Advanced wound healing

and professional
scar management

Switzerland
Patients seeking dermatologic Features of Stratamed and Strataderm –
and plastic surgery interventions the ideal material for advanced
have high expectations wound dressings

Fast wound healing is key to minimize abnormal scar formation.1
“The main focus for clinicians is to achieve rapid epithelialization
as a first measure of wound care to manage abnormal scar
formation. This is particularly important for wounds subjected
to tension due to motion, body location or loss of tissue.”1
There are two key features of Stratamed and Strataderm: their resulting durability
on the skin as a sheet, and their permeability to many molecules (water vapour,
oxygen, drugs, etc.) but their impermeability to water. Stratpharma technologies
provide distinctive properties for innovative health care applications, which can
lead to improved comfort for patients and better patient compliance.2,3
Stratamed and Strataderm features for medical application2,3

Features
> Inert
> No pH value
> Molecular structure
> Strong chemical bonds
> High molecular weight
Facelift Body contouring
> Low chemical reactivity
> Low surface energy
> Hydrophobicity
> Film forming
> Permeability
> Pharmacoeconomic
Breast augmentation Body contouring
Benefits
− Does not host or allow the proliferation of bacterial growth
− Will not stain or corrode other materials
− Does not affect the protective acid mantle of the skin
− Ability to form sheets
− Flexibility and adaptability
− Not susceptible to oxidation
− Not susceptible to thermal degradation
− Not absorbed through the skin
− Not absorbed into the human gastrointestinal tract
− Excreted without modification
− Superior biocompatibility with human tissue and other
body fluids
− Low or non-existing allergenic profile
− Waterproof
− From transient sheets and thin, superficial coverings,
to more substantive, longer-lasting sheets with self-levelling
or adhesive properties
− Modulates the diffusion of many substances (oxygen,
carbon dioxide, water vapor)
− Avoids tissue maceration
− Used to reduce nursing time but also to improve comfort and
reduce wound complications

2 3
Stratamed is an advanced film forming wound dressing in the form Strataderm is a self-drying gel for the management
of a self-drying gel. Stratamed is flexible, adaptable, and creates of hypertrophic scars and keloids.
a full contact surface.
For scars old and new Convenient and easy to use
• Used to soften and flatten raised • Rapidly drying, non-sticky and
• Stratamed is a transparent gel for topical application. It dries into scars4 waterproof
a thin and flexible protective sheet that ensures constant contact
• Used to relieve itching and • Can be used on joints and areas
with the wound surface 24 hours a day.
discomfort4 with contours
• Stratamed creates an optimal environment for
• Used to reduce redness and • Transparent, odorless and can be
faster re-epithelialization resulting in reduced downtime.
discoloration4 covered with make-up or sunscreen

• Stratamed creates an optimal environment for the normalization
of the inflammatory response.
• Stratamed is bacteriostatic (protects compromised skin areas
and open wounds from chemical and microbial invasion) and inert
(it does not affect the protective acid mantle of the skin).
• Stratamed is compatible with secondary absorbent dressings.
• Strataderm is semi-occlusive, which allows the skin to breathe
and remain hydrated. This helps to achieve a softer, smoother and
flatter scar.5,6
• Strataderm forms a durable, flexible and waterproof sheet,
which protects scars from microbial and chemical invasion and helps
normalizing collagen production.6
• Strataderm modulates the level of basic fibroblastic growth factors
(bFGF), which have an influence on the formation of hypertrophic
scar tissue.6,7

Time after 1 1 1 2 1 2 1 2
M

M
IN

ON
W
HO

wound formation
DA

60 24 48 7 14 4 8 12
U

EE

TH
U
TE

KS
YS
RS

S
S

Stages of Delayed epithelializa-

COAGULATION INFLAMMATION tion beyond 10
wound healing
PROLIFERATION to 14 days increases
REMODELLING/MATURATION the incidence of 
EPITHELIALIZATION hypertrophic scarring
dramatically.8
Application of advanced film-forming
Stratamed/Strataderm wound dressing

4 5
Clinical results with Stratamed Clinical results with Strataderm

Face lift surgery9 Case study #210 3 months treatment

Monotherapy Classification: linear hypertrophic scar after nevis
treatment with extraction; Location: chest; Dimensions: 1 inch length; 4
Redness
Stratamed Age of scars before treatment: 14 months 3.5 Elevation
3 Hardness
2.5 Itchiness
Tenderness
2

1.5

1
After surgery Day 20
0.5

0
0 1 2 3 Months
Before treatment After 2 months treatment
Breast surgery scars 9 Left scar remained untreated,
Treatment with right scar treated for 2 months

Stratamed in combina-
tion with CO2 fractional
laser Case study #310 3 months treatment
Classification: linear hypertrophic scar after trauma;
Location: head; Dimensions: 1.75 inch length; 4
Redness
Age of scar before treatment: 2 weeks 3.5 Elevation
3 Hardness
Before treatment Month 5 Itchiness
2.5
Tenderness
2

1.5

MOHS surgery 1

reconstruction10 0.5

Monotherapy 0
0 1 2 3 Months
treatment with Before treatment After 3 months treatment
Stratamed

Before treatment Month 2 Case study #410 5 months treatment

Classification: hypertrophic scar after surgery;
Location: knee; Dimensions: 0.2 inch length; 4 Redness
Elevation
Age of scars before treatment: 13 months 3.5
Hardness
Chronic wound 11 3
Itchiness
Monotherapy 2.5 Tenderness
treatment with 2

Stratamed, twice daily 1.5

0.5

0
0 1 2 3 4 5 Months
After 1 month treatment After 5 months treatment
4 months after surgery, before treatment Day 7

6 7
Dry and moist wound healing –
the difference
Dry wound healing12
Scab
Zone of secondary injury
from dessication
When wounds are kept exposed to
the air they will dry and form a scab.
The scab protects the wound from
environmental contamination, but has
some disadvantages:
• Slower healing
• Cells move below the wound bed
to find a moist area
• Delayed proliferation and remodel­
lation phase
The wound will experience delayed
wound healing.
Appropriate wound dressing should support the natural healing process;
i.e., should provide a moist wound interface, absorb or remove excess exudate,
prevent contamination and provide an environment favorable to the body’s
natural defense mechanisms.
8 9
How the combination of Stratamed
and Strataderm works
Moist wound healing12 Stratamed: Faster re-epithelialization of the wound bed
Protective dressing Stratamed’s protective and hydrophobic film has a semi-occlusive
effect and therefore improves the tissue hydration of the
Wound care. Philadelphia: Wolters Kluwer/Lippincott
injured skin area. This environment allows a faster migration of
Images taken from: Sussman C, Bates-Jensen B.
keratinocytes across the wound bed and supports a more rapid
re-epithelialization. The faster re-epithelialization decreases the incidence of
Williams & Wilkins Health; 2012
abnormal scarring9,11 and gives patients a faster recovery time.
Stratamed: Reduction of inflammatory response
Moist environment Stratamed forms a flexible, protective sheet that weakly bonds
to the injured skin and protects it from chemical and microbial
invasion, but it does not penetrate into the epidermis or dermis.9
Moist wound conditions allow optimal
Startamed has no measurable pH value, and therefore does not
cell migration, proliferation, differentia-
affect the protective acid mantle of the skin and does not react with the newly
tion and neovascularization.13
forming epithelial tissues.9 This environment leads to a reduction in the inflam-
• Stratamed and Strataderm emulate matory response (redness/discoloration, burning sensation, itching, discomfort,
the epidermal barrier and enhance pain etc), and therefore enhances therapeutic results.9
the healing of wounds.
• Stratamed and Strataderm prevent
Strataderm: Scar management
water loss while maintaining the
oxygen transfer rate. After the re-epithelialization of a wound, the stratum corneum
is immature and still allows abnormally high levels of Trans-
The wound is kept under an optimal
Epidermal Water Loss (TEWL). Dehydration is signaled to keratino­
environment for healing.
cytes, which then start to produce cytokines, which activate
dermal fibroblasts to synthesize and release collagen. Excessive
collagen production leads to abnormal scarring.9
At this stage, the Strataderm layer restores the barrier function of the
stratum corneum, reduces TEWL and stops dehydration of the skin, resulting
in a normal mature scar.6
Directions for use
Ensure that the affected skin or wound is clean.
Apply a very thin layer directly to the affected area.
To achieve the best results, leave the gel in constant
contact with the skin (24 hours a day/7 days a week).
Compatible with secondary dressings. Once dry, the gel
may be covered by sunscreen or cosmetics.
How thin to apply?
Without the usage of a secondary dressing, Stratamed and Strataderm dry
to form a flexible, protective sheet on the affected skin that is gas permeable
but semi-occlusive. The layer weakly bonds to the skin and protects it from
chemical and microbial invasion, but it does not penetrate into the epidermis
or dermis6.
In order to ensure the optimal function of Stratamed and Strataderm, the
applied layer should be less than the thickness of this piece of paper or as if
you stretch a piece of household clingfilm over your skin.

Stratamed Strataderm e
onc y
On damaged or broken skin On damaged skin or wounds dail
not requiring a secondary dressing: requiring a secondary dressing:
3–4 min

•A  pply a very thin layer of Stratamed to
the affected area and allow the gel to dry.
• Stratamed should be applied once daily,
or twice daily to exposed areas or as advised
by your physician.
• Once dry, Stratamed can be covered by
sunscreen, cosmetics, pressure garments
or casts.
1 Ensure that the scar is clean and dry. 2 Apply a very thin layer of Strataderm to the
scar and allow to dry. When applied correctly,
Strataderm should be dry in 3–4 minutes.
• Apply a thin layer of Stratamed then cover
with the secondary dressing. Drying is not
necessary.
• Stratamed should be reapplied when changing
the dressing or checking wound progress, or
as advised by your physician.
3 If it takes longer to dry you have probably 4 Once dry, Strataderm can be covered 
applied too much. Gently remove the excess by sunscreen, cosmetics, pressure garments
with a tissue and allow the drying process or casts.
to continue.

Stratamed is available in 0.17 oz, 0.35 oz, 0.7 oz and 1.75 oz tubes. Strataderm is available in 0.17 oz, 0.35 oz, 0.7 oz and 1.75 oz tubes.
Enough to treat a 1–2 inch (2–4 cm) linear incision twice per day
0.17 oz (5g) 0.17 oz (5g) Enough to treat a 1–2 inch (2–3 cm) linear scar for over 90 days.
for over 90 days.
Enough to treat a 2–3 inch (5–8 cm) linear incision twice per day
0.35 oz (10 g) 0.35 oz (10 g) Enough to treat a 2–3 inch (5–7 cm) linear scar for over 90 days.
for over 90 days.
Enough to treat a 4–5 inch (10–12 cm) linear incision twice per day for over
0.7 oz (20 g) 0.7 oz (20 g) Enough to treat a 4–6 inch (10–14 cm) linear scar for over 90 days.
90 days or an area of 2.5 × 5 inch (6 × 12 cm) twice per day for over 60 days.

1.75 oz (50 g) Enough to treat an area of 5 × 6 inch (12 × 15 cm) twice per day for over 60 days. 1.75 oz (50 g) Enough to treat an area of 2.5 × 5 inch (6×12 cm) for over 90 days.

10 11
us.stratamed.com

The usage of Stratamed does not require

changes in any existing wound care
protocol. It is a simple addition to your
usual process – but with great effects.
• C an be applied immediately after interventions
• Bacteriostatic, gas permeable and inert9,11
• C reates optimal environment for faster
re-epithelialization resulting in reduced downtime9
• C reates an optimal environment for normalization
of the inflammatory response9
•H  ydrates and protects superficial wounds and
compromised skin9
• Improves the visible outcome of the treatment9
• P rovides symptomatic relief (redness/discoloration,
itching, discomfort, pain)9
•A  llows management of abnormal scarring to begin
earlier than ever before9

us.strataderm.com

Strataderm – for the management of

hypertrophic scars and keloids.

• For old and new scars

• Once per day application
• Used to soften and flatten raised scars4
•U sed to relieve the itching and discomfort
associated with scars4
• Used to reduce redness and discoloration4

References 7. Hanasono MM et al. Facial Plast Surg 2004;6:88–93

1. Upton Z et al. Wounds Int 2011; 2(1):7–8
2. Curtis JM, Colas A. Biomaterials Science, 2nd Edition; Ratner, B. D., Ed.;
Elsevier: London, UK, 2004, 80
3. Thomas X. Dow Corning technical paper, Form No. 52-1057–01
4. Tobola J. Dermat Estetyczna 2004;35(6):323–328
5. Monstrey S et al. JPRAS 2014;1–9
6. Mustoe TA. Aesth Plast Surg 2008;32:82–92
8. Gauglitz GG et al. Mol Med 2011;17(1–2):113–125
9. Sandhofer M, Schauer P. Skinmed 2012; 10(6):1–7
10. Data on file. Stratpharma AG
11. Monk EC et al. Dermatol Surg 2014; 40:76–79
12. S ussman C, Bates-Jensen B. Wound care. Philadelphia: Wolters Kluwer/Lippincott
Williams & Wilkins Health; 2012
13. Jones K, Fennie K, Lenihan A. Advances in Skin & Wound Care. 2007;20:591–600
SM-SD-US-050-2-0116

Manufactured by: To contact a Stratpharma

Stratpharma AG representative in USA please call
Centralbahnplatz 8 (877) 226-7525
CH-4051 Basel
Switzerland Switzerland