Pharmaceutical technology 2 Lab

Hydrophilic Petrolatum USP

Prepare hydrophilic petrolatum as follows:

Cholesterol 1.5 g
Stearyl alcohol 1.5g
White wax 1.5g
White petrolatum 43g
to make: 50g

NOTE: Boiling wax is extremely flammable. Do not bring the wax to a boil.

1- Melt the stearyl alcohol and white wax together in a beaker

2- Add the cholesterol and stir until completely dissolved (Bulk A)

3- Melt The white petrolatum in a mortar (Bulk B)

3. Add Bulk A to bulk B and mix using mortar and pestle until the base begins to congeal

NOTES:
· Adding Water
· 1- When the base begins to congeal add 50 ml water slowly while mixing until all the
water is absorbed.

·
 Emulsion Bases O/W Type

e.g. Vanishing Cream

Prepare the vanishing cream as follow:

Stearic acid 18.0 g

Potassium hydroxide 0.80 g
Gycerin 5.0 g 1- Melt the stearic acid in a seperat beaker.
Methylparaben 0.020 g
Propylparaben 0.010 g 2- The remaining ingredients are dissolved in the water at
Purified water 76.0 g 75 °C.
to make: 100
3- Discontinue heating. The aqueous solution is added to
the oil phase with agitation.

4- Allow to cool, and stir until congealed.

Q1. State the function of each ingredient

Thank You