosal protection
recommmended for the symptomatic relief of upset stomach
associiated with hyper acidity

Hyper acidity associated with peptic ulcer gastritis peptic esphaghatis

Available OTC

Administer 1 hour apart from other meds

e.g

1. Sodium Bicarbonate

2. Calcium Carbonate (TUMS)

Adverse Reaction
Constipation
Acid rebound
3. Manesium salts (milk of magnesia)
Adverse Reaction
Diarrhea
can lead to nnerve damage
coma

Nursing Resp
Rapid acting
Excreted in Urine

4. Alumnin Salts (MAALOX)

Adverse Reaction
*Severe constipation
*reduce phospahte - Hypophosphatemia Ca+ imbalance

Nurs Rep
Slow acting

5.Sucralfate Crafate

Indication
*Gi Proctectant
*creates a prottective barrier against acid and pepsin

Adverse Reaction
constipation

NR
Given PO on a empty stomach
administer 3 hours apart from other drugs

III. Proton Pump Inhibitors

>suppress gatsric acid secretion

>inhibits the hydrogen-potassium adenosine triphosphate (H+ K+ ATPase)
> short term treat ment of active duodenal ulcers, GERD benign active gastric
ulcers

e.g.
1. Esomeprazole
2. Lansoprazole
3. Pantoprazone
4. Omeparazole

A.R
GI effect
diarrhea
abdomnial pain
dry mouth

CNS efect
dizziness
headache

IV.
Digetsive or Pnacreatic Enzyme Replacemet

Difgestive enzyme - subatance produced in the GI tract

Lubricants
Mineral Oil
- soften stools

Saline Cathartics
gylcerin suppositiories