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Radioactive Decay 2011 4slidesperpage
Radioactive Decay 2011 4slidesperpage
Decay of Radioactivity Nuclear shell model – “orbitals” for protons and neutrons – and
how the energy differences leads to nuclear decay
Differences between isotopes, isobars, isotones, isomers
Know how to diagram basic decays, e.g.
Robert Miyaoka, PhD
rmiyaoka@u.washington.edu
Nuclear Medicine Basic Science Lectures
Conservation principles: Energy (equivalently, mass); linear
https://www.rad.washington.edu/research/Research/groups/irl/ed
momentum; angular momentum (including intrinsic spin);
ucation/basic-science-resident-lectures/2011-12-basic-science- and charge are all conserved in radioactive transitions
resident-lectures Understand where gamma rays come from (shell transitions in
September 12, 2011 the daughter nucleus) and where X-rays come from.
Understand half-life and how to use it
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Activity Decay Constant
• Average number of radioactive decays per unit time (rate) • Fraction of nuclei that will decay per unit time:
• or - Change in number of radioactive nuclei present: = -(dN/dt) / N(t) = A(t) / N(t)
A = -dN/dt • Constant in time, characteristic of each nuclide
• Depends on number of nuclei present (N). During decay of a • Related to activity: A = λ * N
given sample, A will decrease with time. • Measured in (time)-1
• Measured in Becquerel (Bq): Example: Tc-99m has λ= 0.1151 hr-1, i.e., 11.5% decay/hr
1 Bq = 1 disintegration per second (dps) Mo-99 has λ = 0.252 day-1, i.e., 25.2% decay/day
• {Traditionally measured in Curies (Ci): • If nuclide has several decay modes, each has its own λi.
1 Ci = 3.7 x 1010 Bq (1 mCi = 37 MBq) Total decay constant is sum of modes: λ = λ1 + λ2 + λ3 +
Traditionally: 1 Ci is the activity of 1g 226Ra.} • Branching ratio = fraction in particular mode: Bri = λi / λ
Example: 18F: 97% β+, 3% Electron Capture (EC)
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Question Answer
N(0) = 1000, λ = 0.1 sec-1
Example: N(0) = 1000 and λ = 0.1 sec-1
A(0) = 100; N(1) = 900; A(1) = 90; N(2) = 810
What is A(0) = ?
A(t )
$ t '
& "0.693 # T () 1
t Iodine 131 8.02 d 0.0864 d-1
= e(!t ) = e% 1/2
= ( ) T1/2
A(0) 2 λ ≈ 0.693 / T1/2
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Average Lifetime Determining Decay Factors (e-λt)
Table of Decay factors for Tc-99m
Average time until decay varies between nuclides from 'almost Minutes
zero' to 'almost infinity'. Hours
0 15 30 45
This average lifetime is characteristic for each nuclide and 0 1.000 0.972 0.944 0.917
doesn't change over time:
1 0.891 0.866 0.844 0.817
! = 1/ " = T1/2 / ln 2
3 0.707 0.687 0.667 0.648
τ is longer than the half-life by a factor of 1/ln2 (~1.44)
5 0.561 0.545 0.530 0.515
Example: Example:
DF (3.5) = DF (3.5) =
0.088
Examples Answer
C-11 has a half-life of 20 minutes. Initial sample has 1000 C-11 has a half-life of 20 minutes. Initial sample has 1000
nuclei. nuclei.
Q: How many are left after 40 minutes? Q: How many are left after 40 minutes?
After 60 minutes? After 60 minutes?
When is less than 1 left? When is less than 1 left?
t t+Δt t
ad
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• With approximation: DFeff = DF(t) * [1 - (x/2)] = 0.810 • With approximation: DFeff = DF(t) * [1 - (x/2)] = 0.654
⇒ Approximation is very good in this case. ⇒ Approximation is NOT very good in this case.
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Effective Decay Factor Specific Activity
x = 0.693 * !t / T1/ 2
Taylor series expansion: DFeff ( t , !t ) " DF (t ) # [1 $ ( x / 2)] • Ratio of total radioisotope activity to total mass of the
element present
DFeff is accurate to within 1% when x<0.25
• Measured in Bq/g or Bq/mole
• Useful if radioactive and non-radioactive isotopes of the
Midpoint of frame: DFeff ( t , !t ) " DF (t ) # [ t + (!t / 2)] same element are in mixture (sample with carrier)
• Maximum Specific Activity in carrier-free samples:
DFeff is accurate to within 1% when x<0.5 Carrier Free Specific Activity (CFSA)
CFSA [Bq/g] ≈ 4.8 x 1018 /(A x T1/2) for T1/2 given in days, A: atomic
weight
[ DF ( t ) + DF ( t + !t )]
Average of DF's: DFeff ( t , !t ) " CFSA(Tc-99m) = 4.8 x 1018 / (99 * 0.25) = 1.9 x 1017 Bq/g
2 = 5.3 x 106 Ci/g
DFeff is accurate to within 1% when x<0.35
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Question Answer
What has a higher Carrier Free Specific Activity (CFSA) What has a higher Carrier Free Specific Activity (CFSA)
Carbon-11 or Fluorine-18? Carbon-11 or Fluorine-18?
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Decay of Mixed Radionuclide Sample Biologic and Physical Decay
For unrelated radionuclides in a mixture, the total Activity is The effective half-life of a radiopharmaceutical with a physical
the sum of the individual activities: half-life of T1/2,physical and a biological half-life of T1/2, biological is:
( !0.693* t / T1 /2 ,1 ) ( !0.693* t / T1/ 2 ,1 )
At ( t ) = A1(0) * e + A2 (0) * e + ...
1 / T1/2 , eff = (1 / T1/2 , phy sical ) + (1 / T1/2 , bio log ical )
or
At(t) always eventually follows the (T1/ 2, phy sic al ! T1/2 , bio log ical )
slope of the longest half-life nuclide. T1 /2, eff =
(T1/ 2, phy sic al + T1/2 , bio log ical )
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Figure from Physics in Nuclear Medicine (Cherry, Sorenson and Phelps) Fall 2011, Copyright UW Imaging Research Laboratory Figure from Physics in Nuclear Medicine (Cherry, Sorenson and Phelps) Fall 2011, Copyright UW Imaging Research Laboratory
Transient Equilibrium No Equilibrium
If Td > Tp, no equilibrium is possible.
Parent Half-life longer than Daughter’s, but not ‘infinite’
Example: 99Mo (T
1/2 = 66hr) →
99mTc (T
1/2 = 6 hr) Example: 131mTe (T1/2 = 30hr) 131I (T1/2 = 8 days)
Ap decreases significantly over the observation time, so λp≈0. Buildup and decay of daughter shows maximum again.
When parent distribution is gone, further daughter decay is
The daughter activity increases, according to the daughter’s
exceeds that of the parent, decay equation only.
reaches a maximum value,
then decreases and follows the
decay of the parent. Then the
ratio of daughter to parent is
constant: transient equilibrium.
equilibrium
Ad/Ap = [Tp/(Tp - Td)] * BR
Figure from Physics in Nuclear Medicine (Cherry, Sorenson and Phelps) Fall 2011, Copyright UW Imaging Research Laboratory Fall 2011, Copyright UW Imaging Research Laboratory
Summary
Mathematical description of decay only yields probabilities
and averages.