Smart Multifunctional Nano-particles Design As Sensors And Drug

Delivery Systems Based On Supramolecular Chemistry

Iqra Noor , Zainab Zafar , Saman Rasheed
The University Of Lahore 1-KM Defence Road, Lahore.

Introduction Future Perspective

In order to design new nanoarchitectures
“Supramolecular chemistry is defined as based on the supramolecular interactions as Future perspectives should be discussed
the chemistry of non covalent interactions building blocks, it could be obtained from different points of view and at a
by the 1987 Nobel prix winner Jean Marie Supramolecular nanoparticles. These chemical level, for the different
Lehn. These interactions can be used to nanoparticles are synthesized from the application, From supramolecular
form nanoassemblies and new combination of polymer chemistry, systems, based on non covalent
nanomaterial applied to biomedical, supramolecular chemistry and their interactions as antigen-antibodies, specific
pharmaceutical and analytical interaction, applied to the design of new recognition and bioconjugation
determinations”. nanostructures with different applications. techniques, based on organic chemical
Figure 1: Cyclodextrins gold nanoparticles reaction, joined to the knowledge of
Applications of grafted. Molecular Biology, it is possible to get
Supramolecular system targeted biomolecular recognitions,
Tools for
Nanosensors based on
controlled molecular linking over nano-
supramolecular interaction platform surfaces.
Nano- Signal Signal
architecture enhancer transducer Many grafted cyclodextrins quantum dots
(QDs) are developed, exploiting the host-
guest interactions in order to generate
In nanosensors and FRET, quenching and fluorescence
enhanced of QDs applied to biosensors Figure 3:Synthesis of the supramolecular
nanodevices signals
design. These nanostructures are photo- nanocapsules

Joined to micelles and

activated by room light, and the Biodegradable Nanoparticles Figure 5:Fluorescent multilayer core-shell
cyclodextrins cavities allow the formation NPs architecture for DNA detection
vesicles Targeting cancer cells, using PLGA
of host-guest complexes, with different
nanoparticle surface, modified with
For drug delivery organic molecules. References
monoclonal antibody. Moreover, studies of
Nanosystems surface functionalization of PLGA 1. K.M. Goodfellow, C. Chakraborty, R.
nanoparticles, by heparin or chitosan Beams Nano Lett. 15 (2015)
conjugated pluronic on tumor targeting, 2. A. Guillermo Bracamonte, D. Brouard,
Experiments were done in order to enhance tumor A.V. Veglia. (2016)
imaging and therapy . 3. P. A. Burnouf, Y.C. Su, B.M.Chen ACS
Many supramolecular systems can be
Nano10 (2016)
applied in the nanosensors design. The
4. L. Zhang, X. Zhong, E. Pavlica
challenge is to derivatives macrocycles,
Nanotechnol 125 (2016)
enzymes, proteins, DNA etc, with
functional organic groups for covalent Acknowledgement
bond. All these different ways of covalent Figure 2:Chemical structure of the QDs-
linking over metallic surfaces can be concanavalin A-Au-CDs-AuNPs nanobiosensor We are thankful and grateful to our HOD,
applied to electrode surface modification, Respected Dr. Mehr un Nisa who fully
with macrocycles as molecular Nanosensors based on Figure 4:magnetic PLGA nanoparticles for help and cooperate with us during this
recognition sites. Supramolecular interaction diagnosis and treatment of cancer work.