Scribd Logo
Upload

Welcome to Scribd!

  • Pasynkova 2018 Marsu

    Uploaded by

    Сохиб Саидов
    8 views42 pages
    This document discusses the causes and treatment of febrile neutropenia in cancer patients. It notes that the most common causes are bacterial and fungal infections. Effective treatment involves administering broad-spectrum antibiotics to prevent severe infections. Additional treatment may be needed if patients do not respond to initial antibiotics. Proper treatment can reduce mortality from febrile neutropenia from over 50% to less than 10%.

    Original Description:

    Original Title

    208__159_N_771__128__208__190_N_771__130__208__184__208__178__208__190__208__190__208__191_N_771__131_N_771__133__208__190__208__208__208__178_N_771__139__208

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document discusses the causes and treatment of febrile neutropenia in cancer patients. It notes that the most common causes are bacterial and fungal infections. Effective treatment involves administering broad-spectrum antibiotics to prevent severe infections. Additional treatment may be needed if patients do not respond to initial antibiotics. Proper treatment can reduce mortality from febrile neutropenia from over 50% to less than 10%.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    8 views42 pages

    Pasynkova 2018 Marsu

    Uploaded by

    Сохиб Саидов
    This document discusses the causes and treatment of febrile neutropenia in cancer patients. It notes that the most common causes are bacterial and fungal infections. Effective treatment involves administering broad-spectrum antibiotics to prevent severe infections. Additional treatment may be needed if patients do not respond to initial antibiotics. Proper treatment can reduce mortality from febrile neutropenia from over 50% to less than 10%.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 42

    Pasynkova 2018 MarSU

    . . . . .
    Pasynkova 2018 MarSU

    •
    •
    –

    (
    , , )

    ,
    Pasynkova 2018 MarSU

    •
    •
    –
    ,

    – -

    (37%)
    Pasynkova 2018 MarSU

    •
    •
    –

    – 2-5 logs, 100-100000


    – 1010-1012
    –
    Pasynkova 2018 MarSU

    •
    – G1

    – S

    – G2

    – M
    Pasynkova 2018 MarSU

    –S
    ,
    ,
    (
    )
    – ,
    – , ,
    – ,
    – ,
    – ,
    Pasynkova 2018 MarSU

    –
    ,

    – ,
    –

    – ,
    –
    Pasynkova 2018 MarSU

    – G1

    –
    Pasynkova 2018 MarSU

    – G2

    – ,
    –
    Pasynkova 2018 MarSU

    – –
    – –
    – –
    – –
    – –
    – – -
    – –
    – –
    Pasynkova 2018 MarSU

    –
    ,

    –
    –
    –
    –
    –
    Pasynkova 2018 MarSU

    ,
    –
    –
    –
    –
    –
    –
    Pasynkova 2018 MarSU

    – ( ,
    , )
    –
    –Э
    – ,
    Pasynkova 2018 MarSU

    (
    )
    –
    –
    –
    –
    – -
    –
    Pasynkova 2018 MarSU

    –
    –
    –
    Pasynkova 2018 MarSU

    –
    ( , )
    –

    / 2/ .
    Pasynkova 2018 MarSU

    ( )

    –
    Pasynkova 2018 MarSU

    –
    G1
    ( )
    –
    ,
    ,
    ,
    ( ),
    - ,
    ,
    / ,
    ( )
    Pasynkova 2018 MarSU

    – -

    , MDR-
    – 170 Kd-
    gp ( -
    ,

    )
    , ,
    , ,

    –
    Pasynkova 2018 MarSU

    ( )
    –
    , ,
    ( , )
    –

    ,
    ( ,
    )
    –

    /
    Pasynkova 2018 MarSU

    • :
    2-10%,
    – 50-100%
    –
    ( , ,
    , ,
    )
    Pasynkova 2018 MarSU

    •
    •
    • - , , ,
    (
    ,
    )
    • : , , (
    )
    – 1 3-4
    – 7-10
    – - (
    )
    – - - (
    )
    Pasynkova 2018 MarSU

    •
    ,

    • - ,
    -
    (
    , ),
    ( ), (
    )
    Pasynkova 2018 MarSU

    • –
    – 40%-60% (
    )
    •
    ,
    Pasynkova 2018 MarSU

    •
    ( )

    ,
    (
    Staph. aureus
    Enterococcus, )
    Paul M, Borok S, Fraser A, Vidal L, Cohen M, Leibovici L.
    Additional anti-Gram-positive antibiotic treatment for febrile
    neutropenic cancer patients. The Cochrane Database of
    Systematic Reviews 2005, Issue 3.
    Pasynkova 2018 MarSU

    • ( )
    • + - 29% - 1973 . 69% 1994 .
    Staph. aureus – 30-70% ( )
    Staph. epidermidis – 70%
    • - - 71% 31%
    • ,
    • 6%
    Pasynkova 2018 MarSU

    • 1

    Gafter-Gvili A, Fraser A, Paul M, van de Wetering M,


    Kremer L, Leibovici L. Antibiotic prophylaxis for
    bacterial infections in afebrile neutropenic patients
    following chemotherapy. The Cochrane Database of
    Systematic Reviews 2005, Issue 4.
    Pasynkova 2018 MarSU

    • ( , )
    • ( ) .
    : , - ,
    ,
    • (
    , ,
    , - )
    -
    Pasynkova 2018 MarSU

    •
    – ( ,
    , , )
    – ( ,
    , )
    – ,
    -
    Pasynkova 2018 MarSU

    •
    –
    ,
    ,
    Pasynkova Э 2018 MarSU

    Э
    Pasynkova 2018 MarSU

    10-50 6 , / , / , . .

    1-2 / 3 / , / , . .

    2-25 / , 25-50 / , 10-25


    . ., 50-100 . r. 4

    4-25 6 , / , . .

    0,15 / 4 , /
    . .
    Pasynkova 2018 MarSU
    -
    Pasynkova 2018 MarSU

    •
    –
    –
    –
    – +
    –
    –

    – : ,
    ( , ,
    , C.difficile)
    -
    Pasynkova 2018 MarSU

    •
    – : 4
    , 2
    8
    – –
    ,
    –

    – –
    500 6
    -
    Pasynkova 2018 MarSU

    •
    – (
    ),
    – , ,
    Pasynkova 2018 MarSU

    •
    –
    – –
    – , .
    – – ,
    , ,
    Pasynkova 2018 MarSU

    • ( , )
    • ( ,

    )
    – , , –
    >0,2 /
    – –

    – –

    –
    Pasynkova 2018 MarSU

    Р К -

    Э
    Pasynkova 2018 MarSU

    – ( )
    - , ,
    , , ,
    .
    , ,
    , .
    –
    ,
    : . -
    , ,
    , . ,
    , ,
    , , ,
    ,
    , , ,
    ,
    Pasynkova 2018 MarSU

    •
    ,
    –
    –
    –
    –
    –
    –
    –
    –
    –
    –
    –
    -
    Pasynkova 2018 MarSU

    – (2% 5
    )
    –
    (500000 6 ),
    ( 200 5
    )

    You might also like