C (ug/mL) Serapan Kon

0 0 0 0 0 0 0
2.0197 0.0706 0.0708 0.0711 0.071 0.0705 3.150442
8.0788 0.1395 0.139 0.14 0.1392 0.1399 9.247788
10.0985 0.1591 0.1581 0.1589 0.1595 0.1587 10.9823
40.3941 0.4939 0.494 0.4942 0.4935 0.4937 40.61062
45.4433 0.5516 0.5523 0.552 0.5512 0.5519 45.71681
70.6896 0.8284 0.828 0.829 0.8288 0.8283 70.21239

Chart Title Chart Title Chart Title

0.9 0.9 0.9
0.8 f(x) = 0.011314357310.8
xf(x)
+ 0.03479735972 0.8 f(x) = 0.011319517225723 x
= 0.0113181183189 x + 0.0345738368867
0.7 R² = 0.996982722152658
0.7R² = 0.997015308649985 0.7 + 0.034967091114483
0.6 0.6 0.6 R² = 0.99695280237807
0.5 0.5 0.5
0.4 0.4 0.4
0.3 0.3 0.3
0.2 0.2 0.2
0.1 0.1 0.1
0 0
0 10 20 30 40 050 10 60 20 80 40 50 60 070
70 30 0 80
10 20 3 0 4 0 50 60 70 80

Chart Title Chart Title

0.9 0.9
0.8f(x) = 0.011312958401201 x + 0.034846962786591
0.8f(x) = 0.0113143573112 x + 0.0347830740753
0.7R² = 0.996977451247563 0.7R² = 0.996978353853852
0.6 0.6
0.5 0.5
0.4 0.4
0.3 0.3
0.2 0.2
0.1 0.1
0 0
0 10 20 30 40 50 60 700 80 10 20 30 40 50 60 70 80
 Konsentrasi Akurasi (syarat <=15%) Presisi (syarat <=
0 0 0 0 0 0 0 0 0 rata-rata
3.168142 3.185841 3.185841 3.141593 55.98567 56.86199 57.73831 57.73831 55.5475 3.16637168142
9.20354 9.221239 9.221239 9.283186 14.46982 13.92211 14.1412 14.1412 14.90798 9.23539823009
10.89381 11.0177 11.0177 10.9469 8.751804 7.87548 9.102333 9.102333 8.401274 10.9716814159
40.61947 40.57522 40.57522 40.59292 0.536018 0.557926 0.448385 0.448385 0.492201 40.5946902655
45.77876 45.68142 45.68142 45.74336 0.60188 0.738197 0.523985 0.523985 0.660302 45.7203539823
70.17699 70.24779 70.24779 70.20354 -0.675079 -0.725155 -0.625003 -0.625003 -0.687598 70.217699115

a 0.035
b 0.0113
r 0.997
Presisi (syarat <=15%)
sd SBR
0.020180096 0.63732555903
0.0310365981 0.33606128625
0.0525040601 0.47854160265
0.020180096 0.04971117131
0.0417901556 0.09140383209
0.0303992284 0.04329282897
Uji
waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC t-inf
0 0 0 0 0 0
0.5 0.074 3.4513274336 1.238759 0.862832 0.862832
2 0.085 4.4247787611 1.48722 5.90708 6.769912
3.5 0.172 12.123893805 2.495178 12.4115 19.18142
4 0.299 23.362831858 3.151146 8.871681 28.0531 14.6696597321252
6 0.254 19.380530973 2.964269 42.74336 70.79646
8 0.177 12.566371681 2.531024 31.9469 102.7434
10 0.086 4.5132743363 1.507023 17.07965 119.823
12 0.078 3.8053097345 1.336397 8.318584 128.1416
AUC 0-12 16.71102

a 0.035
b 0.0113
r 0.997

3 titik 4 titik 5 titik

3 3.5 3.5
2.5 3 3 f(x) = − 0.254337203599884 x + 4.332
f(x) = − 0.298656735477 x 2.5 f(x) = − 0.2953808133623 x 2.5 R² = 0.931961739032899
2
+ 4.778048897724 2 + 4.7431057285012 2
1.5 R² = 0.934895682948048 1.5
R² = 0.854630505084465 1.5
1 1
1
0.5 0.5 0.5
0 0 0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13 3 4 5 6 7 8 9 10

Pembanding

Waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC t-inf

0 0 0 0 0 0
0.5 0.076 3.6283185841 1.288769 0.90708 0.90708
2 0.095 5.3097345133 1.669542 6.70354 7.610619
3.5 0.172 12.123893805 2.495178 13.07522 20.68584
4 0.299 23.362831858 3.151146 8.871681 29.55752 12.8818880653801
6 0.254 19.380530973 2.964269 42.74336 72.30088
 12.8818880653801

8 0.177 12.566371681 2.531024 31.9469 104.2478

10 0.086 4.5132743363 1.507023 17.07965 121.3274
12 0.078 3.8053097345 1.336397 8.318584 129.646
AUC 0-12 16.94335

a 0.035
b 0.0113
r 0.997

Chart Title Chart Title

3 4
2.5 3
2 f(x) = − 0.2986567354769 x f(x) = − 0.295380813362288 x + 4.74310572850121
1.5 + 4.778048897724 2 R² = 0.934895682948048
R² = 0.854630505084465
1 1
0.5
0 0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13
 Auc 0-inf (ng/mL jam) T 1/2

142.811252652479 2.67155

b 0.2594

5 titik

f(x) = − 0.254337203599884 x + 4.33266963087717

R² = 0.931961739032899

3 4 5 6 7 8 9 10 11 12 13

Auc 0-inf (ng/mL jam) T 1/2

142.527905764495 2.345972
 142.527905764495 2.345972

b 0.2954

Chart Title
4

.74310572850121 3f(x) = − 0.254337203599884 x + 4.33266963087717

R² = 0.931961739032899
2
1

11 12 13 0
3 4 5 6 7 8 9 10 11 12 13
Uji
waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC t-inf
0 0 0 0 0 0
0.5 0.075 3.539823 1.264077 0.884956 0.884956
2 0.089 4.778761 1.564181 6.238938 7.123894
3.5 0.112 6.814159 1.919003 8.69469 15.81858
4 0.263 20.17699 3.004543 6.747788 22.56637 9.3344292644729
6 0.239 18.0531 2.893317 38.23009 60.79646
8 0.176 12.47788 2.523957 30.53097 91.32743
10 0.113 6.902655 1.931906 19.38053 110.708
12 0.071 3.185841 1.158716 10.0885 120.7965
AUC 0-12 16.2597

a 0.035
b 0.0113
r 0.997

Chart Title Chart Title

3 4
2.5 3
2 f(x) = − 0.341310237981 x
+ 5.284628872595 f(x) = − 0.289792711492645 x + 4.73510859005753
1.5 2 R² = 0.976252783302535
R² = 0.994166324470873
1 1
0.5
0 0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13

Pembanding

Waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC t-inf

0 0 0 0 0 0
0.5 0.076 3.628319 1.288769 0.90708 0.90708
2 0.097 5.486726 1.702332 6.836283 7.743363
3.5 0.177 12.56637 2.531024 13.53982 21.28319
4 0.384 30.88496 3.430269 10.86283 32.14602 13.7946338874178
6 0.343 27.25664 3.305297 58.14159 90.28761
 13.7946338874178

8 0.169 11.85841 2.473037 39.11504 129.4027

10 0.145 9.734513 2.275678 21.59292 150.9956
12 0.081 4.070796 1.403839 13.80531 164.8009
AUC 0-12 18.41024

a 0.035
b 0.0113
r 0.997

Chart Title Chart Title

3 4
2.5
f(x) = − 0.267299601 x 3 f(x) = − 0.29508673 x + 5.020243178
2 + 4.723847137
1.5 R² = 0.88288706855604 2 R² = 0.952881595053735
1 1
0.5
0 0
7.5 8 8.5 9 9.5 1010.51111.51212.5 5 6 7 8 9 10 11 12 13
 Auc 0-inf (ng/mL jam) T 1/2

130.130889441464 2.0304717257545

b 0.3413

Chart Title
art Title
3.5
3 f(x) = − 0.232653227407564 x + 4.16371374920672
2.5 R² = 0.926621513149451
45 x + 4.73510859005753 2
1.5
1
0.5
0
3 4 5 6 7 8 9 10 11 12 13
9 10 11 12 13

Auc 0-inf (ng/mL jam) T 1/2

178.59551884317 2.3483564893257
178.59551884317 2.3483564893257

b 0.2951

Chart Title
4
3 f(x) = − 0.254124023430391 x + 4.61061611520652
R² = 0.944001788530052
2
1
0
3 4 5 6 7 8 9 10 11 12 13
Uji
waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC Auc
t-inf0-inf (ng/mL jam)
T 1/2
0 0 0 0 0 0
0.5 0.078 3.80531 1.336397 0.951327 0.951327
2 0.096 5.39823 1.686071 6.902655 7.853982
3.5 0.167 11.68142 2.457999 12.80973 20.66372
4 0.254 19.38053 2.964269 7.765487 28.4292 44.18726 167.6607 4.740082
6 0.197 14.33628 2.662794 33.71681 62.14602
8 0.166 11.59292 2.450395 25.9292 88.07522
10 0.133 8.672566 2.160165 20.26549 108.3407
12 0.108 6.460177 1.865657 15.13274 123.4735
AUC 0-12 17.58375

a 0.035
b 0.0113
r 0.997

Chart Title Chart Title Chart Title

3 3 3.5
2.5 3
2.5 f(x) = − 0.134082026339 x f(x) = − 0.1349926717 x
f(x) = − 0.146184470513 x 2 + 3.491490655897 2.5
2 2 + 3.5005971095
+ 3.620583393754 R² = 0.994589523536152 R² = 0.997278538323137
1.5 R² = 0.999982156942328 1.5
1.5
1 1 1
0.5 0.5 0.5
0 0 0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13 3 4 5 6 7 8 9 10 11 12 13

Pembanding

Waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC Auc

t-inf0-inf (ng/mL jam)
T 1/2
0 0 0 0 0 0
0.5 0.076 3.628319 1.288769 0.90708 0.90708
2 0.107 6.371681 1.851863 7.5 8.40708
3.5 0.177 12.56637 2.531024 14.20354 22.61062
4 0.384 30.88496 3.430269 10.86283 33.47345 13.79463 179.923 2.348356
6 0.343 27.25664 3.305297 58.14159 91.61504
 13.79463 179.923 2.348356

8 0.169 11.85841 2.473037 39.11504 130.7301

10 0.145 9.734513 2.275678 21.59292 152.323
12 0.081 4.070796 1.403839 13.80531 166.1283

AUC 0-12 18.55978

a 0.035
b 0.0113
r 0.997

Chart Title Chart Title Chart Title

3 3.5 4
2.5 3 f(x) = − 0.295086729680597 x 3.5
2
f(x) = − 0.267299600865454 x 2.5 + 5.02024317770858 3f(x) = − 0.25412402343 x + 4.610616
+ 4.72384713701372 R² = 0.944001788530052
2 R² = 0.952881595053735 2.5
1.5 R² = 0.88288706855604
1.5 2
1 1 1.5
0.5 0.5 1
0 0 0.5
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13 0
3 4 5 6 7 8 9 10 11
 b 0.1462

Chart Title

x) = − 0.1349926717 x
+ 3.5005971095
² = 0.997278538323137

5 6 7 8 9 10 11 12 13
 b 0.2951

Chart Title
4
5
3f(x) = − 0.25412402343 x + 4.610616115207
R² = 0.944001788530052
5
2
5
1
5
0
3 4 5 6 7 8 9 10 11 12 13
Uji
waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC Auc
t-inf0-inf (ng/mL jam)
T 1/2
0 0 0 0 0 0
0.5 0.078 3.80531 1.336397 0.951327 0.951327
2 0.096 5.39823 1.686071 6.902655 7.853982
3.5 0.167 11.68142 2.457999 12.80973 20.66372
4 0.254 19.38053 2.964269 7.765487 28.4292 17.24982 121.4312 3.141432
6 0.197 14.33628 2.662794 33.71681 62.14602
8 0.166 11.59292 2.450395 25.9292 88.07522
10 0.086 4.513274 1.507023 16.10619 104.1814
12 0.078 3.80531 1.336397 8.318584 112.5
AUC 0-12 16.40135
a 0.035
b 0.0113
r 0.997

Chart Title Chart Title Chart Title

3 3 3.5
2.5 2.5 3
f(x) = − 0.24612801745 x f(x) = − 0.2205756965377 x
2 f(x) = − 0.2784993018769 x 2 + 4.20430428309 2.5 + 3.948781073917
1.5 + 4.54959798359 1.5 R² = 0.914348400615343 2 R² = 0.933064297241565
1 R² = 0.861777314990605
1 1.5
0.5 0.5 1
0 0 0.5
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13
0
3 4 5 6 7 8 9 10 11 12 13

Pembanding

Waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC Auc

t-inf0-inf (ng/mL jam)
T 1/2
0 0 0 0 0 0
0.5 0.076 3.628319 1.288769 0.90708 0.90708
2 0.095 5.309735 1.669542 6.70354 7.610619
3.5 0.172 12.12389 2.495178 13.07522 20.68584
4 0.299 23.36283 3.151146 8.871681 29.55752 12.88189 142.5279 2.345972
6 0.254 19.38053 2.964269 42.74336 72.30088
 12.88189 142.5279 2.345972

8 0.177 12.56637 2.531024 31.9469 104.2478

10 0.086 4.513274 1.507023 17.07965 121.3274
12 0.078 3.80531 1.336397 8.318584 129.646
AUC 0-12 16.94335
a 0.035
b 0.0113
r 0.997

Chart Title Chart Title Chart Title

3 4 4
2 f(x) = − 0.29865673548 x 3 3 f(x) = − 0.2543372036 x
+ 4.77804889772 f(x) = − 0.2953808133623 x + 4.332669631
2 + 4.7431057285012 2
1 R² = 0.854630505084465 R² = 0.931961739032899
1 R² = 0.934895682948048 1
0 0 0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13 3 4 5 6 7 8 9 10 11 12 13
 b 0.2206
Chart Title

x) = − 0.2205756965377 x
3.948781073917
= 0.933064297241565

5 6 7 8 9 10 11 12 13
 b 0.2954
Chart Title

) = − 0.2543372036 x
4.332669631
= 0.931961739032899

6 7 8 9 10 11 12 13
Uji
waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC Auc
t-inf0-inf (ng/mL jam)
T 1/2
0 0 0 0 0 0
0.5 0.075 3.539823 1.264077 0.884956 0.884956
2 0.089 4.778761 1.564181 6.238938 7.123894
3.5 0.112 6.814159 1.919003 8.69469 15.81858
4 0.263 20.17699 3.004543 6.747788 22.56637 9.334429 120.0424 2.030472
6 0.239 18.0531 2.893317 38.23009 60.79646
8 0.176 12.47788 2.523957 30.53097 91.32743
10 0.113 6.902655 1.931906 19.38053 110.708
12 0.071 3.185841 1.158716 10.0885 120.7965
AUC 0-12 16.2597
a 0.035
b 0.0113
r 0.997

Chart Title Chart Title Chart Title

3 3.5 3.5
2.5 3 3 f(x) = − 0.23265322741 x
f(x) = − 0.341310237981 x 2.5 f(x) = − 0.289792711492645 x
+ 4.73510859005753 2.5 + 4.16371374921
2 + 5.284628872595 R² = 0.926621513149451
R² = 0.994166324470873 2 R² = 0.976252783302535 2
1.5
1.5 1.5
1 1 1
0.5 0.5 0.5
0 0 0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13 3 4 5 6 7 8 9 10 11 12

Pembanding

Waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC Auc

t-inf0-inf (ng/mL jam)
T 1/2
0 0 0 0 0 0
0.5 0.076 3.628319 1.288769 0.90708 0.90708
2 0.097 5.486726 1.702332 6.836283 7.743363
3.5 0.177 12.56637 2.531024 13.53982 21.28319
4 0.384 30.88496 3.430269 10.86283 32.14602 13.79463 178.5955 2.348356
6 0.343 27.25664 3.305297 58.14159 90.28761
 13.79463 178.5955 2.348356

8 0.169 11.85841 2.473037 39.11504 129.4027

10 0.145 9.734513 2.275678 21.59292 150.9956
12 0.081 4.070796 1.403839 13.80531 164.8009
AUC 0-12 18.41024
a 0.035
b 0.0113
r 0.997

Chart Title Chart Title Chart Title

3 3.5 4
2.5 3 3.5
f(x) = − 0.2950867297 x f(x) = − 0.25412402343 x
f(x) = − 0.2672996008655 x + 5.0202431777 3
2 + 4.7238471370137 2.5 + 4.6106161152
R² = 0.952881595053735 2.5 R² = 0.944001788530052
R² = 0.88288706855604 2 2
1.5
1.5 1.5
1
1 1
0.5 0.5 0.5
0 0 0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13 3 4 5 6 7 8 9 10 11 12 13
 b 0.3413
Chart Title

f(x) = − 0.23265322741 x
+ 4.16371374921
R² = 0.926621513149451

4 5 6 7 8 9 10 11 12 13
 b 0.2951
hart Title

− 0.25412402343 x
106161152
.944001788530052

7 8 9 10 11 12 13
Uji
waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC Auc
t-inf0-inf (ng/mL jam)
T 1/2
0 0 0 0 0 0
0.5 0.078 3.80531 1.336397 0.951327 0.951327
2 0.096 5.39823 1.686071 6.902655 7.853982
3.5 0.167 11.68142 2.457999 12.80973 20.66372
4 0.254 19.38053 2.964269 7.765487 28.4292 15.56115 136.6452 2.649083
6 0.197 14.33628 2.662794 33.71681 62.14602
8 0.166 11.59292 2.450395 25.9292 88.07522
10 0.133 8.672566 2.160165 20.26549 108.3407
12 0.081 4.070796 1.403839 12.74336 121.0841
AUC 0-12 17.12193
a 0.035
b 0.0113
r 0.997

Chart Title Chart Title Chart Title

3 3 4
2.5 2.5f(x) = − 0.203354733 x + 3.999490505
f(x) = − 0.261638981678 x 3
2 2R² = 0.910296236129044 f(x) = − 0.181174476 x
+ 4.621189157182 1.5 2 + 3.777687936
1.5 R² = 0.937984437156352
1 1 R² = 0.928451457560138
1
0.5 0.5
0 0 0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 5 6 7 8 9 10 11 12 13 3 4 5 6 7 8 9 10 11 12 13

Pembanding

Waktu Serapan C (ng/mL) Ln C d AUC AUC 0-t AUC Auc

t-inf0-inf (ng/mL jam)
T 1/2
0 0 0 0 0 0
0.5 0.076 3.628319 1.288769 0.90708 0.90708
2 0.107 6.371681 1.851863 7.5 8.40708
3.5 0.177 12.56637 2.531024 14.20354 22.61062
4 0.384 30.88496 3.430269 10.86283 33.47345 13.79463 179.923 2.348356
6 0.343 27.25664 3.305297 58.14159 91.61504
 13.79463 179.923 2.348356

8 0.169 11.85841 2.473037 39.11504 130.7301

10 0.145 9.734513 2.275678 21.59292 152.323
12 0.081 4.070796 1.403839 13.80531 166.1283
AUC 0-12 18.55978
a 0.035
b 0.0113
r 0.997

Chart Title Chart Title Chart Title

3 3.5 4
2.5 3 f(x) = − 0.2950867296806 x 3.5
f(x) = − 0.267299600865454 x + 4.72384713701372 f(x) = − 0.25412402343 x
2.5 + 5.020243177709 3 + 4.61061611521
2 = 0.88288706855604
R²
R² = 0.952881595053735 2.5 R² = 0.944001788530052
1.5 2
2
1 1.5
1.5
0.5 1 1
0.5 0.5
0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 0 0
5 6 7 8 9 10 11 12 13 3 4 5 6 7 8 9 10 11 1
 b 0.2616
art Title

.181174476 x
687936
8451457560138

7 8 9 10 11 12 13
 b 0.2951
Chart Title
4
5
f(x) = − 0.25412402343 x
3 + 4.61061611521
5 R² = 0.944001788530052
2
5
1
5
0
3 4 5 6 7 8 9 10 11 12 13