Amoxicillin

Product Information
Composition

› Each 100gm contains:

– Amoxycillin trihydrate: 46gm equivalent to amoxicillin base 40gm
Amoxicillin

› Amoxycillin
– Semi synthetic antibiotic, an analog of ampicillin.
– Broad spectrum of bactericidal activity.
› Amoxycillin forms
– There are various hydrated forms of amoxicillin, including monohydrate, dihydrate, and trihydrate,
among which, trihydrate is the most stable form.
Pharmacokinetics / Absorption

› Amoxicillin bioavailability reaches 95%

› Amoxicillin is a weak acid;
– In acidic media, it is better absorbed as a non ionized form (lipid soluble) for better penetration of
the intestinal membrane.
– In Alkaline media, it becomes ionized (water soluble) which means it will be eliminated non
absorbable.
Pharmacokinetics / Distribution

› amoxicillin was administered to eight chickens at a dose of 20 mg/kg of body weight

orally;
› Cmax 1.382 µg/ml
› Tmax 2 hr
› T1/2 2.433 hr
› AUC 4.506 µg/h/l
Pharmacokinetics µg/ml
1.8

1.6
1.535
1.4

1.2

1 0.983

0.8
0.738 0.71
0.6

0.4 0.39
0.293
0.2 0.178

0
0.5 1 2 3 4 6 8
Amoxicillin MIC

amoxicillin MIC for 51 Clostriduim Perfringes Strains

5, 10%

46, 90%

MIC = 0.03 µg/ml MIC = 0.06 µg/ml

Bacterial Cell Wall Structure

› Peptidoglycan constitute almost 95% of the cell wall in some Gram positive bacteria
and as little as 5-10% of the cell wall in Gram negative bacteria.
Mechanism of action

› Amoxicillin acts by inhibiting the synthesis of bacterial

cell wall.
› It inhibits cross linkage between the linear
peptidoglycan polymer chains that make up a major
component of the cell walls of both Gram positive and
Gram negative bacteria.
Spectrum of activity

› Bactericidal antibiotic against wide range of gram+ve and gram-ve bacteria:

› Clostridium spp.
› E. coli
› Salmonella spp.
› Penicillin sensitive staphylococci
Indications

› Necrotic and ulcerative enteritis, caused by Clostridium sp.

› Gangrenous dermatitis.
Dosage

› 20mg/kg bird live weight/day for 3 - 5 consecutive days.

› 1 bottle for 10 tons of live body weight.
Administration

› Turn off drinkers for 2 hours.

› Calculate number of amoxicillin WSP bottles to administer.
› Dissolve the contents of each bottle in a small amount of water.
› Immediately add this solution to a volume of water representing bird’s expected
water consumption over the next 2-3 hours.
› Once all the medicated water is consumed, the bird’s normal fresh water supply must
be resumed.
› Repeat this procedure daily for 3-5 days.
Precautions

› No withdrawal period
Package

› Bottle of 500gm
Contact us on;
ossama.motawae@eurekaeg.com
+201023985680