DRUG NAME ROUTE AND CLASSIFICATIO ACTION INDICATION CONTRAINDICATIO ADVERSE NURSING

DOSAGE N N REACTION CONSIDERATIONS

Generic Name: Route: I.V. & Therapeutic Class: Inhibits cell-wall Intra-abdominal, Contraindicated in CV: thrombophlebitis Dosage in expressed as
Ampicillin I.M. Antibiotics synthesis during gynecologic, and patients: total drug. Each 1.5-g vial
sodium – bacterial skin-structure - hypersensitive to drug GI: diarrhea, nausea contains 1 g ampicillin
sulbactam Available Forms: Pharmacologic multiplication infections caused or other penicillins, in sodium and 0.5 g
sodium Injection: Vials Class: by susceptible those with sensitivity to Hematologic: sulbactam sodium
and piggyback Aminopenicillins- strains multiple allergens, and in agranulocytosis,
vials and beta- lactamase those with mononucleosis leukopenia, In patients with impaired
Brand Name: containing 1.5 g inhibitors because of high risk of thrombocytopenia, renal function, decrease
Unasyn (1 g ampicillin maculopapular rash thrombocytopenic frequency of
sodium and 0.5 g - with a history of purpura administration
sulbactam cholestatic jaundice or
sodium), 3 g (2 g hepatic dysfunction Skin: pain at injection Monitor LFT results
ampicillin associated with site, thrombophlebitis, during therapy, especially
sodium and 1 g ampicillin- sulbactam rash, urticarial in patients with impaired
sulbactam injection liver function
sodium)
Use cautiously in patients Other: If large doses are given or
with other drug allergies hypersensitivity if therapy is prolonged,
(especially to reactions bacterial or fungal
cephalosporins) because superinfection may occur,
of possible cross- especially in elderly,
sensitivity and in those debilitated or
with renal impairment immunosuppressed
patients

Watch for signs and

symptoms of
hypersensitivity, such as
erythematous
maculopapular rash,
urticaria, and anaphylaxis

Monitor for CDAD, which

can be fatal. Antibiotic
may need to be stopped
and other treatment begun.