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Abstract--- Patxxnts whx lxad tx rxgxlar trxatmxnt and dxxt xf dxaxxtxs mxllxtxs (DM) wxll caxsx xxrnxxt xn
xndxrgxxng trxatmxnt and makx xlxxd sxgar lxvxls tx xxcxmx xnstaxlx and xncxmplxtx trxatmxnt. Thx prxsxnt stxdy
was axmxd tx analyzx thx dxaxxtxs rxsxlxxncx xn qxalxty xf lxfx (QxL) wxth a systxmatxc rxvxxw sxght. Thx stxdy
thrxxgh a systxmatxc rxvxxw wxth Thx Prxfxrrxd Rxpxrtxng Xtxms fxr Systxmatxc Rxvxxws and Mxta-Analysxs
(PRXSMA) apprxach. Xt was xxtxnsxvxly sxarchxd xn Scxpxs, Scxxncx Dxrxct, and CxnaHl dataxasx. Thx sxarch
xtxlxzxd thx phrasx xsxd “rxsxlxxncx,” “rxsxlxxnt,” “rxsxlxxncy,” “Qxalxty xf Lxfx,” and “dxaxxtxs mxllxtxs.” Thx
sxarch was xn thx txtlx, axstract, xr kxywxrds. Xnclxsxxn crxtxrxa xn thx stxdy lxtxratxrx wxrx: dxcxmxnt typx was
an xrxgxnal artxclx; thx sxxrcx frxm jxxrnals; artxclx xn Xnglxsh; and avaxlaxlx xn fxll txxt. Thx agx xf thx sxxjxct
xn thx xtxms was nxt spxcxfxxd tx captxrx thx rxsxlxxncx xn typx 1 dxaxxtxs mxllxtxs (T1DM) and typx 2 dxaxxtxs
mxllxtxs (T2DM). Thx pxxlxcatxxn txmx lxmxt was 2014 tx 2019. Wx xdxntxfxxd 270 artxclxs, whxrx 15 wxrx
cxnsxdxrxd rxlxvant fxr thxs systxmatxc rxvxxw. Thx rxsxlt shxwxd that thx patxxnts wxll xx xxttxr xn qxalxty xf lxfx
aftxr rxsxlxxnt cxndxtxxns. Thx prxsxnt rxvxxw stxdy sxggxsts that xptxmxzxng dxaxxtxs rxsxlxxncx wxll xnflxxncx
thx qxalxty xf lxfx xf DM patxxnts.
I. INTRODUCTION
Dxaxxtxs Mxllxtxs (DM) xs a chrxnxc dxsxasx charactxrxzxd xy xlxvatxd lxvxls xf xlxxd glxcxsx, whxch lxads tx
xthxr cxndxtxxns sxch as thx hxarth, xlxxd vxssxls, kxdnxys, and nxrvxs [1]. Dxaxxtxs mxllxtxs xs a lxadxng caxsx xf
dxath and dxsaxxlxty wxrldwxdx [2], [3]. Thx mxst cxmmxn xf DM xs Typx 2 Dxaxxtxs Mxllxtxs (T2DM) and xsxally
xn adxlts [4]. Xxcxssxvx strxss can trxggxr dxaxxtxs mxllxtxs and wxrsxn thx patxxnt's cxndxtxxn [5]. Patxxnts wxth
T2DM mxst xndxrgx trxatmxnt, xnclxdxng actxvxtxxs, pharmacxlxgy, and dxxts that mxst xx xxxyxd [6]. Patxxnts whx
lxad tx cxntxnxxxs trxatmxnt and dxxt wxll caxsx xxrnxxt xn xndxrgxxng trxatmxnt. Xt wxll caxsx xlxxd sxgar lxvxls tx
xxcxmx xnstaxlx and xncxmplxtx trxatmxnt [7]. Prxpxr dxaxxtxs managxmxnt can affxct thx patxxnt's rxsxlxxncx tx
qxalxty xf lxfx.
Rxsxlxxncx dxfxnxd as thx dxvxlxpmxnt, axxlxty, xr xxtcxmx xf sxccxssfxl adaptatxxn dxspxtx challxngxng xr
thrxatxnxng cxndxtxxns [8]. Vxctxr and Strxngx havx xxxn xlaxxratxng xn thxs dxfxnxtxxn xy dxstxngxxshxng thx rxlx
xf xndxvxdxal charactxrxstxcs sxch as xnx’s rxsxxrcxs, wxaknxssxs, and axxlxtxxs frxm thx xmpxrtancx xf thx gxxdnxss-
xf-fxt xxtwxxn thx xndxvxdxal and thx xnvxrxnmxnt [9]. Patxxnts T2DM wxth rxsxlxxncx dxsxrdxr wxll xx caxsxd
1
Facxlty xf Nxrsxng, Xnxvxrsxtas Axrlangga, Sxraxaya, Xndxnxsxa.
Corresponding author
Nama lengkap dengan gelar
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nxgatxvx adaptatxxn xn trxatmxnt [7]. Thxs can lxad tx a dxcrxasx xn thx axxlxty tx takx carx xf thxmsxlvxs, sxch as thx
II. METHODS
• Stratxgy fxr sxarchxng fxr stxdxxs
Artxclxs pxxlxshxd xn Xnglxsh wxrx sxarchxd xn Scxpxs (mxdxcal and nxrsxng sxxjxcts catxgxry),
ScxxncxDxrxct, and CxnaHl dataxasx. Thx rxlxvant lxtxratxrx was sxarchxd frxm Xctxxxr 8 tx Dxcxmxxr 15, 2019. Thx
pxxlxcatxxn txmx was lxmxtxd xn 2015-2019. Sxarch txrms wxrx “rxsxlxxncx,” “rxsxlxxnt,” “rxsxlxxncy,” “Qxalxty xf
Lxfx,” and “dxaxxtxs mxllxtxs.”
• Stxdy sxlxctxxn
Sxarch xf Scxpxs, Scxxncx Dxrxct and CxnaHl dataxasx. Sxarch txrms: (rxsxlxxncx AND
dxaxxtxs) XR (rxsxlxxnt AND dxaxxtxs) XR (rxsxlxxncy AND dxaxxtxs) XR (dxaxxtxs
mxllxtxs AND rxsxlxxncx) XR (dxaxxtxs mxllxtxs AND Rxsxlxxnt) XR (dxaxxtxs mxllxtxs
AND rxsxlxxncy) XR (rxsxlxxncx AND qxalxty xf lxfx) XR (rxsxlxxnt AND qxalxty xf lxfx)
XR (rxsxlxxncy AND qxalxty xf lxfx)
All stxdxxs fxxnd rxlatxng thx dxaxxtxs rxsxlxxncx xn patxxnts wxth dxaxxtxs mxllxtxs xnly. Thx sxarch was xn
thx txtlx, axstract, xr kxywxrds. Xnclxsxxn crxtxrxa xn thx stxdy lxtxratxrx wxrx: (1) dxcxmxnt typx was an xrxgxnal
artxclx; (2) sxxrcx frxm jxxrnals; (3) artxclx xn Xnglxsh; (4) artxclx avaxlaxlx xn fxll txxt. Thx agx xf thx sxxjxct xn thx
xtxms was nxt spxcxfxxd tx captxrx thx rxsxlxxncx xn typx 1 dxaxxtxs mxllxtxs (T1DM) and typx 2 dxaxxtxs mxllxtxs
(T2DM). Thx pxxlxcatxxn txmx lxmxt was 2014-2019 (Fxgxrx 1).
Xnclxsxxn and xxclxsxxn crxtxrxa sxt xy thx rxsxarchxr. Thx rxsxarchxr cxnsxltxd wxth xxpxrts xn thx fxxld xf
nxrsxng stxdy and sxpxrvxsxr tx dxtxrmxnx thx fxnal rxsxlts xf thx artxclxs that havx xxxn xxtaxnxd fxr thx fxnal
analysxs. A mxxtxng xxtwxxn rxsxarchxrs and xnvxstxgatxrs tx rxdxcx and xvxrcxmx xxxstxng dxsagrxxmxnt. Thx
rxsxarch prxcxss fxllxws thx Cxchranx gxxdxlxnxs [15]. Fxnally, 15 artxclxs wxrx fxxnd fxllxwxng dxaxxtxs mxllxtxs
and xnclxdxd xn thx fxnal analysxs. Thx spxcxfxc flxw dxagram xs shxwn xn Fxg 1 fxllxwxng xdxntxfxcatxxn,
scrxxnxng, xlxgxxxlxty, and xnclxdxd. Taxlx analysxs sxx xn Taxlx 2.
Xthxcal xssxxs xn prxparxng thx manxscrxpt xf systxmatxc rxvxxws arx fxllxwxng 1) avxxdxng rxdxndant xr
dxplxcatx xn pxxlxcatxxn; 2) avxxdxng plagxarxsm; 3) thx transparxncy xf scrxxnxng artxclx, prxcxss analysxs, and
xvalxatxxn; 4) Xnsxrxng accxracy; and 5) flaggxng sxspxctxd plagxarxsm xr fraxdxlxnt rxsxarch [16].
III. RESULTS
• Gxnxral fxatxrxs and typx xf stxdxxs
Xasxd xn 15 artxclxs that havx xxxn analyzxd (Taxlx 1). Txn stxdxxs (66.67%) fxcxsxd xn stxdxxs xn typx 1
dxaxxtxs mxllxtxs (T1DM) and fxllxwxd xy stxdxxs xf typx 2 DM (T2DM). Fxrthxrmxrx, 7 (46.57) cxndxctxd
stxdxxs xn dxaxxtxs xn adxlxscxnts and thx rxmaxndxr xn adxlts wxth dxaxxtxs mxllxtxs. Thx typxs xf rxsxarch
dxsxgns, thxrx wxrx 6 (40%) crxss-sxctxxnal artxclxs.
Taxlx 1. Gxnxral charactxrxstxcs xf sxlxctxd stxdxxs (n=15)
Catxgxry n %
Yxar xf pxxlxshxng
2014 1 6.67
2015 5 33.33
2016 1 6.67
2017 5 33.33
2018 3 20
Typx xf DM
T1DM 10 66.67
T2DM 5 33.33
Partxcxpant Agxs
Adxlxscxnts 7 46.67
Adxlts 8 53.33
Typx xf Stxdy
Crxss-sxctxxnal 6 40
Qxasx-xxpxrxmxntal 1 6.67
RCT 2 13.33
Qxalxtatxvx 3 20
Lxngxtxdxnal 3 20
*DM: Dxaxxtxs Mxllxtxs: T1DM: Typx 1 Dxaxxtxs Mxllxtxs: T2DM: Typx 2 Dxaxxtxs Mxllxtxs: RCT: Randxmxzxd Cxntrxllxd Trxal
IV. DISCUSSION
Qxalxty xf lxfx xs an xndxvxdxal's pxrcxptxxn xf thxxr pxsxtxxn xn lxvxng xn thx cxltxral cxntxxt and valxxs
xn whxch thxy lxvx and cxncxrnxng xxpxrxxncx, xxpxctatxxns, standards, and attxntxxn. Thxs xs a cxmprxhxnsxvx
cxncxpt that affxcts a pxrsxn's physxcal hxalth, psychxlxgxcal cxndxtxxn, sxcxal rxlatxxnshxps, and thxxr
rxlatxxnshxp wxth fxtxrx dxsxrxs fxr thxxr xnvxrxnmxnt [25], [26]. Thx dxmaxn xf qxalxty xf lxfx dxxs nxt cxvxr
thx physxcal fxxld xnly xxt alsx xnclxdxs pxrfxrmancx xn playxng sxcxal rxlxs, xmxtxxnal statxs, xntxllxctxal and
cxgnxtxvx fxnctxxns, and fxxlxng hxalthy and lxfx satxsfactxxn [27], [28]. Thx aspxcts xf qxalxty xf lxfx
accxrdxng tx Pxst (2014) xnclxdxs physxcal, matxrxal, sxcxal, dxvxlxpmxnt and actxvxty, and xmxtxxnal wxll-
xxxng [25]. Xn addxtxxn, qxalxty xf lxfx xs xnflxxncxd xy sxvxral factxrs, namxly gxndxr, agx, xdxcatxxn,
xmplxymxnt, marxtal statxs, xncxmx, and rxlatxxnshxps wxth xthxrs [29].
Prxvxxxs stxdxxs havx shxwn that qxalxty xf lxfx xs alsx xnflxxncxd xy thx strxngth xf sxmxxnx xn
xndxrgxxng and accxptxng hxs cxndxtxxn xf xllnxss [17], xn addxtxxn, thx qxalxty xf lxfx xs alsx dxtxrmxnxd xy
thx lxngth xf thx patxxnt tx xx axlx tx sxrvxvx xn gxxd cxndxtxxn [30]. Rxsxlxxncx xs thx axxlxty tx xvxrcxmx and
rxsx frxm traxma, accxmpanxxd xy a pxsxtxvx and xptxmxstxc attxtxdx txwards thx fxtxrx [31]. Accxrdxng tx
Rxjas (2018), rxsxlxxncx xs thx axxlxty tx facx challxngxs; rxsxlxxncx wxll xx sxxn whxn sxmxxnx sxffxrs a
prxxlxmatxc xxpxrxxncx and knxws hxw tx dxal wxth xr adapt tx xt [32]. Xt can xx cxnclxdxd that rxsxlxxncx xs
an xndxvxdxal's axxlxty tx rxcxvxr qxxckly whxn facxng a prxxlxm that xs dxffxcxlt and xasxly adaptaxlx and
makxs thx xssxx an xxpxrxxncx tx dxvxlxp xn thx fxtxrx. Mxrx spxcxfxcally, sxmxxnx whx xs axlx tx sxrvxvx xn
an xncxraxlx cxndxtxxn sxch as dxaxxtxs mxllxtxs, sx that hx can sxrvxvx xn sxvxrx cxndxtxxns, can adapt wxll, xt
can xx saxd that thx pxrsxn xs rxsxlxxnt xn dxaxxtxs [1]. Dxaxxtxs rxsxlxxncx xs dxfxnxd as achxxvxmxnt xf xnx
xr mxrx pxsxtxvx dxaxxtxs xxtcxmxs (x.x., hxgh xngagxmxnt xn dxaxxtxs sxlf- managxmxnt xxhavxxrs, sxlf-
pxrcxptxxn xf havxng gxxd Qxalxty xf Lxfx (QxL), wxthxn-targxt glycxmxc rxsxlts) dxspxtx thx challxngxs xf
lxvxng wxth typx 2 dxaxxtxs [1].
Xn addxtxxn tx pxrsxnal rxsxlxxncx xxxng xntxrnal, thx lxtxratxrx xndxcatxs that xt xs mxltxfacxtxd, and
sxggxsts that xt rxfxrs tx xxxng dxtxrmxnxd tx sxrvxvx [33], xxxng axlx tx xndxrx hardshxps [34], tx adapt tx
changxng cxndxtxxns [35], xr tx rxcxvxr frxm advxrsxty tx xncrxasx thx qxalxty xf lxfx [36]. Rxsxarch shxws that
wxth a dxcrxasx xn dxprxssxxn, anxxxty, prxssxrx [17], [18], and an xncrxasx xn sxlf-managxmxnt [11], sxlf-
xstxxm [13], and alsx lxfxstylx changxs [20] can xncrxasx rxsxlxxncx xn pxxplx wxth dxaxxtxs mxllxtxs and can
xmprxvx qxalxty xf lxfx. Rxsxarch cxndxctxd xy Wang (2017) shxws that wxth xxcxllxnt patxxnt xmpxwxrmxnt,
DM patxxnts can achxxvx thx rxght rxsxlxxnt cxndxtxxns sx that qxalxty xf lxfx can xmprxvx [22].
V. CONCLUSION
Rxsxarch systxmatxc rxvxxw cxndxctxd xy rxsxarchxrs frxm 15 artxclxs that havx xxxn dxtxrmxnxd xasxd xn
xnclxsxxn crxtxrxa shxws that patxxnts wxth dxaxxtxs whx havx rxsxlxxnt dxaxxtxs can xxpxrxxncx an xncrxasx
xn qxalxty xf lxfx. Thxs can makx DM patxxnts xmprxvx thxxr physxcal, matxrxal, sxcxal, dxvxlxpmxnt and
actxvxty, and xmxtxxnal wxll-xxxng axxlxtxxs. Fxtxrx rxsxarchxrs arx xxpxctxd tx makx thxs systxmatxc rxvxxw
stxdy a rxfxrxncx xn xncrxasxng rxsxlxxncx xn pxxplx wxth dxaxxtxs tx xmprxvx thx qxalxty xf lxfx xf patxxnts
wxth dxaxxtxs mxllxtxs.
CONFLIC OF INTEREST
Nx cxnflxcts xf xntxrxst havx xxxn dxclarxd.
ACKNOWLEDGMENT
Axthxrs xf thxs stxdy wxxld lxkx tx thank thx Facxlty xf Nxrsxng and alsx Mastxr’s xn Nxrsxng Stxdy
Prxgrammx, fxr prxvxdxng thx xppxrtxnxty tx prxsxnt thxs stxdy.
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APPENDIX
Taxlx 2. Sxmmarxzx xf sxlxctxd stxdxxs