Ajman University Pharmaceutical Sciences Department Physical Pharmacy

Student name: Amr Yasser

Student id: 202010304

Lab Report:
Experiment Name:
Determination of solubility of some pharmaceutical solids

Objective:
To determine the solubility of the salicylic acid in water and 10% alcohol

Chemicals & Instruments:

Funnel – Filter paper – Burette – sodium hydroxide – indicator(phenol
phthalein) – distilled water – conical flask – salicylic acid – glass road –
electronic weigher – beaker – burette stand – measuring culinder -
droper

Procedure:
1. Take 50 ml of distilled water in a clean dry conical flask, add a 5g
of salicylic acid and shake vigorously for 30 minutes. If the added salicylic
acid has dissolved, add another 5g of salicylic acid and continue shaking
to obtain a saturated solution. (count how many grams did you take)
2. Filter the contents into a clean dry beaker.
3. Titrate 10 ml of the filtrate with 0.025 N sodium hydroxide
solution twice using phenolphthalein as indicator (discard the chemical
from the flask and rinse it with distilled water after titrating each 10 ml)
4. Calculate the solubility of salicylic acid in water.
Ajman University Pharmaceutical Sciences Department Physical Pharmacy

Calculations:

No. Solution in Initial burette Final burette Titre value

conical flask reading reading (final – initial)

1 10 ml aqueous 30 16.5 13.5

solution
2 10 ml aqueous 30 21.5 8.5
solution

Average : 13.5 + 8.5 /2 = 11

Calculation of solubility of salicylic acid in water:

Salicylic acid solubility in mg/10 ml =

Titre value x I.P factor*

Salicylic acid solubility in mg/100 ml =

Titre value x I.P factor* x 10

*I.P factor: Each ml of 0.025 N NaOH is equivalent to 3.45 mg of salicylic acid.

11 x 3.45 x 10 = 379.5

The solubility of salicylic acid in water is 379.5 mg/100ml