Drug Study

NAME MECHANISM DOSAGE INDICATIONS CONTRA ADVERSE NURSING

OF OF ACTION INDICATIONS REACTION ALERT
THE
DRUG
Generi Interferes PO(Adults):1– •Used for the •Contraindicated •CV: ●Instruct
c with DNA 5mg/kg/day. treatment of a in patients cardiotoxicity patient to
Name: replication PO (Children): variety of solid hypersensitive to •GI: take dose
Cyclo and RNA Induction—2–8 tumors, NHL, drug and in those anorexia, nausea, in early
phos transcriptio mg/kg/day (60–250 Hodgkin with severe bone vomiting, morning.
pha n, mg/m2/day) in lymphoma, and marrow abdominal pain, Emphasize
mide ultimately divided doses for 6 ALL; oral suppression. stomatitis, need for
disrupting days or longer. cyclophosphami •Use cautiously mucositis. adequate
Brand protein Maintenance—2–5 de used for in patients with •GU: fluid intake
Name: synthesis mg/kg(50–150 nephrotic impaired renal or hemorrhagic for 72 hr
Cyto (cell-cycle mg/m2/day)twice syndrome in hepatic function, cystitis, fertility after
xan phase– weekly. pediatric leukopenia, impairment. therapy.
nonspecific) IV (Adults): 40–50 patients. thrombocytopeni •Hematologic: ●Instruct
. mg/kg in divided a, or malignant leukopenia, patient to
doses over 2–5 cell infiltration of thrombocytopeni notify
days or 10–15 bone marrow a, anemia. healthcare
mg/kg q 7– 10 days and in those who •Hepatic: professiona
or 3–5 mg/kg twice have recently hepatotoxicity. l promptly
weekly or 1.5–3 undergone •Metabolic: if fever;
mg/kg/day. Other radiation therapy hyperurecemia. sore throat;
regimens may use or •Respiratory: signs of
larger doses. chemotherapy. pulmonary infection;
IV (Children): fibrosis lower back
Induction—2–8 •Skin: reversible or side
mg/kg/day (60–250 alopecia. pain;
mg/m2/day) in difficult or
divided doses for 6 painful
days or longer. urination;
Total dose for 7 sores in the
days may be given mouth;
as a single weekly yellow
dose. Maintenance discoloratio
—10– n of skin or
15mg/kgevery7– eyes;
10daysor30mg/kgq bleeding
3–4wk. gums;
blood in
urine, stool,
shortness
of breath;
cough, 24
hrs
dizziness.