V.

DATA HASIL PENGAMATAN

Waktu (jam) Cp (µg/ml) Log Cp (µg/ml) Cp’ Log cp’

0,25 2,85 0,4548 45,4988 1,6579

0,50 5,43 0,7347 44,5143 1,6484
0,75 7,75 0,8893 43,5511 1,6389
1,00 9,84 0,9929 42,6088 1,6294
2,00 16,20 1,2095 39,0301 1,5913
4,00 22,15 1,3453 32,7491 1,5151
6,00 23,01 1,3619 27,4852 1,4390
10,00 19,09 1,2808
14,00 13,90 1,1430
20,00 7,97 0,9014

Cr = cp – cp’ Log cr
-42,6488 1,6299
-39,0843 1,5920
-35,8011 1,5538
-32,7688 1,5154
-22,8301 1,3585
-10,5991 1,0252
-4,4752 0,6508

kurva log cp vs t
konsentrasi plasma (cp)

15
10
5
0
0 5 10 15 20 25
Waktu (jam)

Persamaan yang didapat dari log cp vs t (T eliminasi dari 10-20 jam)

a = 1,6675 b = -0,0381 r = -0,0991

Y = a + bx

Y = 1,6675 - 0,0381x

Jadi b = -K

2,303
-0,0381 = -K

2,303

K = 0,0877

Log cp’ = log A – α.t

2,303

Log A = a b=-α

= 1,6675 2,303

A = 46,5050 -0,0381 = - α

2,303

Α = 0,0877

Log cp’ = log A – α.t

2,303

−αt
Log CPl = Log A
2,303
−α
Log A = a b=
2,303
−α
A = 46,5050 -0,0381 =
2,303
α =0,0877

−αt −αt
Log CPl = Log A Log CPl = Log A
2,303 2,303
−0,0877 . 0,25
= Log 46,5050 = Log 46,5050
2,303
−0,0877 . 0,50
2,303
= 1,6675 – 0,0095 = 1,6675 – 0,0190
= 1,6580 = 1,6485
l l
CP = 45,4988 CP = 44,5143

−αt −αt
Log CPl = Log A Log CPl = Log A
2,303 2,303
−0,0877 . 0,75
= Log 46,5050 = Log 46,5050
2,303
−0,0877 .1,00
2,303
 = 1,6675 – 0,0285 = 1,6675 – 0,0380
= 1,6390 = 1,6295
l l
CP = 43,5511 CP = 42,6088

−αt −αt
Log CPl = Log A Log CPl = Log A
2,303 2,303
−0,0877 . 2,00
= Log 46,5050 = Log 46,5050
2,303
−0,0877 . 4,00
2,303
= 1,6675 – 0,0761 = 1,6675 – 0,1523
= 1,5914 = 1,5152
l l
CP = 39,0301 CP = 32,7491

−αt
Log CPl = Log A
2,303
−0,0877 . 6,00
= Log 46,5050
2,303
= 1,6675 – 0,2284
= 1,4391 -K=b
l
CP = 27,4852 - K = - 0,1692
K = 0,1692

Persamaan regresi linear log cr vs t

y = a + bx a : 1,6827 −ka ln 2
 b= t1/2 =
y = 1,6827 + (-0,1692)x b : -0,1692 2,303 α
y = 1,6827 – 0,1692x r : -0,9993 −ka −0,693
 -0,1692 = =
2,303 0,0877
 ka = 0,2896 = 7,9019