Two Way Repeated Measures ANOVA (One Factor Repetition) martes, noviembre 15, 2022, 10:16:28

p. m.

Data source: RESPIRACIÓN in ANOVA CARDIACA Y RESPIRATORIA

General Linear Model

Dependent Variable: DATOS

Normality Test (Shapiro-Wilk) Failed (P < 0.050)

Equal Variance Test: Passed (P = 0.299)

Source of Variation DF SS MS F P
TRATAMIENTO 2 9247.427 4623.714 13.292 0.004
SUJETO (TRATAMIENTO) 7 2473.077 353.297
TIEMPO 8 614.268 76.783 1.688 0.125
TRATAMIENTO x TIEMPO16 5479.144 342.446 7.529 <0.001
Residual 50 2274.256 45.485
Total 83 19775.238 238.256

Main effects cannot be properly interpreted if significant interaction is determined. This is because the size
of a factor's effect depends upon the level of the other factor.

The effect of different levels of TRATAMIENTO depends on what level of TIEMPO is present. There is a
statistically significant interaction between TRATAMIENTO and TIEMPO. (P = <0.001)

Power of performed test with alpha = 0.0500: for TRATAMIENTO : 0.952

Power of performed test with alpha = 0.0500: for TIEMPO : 0.278
Power of performed test with alpha = 0.0500: for TRATAMIENTO x TIEMPO : 1.000

Expected Mean Squares:

Approximate DF Residual for TRATAMIENTO = 7.032

Expected MS(TRATAMIENTO) = var(res) + 8.143 var(SUJETO (TRATAMIENTO)) +

var(TRATAMIENTO)
Expected MS(SUJETO (TRATAMIENTO)) = var(res) + 7.999 var(SUJETO (TRATAMIENTO))
Expected MS(TIEMPO) = var(res) + var(TIEMPO)
Expected MS(TRATAMIENTO x TIEMPO) = var(res) + var(TRATAMIENTO x TIEMPO)
Expected MS(Residual) = var(res)

Least square means for TRATAMIENTO :

Group Mean SEM
SSS 56.293 3.526
ISOPROTERENOL76.667 3.617
PILOCARPINA 51.683 3.867

Least square means for TIEMPO :

Group Mean SEM
-1.000 64.194 2.152
0.000 64.750 2.152
3.000 65.167 2.152
6.000 63.306 2.152
9.000 62.194 2.152
12.000 58.122 2.267
15.000 59.900 2.267
18.000 58.702 2.470
21.000 57.590 2.470

Least square means for TRATAMIENTO x TIEMPO :

Group Mean SEM
SSS x -1.000 67.250 3.372
SSS x 0.000 63.250 3.372
SSS x 3.000 61.500 3.372
SSS x 6.000 56.250 3.372
SSS x 9.000 55.250 3.372
SSS x 12.000 48.033 3.990
SSS x 15.000 52.033 3.990
SSS x 18.000 52.367 3.990
SSS x 21.000 50.700 3.990
ISOPROTERENOL x -1.000 62.000 3.894
ISOPROTERENOL x 0.000 63.667 3.894
ISOPROTERENOL x 3.000 72.000 3.894
ISOPROTERENOL x 6.000 74.667 3.894
ISOPROTERENOL x 9.000 79.333 3.894
ISOPROTERENOL x 12.000 80.333 3.894
ISOPROTERENOL x 15.000 84.333 3.894
ISOPROTERENOL x 18.000 85.667 3.894
ISOPROTERENOL x 21.000 88.000 3.894
PILOCARPINA x -1.000 63.333 3.894
PILOCARPINA x 0.000 67.333 3.894
PILOCARPINA x 3.000 62.000 3.894
PILOCARPINA x 6.000 59.000 3.894
PILOCARPINA x 9.000 52.000 3.894
PILOCARPINA x 12.000 46.000 3.894
PILOCARPINA x 15.000 43.333 3.894
PILOCARPINA x 18.000 38.071 4.881
PILOCARPINA x 21.000 34.071 4.881

All Pairwise Multiple Comparison Procedures (Student-Newman-Keuls Method) :

Comparisons for factor: TRATAMIENTO

Comparison Diff of Means p q P P<0.050
ISOPROTERENOL vs. PILOCARPINA 24.984 3 6.673 0.005 Yes
ISOPROTERENOL vs. SSS 20.374 2 5.704 0.005 Yes
SSS vs. PILOCARPINA 4.610 2 1.246 0.408 No

Comparisons for factor: TIEMPO

Comparison Diff of Means p q P P<0.050
3.000 vs. 21.000 7.576 9 3.270 0.355 No
3.000 vs. 12.000 7.044 8 3.187 0.339 Do Not Test
3.000 vs. 18.000 6.465 7 2.791 0.444 Do Not Test
3.000 vs. 15.000 5.267 6 2.383 0.548 Do Not Test
3.000 vs. 9.000 2.972 5 1.381 0.865 Do Not Test
3.000 vs. 6.000 1.861 4 0.865 0.928 Do Not Test
3.000 vs. -1.000 0.972 3 0.452 0.945 Do Not Test
3.000 vs. 0.000 0.417 2 0.194 0.892 Do Not Test
0.000 vs. 21.000 7.160 8 3.090 0.378 Do Not Test
0.000 vs. 12.000 6.628 7 2.999 0.357 Do Not Test
0.000 vs. 18.000 6.048 6 2.611 0.447 Do Not Test
0.000 vs. 15.000 4.850 5 2.194 0.535 Do Not Test
0.000 vs. 9.000 2.556 4 1.187 0.835 Do Not Test
0.000 vs. 6.000 1.444 3 0.671 0.884 Do Not Test
0.000 vs. -1.000 0.556 2 0.258 0.856 Do Not Test
-1.000 vs. 21.000 6.604 7 2.851 0.418 Do Not Test
-1.000 vs. 12.000 6.072 6 2.747 0.389 Do Not Test
-1.000 vs. 18.000 5.493 5 2.371 0.457 Do Not Test
-1.000 vs. 15.000 4.294 4 1.943 0.521 Do Not Test
-1.000 vs. 9.000 2.000 3 0.929 0.789 Do Not Test
-1.000 vs. 6.000 0.889 2 0.413 0.772 Do Not Test
6.000 vs. 21.000 5.715 6 2.467 0.510 Do Not Test
6.000 vs. 12.000 5.183 5 2.345 0.469 Do Not Test
6.000 vs. 18.000 4.604 4 1.987 0.502 Do Not Test
6.000 vs. 15.000 3.406 3 1.541 0.525 Do Not Test
6.000 vs. 9.000 1.111 2 0.516 0.717 Do Not Test
9.000 vs. 21.000 4.604 5 1.987 0.627 Do Not Test
9.000 vs. 12.000 4.072 4 1.842 0.566 Do Not Test
9.000 vs. 18.000 3.493 3 1.508 0.539 Do Not Test
9.000 vs. 15.000 2.294 2 1.038 0.466 Do Not Test
15.000 vs. 21.000 2.310 4 0.974 0.901 Do Not Test
15.000 vs. 12.000 1.778 3 0.784 0.845 Do Not Test
15.000 vs. 18.000 1.198 2 0.506 0.722 Do Not Test
18.000 vs. 21.000 1.111 3 0.450 0.946 Do Not Test
18.000 vs. 12.000 0.579 2 0.244 0.864 Do Not Test
12.000 vs. 21.000 0.532 2 0.224 0.875 Do Not Test

Comparisons for factor: TIEMPO within SSS

Comparison Diff of Means p q P P<0.05
-1.000 vs. 12.000 19.217 9 5.202 0.015 Yes
-1.000 vs. 21.000 16.550 8 4.480 0.049 Yes
-1.000 vs. 15.000 15.217 7 4.119 0.074 No
-1.000 vs. 18.000 14.883 6 4.029 0.066 Do Not Test
-1.000 vs. 9.000 12.000 5 3.559 0.103 Do Not Test
-1.000 vs. 6.000 11.000 4 3.262 0.110 Do Not Test
-1.000 vs. 3.000 5.750 3 1.705 0.455 Do Not Test
-1.000 vs. 0.000 4.000 2 1.186 0.406 Do Not Test
0.000 vs. 12.000 15.217 8 4.119 0.092 No
0.000 vs. 21.000 12.550 7 3.397 0.219 Do Not Test
0.000 vs. 15.000 11.217 6 3.036 0.281 Do Not Test
0.000 vs. 18.000 10.883 5 2.946 0.243 Do Not Test
0.000 vs. 9.000 8.000 4 2.372 0.346 Do Not Test
0.000 vs. 6.000 7.000 3 2.076 0.315 Do Not Test
0.000 vs. 3.000 1.750 2 0.519 0.715 Do Not Test
3.000 vs. 12.000 13.467 7 3.646 0.155 Do Not Test
3.000 vs. 21.000 10.800 6 2.924 0.321 Do Not Test
3.000 vs. 15.000 9.467 5 2.563 0.378 Do Not Test
3.000 vs. 18.000 9.133 4 2.472 0.310 Do Not Test
3.000 vs. 9.000 6.250 3 1.853 0.396 Do Not Test
3.000 vs. 6.000 5.250 2 1.557 0.276 Do Not Test
6.000 vs. 12.000 8.217 6 2.224 0.620 Do Not Test
6.000 vs. 21.000 5.550 5 1.502 0.825 Do Not Test
6.000 vs. 15.000 4.217 4 1.141 0.851 Do Not Test
6.000 vs. 18.000 3.883 3 1.051 0.739 Do Not Test
6.000 vs. 9.000 1.000 2 0.297 0.835 Do Not Test
9.000 vs. 12.000 7.217 5 1.954 0.642 Do Not Test
9.000 vs. 21.000 4.550 4 1.232 0.820 Do Not Test
9.000 vs. 15.000 3.217 3 0.871 0.812 Do Not Test
9.000 vs. 18.000 2.883 2 0.781 0.584 Do Not Test
18.000 vs. 12.000 4.333 4 1.086 0.869 Do Not Test
18.000 vs. 21.000 1.667 3 0.418 0.953 Do Not Test
18.000 vs. 15.000 0.333 2 0.0835 0.953 Do Not Test
15.000 vs. 12.000 4.000 3 1.003 0.759 Do Not Test
15.000 vs. 21.000 1.333 2 0.334 0.814 Do Not Test
21.000 vs. 12.000 2.667 2 0.668 0.639 Do Not Test

Comparisons for factor: TIEMPO within ISOPROTERENOL

Comparison Diff of Means p q P P<0.05
21.000 vs. -1.000 26.000 9 6.677 <0.001 Yes
21.000 vs. 0.000 24.333 8 6.249 0.001 Yes
21.000 vs. 3.000 16.000 7 4.109 0.075 No
21.000 vs. 6.000 13.333 6 3.424 0.169 Do Not Test
21.000 vs. 9.000 8.667 5 2.226 0.521 Do Not Test
21.000 vs. 12.000 7.667 4 1.969 0.510 Do Not Test
21.000 vs. 15.000 3.667 3 0.942 0.784 Do Not Test
21.000 vs. 18.000 2.333 2 0.599 0.674 Do Not Test
18.000 vs. -1.000 23.667 8 6.078 0.002 Yes
18.000 vs. 0.000 22.000 7 5.650 0.004 Yes
18.000 vs. 3.000 13.667 6 3.510 0.149 Do Not Test
18.000 vs. 6.000 11.000 5 2.825 0.282 Do Not Test
18.000 vs. 9.000 6.333 4 1.627 0.661 Do Not Test
18.000 vs. 12.000 5.333 3 1.370 0.600 Do Not Test
18.000 vs. 15.000 1.333 2 0.342 0.810 Do Not Test
15.000 vs. -1.000 22.333 7 5.736 0.003 Yes
15.000 vs. 0.000 20.667 6 5.308 0.006 Yes
15.000 vs. 3.000 12.333 5 3.167 0.182 Do Not Test
15.000 vs. 6.000 9.667 4 2.483 0.307 Do Not Test
15.000 vs. 9.000 5.000 3 1.284 0.638 Do Not Test
15.000 vs. 12.000 4.000 2 1.027 0.471 Do Not Test
12.000 vs. -1.000 18.333 6 4.708 0.019 Yes
12.000 vs. 0.000 16.667 5 4.280 0.031 Yes
12.000 vs. 3.000 8.333 4 2.140 0.437 Do Not Test
12.000 vs. 6.000 5.667 3 1.455 0.562 Do Not Test
12.000 vs. 9.000 1.000 2 0.257 0.857 Do Not Test
9.000 vs. -1.000 17.333 5 4.452 0.022 Yes
9.000 vs. 0.000 15.667 4 4.023 0.032 Yes
9.000 vs. 3.000 7.333 3 1.883 0.385 Do Not Test
9.000 vs. 6.000 4.667 2 1.198 0.401 Do Not Test
6.000 vs. -1.000 12.667 4 3.253 0.112 No
6.000 vs. 0.000 11.000 3 2.825 0.123 Do Not Test
6.000 vs. 3.000 2.667 2 0.685 0.630 Do Not Test
3.000 vs. -1.000 10.000 3 2.568 0.175 Do Not Test
3.000 vs. 0.000 8.333 2 2.140 0.137 Do Not Test
0.000 vs. -1.000 1.667 2 0.428 0.764 Do Not Test
Comparisons for factor: TIEMPO within PILOCARPINA
Comparison Diff of Means p q P P<0.05
0.000 vs. 21.000 33.262 9 7.534 <0.001 Yes
0.000 vs. 18.000 29.262 8 6.628 <0.001 Yes
0.000 vs. 15.000 24.000 7 6.164 0.001 Yes
0.000 vs. 12.000 21.333 6 5.479 0.004 Yes
0.000 vs. 9.000 15.333 5 3.938 0.056 No
0.000 vs. 6.000 8.333 4 2.140 0.437 Do Not Test
0.000 vs. 3.000 5.333 3 1.370 0.600 Do Not Test
0.000 vs. -1.000 4.000 2 1.027 0.471 Do Not Test
-1.000 vs. 21.000 29.262 8 6.628 <0.001 Yes
-1.000 vs. 18.000 25.262 7 5.722 0.003 Yes
-1.000 vs. 15.000 20.000 6 5.136 0.008 Yes
-1.000 vs. 12.000 17.333 5 4.452 0.022 Yes
-1.000 vs. 9.000 11.333 4 2.911 0.181 Do Not Test
-1.000 vs. 6.000 4.333 3 1.113 0.713 Do Not Test
-1.000 vs. 3.000 1.333 2 0.342 0.810 Do Not Test
3.000 vs. 21.000 27.929 7 6.326 <0.001 Yes
3.000 vs. 18.000 23.929 6 5.420 0.005 Yes
3.000 vs. 15.000 18.667 5 4.794 0.012 Yes
3.000 vs. 12.000 16.000 4 4.109 0.027 Yes
3.000 vs. 9.000 10.000 3 2.568 0.175 Do Not Test
3.000 vs. 6.000 3.000 2 0.770 0.588 Do Not Test
6.000 vs. 21.000 24.929 6 5.646 0.003 Yes
6.000 vs. 18.000 20.929 5 4.740 0.013 Yes
6.000 vs. 15.000 15.667 4 4.023 0.032 Yes
6.000 vs. 12.000 13.000 3 3.339 0.057 No
6.000 vs. 9.000 7.000 2 1.798 0.210 Do Not Test
9.000 vs. 21.000 17.929 5 4.061 0.045 Yes
9.000 vs. 18.000 13.929 4 3.155 0.129 No
9.000 vs. 15.000 8.667 3 2.226 0.266 Do Not Test
9.000 vs. 12.000 6.000 2 1.541 0.281 Do Not Test
12.000 vs. 21.000 11.929 4 2.702 0.237 No
12.000 vs. 18.000 7.929 3 1.796 0.419 Do Not Test
12.000 vs. 15.000 2.667 2 0.685 0.630 Do Not Test
15.000 vs. 21.000 9.262 3 2.098 0.308 Do Not Test
15.000 vs. 18.000 5.262 2 1.192 0.404 Do Not Test
18.000 vs. 21.000 4.000 2 0.819 0.565 Do Not Test

Comparisons for factor: TRATAMIENTO within -1

Comparison Diff of Means p q P P<0.05
SSS vs. ISOPROTERENOL 5.250 3 1.065 0.735 No
SSS vs. PILOCARPINA 3.917 2 0.795 0.580 Do Not Test
PILOCARPINA vs. ISOPROTERENOL 1.333 2 0.253 0.860 Do Not Test

Comparisons for factor: TRATAMIENTO within 0

Comparison Diff of Means p q P P<0.05
PILOCARPINA vs. SSS 4.083 3 0.828 0.829 No
PILOCARPINA vs. ISOPROTERENOL 3.667 2 0.696 0.627 Do Not Test
ISOPROTERENOL vs. SSS 0.417 2 0.0845 0.953 Do Not Test

Comparisons for factor: TRATAMIENTO within 3

Comparison Diff of Means p q P P<0.05
ISOPROTERENOL vs. SSS 10.500 3 2.130 0.307 No
ISOPROTERENOL vs. PILOCARPINA 10.000 2 1.898 0.193 Do Not Test
PILOCARPINA vs. SSS 0.500 2 0.101 0.944 Do Not Test

Comparisons for factor: TRATAMIENTO within 6

Comparison Diff of Means p q P P<0.05
ISOPROTERENOL vs. SSS 18.417 3 3.737 0.037 Yes
ISOPROTERENOL vs. PILOCARPINA 15.667 2 2.973 0.047 Yes
PILOCARPINA vs. SSS 2.750 2 0.558 0.697 No

Comparisons for factor: TRATAMIENTO within 9

Comparison Diff of Means p q P P<0.05
ISOPROTERENOL vs. PILOCARPINA 27.333 3 5.188 0.004 Yes
ISOPROTERENOL vs. SSS 24.083 2 4.886 0.002 Yes
SSS vs. PILOCARPINA 3.250 2 0.659 0.646 No

Comparisons for factor: TRATAMIENTO within 12

Comparison Diff of Means p q P P<0.05
ISOPROTERENOL vs. PILOCARPINA 34.333 3 6.516 <0.001 Yes
ISOPROTERENOL vs. SSS 32.300 2 6.055 <0.001 Yes
SSS vs. PILOCARPINA 2.033 2 0.381 0.790 No

Comparisons for factor: TRATAMIENTO within 15

Comparison Diff of Means p q P P<0.05
ISOPROTERENOL vs. PILOCARPINA 41.000 3 7.781 <0.001 Yes
ISOPROTERENOL vs. SSS 32.300 2 6.055 <0.001 Yes
SSS vs. PILOCARPINA 8.700 2 1.631 0.261 No

Comparisons for factor: TRATAMIENTO within 18

Comparison Diff of Means p q P P<0.05
ISOPROTERENOL vs. PILOCARPINA 47.595 3 7.966 <0.001 Yes
ISOPROTERENOL vs. SSS 33.300 2 6.242 <0.001 Yes
SSS vs. PILOCARPINA 14.295 2 2.370 0.107 No

Comparisons for factor: TRATAMIENTO within 21

Comparison Diff of Means p q P P<0.05
ISOPROTERENOL vs. PILOCARPINA 53.929 3 9.027 <0.001 Yes
ISOPROTERENOL vs. SSS 37.300 2 6.992 <0.001 Yes
SSS vs. PILOCARPINA 16.629 2 2.757 0.064 No

A result of "Do Not Test" occurs for a comparison when no significant difference is found between two
means that enclose that comparison. For example, if you had four means sorted in order, and found no
difference between means 4 vs. 2, then you would not test 4 vs. 3 and 3 vs. 2, but still test 4 vs. 1 and 3 vs. 1
(4 vs. 3 and 3 vs. 2 are enclosed by 4 vs. 2: 4 3 2 1). Note that not testing the enclosed means is a
procedural rule, and a result of Do Not Test should be treated as if there is no significant difference between
the means, even though one may appear to exist.