ANALYTICAL CHEMISTRY

ANALYTICAL CHEMISTRY

REPORT SHEET

Experiment No 5

Title ACID – BASED TITRATION II

DETERMINATION THE PERCENT (W/W) OF THE

ACTIVE

INGREDIENT IN ASPIRIN TABLET

Name MUHAMMAD AKMAL SYAHMIE BIN

BAHARIN
Student ID 2018281842

Course AS120
Group RAS1204A
Date of Experiment 28/4/2020

Date of Submission 12/5/2020

Lecturer’s Name DR. JEYASHELLY ANDAS
 ANALYTICAL CHEMISTRY

EXPERIMENT 5
ACID – BASED TITRATION II

1. State the objective of the experiment.

To determine the percent (w/w) of the active ingredient, acetlysalicyclic acid

(C9H8O4) in aspirin tablet.
2. Describe the procedure (use schematic diagram if necessary). Show all the calculations
involved during the preparation of solutions.

A. Hydrolysis of aspirin

1. Collect one commercial aspirin tablet (300 mg ASA) from your lecturer. Record the
brand name, the manufacturer’s name and % content (mass) of the active ingredient
in the tablet (use 2 tablets if the ASA content is 100 mg).

2. Weigh the aspirin tablet accurately in a weighing paper and transfer the tablets into
a 250 mL conical flask.

3. Add 25 mL (use pipette) 1.0 M NaOH solution and 25 mL of water to the tablet.
Heat this mixture until it boils for about 10 minutes in order to hydrolyze the
aspirin.

4. Cool the solution at room temperature then transfer quantitatively into 250 mL
volumetric flask. Dilute the solution to the mark carefully using dropper when the
level is close to the calibration mark.

B. Titration (back titration)

1. Pipette 20 mL of aspirin solution into a 250 mL conical flask .

2. Add 1-2 drops of phenol red or phenolphthalein indicator
3. Titrate the aspirin solution in the 250 mL conical flask with the diluted 0.1 M HCI
solution from the burette slowly while shaking the flask until the indicator changes
color (phenol red: light red to light yellow; phenolphthalein: pink to colorless).
Record your reading at the end point of the titration.
4. Repeat 2 – 3 times and record all your readings in a table.
5. Calculate the % w/w of acetylsalicylic per tablet.
ANALYTICAL CHEMISTRY

3. Result/Data

Table 5.1

Commercial/brand name of aspirin tablet

Name of manufacturer

Mass per tablet of active ingredient

(acetylsalicylic acid) stated on the label

Mass of aspirin tablet

Calculated % w/w

Table 5.2 Standardization of HCl solution.

Titration Rough 1 2 3
Final burette reading 23.70 23.70 23.80
Initial burette reading 0.00 0.00 0.00
Volume of HCl used 23.70 23.70 23.80

a) Average volume of HCl: 23.73 mL

b) Volume of Na2CO3 used: 25.00 mL

c) Molarity of Na2CO3 : 0.05 M

5.3 Titration of aspirin solution with HCl

Titration Rough 1 2 3
Final burette reading 13.90 13.10 13.10
Initial burette reading 0.00 0.00 0.00
Volume of HCl used 13.90 13.10 13.10

a) Average volume of HCl: 13.37 mL

b) Initial volume of NaOH used to hydrolyze aspirin: 25.00 mL

4. Calculation

a) Based on the data obtained in Table 5.2 calculate the exact molarity of HCl.

Na2CO3 + 2HCl = 2NaCl + CO2 + H2O

1 mol of Na2CO3 = 0.05 x 25 / 1000
= 1.25 x 10-3
1 mol of Na2CO3 : 2 mol of HCl

1.25 x 10-3 mol : 2.5 x 10-3 mol

M of HCl = 2.5 x 10-3 mol / 0.02373 L = 0.1054 M

 b) Using back titration method, calculate the % (w/w) aspirin in the aspirin tablet.

i) Calculate the initial mole of NaOH used for hydrolysis.

n of NaOH = 1 x 25 / 1000

= 0.025 mol

ii) Based on Equation (2), calculate the mole of excess (unreacted) NaOH.

Mol of HCl = 0.1 x 13.37 / 1000

= 1.34 x 10-3 mol

1 mol of HCl = 1 mol of NaOH

n of NaOH = 1.34 X 10-3 mol

iii) Calculate the mole of NaOH that has actually reacted with acetylsalicylic acid.

The reacted NaOH = initial mode – non reacted

= 0.025 – 1.34 x 10-3
= 0.02366 mol

iv) Based on Equation (1), calculate the mole of acetylsalicylic acid in the solution.

1
= x 0.02366
2
= 0.01183 mol

v) Calculate the mass then the % w/w of acetylsalicylic acid in the tablet.

Mass = 0.01183 mol x 180 g/mol

= 2.1294g

% w/w = (2.1294 / 1.1567 g) x 100

= 184%

vi) Compare the % w/w calculated in Table 5.1 and the result obtained in (e).
Calculate the % error.

% error = ( 184 – 77.81) / 77.81 x 100

= 136.47 %

5. Conclusion

- In this experiment, we are able to determine the percent (w/w) of the active
ingredient, acetlysalicyclic acid (C9H8O4) in aspirin tablet.