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Pharmacology
Dr. Likith HV (JR – I; Presenter)
Dr. Abhijeet Joshi (Presentation supervisor)
Table of Contents
Definitions
Metrology
Therapeutic dose : The amount of the drug required to effect the cure
of a disease or to correct the manifestations of a deficiency of a
particular factor in the diet
The practical aspects of pharmacology can be considered
under
Pharmacy
Experimental Pharmacology
Clinical Pharmacology
Pharmacy
selection
preservation
standardisation
their stability
shelf life
Weight – kilogram
Capacity- litres
1 Kilogram 1000 g 1 litre 1000 ml
1 Ounce = 29.57 ml
65 ml 4 dessert spoon
30 ml 2 table spoons
0.05 ml 1 drop
4 ml 1 teaspoon
Weight/Weight
Weight/Volume
Volume/Volume
?
1% w/w – 1 gram of solute in 100gm of solution
The animals used are Rat, Mouse, Rabbits and Guinea pigs .
New Drug Development
Insilco Trail
Clinical Trail
Insilco Trial
AIM : To discover a lead compound
Approach : Target approach (i.e. finding a suitable compound to the target )
Here it involves computer based molecular modelling of compounds and can
produce a compound that best fit the receptor.
Structure of the target Drug library structure of many compounds
Screening of compounds
(Throughput Screening)
Lead compound
RAT
o Weight : 200 gms
o Weight : 25gms
o USED:
Toxicological studies
Teratogenicity studies
Pyrogen testing
While lifting , it should be held firmly from the base of the tail and
not the tip
Experimental animals should be taken care like humans and not like
animals
Prior to any clinical evaluation should obtain clear answers
to the important questions
Phases : Phase 1
Phase 2
Phase 3
Phase 4
Phase 0 studies
Sub therapeutic micro doses of the drug are administered for approximately
a week and pharmacokinetic properties are assessed
programme
Phase 1 clinical trial
Done on Patients
Multicentric trial
Objective: To cross check the value of Phase2 trial àka cross checking trial
What is Pharmacy?
What is metrology ?