REPUBLIC of the PHILIPPINES

City of Makati
COLLEGE OF ALLIED HEALTH STUDIES
J. P. Rizal Extension, West Rembo, Makati City 1215
Telephone No. : (+632) – 881 – 1571
_____________________________________________________________________________________
DRUG STUDY
Drug Name Mechanism of Action Indication Side Effects/Adverse Contraindication Nursing Consideration
Effect
Generic Name: Metronidazole is converted to Prophylaxis of post-op GI disturbances (e.g. Hypersensitivity to - Assess the 12 Rights in Giving Medication
Metronidazole reduction products that interact w/ anaerobic bacterial infections nausea, anorexia, metronidazole and other
Brand Name: DNA to cause destruction of helical unpleasant metallic taste, nitroimidazoles. - Monitor total and differential leukocyte counts.
Flagyl Forte DNA structure and strand leading vomiting, diarrhoea, - Special precautions to patients w/ CNS disease, history of
Dosage to a protein synthesis inhibition and abdominal discomfort, blood dyscrasias, ESRD. Re-administer immediately after
Intravenous cell death in susceptible organisms. constipation); furred haemodialysis. Severe hepatic impairment esp hepatic
Prophylaxis of It is active against most anaerobic tongue, glossitis, encephalopathy. Pregnancy and lactation
postoperative anaerobic protozoa, some gm+ve, gm-ve and stomatitis; weakness, - Advise patient that it may impair ability to drive or operate
bacterial infections facultative anaerobes dizziness, ataxia, machinery.
Adult:  500 mg shortly headache, drowsiness, - Evaluate therapeutic response.
before operation and insomnia, hallucinations,
repeated 8 hrly. changes in mood or
Alternatively, 15 mg/kg mental state (e.g.
infused over 30-60 min depression or confusion);
and completed approx 1 Reference: urethral discomfort,
hr before surgery, MIMS 151st Edition 2017 darkening of the urine;
followed by 7.5 mg/kg DRUG REFERENCE: rashes, urticaria, pruritus;
infused over 30-60 min at https://www.mims.com/ raised liver enzyme
6 and 12 hr after the initial values, cholestatic
dose. hepatitis, jaundice,
pancreatitis,
thrombophlebitis (IV).
Rarely, agranulocytosis,
leucopenia, pancytopenia,
thrombocytopenia,
erythema multiforme,
angioedema, anaphylaxis,
 REPUBLIC of the PHILIPPINES
City of Makati
COLLEGE OF ALLIED HEALTH STUDIES
J. P. Rizal Extension, West Rembo, Makati City 1215
Telephone No. : (+632) – 881 – 1571
_____________________________________________________________________________________
DRUG STUDY
antibiotic-associated
colitis.