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  • Tugas Farmakokinetik - Aka Frastiyana - 19334753

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    Boy Jiu
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    This document contains pharmacokinetic data for a subject named Aka Frastiyana including time points, plasma concentrations (Cp), and log transformed Cp values. It also provides the given information of subject weight of 75kg and drug dose of 2 ng/kg. The tasks are to calculate the volume of distribution (Vd), half-life (t1/2), and total clearance (Cl). The summary calculates these values as follows: Vd is 19.5927 L, t1/2 is 2.91 hours, and Cl is 4.6630 L/hour.

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    Tugas Farmakokinetik_ Aka Frastiyana_ 19334753

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    This document contains pharmacokinetic data for a subject named Aka Frastiyana including time points, plasma concentrations (Cp), and log transformed Cp values. It also provides the given information of subject weight of 75kg and drug dose of 2 ng/kg. The tasks are to calculate the volume of distribution (Vd), half-life (t1/2), and total clearance (Cl). The summary calculates these values as follows: Vd is 19.5927 L, t1/2 is 2.91 hours, and Cl is 4.6630 L/hour.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    11 views2 pages

    Tugas Farmakokinetik - Aka Frastiyana - 19334753

    Uploaded by

    Boy Jiu
    This document contains pharmacokinetic data for a subject named Aka Frastiyana including time points, plasma concentrations (Cp), and log transformed Cp values. It also provides the given information of subject weight of 75kg and drug dose of 2 ng/kg. The tasks are to calculate the volume of distribution (Vd), half-life (t1/2), and total clearance (Cl). The summary calculates these values as follows: Vd is 19.5927 L, t1/2 is 2.91 hours, and Cl is 4.6630 L/hour.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 2

    Tugas Farmakokinetik

    Nama : Aka Frastiyana


    NIM : 19334753
    t (jam) Cp Log Cp
    0,16 9,5 0,9777
    0,33 7,4 0,8692
    0,50 6,3 0,7993
    1,00 5,3 0,7242
    2,00 4,2 0,6232
    4,00 2,9 0,4623
    8,00 1,2 0,07918

    Diketahui : BB 75 kg. Dosis obat 2 ng/kg


    Dit : Volume distribusi (Vd), Waktu paruh (t1/2), Clearence total (Cl)
    Jawab :
    • Dosis (DB0) : Dosis tunggal x BB
    : 2 mcg/kg x 75 kg = 150 mcg
    • Cari Persamaan Linear dari “Log Cp”, didapat y = -0,1036x + 0,8832
    1.2

    y = -0.1036x + 0.8846
    1 R² = 0.9628

    0.8
    t (waktu)

    0.6

    0.4

    0.2

    0 Series1 Linear (Series1) Linear (Series1) Linear (Series1)


    0 2 4 Log Cp 6 8 10

    • Mencari Cp0
    Cp = 100,884 = 7,6559 mcg/L

    • Volume Distribusi (VD)


    VD = DB0 / Cp0 = 150 mcg : 7,6559 mcg/L = 19,5927 L
    • Mencari k
    Slope = -k/2,303
    -k = slope x 2,303
    -k = -0,1036 x 2,303
    k = 0,238/jam

    • Mencari Waktu Paruh (t1/2)


    t1/2 = 0,693/k
    1/2
    t = 0,693/0,238
    t1/2 = 2,91 jam

    • Mencari Clearence (Cl)


    Cl = k.VD
    Cl = 0,238 x 19,5927 = 4,6630 L/jam

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