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  • First Generation Agents Self-Injectables Drug Brand Name MOA

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    Asma Alfaouri
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    This document summarizes first generation disease-modifying therapies for multiple sclerosis, including self-injectable drugs and intravenous infusions. It lists the brand names, mechanisms of action, dosages, indications, side effects, monitoring requirements, and comments for interferon-betas, glatiramer acetate, and mitoxantrone. The therapies work by suppressing inflammation, activating lymphocytes, or suppressing immune cell proliferation and are used to treat relapsing-remitting MS. Common side effects include flu-like symptoms, injection site reactions, and potential bone marrow suppression or cardiotoxicity depending on the drug.

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    This document summarizes first generation disease-modifying therapies for multiple sclerosis, including self-injectable drugs and intravenous infusions. It lists the brand names, mechanisms of action, dosages, indications, side effects, monitoring requirements, and comments for interferon-betas, glatiramer acetate, and mitoxantrone. The therapies work by suppressing inflammation, activating lymphocytes, or suppressing immune cell proliferation and are used to treat relapsing-remitting MS. Common side effects include flu-like symptoms, injection site reactions, and potential bone marrow suppression or cardiotoxicity depending on the drug.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    5 views1 page

    First Generation Agents Self-Injectables Drug Brand Name MOA

    Uploaded by

    Asma Alfaouri
    This document summarizes first generation disease-modifying therapies for multiple sclerosis, including self-injectable drugs and intravenous infusions. It lists the brand names, mechanisms of action, dosages, indications, side effects, monitoring requirements, and comments for interferon-betas, glatiramer acetate, and mitoxantrone. The therapies work by suppressing inflammation, activating lymphocytes, or suppressing immune cell proliferation and are used to treat relapsing-remitting MS. Common side effects include flu-like symptoms, injection site reactions, and potential bone marrow suppression or cardiotoxicity depending on the drug.

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    of 1

    First

    generation agents
    Self-injectables
    Drug Interferon-beta 1a Interferon-beta Pegylated Glatiramer acetate
    1b Interferon-beta
    Brand Avonex , Rebif Betaseron,extavia plegrid Copaxone ,Glatopa
    name
    MOA Suppresses expression of inflammatory cytokines and increases of Activates T lymphocytes suppress cell
    anti-inflammatory cytokines

    DOSE IM:30 mcg once/wk SC:0.0625-0.25 SC: 125mcg SC: 20 mg once daily/ 40 mg 3x/wk
    SC:125 every other wk mg every other every other wk
    day
    Indication RFMS
    SE depression, flu-like symptoms, leukopenia, injection site reactions. Immediate Post-Injection Reaction
    chest tightness, flushing, and dyspnea beginning
    Monitor Electrolytes ,CBC, LFTs, thyroid function, depression MRI, tissue necrosis, Post-Injection Reaction
    Comment Avoid use in untreated severe depression
    IV infusion
    Drug mitoxantrone
    Brand Novantrone
    name
    MOA Suppresses proliferation of T cell , B cell, and macrophages
    Dose IV:12 mg/m2 q3m to lifetime max of 140mg/m2
    Indication SPMS, PRMS and worsening RRMS
    SE Bone marrow suppression, neutropenia, cardiotoxicity, AML ,N/V , diarrhea , alopecia
    Monitor CBC, ECG, LVEF, LEFs
    Comment D/c due to risk of PML

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