IRBESARTAN MURNI

Persamaan Regresi y = 0,0459x - 0,0107

PENGULANGAN 1
5' 10' 15' 20' 30' 45'
y = 0.2686 y = 0.4302 y = 0.6572 y = 0.6754 y = 0.7027 y = 0.7558
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 6.0824 µg/ml x = 9.6008 µg/ml x = 14.5431 µg/ml x = 14.9394 µg/ml x = 15.5337 µg/ml x = 16.6899 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 36.4944 mg c = 57.6048 mg c = 87.2587 mg c = 89.6362 mg c = 93.2025 mg c = 100.1391 mg
% td = 36.4944 % fk = 0.4055 mg fk = 0.6401 mg fk = 0.9695 mg fk = 0.9960 mg fk = 1.0356 mg
ksk = 58.0103 mg ksk = 87.8987 mg ksk = 90.6057 mg ksk = 94.1984 mg ksk = 101.1747 mg
% td = 58.0103 % % td = 87.8987 % % td = 90.6057 % % td = 94.1984 % % td = 101.1747 %

PENGULANGAN 2
5' 10' 15' 20' 30' 45'
y = 0.3026 y = 0.4917 y = 0.6488 y = 0.6808 y = 0.7583 y = 0.7682
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 6.8227 µg/ml x = 10.9398 µg/ml x = 14.3602 µg/ml x = 15.0569 µg/ml x = 16.7443 µg/ml x = 16.9598 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 40.9360 mg c = 65.6388 mg c = 86.1613 mg c = 90.3416 mg c = 100.4657 mg c = 101.7590 mg
% td = 40.9360 % fk = 0.4548 mg fk = 0.7293 mg fk = 0.9573 mg fk = 1.0038 mg fk = 1.1163 mg
ksk = 66.0936 mg ksk = 86.8907 mg ksk = 91.2990 mg ksk = 101.4695 mg ksk = 102.8753 mg
% td = 66.0936 % % td = 86.8907 % % td = 91.2990 % % td = 101.4695 % % td = 102.8753 %

PENGULANGAN 3
5' 10' 15' 20' 30' 45'
y = 0.3761 y = 0.5813 y = 0.7084 y = 0.7384 y = 0.7498 y = 0.7627
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 8.4229 µg/ml x = 12.8906 µg/ml x = 15.6578 µg/ml x = 16.3110 µg/ml x = 16.5592 µg/ml x = 16.8401 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 50.5376 mg c = 77.3436 mg c = 93.9471 mg c = 97.8661 mg c = 99.3553 mg c = 101.0405 mg
% td = 50.5376 % fk = 0.5615 mg fk = 0.8594 mg fk = 1.0439 mg fk = 1.0874 mg fk = 1.1039 mg
ksk = 77.9051 mg ksk = 94.8065 mg ksk = 98.9100 mg ksk = 100.4427 mg ksk = 102.1444 mg
 % td = 77.9051 % % td = 94.8065 % % td = 98.9100 % % td = 100.4427 % % td = 102.1444 %

SISTEM BINER

PENGULANGAN 1
5' 10' 15' 20' 30' 45'
y = 0.5897 y = 0.5999 y = 0.6018 y = 0.6069 y = 0.6415 y = 0.5829
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 13.0735 µg/ml x = 13.2956 µg/ml x = 13.3369 µg/ml x = 13.4480 µg/ml x = 14.2013 µg/ml x = 12.9254 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 78.4409 mg c = 79.7734 mg c = 80.0216 mg c = 80.6878 mg c = 85.2077 mg c = 77.5526 mg
% td = 78.4409 % fk = 0.8716 mg fk = 0.8864 mg fk = 0.8891 mg fk = 0.8965 mg fk = 0.9468 mg
ksk = 80.6449 mg ksk = 80.9079 mg ksk = 81.5769 mg ksk = 86.1042 mg ksk = 78.4993 mg
% td = 80.6449 % % td = 80.9079 % % td = 81.5769 % % td = 86.1042 % % td = 78.4993 %

PENGULANGAN 2
5' 10' 15' 20' 30' 45'
y = 0.5062 y = 0.6069 y = 0.6125 y = 0.6128 y = 0.6310 y = 0.5907
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 11.2555 µg/ml x = 13.4480 µg/ml x = 13.5699 µg/ml x = 13.5764 µg/ml x = 13.9727 µg/ml x = 13.0953 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 67.5330 mg c = 80.6878 mg c = 81.4193 mg c = 81.4585 mg c = 83.8361 mg c = 78.5715 mg
% td = 67.5330 % fk = 0.7504 mg fk = 0.8965 mg fk = 0.9047 mg fk = 0.9051 mg fk = 0.9315 mg
ksk = 81.4382 mg ksk = 82.3159 mg ksk = 82.3632 mg ksk = 84.7411 mg ksk = 79.5030 mg
% td = 81.4382 % % td = 82.3159 % % td = 82.3632 % % td = 84.7411 % % td = 79.5030 %

PENGULANGAN 3
5' 10' 15' 20' 30' 45'
y = 0.5612 y = 0.5745 y = 0.6099 y = 0.6201 y = 0.6287 y = 0.5878
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 12.4530 µg/ml x = 12.7425 µg/ml x = 13.5133 µg/ml x = 13.7354 µg/ml x = 13.9226 µg/ml x = 13.0321 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 74.7178 mg c = 76.4553 mg c = 81.0797 mg c = 82.4121 mg c = 83.5356 mg c = 78.1927 mg
% td = 74.7178 % fk = 0.8302 mg fk = 0.8495 mg fk = 0.9009 mg fk = 0.9157 mg fk = 0.9282 mg
 ksk = 77.2855 mg ksk = 81.9292 mg ksk = 83.3130 mg ksk = 84.4513 mg ksk = 79.1209 mg
% td = 77.2855 % % td = 81.9292 % % td = 83.3130 % % td = 84.4513 % % td = 79.1209 %

CAMPURAN FISIK

PENGULANGAN 1
5' 10' 15' 20' 30' 45'
y = 0.3394 y = 0.4941 y = 0.5403 y = 0.5803 y = 0.6445 y = 0.5490
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 7.6239 µg/ml x = 10.9921 µg/ml x = 11.9979 µg/ml x = 12.8688 µg/ml x = 14.2666 µg/ml x = 12.1874 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 45.7433 mg c = 65.9523 mg c = 71.9876 mg c = 77.2129 mg c = 85.5996 mg c = 73.1241 mg
% td = 45.7433 % fk = 0.5083 mg fk = 0.7328 mg fk = 0.7999 mg fk = 0.8579 mg fk = 0.9511 mg
ksk = 66.4606 mg ksk = 72.7204 mg ksk = 78.0128 mg ksk = 86.4575 mg ksk = 74.0752 mg
% td = 66.4606 % % td = 72.7204 % % td = 78.0128 % % td = 86.4575 % % td = 74.0752 %

5' 10' 15' 20' 30' 45'

y = 0.3376 y = 0.5170 y = 0.5878 y = 0.6121 y = 0.6384 y = 0.5674
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 7.5847 µg/ml x = 11.4906 µg/ml x = 13.0321 µg/ml x = 13.5612 µg/ml x = 14.1338 µg/ml x = 12.5880 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 45.5082 mg c = 68.9438 mg c = 78.1927 mg c = 81.3671 mg c = 84.8027 mg c = 75.5278 mg
% td = 45.5082 % fk = 0.5056 mg fk = 0.7660 mg fk = 0.8688 mg fk = 0.9041 mg fk = 0.9423 mg
ksk = 69.4495 mg ksk = 78.9587 mg ksk = 82.2359 mg ksk = 85.7068 mg ksk = 76.4700 mg
% td = 69.4495 % % td = 78.9587 % % td = 82.2359 % % td = 85.7068 % % td = 76.4700 %

5' 10' 15' 20' 30' 45'

y = 0.3523 y = 0.4182 y = 0.5626 y = 0.5958 y = 0.6502 y = 0.5693
a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459 a = 0.0459
b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108 b = 0.0108
x = 7.9047 µg/ml x = 9.3395 µg/ml x = 12.4835 µg/ml x = 13.2063 µg/ml x = 14.3907 µg/ml x = 12.6293 µg/ml
fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667 fp = 6.6667
c = 47.4285 mg c = 56.0372 mg c = 74.9007 mg c = 79.2378 mg c = 86.3442 mg c = 75.7760 mg
% td = 47.4285 % fk = 0.5270 mg fk = 0.6226 mg fk = 0.8322 mg fk = 0.8804 mg fk = 0.9594 mg
 ksk = 56.5642 mg ksk = 75.5234 mg ksk = 80.0700 mg ksk = 87.2246 mg ksk = 76.7353 mg
% td = 56.5642 % % td = 75.5234 % % td = 80.0700 % % td = 87.2246 % % td = 76.7353 %
 Nilai Efisiensi Disolusi Rata-rata
Nama Rata-rata % Terdisolusi
Pengulangan 1 Pengulangan 2 Pengulangan 3 0 5 10 15 20 30
Irbesartan IRB 0 42.6560 67.3364 89.8653 93.6049 98.7036
Sistem Biner SB 0 73.5639 79.7895 81.7177 82.4177 85.0989
Campuran Fisik CF 0 46.2266 64.1581 75.7342 80.1062 86.4630

Kurva Profil Disolusi

120

100

80

% Terdisolusi
IRB
60 SB
CF
40

20

0
0 5 10 15 20 25 30 35 40 45 50
Waktu (menit)
 Nilai Efisiensi Disolusi
Nama Rata-rata
Pengulangan 1 Pengulangan 2 Pengulangan 3
Irbesartan
Sistem Biner
Campuran Fisik
 45
102.0648
79.0411
75.7602