DRUG NAME MODE OF ACTION INDICATION / ADVERSE EFFECT NURSING RESPONSIBILITIES

CONTRAINDICATION

GENERIC: INDICATIONs: CNS: Dx:

Thioridazine Typical antipsychotics, Major depressive disorder. Panic Drowsiness, Nocturnal confusion, a. Assess for px need of drug.
BRAND: including thioridazine, work to disorder. Obsessive-compulsive disorder hyperactivity, lethargy, psychotic b. have a baseline ECG performed
Mellaril, Mellaril-S treat psychosis by blocking (OCD). Post-traumatic stress disorder reactions, restlessness, and headache and serum potassium levels
CLASS: dopamine (DA) receptors. (PTSD). Social anxiety disorder AUTO NS: measured.
Phenothiazines These medications are effective (SOCIAL PHOBIA). Premenstrual Dryness of mouth, blurred vision, c. Assess baseline mental status
DOSAGE: in treating the positive dysphoric disorder (PMDD) constipation, nausea, vomiting, Tx:
tablet symptoms of schizophrenia, diarrhea, nasal stuffiness, and pallor. a. Monitor for warning signs like
10mg such as hallucinations, CONTRAINDICATION: ENDO S: hypotension that may lead to
25mg delusions, and disorganization. Hypersensitivity; concurrent use of Galactorrhea, breast engorgement, cardiac arrest.
50mg MAO-like drugs (linezolid or methylene amenorrhea, inhibition of ejaculation, b. Serum potassium should be
100mg SOURCE:
https://www.ncbi.nlm.nih.gov/books/NBK459140/#:~:text=3%5D%5B4%5D-,Mechanism%20of
blue); concurrent use of pimozide; oral and peripheral edema. normalized before initiating
ROUTE: %20Action,hallucinations%2C%20delusions%2C%20and%20disorganization.
concentrate contains alcohol; avoid DERM: treatment and patients with a QTc
ORAL patients with known intolerance. Dermatitis and skin eruptions of the interval greater than 450 msec
urticarial type have been observed should not receive thioridazine
DRUG TO DRUG INTERACTION: infrequently. Photosensitivity is treatment.
extremely rare. c. Perform a thorough physical
CVS: assessment to establish baseline
DRUG TO FOOD INTERACTION: Thioridazine produces a dose related data before drug therapy begins,
_________________ prolongation of the QTc interval, which to determine the effectiveness of
is associated with the ability to cause therapy.
torsade de pointes-type arrhythmias, a d. Monitor for adverse effects.
potentially fatal polymorphic e. periodically monitor ECG's and
ventricular tachycardia. Both torsade de serum potassium during
pointes-type arrhythmias and sudden thioridazine treatment, especially
death have been reported in association during a period of dose
with thioridazine. A causal relationship adjustment.
between these events and thioridazine f. Patients taking thioridazine who
therapy has not been established but, experience symptoms that may be
given the ability of thioridazine to associated with the occurrence of
prolong the QTc interval, such a torsade de pointes (e.g., dizziness,
relationship is possible. Other ECG palpitations, or syncope) may
changes have been reported warrant further cardiac
Allergic Reactions: evaluation; in particular, Holter
Fever, laryngeal edema, angioneurotic monitoring should be considered
edema, asthma. EDx:

a. Caution patient that drowsiness or

dizziness may occur.
b. Instruct pt. SO to report diarrhea,
nausea, drowsiness, dizziness, or
persistent headache.
c. Educate client and subjective
others on drug therapy to promote
compliance.
d. Ensure the patient took the
medication as prescribed.