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Mood disorders
Mood disorders
Mood disorders (“affective disorders”) are A change in mood that is more than normal. Prolonged
feeling of sadness and grief(intense sorrow caused by loss of a loved one ). It must affect normal
functioning such as thinking, behavior, sleep and eating.
Definition
The mood or affective disorders are mental disorders that primarily affect mood and interfere with the
activities of daily living . Usually it includes major depressive disorder
(MDD) and bipolar disorder(also called manic depressive psychosis)
Classification
Manic episode
Depressive episode
Etiology
1. Biological theories
Genetic hypothesis
Lifetime risk for first degree relatives of parents with bipolar mood disorder is 25% and of
normal control is 7%.
Monozygotic twins(either of two twins developed from the same fertilized ovum ,or having
the same genetic material.) with mood disorder is 65%
Dizygotic twins(either of two twins who developed from two separate fertilized eggs) with
mood disorder is 15%
2. Biochemical theories
A deficiency of nor-epinephrine and serotonin has been found in depressed patient and they are
elevated in mania. Dopamine, GABA and acetylcholine are also presumably involved.
3. Psychological causes
One of the leading psychoanalytic theories concerning depression was first proposed was first proposed
by Sigmund Freud. Freud argued that at some point in early childhood, the depressed patient suffered
the loss, real or imagined, of someone with whom they were very closed. According to Freud depression
result due to loss of a “loved object "and fixation in the oral sadistic phase of development, in this
model, mania is viewed as a denial of depression.
Psychological:
Guilt
Over sensitivity
lack of love
4. Behavioral theory
According to his model, depression is conditioned by repeated losses in the past.(hopeless, loss of
positive reinforcement)
5.Cognitive theory
Cognitive theory: according to this theory depression is due to negative attitude about self , the
environment, and future, bad or inadequate judgment.
6.Social theory:
classification
MANIA:
Mania refers to a syndrome in which the central features are over active, mood change and self imports
ideas.
It is an unfound elation, recognized by extreme talkativeness, grandiose plans and new ideas, new bursts
of creativity, pressured, constant speech with jokes, plays on words, rhyming, distractibility, flight of
ideas, speech difficult to interpret. This can make a manic person socially intrusive and lack inhibitions.
at first the mania feels good, often starts off with hypomania the milder form of mania, but everything
seems to get out of control, paranoid and delusion start to occur(sometimes eshallucination).the life
time risk of mania is about 0.8-1%
Classification of mania
1. Hypomania
2. Mania with psychotic symptoms
3. Mania without psychotic symptims
4. Manic episode unspecified
1. Hypomania
It is lesser degree of mania, in which abnormalities of most and behaviour are too presistent but are not
accompanied by hallucinations or delusions.There is persistent mild elevation of mood ,increased energy
and activity , and usually marked feelings of well being and both physical and mental efficiency
.Increased sociability, talkativeness, over familiarity, increased sexual energy, and a decreased need for
sleep are often present but not to the extent that they lead to severe disruption of work or result in
social rejection.
Flight of ideas.
Pressure of speech.
Delusion of persecution
Distractibility
4. Other features
More goals, and goal oriented activities, with word, school and sexually.
Poor judgement
Absent insight
Agitation
Diagnostic criteria
1 .Mood must be predominantly elevated, expensive, or irritable , and definitely abnormal for the
individual concerned . The mood change must be prominent and sustained for least 1 week.
2 .At least three o the following signs must be present, leading to severe interference with personal
functioning of daily living.
Fight of idea.
Loss of normal social inhibitions resulting in behavior that is inappropriate to the circumstances.
Grandiosity.
4. The mood disturbances is sufficient to caused impairment at work or danger are present to the
patient or other.
The commonest examples are those with grandiose, self referential ,or persecutory content.
The episode is not attributable to psychoactive substance use or to any organic mental disorder.
Diagnosis
Proper history taking.
Treatment.
1. hospitalization.
2. Pharmacotherapy
Lithium 900-2100mg/day
Carbamazepine 600-1800mg/day
Electroconvulsive therapy.
Psychosocial treatmet.
Nursing management
DIET: special attention must be given to the patient`s diet because he is usually too busy to eat
and hence may loose weight and dehydration may occur. Meals and fluids are given under
supervision.
DRUG: drugs are of great in dealing with problems of restless, sleepleness and fatigue
associated with overactivity.
Maintain safety :because of excitement and destructive activities may result in injuries.
Supervision and direction to maintain personal hygiene like bathing, oral hygiene.
The ward must be quite and pleasant, factors that irritate the patient like excessive noise, bright
colors etc are to be avoided.
Bipolar disorders
This characterized by recurrent episodes of mania and depression in the same patient at differen
times.bipolar disorder is further classified into bipolar I and bipolar II disorder.
1. Bipolar 1 disorder
2. bipolarII
1.Bipolar 1 disorder
Bipolar 1 disorder:is a mood disorder characterized by one or more episodes, possible alternating with
major depressive episodes and severe mania.
2.Bipolar II disorder
Bipolar II disorder is a mood disorder with a clinical course that is characterized by at least one major
depressive episode(s) and at least one hypo-manic episode(s)and at least one hypo-manic episode(s)
Mood stabilizers
Anti-depressants
Anti –psychotics
Antimanic.
DEPRESSION
Depression is recognized as a depressed mood, irritability, loss of interest and inability to do the things.
Sleep disturbances is common, with either insomnia(inability to sleep) or hypersomnia (sleeping too
long).appetite changes are commonly visible with either increased appetite or decreased appetite.
These symptoms and other symptoms should at least 2 weeks.
Epidemiology of depression
About 6% the general population suffers from depression. The life-time risk of depression in males is 18-
12% and in females is 20-26%. Depression occurs twice as frequently in women as in men.
Etiology
1. Biological factors
Genetic hypothesis :- the life time risk for the first – degree relatives.
Biological theorizes :-a deficiency of nor-epinephrine and serotonin has been found in depressed
patient
2. Psychosocial factor :-
- Guilt
- Feeling of failure
3. Cognitive theory: according to this theory depression due to negative cognitions , which include
- Inadequate judgment .
Social situation that bring feeling of powerlessness and low self esteem.
• Unemployment
Classification (ICD10)
1. Depressive episode
• Endogenous depression
• Reactive depression
Refers to syndrome thought to come from inside , i.e. result from internal biological factors and seems
to have a life of its own, rather than being dependent of environment influence . The main feature are
- Absence of environmental precipitant ( deaths , personal losses) and stable premorbid personality .
Melancholic Feature .
- When faced with stimuli that are pleasurable there will be lack of reaction .
- Depress mood .
- Psychomotor retardation .
- Weight loss.
REACTIVE DEPRESSION
Refers to a syndrome triggered by factor in the environment , rather than biological factor . Such as
depression are characterized by obvious precipitation events , and life stresses , fluctuating of symptoms
according to psychological and environmental factors , and unstable “neurotic” premorbid personality
pattern.
Loss of concentration
Poor memory
Felling helpless.
Irritability, restlessness.
Irritability , restlessness.
Diagnostic