CURCUMIN EXTRACTION

[EIRI/EDPR/3689] J.C.: 1776

INTRODUCTION

Curcumin is the main active ingredients in Turmeric. Curcumin is primarily used

as a cholinergic and used to improve joint health. Curcumin synergizes
particularly well with piperine, greatly increasing its bioavailability. Curcumin
supplements can reduce age related memory loss by inhibiting the buildup of beta
amyloid, a peptide commonly found in age related degenerative diseases of the
brain. Curcumin Induces flow of bile which breaks down fat, keeps heart healthy
by normalizing cholesterol level. Curcumin is helpful in digestive support and
arthritis pain relief.

Curcumin (synonyms: turmeric yellow, kurkum, INS No. 100(i)) is an orange-

yellow crystalline powder. Minor amounts of oils and resins naturally occurring in
turmeric may be present.

The origin of the plant Curcuma longa L., which belongs to Zingiberaceae family is
India. The plant is distributed throughout tropical and subtropical regions of the
world, being widely cultivated in southeast Asian countries. Turmeric, i.e., the
ground rhizomes of Curcuma longa L., has a long history of use in food as a spice,
mainly as an ingredient in many varieties of curry powders and sauces, where
curcumin from turmeric is a main colouring substance.

The turmeric (Curcuma longa) plant, a perennial herb belonging to the ginger
family, is cultivated extensively in south and southeast tropical Asia. The rhizome
of this plant is also referred to as the ―root and is the most useful part of the
plant for culinary and medicinal purposes. The most active component of turmeric
is curcumin, which makes up 2 to 5% of the spice.

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The characteristic yellow color of turmeric is due to the curcuminoids, first
isolated by Vogel in 1842. Curcumin is an orange–yellow crystalline powder
practically insoluble in water. The structure of curcumin (C 21 H 20 O 6) was first
described in 1910 by Lampe and Milobedeska and shown to be diferuloylmethane.
Turmeric is used as a dietary spice, coloring agent in foods and textiles, and a
treatment for a wide variety of ailments. It is widely used in traditional Indian
medicine to cure biliary disorders, anorexia, cough, diabetic wounds, hepatic
disorders, rheumatism, and sinusitis. Turmeric paste in slaked lime is a popular
home remedy for the treatment of inflammation and wounds. For centuries,
curcumin has been consumed as a dietary spice at doses up to 100 mg/d.
Extensive investigation over the last five decades has indicated that curcumin
reduces blood cholesterol.

Turmeric was described as C. longa by Linnaeus and its taxonomic position is as

follows:

Class Liliopsida
Subclass Commelinids
Order Zingiberales
Family Zingiberaceae
Genus Curcuma
Species Curcuma longa

The wild turmeric is called C. aromatica and the domestic species is called C.
longa. For the last few decades, extensive work has been done to establish the
biological activities and pharmacological actions of turmeric and its extracts.
Curcumin (diferuloylmethane), the main yellow bioactive component of turmeric
has been shown to have a wide spectrum of biological actions. These include its
anti-inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant,
antifertility, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral,
antifibrotic, antivenom, antiulcer, hypotensive and hypocholesteremic activities.

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Its anticancer effect is mainly mediated through induction of apoptosis. It’s anti-
inflammatory, anticancer and antioxidant roles may be clinically exploited to
control rheumatism, carcinogenesis and oxidative stress-related pathogenesis.
Clinically, curcumin has already been used to reduce post-operative inflammation.
Safety evaluation studies indicate that both turmeric and curcumin are well
tolerated at a very high dose without any toxic effects. Thus, both turmeric and
curcumin have the potential for the development of modern medicine for the
treatment of various diseases.

Turmeric (Curcuma longa) is a native of Asia & India. The tuberous rhizone or
underground steam of turmeric are used from antiquity as condiments. A dye and
as an aromatic stimulants in several medicines. Turmeric is a very important
spice in India, which produces nearly the whole world crop & uses 80% of it
presently. It is cultivated in china, Taiwan, Indonesia, Sri Lanka, Australia, Africa,
Peru & the West Indies. Turmeric uses dates back nearly 4000 years, to the vodic
culture in India, when turmeric was the principal spice & also of religious
significance. It is much reversed by thindus & associated with fertility. In to days
India's, turmeric still added to nearly every dish be it meat or vegetables. Turmeric
has been used in Indian systems of medicine for a long time.

The turmeric has been used in herbal dating from about 600 BC and it also
mentioned by Dioscorides. In malaysia the paste of turmeric is spread on the
mothers abdomen and on the umbilical cord after child Birth. Not only to warm off
one spirits, but also for its medicinal value. Bath the East & West have held its
medicinal properties in high regards. Rhizomes are the used plant port. Fresh
turmeric leaves are used in some regions of Indonesia as flavouring. The rootstick
has aromatic & Spicy pogoonce, which by drying gives way to a more medicinal
Aroma. On storing, the smell rather quickly change to earthy and unpleasant.
Similarly the colour of ground turmeric tends to fade if the spice is trolong. It is
called Indian saffron because of its orange yellow colour. In language the name of
turmeric just mean yellow root, English turmeric derived from the (Now absolute)
french terremerite, probably because ground turmeric resembles mineral pigments
(ochor),. The genus name Curcuma is of the same origin, being a latinization of
Arabic Kurkum meaning saffron.

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 CONTENTS
INTRODUCTION
WHAT IS TURMERIC?
WHAT IS CURCUMIN?
PRODUCT SPECIFICATION
WHAT IS THE HISTORY OF TURMERIC AND CURCUMIN?
ARE THERE ANY SIDE EFFECTS OR INTERACTIONS?
WHY HASN’T THE PHARMACEUTICAL INDUSTRY PATENTED TURMERIC
AND CURCUMIN?
USES AND APPLICATION
IS IS MOSTLY USED IN THE FOLLOWING FIELDS:-
OPPORTUNITY AND RISE OF TURMERIC AND CURCUMIN
PROPERTIES OF CURCUMIN
PRODUCT DETAILS:
PRODUCT SPECIFIC LITERATURE REFERENCE:
GENERAL INFORMATION:
CHEMICAL CHARACTERIZATION OF CURCUMIN
COMPOSITION OF THE FOOD ADDITIVE
PHYSICO-CHEMICAL PROPERTIES
CURCUMIN - THE YELLOW EXTRACT FROM TURMERIC
FIGURE: CURCUMA LONGA (TURMERIC PLANT) WITH ITS RHIZOME OR ROOT
CHEMICAL COMPOSITION OF TURMERIC
BIOLOGICAL ACTIVITY OF TURMERIC AND ITS COMPOUNDS
PHARMACOLOGICAL ACTION OF TURMERIC AND IT’S EXTRACT
FRAGRANCE AND FLAVOUR
RAW MATERIALS SCENARIO (INDIA AND GLOBAL)
INTERNATIONAL SCENARIO
OVERVIEW OF CURCUMIN MARKET
MARKET SURVEY
CURCUMIN MARKET CAN BE SEGMENTED ON THE BASIS OF
THERAPEUTIC APPLICATIONS
PRODUCTION OF CURCUMIN IN INDIA
GLOBAL MARKET POSITION AND DEMAND OF CURCUMIN
U.S. CURCUMIN MARKET, BY APPLICATION, 2016-2024, (TONS)
CURCUMIN MARKET, BY APPLICATION
CURCUMIN MARKET, BY REGION
COMPETITIVE MARKET SHARE
DETAILED EXPORT DATA OF CURCUMIN
PRESENT MANUFACTURERS OF CURCUMIN
PROCESS OUTLINE FOR CURCUMIN EXTRACTION
MANUFACTURING PROCESS OF CURCUMIN
RAW MATERIAL REQUIRED:

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BASIC PLANT AND MACHINERY REQUIRED.
SALIENT FEATURE OF THE PROCESS
MANUFACTURING PROCESS DIAGRAM
BLOCK DIAGRAM FOR CURCUMIN EXTRACTION
TECHNICAL PRINCIPAL OF CURCUMIN EXTRACTION
TECHNOLOGICAL PROCESS OF CURCUMIN EXTRACTION PLANT
TECHNICAL DETAILS FOR CURCUMIN EXTRACTION
METHODS.
GRINDING OF DRIED TURMERIC AND SEPARATION
SOLVENT EXTRACTION OF TURMERIC USING ETHANOL AND WATER
SOLVENT EXTRACTION OF TURMERIC (250 Μ SIZE) USING ETHANOL
AND WATER.
MOISTURE ANALYSIS OF DRIED TURMERIC POWDER
OPTIMIZATION OF SOLVENT EXTRACTION OF TURMERIC AT DIFFERENT
TIME INTERVALS
OPTIMIZATION OF SOLVENT EXTRACTION METHOD OF TURMERIC.
SOLVENT EXTRACTION USING MIXTURE OF SOLVENT OF ETHANOL
AND WATER.
SOLVENT EXTRACTION OF TURMERIC USING PET ETHER.
QUALITATIVE ANALYSIS OF ANTIMICROBIAL ACTIVITY OF CURCUMIN
AGAINST E.COLI
RESULT AND DISCUSSION.
SOLVENT EXTRACTION OF TURMERIC (250 Μ SIZE) USING ETHANOL
AND WATER.
OPTIMIZATION OF SOLVENT EXTRACTION OF TURMERIC AT DIFFERENT
TIME INTERVALS
SOLVENT EXTRACTION USING MIXTURE OF SOLVENT OF ETHANOL
AND WATER
SOLVENT EXTRACTION OF TURMERIC USING PET ETHER
EXTRACTION AND PROCESSING OF CURCUMIN
TURMERIC HAS BEEN FOUND TO HAVE THE COMPOSITION AS SHOWN
IN TABLE BELOW
TYPICAL COMPOSITION OF TURMERIC
FIGURE: THE THREE STRUCTURES OF CURCUMIN AND OTHER
CURCUMINOIDS
FIGURE TURMERIC RHIZOME AND CURCUMIN THAT WAS EXTRACTED
REFINEMENT OF CURCUMIN:
FILTRATION:
OLEORESIN TO CURCUMIN:
PURITY TESTING TECHNIQUES:
SWOT ANALYSIS OF CURCUMIN
STRENGTH
OPPORTUNITIES
WEAKNESSES

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THREAT
PLANT LAYOUT
SUPPLIERS OF RAW MATERIAL (INDIAN)
N-HAXANE
LABORATORY CHEMICALS
SUPPLIERS OF RAW MATERIAL (GLOBAL)
SUPPLIERS OF PLANT AND MACHINRY (IMPORTED)
SUPPLIERS OF PLANT AND MACHINRY
CRUSHER
EVAPORATORS
FILTER PRESS
BOILERS
LAB TESTING EQUIPMENT
STORAGE TANK
MATERIAL HANDLING EQUIPMENTS
EXTRACTOR
STEAM DISTILATION PLANT
PUMPS
DIGITAL WEIGHING SCALE
OTHER MACHINERY

APPENDIX – A:

01. PLANT ECONOMICS

02. LAND & BUILDING
03. PLANT AND MACHINERY
04. OTHER FIXED ASSESTS
05. FIXED CAPITAL
06. RAW MATERIAL
07. SALARY AND WAGES
08. UTILITIES AND OVERHEADS
09. TOTAL WORKING CAPITAL
10. TOTAL CAPITAL INVESTMENT
11. COST OF PRODUCTION
12. TURN OVER/ANNUM
13. BREAK EVEN POINT
14. RESOURCES FOR FINANCE
15. INSTALMENT PAYABLE IN 5 YEARS
16. DEPRECIATION CHART FOR 5 YEARS
17. PROFIT ANALYSIS FOR 5 YEARS
18. PROJECTED BALANCE SHEET FOR (5 YEARS)

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 COST ESTIMATION

Plant Capacity 50 Kg/Day

Land & Building (1500 sq.mt.) Rs. 2.14 Cr
Plant & Machinery Rs. 1.70 Cr
Working Capital for 2 Months Rs. 1.24 Cr
Total Capital Investment Rs. 5.33 Cr
Rate of Return 20%
Break Even Point 64%

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