DDSolver Zero-order Dissolution Modeling

DDSolver 1.
0 Dissolution Data Modeling of Zero-order Model
Time Unit h Analyst Windows User

Model Zero-order Date 2020-10-14
Equation F=k0*t Time 12:41:34
Time No.1
(h) F(%) Mean SD RSD(%)
0 0.00 0.00
1 0.01 0.01
2 0.02 0.02
4 0.04 0.04
8 0.08 0.08
12 0.12 0.12
24 0.24 0.24
Time No.1
(h) F(%)_Pre Mean SD RSD(%)
0 0.00 0.00
1 0.01 0.01
2 0.02 0.02
4 0.04 0.04
8 0.08 0.08
12 0.12 0.12
24 0.24 0.24
Best-fit Values
Parameter No.1 Mean SD RSD(%)
k0 0.010 0.010
Secondary Parameter
T25 2475.618 2475.618
T50 4951.237 4951.237
T75 7426.855 7426.855
T80 7921.979 7921.979
T90 8912.226 8912.226
Goodness of Fit
Parameter No.1
N_observed 7
DF 6
R_obs-pre 1.0000
Rsqr 0.9999
Rsqr_adj 0.9999
MSE 0.0000
MSE_root 0.0010
Weighting 1
SS 0.0000
WSS 0.0000
AIC -82.5293
MSC 8.5305
No.1
0.3
Observed
0.25 Predicted
Fraction dissolved (%)
0.2
0.15
0.1
0.05
0
0 5 10 15 20 25 30
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
Predicted Data
Time
0.15 No.1
0 0.00 0.00
0.10.48 0.00 0.00
0.96 0.01 0.01
1.44 0.01 0.01
0.05
1.92 0.02 0.02
2.4 0.02 0.02
02.88 0.03 0.03
3.36
0 50.03 10 0.03 15 20 25 30
Time (h)
0.05
0
0 5 10 15 20 25 30
3.84 0.04 Time (h)
0.04
4.32 0.04 0.04
4.8 0.05 0.05
5.28 0.05 0.05
5.76 0.06 0.06
6.24 0.06 0.06
6.72 0.07 0.07
7.2 0.07 0.07
7.68 0.08 0.08
8.16 0.08 0.08
8.64 0.09 0.09
9.12 0.09 0.09
9.6 0.10 0.10
10.08 0.10 0.10
10.56 0.11 0.11
11.04 0.11 0.11
11.52 0.12 0.12
12 0.12 0.12
12.48 0.13 0.13
12.96 0.13 0.13
13.44 0.14 0.14
13.92 0.14 0.14
14.4 0.15 0.15
14.88 0.15 0.15
15.36 0.16 0.16
15.84 0.16 0.16
16.32 0.16 0.16
16.8 0.17 0.17
17.28 0.17 0.17
17.76 0.18 0.18
18.24 0.18 0.18
18.72 0.19 0.19
19.2 0.19 0.19
19.68 0.20 0.20
20.16 0.20 0.20
20.64 0.21 0.21
21.12 0.21 0.21
21.6 0.22 0.22
22.08 0.22 0.22
22.56 0.23 0.23
23.04 0.23 0.23
23.52 0.24 0.24
24 0.24 0.24
DDSolver 1.0 Dissolution Data Modeling of First-order Model

Model First-order Date 44118.000000
Equation F=100*[1-Exp(-k1*t)] Time 0.551458
Time No.1
0.000000 0.000000 0.000000
1.000000 0.010005 0.010005
2.000000 0.020229 0.020229
4.000000 0.041335 0.041335
8.000000 0.082454 0.082454
12.000000 0.122037 0.122037
24.000000 0.241225 0.241225
Time No.1
0.000000 0.000000 0.000000
1.000000 0.010108 0.010108
2.000000 0.020215 0.020215
4.000000 0.040427 0.040427
8.000000 0.080837 0.080837
12.000000 0.121231 0.121231
24.000000 0.242316 0.242316
Best-fit Values
k1 0.000101 0.000101
Secondary Parameter
T25 2845.871977 2845.871977
T50 6856.903248 6856.903248
T75 13713.806496 13713.806496
T80 15921.236295 15921.236295
T90 22778.139543 22778.139543
Goodness of Fit
Parameter No.1
N_observed 7.000000
DF 6.000000
R_obs-pre 0.999954
Rsqr 0.999880
Rsqr_adj 0.999880
MSE 0.000001
MSE_root 0.000939
Weighting 1.000000
SS 0.000005
WSS 0.000005
AIC -83.053144
MSC 8.605348
No.1
0.3
Observed
0.25 Predicted
No.1
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
0.480000 0.004852 0.004852
0.960000 0.009704 0.009704
1.440000 0.014556 0.014556
1.920000 0.019407 0.019407
2.400000 0.024258 0.024258
2.880000 0.029109 0.029109
3.360000 0.033960 0.033960
3.840000 0.038810 0.038810
4.320000 0.043660 0.043660
4.800000 0.048510 0.048510
5.280000 0.053360 0.053360
5.760000 0.058209 0.058209
6.240000 0.063059 0.063059
6.720000 0.067908 0.067908
7.200000 0.072757 0.072757
7.680000 0.077605 0.077605
8.160000 0.082453 0.082453
8.640000 0.087301 0.087301
9.120000 0.092149 0.092149
9.600000 0.096997 0.096997
10.080000 0.101844 0.101844
10.560000 0.106691 0.106691
11.040000 0.111538 0.111538
11.520000 0.116385 0.116385
12.000000 0.121231 0.121231
12.480000 0.126078 0.126078
12.960000 0.130924 0.130924
13.440000 0.135769 0.135769
13.920000 0.140615 0.140615
14.400000 0.145460 0.145460
14.880000 0.150305 0.150305
15.360000 0.155150 0.155150
15.840000 0.159994 0.159994
16.320000 0.164839 0.164839
16.800000 0.169683 0.169683
17.280000 0.174527 0.174527
17.760000 0.179370 0.179370
18.240000 0.184214 0.184214
18.720000 0.189057 0.189057
19.200000 0.193900 0.193900
19.680000 0.198742 0.198742
20.160000 0.203585 0.203585
20.640000 0.208427 0.208427
21.120000 0.213269 0.213269
21.600000 0.218111 0.218111
22.080000 0.222952 0.222952
22.560000 0.227794 0.227794
23.040000 0.232635 0.232635
23.520000 0.237475 0.237475
24.000000 0.242316 0.242316
DDSolver 1.0 Dissolution Data Modeling of Higuchi Model

Model Higuchi Date 44118.000000
Equation F=kH*t^0.5 Time 0.554340
Time No.1
0.000000 0.000000 0.000000
1.000000 0.010005 0.010005
2.000000 0.020229 0.020229
4.000000 0.041335 0.041335
8.000000 0.082454 0.082454
12.000000 0.122037 0.122037
24.000000 0.241225 0.241225
Time No.1
0.000000 0.000000 0.000000
1.000000 0.038412 0.038412
2.000000 0.054323 0.054323
4.000000 0.076824 0.076824
8.000000 0.108645 0.108645
12.000000 0.133063 0.133063
24.000000 0.188179 0.188179
Best-fit Values
kH 0.038412 0.038412
Secondary Parameter
T25 423594.057960 423594.057960
T50 1694376.231840 1694376.231840
T75 3812346.521640 3812346.521640
T80 4337603.153510 4337603.153510
T90 5489778.991161 5489778.991161
Goodness of Fit
Parameter No.1
N_observed 7.000000
DF 6.000000
R_obs-pre 0.955520
Rsqr 0.843862
Rsqr_adj 0.843862
MSE 0.001142
MSE_root 0.033789
Weighting 1.000000
SS 0.006850
WSS 0.006850
AIC -32.884324
MSC 1.438374
No.1
0.3
Observed
0.25 Predicted
No.1
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
0.480000 0.026613 0.026613
0.960000 0.037636 0.037636
1.440000 0.046094 0.046094
1.920000 0.053225 0.053225
2.400000 0.059507 0.059507
2.880000 0.065187 0.065187
3.360000 0.070410 0.070410
3.840000 0.075272 0.075272
4.320000 0.079838 0.079838
4.800000 0.084156 0.084156
5.280000 0.088264 0.088264
5.760000 0.092188 0.092188
6.240000 0.095953 0.095953
6.720000 0.099575 0.099575
7.200000 0.103070 0.103070
7.680000 0.106450 0.106450
8.160000 0.109726 0.109726
8.640000 0.112907 0.112907
9.120000 0.116001 0.116001
9.600000 0.119015 0.119015
10.080000 0.121954 0.121954
10.560000 0.124824 0.124824
11.040000 0.127629 0.127629
11.520000 0.130374 0.130374
12.000000 0.133063 0.133063
12.480000 0.135698 0.135698
12.960000 0.138283 0.138283
13.440000 0.140820 0.140820
13.920000 0.143313 0.143313
14.400000 0.145763 0.145763
14.880000 0.148172 0.148172
15.360000 0.150543 0.150543
15.840000 0.152877 0.152877
16.320000 0.155176 0.155176
16.800000 0.157442 0.157442
17.280000 0.159675 0.159675
17.760000 0.161878 0.161878
18.240000 0.164050 0.164050
18.720000 0.166195 0.166195
19.200000 0.168312 0.168312
19.680000 0.170403 0.170403
20.160000 0.172469 0.172469
20.640000 0.174510 0.174510
21.120000 0.176527 0.176527
21.600000 0.178522 0.178522
22.080000 0.180495 0.180495
22.560000 0.182446 0.182446
23.040000 0.184377 0.184377
23.520000 0.186288 0.186288
24.000000 0.188179 0.188179
t (h) A V (ml) mcg/ml mcg na s-ca vo V kum mcg oslo API
0 0
1 0.3794 1 20.01055 20.0105485232068 20.01054852
2 0.3801 1.02 20.04747 20.448417721519 40.458966241519
4 0.3811 2.1 20.10021 42.2104430379747 82.6694092794937
8 0.3803 4.1 20.05802 82.2378691983122 164.907278477806
12 0.38 3.95 20.04219 79.1666666666667 244.073945144473
24 0.3798 11.9 20.03165 238.376582278481 482.450527422954
A(St) C(St)mcg/ml
0.1896 10
Ddsolver Ddsolver
o red k=20.12 k=0.101 %/h 1 red k=0.124 k=0.000101h-1
mcg/h (m.edinica) h-1 (m.edinica)
O red
600 7
500 6 f(x) = 0.12401192

R² = 0.821446527
f(x) = 20.12091166493 x + 1.20059716783071
400 R² = 0.999901110741592 5
O red
Linear (O red) 4
300
3
200
2
100
1
0 0
0 5 10 15 20 25 30 0 5 10
%na oslobodena API ln t^1/2
0 Err:502 0 Komentar
0.01000527426 2.99626 1 Disolucijata e najdobro da se izveduva po ravenkata od nulti red bidejk
0.02022948312076 3.700288 1.414214
0.041334704639747 4.41485 2 Komentar za Ddsolver
0.082453639238903 5.105383 2.828427 Osloboduvanjeto e od prv red
0.122036972572236 5.497471 3.464102
0.241225263711477 6.178878 4.898979
Ddsolver
Higuchi k=99.42 0.0384 %/h
mcg/h^1/2 ( merna edinica)
1 red Higu
7 600
6 f(x) = 0.124011921036181 x + 3.59475374748764

R² = 0.82144652773125 500
5
400
1 red f(x) = 99.4243406236069 x −
4 R² = 0.91301922886166
Linear (1 red) 300
3
200
2
1 100
0 0
0 5 10 15 20 25 30 0 1 2 3 4
ravenkata od nulti red bidejki ima njolem R
Higuchi
f(x) = 99.4243406236069 x − 73.8597033747931 Higuchi

R² = 0.91301922886166 Linear (Higuchi)
1 2 3 4 5 6
DDSolver 1.0 Dissolution Data Modeling of Zero-order Model

Model Zero-order Date 44118.000000
Equation F=k0*t Time 0.556481
Time No.1
0.000000 0.000000 0.000000
1.000000 0.010005 0.010005
2.000000 0.020229 0.020229
4.000000 0.041335 0.041335
8.000000 0.082454 0.082454
12.000000 0.122037 0.122037
24.000000 0.241225 0.241225
Time No.1
0.000000 0.000000 0.000000
1.000000 0.010098 0.010098
2.000000 0.020197 0.020197
4.000000 0.040394 0.040394
8.000000 0.080788 0.080788
12.000000 0.121182 0.121182
24.000000 0.242364 0.242364
Best-fit Values
k0 0.010098 0.010098
Secondary Parameter
T25 2475.618335 2475.618335
T50 4951.236671 4951.236671
T75 7426.855006 7426.855006
T80 7921.978673 7921.978673
T90 8912.226007 8912.226007
Goodness of Fit
Parameter No.1
N_observed 7.000000
DF 6.000000
R_obs-pre 0.999951
Rsqr 0.999870
Rsqr_adj 0.999870
MSE 0.000001
MSE_root 0.000974
Weighting 1.000000
SS 0.000006
WSS 0.000006
AIC -82.529335
MSC 8.530518
No.1
0.3
Observed
0.25 Predicted
No.1
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
0.480000 0.004847 0.004847
0.960000 0.009695 0.009695
1.440000 0.014542 0.014542
1.920000 0.019389 0.019389
2.400000 0.024236 0.024236
2.880000 0.029084 0.029084
3.360000 0.033931 0.033931
3.840000 0.038778 0.038778
4.320000 0.043625 0.043625
4.800000 0.048473 0.048473
5.280000 0.053320 0.053320
5.760000 0.058167 0.058167
6.240000 0.063015 0.063015
6.720000 0.067862 0.067862
7.200000 0.072709 0.072709
7.680000 0.077556 0.077556
8.160000 0.082404 0.082404
8.640000 0.087251 0.087251
9.120000 0.092098 0.092098
9.600000 0.096945 0.096945
10.080000 0.101793 0.101793
10.560000 0.106640 0.106640
11.040000 0.111487 0.111487
11.520000 0.116335 0.116335
12.000000 0.121182 0.121182
12.480000 0.126029 0.126029
12.960000 0.130876 0.130876
13.440000 0.135724 0.135724
13.920000 0.140571 0.140571
14.400000 0.145418 0.145418
14.880000 0.150265 0.150265
15.360000 0.155113 0.155113
15.840000 0.159960 0.159960
16.320000 0.164807 0.164807
16.800000 0.169655 0.169655
17.280000 0.174502 0.174502
17.760000 0.179349 0.179349
18.240000 0.184196 0.184196
18.720000 0.189044 0.189044
19.200000 0.193891 0.193891
19.680000 0.198738 0.198738
20.160000 0.203586 0.203586
20.640000 0.208433 0.208433
21.120000 0.213280 0.213280
21.600000 0.218127 0.218127
22.080000 0.222975 0.222975
22.560000 0.227822 0.227822
23.040000 0.232669 0.232669
23.520000 0.237516 0.237516
24.000000 0.242364 0.242364

Time No.1
0.000000 0.000000 0.000000
1.000000 0.010005 0.010005
2.000000 0.020229 0.020229
4.000000 0.041335 0.041335
8.000000 0.082454 0.082454
12.000000 0.122037 0.122037
24.000000 0.241225 0.241225
Time No.1
0.000000 0.000000 0.000000
1.000000 0.010108 0.010108
2.000000 0.020215 0.020215
4.000000 0.040427 0.040427
8.000000 0.080837 0.080837
12.000000 0.121231 0.121231
24.000000 0.242316 0.242316
Best-fit Values
k1 0.000101 0.000101
Secondary Parameter
T25 2845.871977 2845.871977
T50 6856.903248 6856.903248
T75 13713.806496 13713.806496
T80 15921.236295 15921.236295
T90 22778.139543 22778.139543
Goodness of Fit
Parameter No.1
N_observed 7.000000
DF 6.000000
R_obs-pre 0.999954
Rsqr 0.999880
Rsqr_adj 0.999880
MSE 0.000001
MSE_root 0.000939
Weighting 1.000000
SS 0.000005
WSS 0.000005
AIC -83.053144
MSC 8.605348
No.1
0.3
Observed
0.25 Predicted
No.1
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
0.480000 0.004852 0.004852
0.960000 0.009704 0.009704
1.440000 0.014556 0.014556
1.920000 0.019407 0.019407
2.400000 0.024258 0.024258
2.880000 0.029109 0.029109
3.360000 0.033960 0.033960
3.840000 0.038810 0.038810
4.320000 0.043660 0.043660
4.800000 0.048510 0.048510
5.280000 0.053360 0.053360
5.760000 0.058209 0.058209
6.240000 0.063059 0.063059
6.720000 0.067908 0.067908
7.200000 0.072757 0.072757
7.680000 0.077605 0.077605
8.160000 0.082453 0.082453
8.640000 0.087301 0.087301
9.120000 0.092149 0.092149
9.600000 0.096997 0.096997
10.080000 0.101844 0.101844
10.560000 0.106691 0.106691
11.040000 0.111538 0.111538
11.520000 0.116385 0.116385
12.000000 0.121231 0.121231
12.480000 0.126078 0.126078
12.960000 0.130924 0.130924
13.440000 0.135769 0.135769
13.920000 0.140615 0.140615
14.400000 0.145460 0.145460
14.880000 0.150305 0.150305
15.360000 0.155150 0.155150
15.840000 0.159994 0.159994
16.320000 0.164839 0.164839
16.800000 0.169683 0.169683
17.280000 0.174527 0.174527
17.760000 0.179370 0.179370
18.240000 0.184214 0.184214
18.720000 0.189057 0.189057
19.200000 0.193900 0.193900
19.680000 0.198742 0.198742
20.160000 0.203585 0.203585
20.640000 0.208427 0.208427
21.120000 0.213269 0.213269
21.600000 0.218111 0.218111
22.080000 0.222952 0.222952
22.560000 0.227794 0.227794
23.040000 0.232635 0.232635
23.520000 0.237475 0.237475
24.000000 0.242316 0.242316

Time No.1
0.000000 0.000000 0.000000
1.000000 0.010005 0.010005
2.000000 0.020229 0.020229
4.000000 0.041335 0.041335
8.000000 0.082454 0.082454
12.000000 0.122037 0.122037
24.000000 0.241225 0.241225
Time No.1
0.000000 0.000000 0.000000
1.000000 0.038412 0.038412
2.000000 0.054323 0.054323
4.000000 0.076824 0.076824
8.000000 0.108645 0.108645
12.000000 0.133063 0.133063
24.000000 0.188179 0.188179
Best-fit Values
kH 0.038412 0.038412
Secondary Parameter
T25 423594.057960 423594.057960
T50 1694376.231840 1694376.231840
T75 3812346.521640 3812346.521640
T80 4337603.153510 4337603.153510
T90 5489778.991161 5489778.991161
Goodness of Fit
Parameter No.1
N_observed 7.000000
DF 6.000000
R_obs-pre 0.955520
Rsqr 0.843862
Rsqr_adj 0.843862
MSE 0.001142
MSE_root 0.033789
Weighting 1.000000
SS 0.006850
WSS 0.006850
AIC -32.884324
MSC 1.438374
No.1
0.3
Observed
0.25 Predicted
No.1
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
0.480000 0.026613 0.026613
0.960000 0.037636 0.037636
1.440000 0.046094 0.046094
1.920000 0.053225 0.053225
2.400000 0.059507 0.059507
2.880000 0.065187 0.065187
3.360000 0.070410 0.070410
3.840000 0.075272 0.075272
4.320000 0.079838 0.079838
4.800000 0.084156 0.084156
5.280000 0.088264 0.088264
5.760000 0.092188 0.092188
6.240000 0.095953 0.095953
6.720000 0.099575 0.099575
7.200000 0.103070 0.103070
7.680000 0.106450 0.106450
8.160000 0.109726 0.109726
8.640000 0.112907 0.112907
9.120000 0.116001 0.116001
9.600000 0.119015 0.119015
10.080000 0.121954 0.121954
10.560000 0.124824 0.124824
11.040000 0.127629 0.127629
11.520000 0.130374 0.130374
12.000000 0.133063 0.133063
12.480000 0.135698 0.135698
12.960000 0.138283 0.138283
13.440000 0.140820 0.140820
13.920000 0.143313 0.143313
14.400000 0.145763 0.145763
14.880000 0.148172 0.148172
15.360000 0.150543 0.150543
15.840000 0.152877 0.152877
16.320000 0.155176 0.155176
16.800000 0.157442 0.157442
17.280000 0.159675 0.159675
17.760000 0.161878 0.161878
18.240000 0.164050 0.164050
18.720000 0.166195 0.166195
19.200000 0.168312 0.168312
19.680000 0.170403 0.170403
20.160000 0.172469 0.172469
20.640000 0.174510 0.174510
21.120000 0.176527 0.176527
21.600000 0.178522 0.178522
22.080000 0.180495 0.180495
22.560000 0.182446 0.182446
23.040000 0.184377 0.184377
23.520000 0.186288 0.186288
24.000000 0.188179 0.188179
t (h) A V (ml) mcg/ml mcg na s-ca vo V kum mcg osl. API
0 0
1 0.2446 1.1 12.90084 14.1909282700422 14.19092827
2 0.2465 1 13.00105 13.0010548523207 27.1919831223207
4 0.2455 2.1 12.94831 27.1914556962025 54.3834388185232
8 0.2461 4 12.97996 51.9198312236287 106.303270042152
12 0.2474 3.9 13.04852 50.8892405063291 157.192510548481
24 0.2463 12.1 12.99051 157.185126582278 314.37763713076
A(St) C(St)mcg/ml
0.1896 10
0 red k=13.05 1red k=0.121 Higuchi
o-red
350 7
300 f(x) = 13.0585792453453 x + 1.09317520280384 6

f(x) = 0.1215516504
R² = 0.999956154755241 R² = 0.83299245204
250 5
o-red
200 4
Linear (o-red)
150 3
100 2
50 1
0 0
0 5 10 15 20 25 30 0 5 10
kum % ols.API ln t^1/2
0 Err:502 0
0.007095464135 2.652603 1
0.0135959915612 3.302922 1.414214
0.0271917194093 3.99606 2
0.0531516350211 4.666296 2.828427
0.0785962552742 5.057471 3.464102
0.1571888185654 5.750595 4.898979
k=64.46
1 red Higu
7 350
6 300
f(x) = 0.121551650419403 x + 3.20446880219775
R² = 0.832992452044149 250 f(x) = 64.4675106777394 x −
5
1 red R² = 0.911388711496531
4 200
Linear (1 red)
3 150
2 100
1 50
0 0
0 5 10 15 20 25 30 0 1 2 3 4
Higuchi
f(x) = 64.4675106777394 x − 47.4888954368714

R² = 0.911388711496531 Higuchi
Linear (Higuchi)
1 2 3 4 5 6

Time No.1
0.000000 0.000000 0.000000
1.000000 0.010005 0.010005
2.000000 0.020229 0.020229
4.000000 0.041335 0.041335
8.000000 0.082454 0.082454
12.000000 0.122037 0.122037
24.000000 0.241225 0.241225
Time No.1
0.000000 0.000000 0.000000
1.000000 0.010098 0.010098
2.000000 0.020197 0.020197
4.000000 0.040394 0.040394
8.000000 0.080788 0.080788
12.000000 0.121182 0.121182
24.000000 0.242364 0.242364
Best-fit Values
k0 0.010098 0.010098
Secondary Parameter
T25 2475.618335 2475.618335
T50 4951.236671 4951.236671
T75 7426.855006 7426.855006
T80 7921.978673 7921.978673
T90 8912.226007 8912.226007
Goodness of Fit
Parameter No.1
N_observed 7.000000
DF 6.000000
R_obs-pre 0.999951
Rsqr 0.999870
Rsqr_adj 0.999870
MSE 0.000001
MSE_root 0.000974
Weighting 1.000000
SS 0.000006
WSS 0.000006
AIC -82.529335
MSC 8.530518
No.1
0.3
Observed
0.25 Predicted
No.1
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
0.480000 0.004847 0.004847
0.960000 0.009695 0.009695
1.440000 0.014542 0.014542
1.920000 0.019389 0.019389
2.400000 0.024236 0.024236
2.880000 0.029084 0.029084
3.360000 0.033931 0.033931
3.840000 0.038778 0.038778
4.320000 0.043625 0.043625
4.800000 0.048473 0.048473
5.280000 0.053320 0.053320
5.760000 0.058167 0.058167
6.240000 0.063015 0.063015
6.720000 0.067862 0.067862
7.200000 0.072709 0.072709
7.680000 0.077556 0.077556
8.160000 0.082404 0.082404
8.640000 0.087251 0.087251
9.120000 0.092098 0.092098
9.600000 0.096945 0.096945
10.080000 0.101793 0.101793
10.560000 0.106640 0.106640
11.040000 0.111487 0.111487
11.520000 0.116335 0.116335
12.000000 0.121182 0.121182
12.480000 0.126029 0.126029
12.960000 0.130876 0.130876
13.440000 0.135724 0.135724
13.920000 0.140571 0.140571
14.400000 0.145418 0.145418
14.880000 0.150265 0.150265
15.360000 0.155113 0.155113
15.840000 0.159960 0.159960
16.320000 0.164807 0.164807
16.800000 0.169655 0.169655
17.280000 0.174502 0.174502
17.760000 0.179349 0.179349
18.240000 0.184196 0.184196
18.720000 0.189044 0.189044
19.200000 0.193891 0.193891
19.680000 0.198738 0.198738
20.160000 0.203586 0.203586
20.640000 0.208433 0.208433
21.120000 0.213280 0.213280
21.600000 0.218127 0.218127
22.080000 0.222975 0.222975
22.560000 0.227822 0.227822
23.040000 0.232669 0.232669
23.520000 0.237516 0.237516
24.000000 0.242364 0.242364

Time No.1
0.000000 0.000000 0.000000
1.000000 0.010005 0.010005
2.000000 0.020229 0.020229
4.000000 0.041335 0.041335
8.000000 0.082454 0.082454
12.000000 0.122037 0.122037
24.000000 0.241225 0.241225
Time No.1
0.000000 0.000000 0.000000
1.000000 0.010108 0.010108
2.000000 0.020215 0.020215
4.000000 0.040427 0.040427
8.000000 0.080837 0.080837
12.000000 0.121231 0.121231
24.000000 0.242316 0.242316
Best-fit Values
k1 0.000101 0.000101
Secondary Parameter
T25 2845.871977 2845.871977
T50 6856.903248 6856.903248
T75 13713.806496 13713.806496
T80 15921.236295 15921.236295
T90 22778.139543 22778.139543
Goodness of Fit
Parameter No.1
N_observed 7.000000
DF 6.000000
R_obs-pre 0.999954
Rsqr 0.999880
Rsqr_adj 0.999880
MSE 0.000001
MSE_root 0.000939
Weighting 1.000000
SS 0.000005
WSS 0.000005
AIC -83.053144
MSC 8.605348
No.1
0.3
Observed
0.25 Predicted
No.1
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
0.480000 0.004852 0.004852
0.960000 0.009704 0.009704
1.440000 0.014556 0.014556
1.920000 0.019407 0.019407
2.400000 0.024258 0.024258
2.880000 0.029109 0.029109
3.360000 0.033960 0.033960
3.840000 0.038810 0.038810
4.320000 0.043660 0.043660
4.800000 0.048510 0.048510
5.280000 0.053360 0.053360
5.760000 0.058209 0.058209
6.240000 0.063059 0.063059
6.720000 0.067908 0.067908
7.200000 0.072757 0.072757
7.680000 0.077605 0.077605
8.160000 0.082453 0.082453
8.640000 0.087301 0.087301
9.120000 0.092149 0.092149
9.600000 0.096997 0.096997
10.080000 0.101844 0.101844
10.560000 0.106691 0.106691
11.040000 0.111538 0.111538
11.520000 0.116385 0.116385
12.000000 0.121231 0.121231
12.480000 0.126078 0.126078
12.960000 0.130924 0.130924
13.440000 0.135769 0.135769
13.920000 0.140615 0.140615
14.400000 0.145460 0.145460
14.880000 0.150305 0.150305
15.360000 0.155150 0.155150
15.840000 0.159994 0.159994
16.320000 0.164839 0.164839
16.800000 0.169683 0.169683
17.280000 0.174527 0.174527
17.760000 0.179370 0.179370
18.240000 0.184214 0.184214
18.720000 0.189057 0.189057
19.200000 0.193900 0.193900
19.680000 0.198742 0.198742
20.160000 0.203585 0.203585
20.640000 0.208427 0.208427
21.120000 0.213269 0.213269
21.600000 0.218111 0.218111
22.080000 0.222952 0.222952
22.560000 0.227794 0.227794
23.040000 0.232635 0.232635
23.520000 0.237475 0.237475
24.000000 0.242316 0.242316

Time No.1
0.000000 0.000000 0.000000
1.000000 0.010005 0.010005
2.000000 0.020229 0.020229
4.000000 0.041335 0.041335
8.000000 0.082454 0.082454
12.000000 0.122037 0.122037
24.000000 0.241225 0.241225
Time No.1
0.000000 0.000000 0.000000
1.000000 0.038412 0.038412
2.000000 0.054323 0.054323
4.000000 0.076824 0.076824
8.000000 0.108645 0.108645
12.000000 0.133063 0.133063
24.000000 0.188179 0.188179
Best-fit Values
kH 0.038412 0.038412
Secondary Parameter
T25 423594.057960 423594.057960
T50 1694376.231840 1694376.231840
T75 3812346.521640 3812346.521640
T80 4337603.153510 4337603.153510
T90 5489778.991161 5489778.991161
Goodness of Fit
Parameter No.1
N_observed 7.000000
DF 6.000000
R_obs-pre 0.955520
Rsqr 0.843862
Rsqr_adj 0.843862
MSE 0.001142
MSE_root 0.033789
Weighting 1.000000
SS 0.006850
WSS 0.006850
AIC -32.884324
MSC 1.438374
No.1
0.3
Observed
0.25 Predicted
No.1
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Mean
0.3
Observed
0.25 Predicted
0.2
0.15
0.1
0.05
0
0.000000 5.000000 10.000000 15.000000 20.000000 25.000000 30.000000
Time (h)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
0.480000 0.026613 0.026613
0.960000 0.037636 0.037636
1.440000 0.046094 0.046094
1.920000 0.053225 0.053225
2.400000 0.059507 0.059507
2.880000 0.065187 0.065187
3.360000 0.070410 0.070410
3.840000 0.075272 0.075272
4.320000 0.079838 0.079838
4.800000 0.084156 0.084156
5.280000 0.088264 0.088264
5.760000 0.092188 0.092188
6.240000 0.095953 0.095953
6.720000 0.099575 0.099575
7.200000 0.103070 0.103070
7.680000 0.106450 0.106450
8.160000 0.109726 0.109726
8.640000 0.112907 0.112907
9.120000 0.116001 0.116001
9.600000 0.119015 0.119015
10.080000 0.121954 0.121954
10.560000 0.124824 0.124824
11.040000 0.127629 0.127629
11.520000 0.130374 0.130374
12.000000 0.133063 0.133063
12.480000 0.135698 0.135698
12.960000 0.138283 0.138283
13.440000 0.140820 0.140820
13.920000 0.143313 0.143313
14.400000 0.145763 0.145763
14.880000 0.148172 0.148172
15.360000 0.150543 0.150543
15.840000 0.152877 0.152877
16.320000 0.155176 0.155176
16.800000 0.157442 0.157442
17.280000 0.159675 0.159675
17.760000 0.161878 0.161878
18.240000 0.164050 0.164050
18.720000 0.166195 0.166195
19.200000 0.168312 0.168312
19.680000 0.170403 0.170403
20.160000 0.172469 0.172469
20.640000 0.174510 0.174510
21.120000 0.176527 0.176527
21.600000 0.178522 0.178522
22.080000 0.180495 0.180495
22.560000 0.182446 0.182446
23.040000 0.184377 0.184377
23.520000 0.186288 0.186288
24.000000 0.188179 0.188179
razreden nativen
t (h) A V (ml) mcg/ml razreduvane mcg na sups. Vo V
0
1 0.5498 1 28.99789 2899.78902953586 2899.78902953586
2 0.7592 1.1 40.04219 400.42194092827 440.464135021097
4 0.5692 2.05 30.0211 300.210970464135 615.432489451477
8 0.474 4.1 25 250 1025
12 0.4173 3.99 22.00949 220.094936708861 878.178797468354
24 0.3792 12.1 20 200 2420
A(St) C(St)mcg/ml
0.1896 10
o red k=278.4 1 red k=0.043
o red
9000 9.2
f(x) = 278.41537296798 x + 2159.2797694973 9 f(x) = 0.043432627436
8000 R² = 0.837277810536671 R² = 0.9366867769028
7000 8.8
6000 8.6
o red
5000 Linear (o red) 8.4
4000 8.2
3000 8
2000 7.8
1000 7.6
0 7.4
0 5 10 15 20 25 30 0 5 10
kum mcg na osl API kum % na ols API ln kum mcg t^1/2
0 0 Err:502 0
2899.78903 14.49894515 7.972393265 1 Komentar
3340.2531650211 16.7012658251055 8.113801881 1.414214 Higuci I vo dvata slucaevi se osloboduva
3955.68565447257 19.7784282723629 8.282909229 2
4980.68565447257 24.9034282723629 8.513322842 2.828427
5858.86445194093 29.2943222597046 8.675711084 3.464102
8278.86445194093 41.3943222597046 9.021461094 4.898979
Higuchi k=1550
1 red Higu
9.2 9000
9 f(x) = 0.043432627436975 x + 8.06075589947109 8000 f(x) = 1549.99748384139 x + 732.18
R² = 0.936686776902863 R² = 0.970460555692281
8.8 7000
8.6 6000
1 red
8.4 Linear (1 red) 5000
8.2 4000
8 3000
7.8 2000
7.6 1000
7.4 0
0 5 10 15 20 25 30 0 1 2 3 4
o dvata slucaevi se osloboduva
Higuchi
f(x) = 1549.99748384139 x + 732.187557599006

R² = 0.970460555692281
Higuchi
Linear (Higuchi)
1 2 3 4 5 6
Time Unit min Analyst Windows User

Time No.1
(min) F(%) Mean SD RSD(%)
0.000000 0.000000 0.000000
15.000000 6.684906 6.684906
30.000000 18.194340 18.194340
45.000000 34.043400 34.043400
60.000000 51.024530 51.024530
Time No.1
(min) F(%)_Pre Mean SD RSD(%)
0.000000 0.000000 0.000000
15.000000 11.643397 11.643397
30.000000 23.286794 23.286794
45.000000 34.930191 34.930191
60.000000 46.573587 46.573587
Best-fit Values
k0 0.776226 0.776226
Secondary Parameter
T25 32.207096 32.207096
T50 64.414192 64.414192
T75 96.621288 96.621288
T80 103.062707 103.062707
T90 115.945546 115.945546
Goodness of Fit
Parameter No.1
N_observed 5.000000
DF 4.000000
R_obs-pre 0.986580
Rsqr 0.958665
Rsqr_adj 0.958665
MSE 17.779252
MSE_root 4.216545
Weighting 1.000000
SS 71.117007
WSS 71.117007
AIC 23.321633
MSC 2.456091
No.1
60
Observed
50 Predicted
ed (%)
40
No.1
60
Observed
Fraction dissolved (%) 50 Predicted
40
30
20
10
0
0.000000 20.000000 40.000000 60.000000 80.000000
Time (min)
Mean
60
Observed
50 Predicted
40
30
20
10
0
0.000000 20.000000 40.000000 60.000000 80.000000
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
1.200000 0.931472 0.931472
2.400000 1.862943 1.862943
3.600000 2.794415 2.794415
4.800000 3.725887 3.725887
6.000000 4.657359 4.657359
7.200000 5.588830 5.588830
8.400000 6.520302 6.520302
9.600000 7.451774 7.451774
10.800000 8.383246 8.383246
12.000000 9.314717 9.314717
13.200000 10.246189 10.246189
14.400000 11.177661 11.177661
15.600000 12.109133 12.109133
16.800000 13.040604 13.040604
18.000000 13.972076 13.972076
19.200000 14.903548 14.903548
20.400000 15.835020 15.835020
21.600000 16.766491 16.766491
22.800000 17.697963 17.697963
24.000000 18.629435 18.629435
25.200000 19.560907 19.560907
26.400000 20.492378 20.492378
27.600000 21.423850 21.423850
28.800000 22.355322 22.355322
30.000000 23.286794 23.286794
31.200000 24.218265 24.218265
32.400000 25.149737 25.149737
33.600000 26.081209 26.081209
34.800000 27.012681 27.012681
36.000000 27.944152 27.944152
37.200000 28.875624 28.875624
38.400000 29.807096 29.807096
39.600000 30.738568 30.738568
40.800000 31.670039 31.670039
42.000000 32.601511 32.601511
43.200000 33.532983 33.532983
44.400000 34.464455 34.464455
45.600000 35.395926 35.395926
46.800000 36.327398 36.327398
48.000000 37.258870 37.258870
49.200000 38.190342 38.190342
50.400000 39.121813 39.121813
51.600000 40.053285 40.053285
52.800000 40.984757 40.984757
54.000000 41.916229 41.916229
55.200000 42.847700 42.847700
56.400000 43.779172 43.779172
57.600000 44.710644 44.710644
58.800000 45.642116 45.642116
60.000000 46.573587 46.573587

Time No.1
0.000000 0.000000 0.000000
15.000000 6.684906 6.684906
30.000000 18.194340 18.194340
45.000000 34.043400 34.043400
60.000000 51.024530 51.024530
Time No.1
0.000000 0.000000 0.000000
15.000000 13.282496 13.282496
30.000000 24.800746 24.800746
45.000000 34.789084 34.789084
60.000000 43.450721 43.450721
Best-fit Values
k1 0.009501 0.009501
Secondary Parameter
T25 30.279256 30.279256
T50 72.955471 72.955471
T75 145.910942 145.910942
T80 169.397358 169.397358
T90 242.352829 242.352829
Goodness of Fit
Parameter No.1
N_observed 5.000000
DF 4.000000
R_obs-pre 0.969556
Rsqr 0.915669
Rsqr_adj 0.915669
MSE 36.272855
MSE_root 6.022695
Weighting 1.000000
SS 145.091419
WSS 145.091419
AIC 26.886820
MSC 1.743053
No.1
60
Observed
50 Predicted
ed (%)
40
No.1
60
Observed
40
30
20
10
0
0.000000 20.000000 40.000000 60.000000 80.000000
Time (min)
Mean
60
Observed
50 Predicted
40
30
20
10
0
0.000000 20.000000 40.000000 60.000000 80.000000
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
1.200000 1.133641 1.133641
2.400000 2.254430 2.254430
3.600000 3.362514 3.362514
4.800000 4.458036 4.458036
6.000000 5.541138 5.541138
7.200000 6.611963 6.611963
8.400000 7.670648 7.670648
9.600000 8.717331 8.717331
10.800000 9.752148 9.752148
12.000000 10.775235 10.775235
13.200000 11.786723 11.786723
14.400000 12.786745 12.786745
15.600000 13.775430 13.775430
16.800000 14.752907 14.752907
18.000000 15.719303 15.719303
19.200000 16.674743 16.674743
20.400000 17.619352 17.619352
21.600000 18.553253 18.553253
22.800000 19.476566 19.476566
24.000000 20.389413 20.389413
25.200000 21.291911 21.291911
26.400000 22.184178 22.184178
27.600000 23.066330 23.066330
28.800000 23.938481 23.938481
30.000000 24.800746 24.800746
31.200000 25.653235 25.653235
32.400000 26.496060 26.496060
33.600000 27.329331 27.329331
34.800000 28.153155 28.153155
36.000000 28.967640 28.967640
37.200000 29.772892 29.772892
38.400000 30.569015 30.569015
39.600000 31.356113 31.356113
40.800000 32.134288 32.134288
42.000000 32.903642 32.903642
43.200000 33.664273 33.664273
44.400000 34.416282 34.416282
45.600000 35.159766 35.159766
46.800000 35.894821 35.894821
48.000000 36.621544 36.621544
49.200000 37.340028 37.340028
50.400000 38.050367 38.050367
51.600000 38.752653 38.752653
52.800000 39.446978 39.446978
54.000000 40.133432 40.133432
55.200000 40.812104 40.812104
56.400000 41.483082 41.483082
57.600000 42.146453 42.146453
58.800000 42.802305 42.802305
60.000000 43.450721 43.450721

Time No.1
0.000000 0.000000 0.000000
15.000000 6.684906 6.684906
30.000000 18.194340 18.194340
45.000000 34.043400 34.043400
60.000000 51.024530 51.024530
Time No.1
0.000000 0.000000 0.000000
15.000000 19.342955 19.342955
30.000000 27.355069 27.355069
45.000000 33.502980 33.502980
60.000000 38.685909 38.685909
Best-fit Values
kH 4.994329 4.994329
Secondary Parameter
T25 25.056802 25.056802
T50 100.227210 100.227210
T75 225.511222 225.511222
T80 256.581657 256.581657
T90 324.736160 324.736160
Goodness of Fit
Parameter No.1
N_observed 5.000000
DF 4.000000
R_obs-pre 0.898578
Rsqr 0.769440
Rsqr_adj 0.769440
MSE 99.169693
MSE_root 9.958398
Weighting 1.000000
SS 396.678771
WSS 396.678771
AIC 31.915634
MSC 0.737290
No.1
60
Observed
50 Predicted
ed (%)
40
No.1
60
Observed
40
30
20
10
0
0.000000 20.000000 40.000000 60.000000 80.000000
Time (min)
Mean
60
Observed
50 Predicted
40
30
20
10
0
0.000000 20.000000 40.000000 60.000000 80.000000
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
1.200000 5.471014 5.471014
2.400000 7.737182 7.737182
3.600000 9.476074 9.476074
4.800000 10.942028 10.942028
6.000000 12.233559 12.233559
7.200000 13.401192 13.401192
8.400000 14.474942 14.474942
9.600000 15.474364 15.474364
10.800000 16.413041 16.413041
12.000000 17.300865 17.300865
13.200000 18.145300 18.145300
14.400000 18.952148 18.952148
15.600000 19.726021 19.726021
16.800000 20.470659 20.470659
18.000000 21.189145 21.189145
19.200000 21.884055 21.884055
20.400000 22.557568 22.557568
21.600000 23.211546 23.211546
22.800000 23.847596 23.847596
24.000000 24.467117 24.467117
25.200000 25.071335 25.071335
26.400000 25.661329 25.661329
27.600000 26.238060 26.238060
28.800000 26.802384 26.802384
30.000000 27.355069 27.355069
31.200000 27.896806 27.896806
32.400000 28.428221 28.428221
33.600000 28.949884 28.949884
34.800000 29.462311 29.462311
36.000000 29.965976 29.965976
37.200000 30.461315 30.461315
38.400000 30.948727 30.948727
39.600000 31.428581 31.428581
40.800000 31.901218 31.901218
42.000000 32.366954 32.366954
43.200000 32.826083 32.826083
44.400000 33.278878 33.278878
45.600000 33.725594 33.725594
46.800000 34.166470 34.166470
48.000000 34.601729 34.601729
49.200000 35.031581 35.031581
50.400000 35.456222 35.456222
51.600000 35.875836 35.875836
52.800000 36.290600 36.290600
54.000000 36.700676 36.700676
55.200000 37.106221 37.106221
56.400000 37.507381 37.507381
57.600000 37.904295 37.904295
58.800000 38.297096 38.297096
60.000000 38.685909 38.685909
t min A mg/ml mg vo 5 ml mg vo 1000 ml kum mg kum %
0 0 0 0 0 0 0
15 0.03543 0.033425 0.167122642 6.68490566038 6.684906 6.684906
30 0.061 0.057547 0.287735849 11.5094339623 18.19434 18.19434
45 0.084 0.079245 0.396226415 15.8490566038 34.0434 34.0434
60 0.09 0.084906 0.424528302 16.9811320755 51.02453 51.02453
Cst=0.09mg/ml
Ast=0.0954

Time No.1
0.000000 0.000000 0.000000
30.000000 5.502667 5.502667
60.000000 11.528000 11.528000
90.000000 18.582667 18.582667
120.000000 27.073333 27.073333
150.000000 76.163358 76.163358
180.000000 84.881476 84.881476
210.000000 88.851041 88.851041
240.000000 96.145423 96.145423
Time No.1
0.000000 0.000000 0.000000
30.000000 12.126600 12.126600
60.000000 24.253199 24.253199
90.000000 36.379799 36.379799
120.000000 48.506398 48.506398
150.000000 60.632998 60.632998
180.000000 72.759597 72.759597
210.000000 84.886197 84.886197
240.000000 97.012797 97.012797
Best-fit Values
k0 0.404220 0.404220
Secondary Parameter
T25 61.847511 61.847511
T50 123.695022 123.695022
T75 185.542533 185.542533
T80 197.912035 197.912035
T90 222.651039 222.651039
Goodness of Fit
Parameter No.1
N_observed 9.000000
DF 8.000000
R_obs-pre 0.956396
Rsqr 0.891877
Rsqr_adj 0.891877
MSE 173.315714
MSE_root 13.164943
Weighting 1.000000
SS 1386.525709
WSS 1386.525709
AIC 67.111008
MSC 1.826916
No.1
120
Observed
100 Predicted
80
60
40
20
Time (min)
Mean
120
Observed
100 Predicted
80
60
40
20
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
4.800000 1.940256 1.940256
9.600000 3.880512 3.880512
14.400000 5.820768 5.820768
19.200000 7.761024 7.761024
24.000000 9.701280 9.701280
28.800000 11.641536 11.641536
33.600000 13.581792 13.581792
38.400000 15.522047 15.522047
43.200000 17.462303 17.462303
48.000000 19.402559 19.402559
52.800000 21.342815 21.342815
57.600000 23.283071 23.283071
62.400000 25.223327 25.223327
67.200000 27.163583 27.163583
72.000000 29.103839 29.103839
76.800000 31.044095 31.044095
81.600000 32.984351 32.984351
86.400000 34.924607 34.924607
91.200000 36.864863 36.864863
96.000000 38.805119 38.805119
100.800000 40.745375 40.745375
105.600000 42.685631 42.685631
110.400000 44.625886 44.625886
115.200000 46.566142 46.566142
120.000000 48.506398 48.506398
124.800000 50.446654 50.446654
129.600000 52.386910 52.386910
134.400000 54.327166 54.327166
139.200000 56.267422 56.267422
144.000000 58.207678 58.207678
148.800000 60.147934 60.147934
153.600000 62.088190 62.088190
158.400000 64.028446 64.028446
163.200000 65.968702 65.968702
168.000000 67.908958 67.908958
172.800000 69.849214 69.849214
177.600000 71.789470 71.789470
182.400000 73.729725 73.729725
187.200000 75.669981 75.669981
192.000000 77.610237 77.610237
196.800000 79.550493 79.550493
201.600000 81.490749 81.490749
206.400000 83.431005 83.431005
211.200000 85.371261 85.371261
216.000000 87.311517 87.311517
220.800000 89.251773 89.251773
225.600000 91.192029 91.192029
230.400000 93.132285 93.132285
235.200000 95.072541 95.072541
240.000000 97.012797 97.012797

Time No.1
0.000000 0.000000 0.000000
30.000000 5.502667 5.502667
60.000000 11.528000 11.528000
90.000000 18.582667 18.582667
120.000000 27.073333 27.073333
150.000000 76.163358 76.163358
180.000000 84.881476 84.881476
210.000000 88.851041 88.851041
240.000000 96.145423 96.145423
Time No.1
0.000000 0.000000 0.000000
30.000000 17.076837 17.076837
60.000000 31.237491 31.237491
90.000000 42.979953 42.979953
120.000000 52.717173 52.717173
150.000000 60.791585 60.791585
180.000000 67.487142 67.487142
210.000000 73.039310 73.039310
240.000000 77.643343 77.643343
Best-fit Values
k1 0.006242 0.006242
Secondary Parameter
T25 46.089168 46.089168
T50 111.048203 111.048203
T75 222.096406 222.096406
T80 257.845942 257.845942
T90 368.894145 368.894145
Goodness of Fit
Parameter No.1
N_observed 9.000000
DF 8.000000
R_obs-pre 0.916230
Rsqr 0.773351
Rsqr_adj 0.773351
MSE 363.306451
MSE_root 19.060599
Weighting 1.000000
SS 2906.451610
WSS 2906.451610
AIC 73.772194
MSC 1.086784
No.1
120
Observed
100 Predicted
80
60
40
20
Time (min)
Mean
120
Observed
100 Predicted
80
60
40
20
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
4.800000 2.951654 2.951654
9.600000 5.816186 5.816186
14.400000 8.596166 8.596166
19.200000 11.294091 11.294091
24.000000 13.912383 13.912383
28.800000 16.453392 16.453392
33.600000 18.919399 18.919399
38.400000 21.312618 21.312618
43.200000 23.635197 23.635197
48.000000 25.889222 25.889222
52.800000 28.076716 28.076716
57.600000 30.199643 30.199643
62.400000 32.259908 32.259908
67.200000 34.259361 34.259361
72.000000 36.199797 36.199797
76.800000 38.082959 38.082959
81.600000 39.910536 39.910536
86.400000 41.684169 41.684169
91.200000 43.405451 43.405451
96.000000 45.075926 45.075926
100.800000 46.697095 46.697095
105.600000 48.270412 48.270412
110.400000 49.797291 49.797291
115.200000 51.279101 51.279101
120.000000 52.717173 52.717173
124.800000 54.112799 54.112799
129.600000 55.467230 55.467230
134.400000 56.781684 56.781684
139.200000 58.057339 58.057339
144.000000 59.295341 59.295341
148.800000 60.496802 60.496802
153.600000 61.662800 61.662800
158.400000 62.794382 62.794382
163.200000 63.892563 63.892563
168.000000 64.958329 64.958329
172.800000 65.992638 65.992638
177.600000 66.996418 66.996418
182.400000 67.970570 67.970570
187.200000 68.915968 68.915968
192.000000 69.833461 69.833461
196.800000 70.723873 70.723873
201.600000 71.588003 71.588003
206.400000 72.426627 72.426627
211.200000 73.240497 73.240497
216.000000 74.030345 74.030345
220.800000 74.796880 74.796880
225.600000 75.540789 75.540789
230.400000 76.262740 76.262740
235.200000 76.963382 76.963382
240.000000 77.643343 77.643343

Time No.1
0.000000 0.000000 0.000000
30.000000 5.502667 5.502667
60.000000 11.528000 11.528000
90.000000 18.582667 18.582667
120.000000 27.073333 27.073333
150.000000 76.163358 76.163358
180.000000 84.881476 84.881476
210.000000 88.851041 88.851041
240.000000 96.145423 96.145423
Time No.1
0.000000 0.000000 0.000000
30.000000 27.593871 27.593871
60.000000 39.023626 39.023626
90.000000 47.793986 47.793986
120.000000 55.187741 55.187741
150.000000 61.701770 61.701770
180.000000 67.590903 67.590903
210.000000 73.006519 73.006519
240.000000 78.047252 78.047252
Best-fit Values
kH 5.037928 5.037928
Secondary Parameter
T25 24.624988 24.624988
T50 98.499952 98.499952
T75 221.624891 221.624891
T80 252.159876 252.159876
T90 319.139844 319.139844
Goodness of Fit
Parameter No.1
N_observed 9.000000
DF 8.000000
R_obs-pre 0.878713
Rsqr 0.690067
Rsqr_adj 0.690067
MSE 496.805740
MSE_root 22.289139
Weighting 1.000000
SS 3974.445917
WSS 3974.445917
AIC 76.588766
MSC 0.773832
No.1
120
Observed
100 Predicted
80
60
40
20
Time (min)
Mean
120
Observed
100 Predicted
80
60
40
20
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
4.800000 11.037548 11.037548
9.600000 15.609450 15.609450
14.400000 19.117594 19.117594
19.200000 22.075096 22.075096
24.000000 24.680708 24.680708
28.800000 27.036361 27.036361
33.600000 29.202608 29.202608
38.400000 31.218901 31.218901
43.200000 33.112645 33.112645
48.000000 34.903792 34.903792
52.800000 36.607406 36.607406
57.600000 38.235189 38.235189
62.400000 39.796446 39.796446
67.200000 41.298724 41.298724
72.000000 42.748240 42.748240
76.800000 44.150193 44.150193
81.600000 45.508977 45.508977
86.400000 46.828351 46.828351
91.200000 48.111557 48.111557
96.000000 49.361416 49.361416
100.800000 50.580400 50.580400
105.600000 51.770690 51.770690
110.400000 52.934222 52.934222
115.200000 54.072722 54.072722
120.000000 55.187741 55.187741
124.800000 56.280674 56.280674
129.600000 57.352783 57.352783
134.400000 58.405215 58.405215
139.200000 59.439016 59.439016
144.000000 60.455141 60.455141
148.800000 61.454468 61.454468
153.600000 62.437802 62.437802
158.400000 63.405887 63.405887
163.200000 64.359413 64.359413
168.000000 65.299016 65.299016
172.800000 66.225289 66.225289
177.600000 67.138785 67.138785
182.400000 68.040017 68.040017
187.200000 68.929467 68.929467
192.000000 69.807584 69.807584
196.800000 70.674793 70.674793
201.600000 71.531488 71.531488
206.400000 72.378044 72.378044
211.200000 73.214812 73.214812
216.000000 74.042124 74.042124
220.800000 74.860294 74.860294
225.600000 75.669618 75.669618
230.400000 76.470377 76.470377
235.200000 77.262838 77.262838
240.000000 78.047252 78.047252
Spored propisot vo praktikumot 75 mg inicijalno dotspen Dikolefenak (25 mg gastrorezistenti + 50 mg so prodolzheno oslob)
*po 2 casa pH 1.2 e zamenet so pH 6.8 (celata kolichina oslobodena vo pH 1.2 treba da se vkluchi vo sekoja od vrednostite vo
t min A mg/ml razr 1:10 mg vo 5 ml mg vo 1000 ml kum mg kum %

0 0 0 0 0 0 0 0
30 0.013705 0.004127 0.004127 0.020635 4.127 4.127 5.502667
60 0.015008 0.004519 0.004519 0.022595 4.519 8.646 11.528
90 0.017572 0.005291 0.005291 0.026455 5.291 13.937 18.58267
120 0.021149 0.006368 0.006368 0.03184 6.368 20.305 27.07333
150 0.1164 0.003682 0.036818 0.18408759 36.8175182482 57.12252 76.16336
180 0.13649 0.004317 0.043172 0.2158601 43.1720194647 63.66111 84.88148
210 0.14522 0.004593 0.045933 0.22966667 45.9333333333 66.63828 88.85104
240 0.16179 0.005117 0.051174 0.25587226 51.1744525547 72.10907 96.14542
A(St) C(St)mg/ml
pH 1.2 0.43174 0.13
pH 6.8 0.822 0.026 * razr 1:10
0 mg so prodolzheno oslob)
vo sekoja od vrednostite vo pH 6.8)

Time No.1
0.000000 0.000000 0.000000
30.000000 4.667544 4.667544
60.000000 11.975088 11.975088
90.000000 21.735627 21.735627
120.000000 33.774204 33.774204
150.000000 57.475040 57.475040
180.000000 86.043278 86.043278
210.000000 119.626259 119.626259
240.000000 156.596418 156.596418
Time No.1
0.000000 0.000000 0.000000
30.000000 15.307409 15.307409
60.000000 30.614818 30.614818
90.000000 45.922227 45.922227
120.000000 61.229636 61.229636
150.000000 76.537045 76.537045
180.000000 91.844454 91.844454
210.000000 107.151863 107.151863
240.000000 122.459272 122.459272
Best-fit Values
k0 0.510247 0.510247
Secondary Parameter
T25 48.995882 48.995882
T50 97.991763 97.991763
T75 146.987645 146.987645
T80 156.786821 156.786821
T90 176.385174 176.385174
Goodness of Fit
Parameter No.1
N_observed 9.000000
DF 8.000000
R_obs-pre 0.954034
Rsqr 0.856043
Rsqr_adj 0.856043
MSE 439.675952
MSE_root 20.968451
Weighting 1.000000
SS 3517.407619
WSS 3517.407619
AIC 75.489316
MSC 1.585616
No.1
180
160 Observed
Predicted
140
120
100
80
60
40
20
Time (min)
Mean
180
160 Observed
Predicted
140
120
100
80
60
40
20
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
4.800000 2.449185 2.449185
9.600000 4.898371 4.898371
14.400000 7.347556 7.347556
19.200000 9.796742 9.796742
24.000000 12.245927 12.245927
28.800000 14.695113 14.695113
33.600000 17.144298 17.144298
38.400000 19.593484 19.593484
43.200000 22.042669 22.042669
48.000000 24.491854 24.491854
52.800000 26.941040 26.941040
57.600000 29.390225 29.390225
62.400000 31.839411 31.839411
67.200000 34.288596 34.288596
72.000000 36.737782 36.737782
76.800000 39.186967 39.186967
81.600000 41.636153 41.636153
86.400000 44.085338 44.085338
91.200000 46.534523 46.534523
96.000000 48.983709 48.983709
100.800000 51.432894 51.432894
105.600000 53.882080 53.882080
110.400000 56.331265 56.331265
115.200000 58.780451 58.780451
120.000000 61.229636 61.229636
124.800000 63.678822 63.678822
129.600000 66.128007 66.128007
134.400000 68.577192 68.577192
139.200000 71.026378 71.026378
144.000000 73.475563 73.475563
148.800000 75.924749 75.924749
153.600000 78.373934 78.373934
158.400000 80.823120 80.823120
163.200000 83.272305 83.272305
168.000000 85.721491 85.721491
172.800000 88.170676 88.170676
177.600000 90.619861 90.619861
182.400000 93.069047 93.069047
187.200000 95.518232 95.518232
192.000000 97.967418 97.967418
196.800000 100.416603 100.416603
201.600000 102.865789 102.865789
206.400000 105.314974 105.314974
211.200000 107.764160 107.764160
216.000000 110.213345 110.213345
220.800000 112.662530 112.662530
225.600000 115.111716 115.111716
230.400000 117.560901 117.560901
235.200000 120.010087 120.010087
240.000000 122.459272 122.459272

Time No.1
0.000000 0.000000 0.000000
30.000000 4.667544 4.667544
60.000000 11.975088 11.975088
90.000000 21.735627 21.735627
120.000000 33.774204 33.774204
150.000000 57.475040 57.475040
180.000000 86.043278 86.043278
210.000000 119.626259 119.626259
240.000000 156.596418 156.596418
Time No.1
0.000000 0.000000 0.000000
30.000000 21.225726 21.225726
60.000000 37.946137 37.946137
90.000000 51.117520 51.117520
120.000000 61.493181 61.493181
150.000000 69.666532 69.666532
180.000000 76.105031 76.105031
210.000000 81.176912 81.176912
240.000000 85.172249 85.172249
Best-fit Values
k1 0.007953 0.007953
Secondary Parameter
T25 36.173728 36.173728
T50 87.157734 87.157734
T75 174.315468 174.315468
T80 202.373991 202.373991
T90 289.531725 289.531725
Goodness of Fit
Parameter No.1
N_observed 9.000000
DF 8.000000
R_obs-pre 0.847952
Rsqr 0.614979
Rsqr_adj 0.614979
MSE 1175.933949
MSE_root 34.291893
Weighting 1.000000
SS 9407.471594
WSS 9407.471594
AIC 84.343336
MSC 0.601836
No.1
180
160 Observed
Predicted
140
120
100
80
60
40
20
Time (min)
Mean
180
160 Observed
Predicted
140
120
100
80
60
40
20
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
4.800000 3.745397 3.745397
9.600000 7.350515 7.350515
14.400000 10.820606 10.820606
19.200000 14.160728 14.160728
24.000000 17.375750 17.375750
28.800000 20.470357 20.470357
33.600000 23.449058 23.449058
38.400000 26.316195 26.316195
43.200000 29.075946 29.075946
48.000000 31.732333 31.732333
52.800000 34.289229 34.289229
57.600000 36.750358 36.750358
62.400000 39.119309 39.119309
67.200000 41.399532 41.399532
72.000000 43.594353 43.594353
76.800000 45.706968 45.706968
81.600000 47.740458 47.740458
86.400000 49.697785 49.697785
91.200000 51.581803 51.581803
96.000000 53.395257 53.395257
100.800000 55.140790 55.140790
105.600000 56.820945 56.820945
110.400000 58.438173 58.438173
115.200000 59.994828 59.994828
120.000000 61.493181 61.493181
124.800000 62.935414 62.935414
129.600000 64.323630 64.323630
134.400000 65.659852 65.659852
139.200000 66.946027 66.946027
144.000000 68.184029 68.184029
148.800000 69.375664 69.375664
153.600000 70.522667 70.522667
158.400000 71.626710 71.626710
163.200000 72.689403 72.689403
168.000000 73.712293 73.712293
172.800000 74.696872 74.696872
177.600000 75.644575 75.644575
182.400000 76.556782 76.556782
187.200000 77.434824 77.434824
192.000000 78.279979 78.279979
196.800000 79.093480 79.093480
201.600000 79.876513 79.876513
206.400000 80.630217 80.630217
211.200000 81.355692 81.355692
216.000000 82.053996 82.053996
220.800000 82.726145 82.726145
225.600000 83.373119 83.373119
230.400000 83.995862 83.995862
235.200000 84.595281 84.595281
240.000000 85.172249 85.172249

Time No.1
0.000000 0.000000 0.000000
30.000000 4.667544 4.667544
60.000000 11.975088 11.975088
90.000000 21.735627 21.735627
120.000000 33.774204 33.774204
150.000000 57.475040 57.475040
180.000000 86.043278 86.043278
210.000000 119.626259 119.626259
240.000000 156.596418 156.596418
Time No.1
0.000000 0.000000 0.000000
30.000000 34.041711 34.041711
60.000000 48.142250 48.142250
90.000000 58.961973 58.961973
120.000000 68.083423 68.083423
150.000000 76.119580 76.119580
180.000000 83.384823 83.384823
210.000000 90.065902 90.065902
240.000000 96.284500 96.284500
Best-fit Values
kH 6.215138 6.215138
Secondary Parameter
T25 16.180000 16.180000
T50 64.719998 64.719998
T75 145.619996 145.619996
T80 165.683195 165.683195
T90 209.692794 209.692794
Goodness of Fit
Parameter No.1
N_observed 9.000000
DF 8.000000
R_obs-pre 0.841631
Rsqr 0.607105
Rsqr_adj 0.607105
MSE 1199.982144
MSE_root 34.640758
Weighting 1.000000
SS 9599.857153
WSS 9599.857153
AIC 84.525531
MSC 0.581592
No.1
180
160 Observed
Predicted
140
120
100
80
60
40
20
Time (min)
Mean
180
160 Observed
Predicted
140
120
100
80
60
40
20
Time (min)
Predicted Data
Time No.1
0.000000 0.000000 0.000000
4.800000 13.616685 13.616685
9.600000 19.256900 19.256900
14.400000 23.584789 23.584789
19.200000 27.233369 27.233369
24.000000 30.447832 30.447832
28.800000 33.353929 33.353929
33.600000 36.026361 36.026361
38.400000 38.513800 38.513800
43.200000 40.850054 40.850054
48.000000 43.059737 43.059737
52.800000 45.161433 45.161433
57.600000 47.169579 47.169579
62.400000 49.095654 49.095654
67.200000 50.948968 50.948968
72.000000 52.737192 52.737192
76.800000 54.466738 54.466738
81.600000 56.143028 56.143028
86.400000 57.770700 57.770700
91.200000 59.353752 59.353752
96.000000 60.895664 60.895664
100.800000 62.399487 62.399487
105.600000 63.867912 63.867912
110.400000 65.303325 65.303325
115.200000 66.707858 66.707858
120.000000 68.083423 68.083423
124.800000 69.431740 69.431740
129.600000 70.754368 70.754368
134.400000 72.052722 72.052722
139.200000 73.328090 73.328090
144.000000 74.581653 74.581653
148.800000 75.814491 75.814491
153.600000 77.027600 77.027600
158.400000 78.221897 78.221897
163.200000 79.398232 79.398232
168.000000 80.557392 80.557392
172.800000 81.700107 81.700107
177.600000 82.827058 82.827058
182.400000 83.938881 83.938881
187.200000 85.036167 85.036167
192.000000 86.119474 86.119474
196.800000 87.189323 87.189323
201.600000 88.246201 88.246201
206.400000 89.290572 89.290572
211.200000 90.322867 90.322867
216.000000 91.343497 91.343497
220.800000 92.352848 92.352848
225.600000 93.351286 93.351286
230.400000 94.339158 94.339158
235.200000 95.316792 95.316792
240.000000 96.284500 96.284500
t min A волумен ml mg/ml razr 1:10 mg vo V kum mg % na osl
0 0 0 0 0 0 0 0
30 0.10545 147 0.031752 0.031752 4.667544 4.667544 6.223392
60 0.05845 150 0.0176 0.0176 2.64 7.307544 9.743392
90 0.05395 151 0.016245 0.016245 2.452995 9.760539 13.01405
120 0.05182 146 0.015603 0.015603 2.278038 12.03858 16.05144
* 150 0.23942 154 0.007573 0.075729 11.66226 23.70084 31.60111
* 180 0.10124 152 0.003202 0.032022 4.867402 28.56824 38.09098
* 210 0.10295 154 0.003256 0.032563 5.014742 33.58298 44.77731
* 240 0.069537 154 0.002199 0.021995 3.387179 36.97016 49.29355
A(St) C(St)mg/ml
0.43174 0.13 pH 1.2
0.822 0.026 pH 6.8 * razr 1:10

DDSolver Zero-order Dissolution Modeling

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DDSolver Zero-order Dissolution Modeling

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DDSolver 1.

0 Dissolution Data Modeling of Zero-order Model

Time Unit h Analyst Windows User

Time Unit h Analyst Windows User

Time Unit h Analyst Windows User

500 6 f(x) = 0.12401192

6 f(x) = 0.124011921036181 x + 3.59475374748764

f(x) = 99.4243406236069 x − 73.8597033747931 Higuchi

Time Unit h Analyst Windows User

Time Unit h Analyst Windows User

Time Unit h Analyst Windows User

0 red k=13.05 1red k=0.121 Higuchi

300 f(x) = 13.0585792453453 x + 1.09317520280384 6

f(x) = 64.4675106777394 x − 47.4888954368714

Time Unit h Analyst Windows User

Time Unit h Analyst Windows User

Time Unit h Analyst Windows User

o red k=278.4 1 red k=0.043

f(x) = 1549.99748384139 x + 732.187557599006

Time Unit min Analyst Windows User

Time Unit min Analyst Windows User

Time Unit min Analyst Windows User

Time Unit min Analyst Windows User

Time Unit min Analyst Windows User

Time Unit min Analyst Windows User

t min A mg/ml razr 1:10 mg vo 5 ml mg vo 1000 ml kum mg kum %

Time Unit min Analyst Windows User

Time Unit min Analyst Windows User

Time Unit min Analyst Windows User

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