REGULASI SISTEM
SISTEM IIMUN
MUN
This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.
Ratna
Ratna Ku
Kusum
sumaw
awat
atii
Privacy Policy

Marketing

Personalization
Fakul
akultas
tas Ked
Kedokt
okter
eran
an
Analytics Univ
Univer
ersi
sita
tass Se
Sebe
bela
lass Ma
Marret
Save Accept All Surakarta
 

ANATOMY
ANATOMY OF THE IMMUNE
IMMUN E SYSTEM
SYSTEM

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

CELLS OF THE IMMUNE SYSTEM

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

FUNCTIONING OF THE IMMUNE SYSTEM

HUMO
HUMORA
RAL
L (ANT
(ANTIB
IBOD
ODY
Y MEDI
MEDIA
ATED)
TED) IMMU
IMMUNE
NE RESP
RESPON
ONSE
SE CELL
CELL MEDI
MEDIA
ATE
TED
D IMM
IMMUN
UNE
E RESP
RESPON
ONSE
SE
ANTIGEN (1ST EXPOSURE)
ENGULFED BY

MACROPHAGE
ANTIGENS
FREE
DISPLAYED
ANTIGENS BECOMES
BY
DIRECTLY
INFECTED
ACTIVATE
APC CELLS
This website stores data such as ACTIVATE
cookies to enable essential site STIMULATES

functionality, as well as marketing,

HELPER
personalization, and analytics. You
B CELLS
CYTOTOXIC
STIMULATES T CELLS STIMULATES
may change your settings at any time T CELL
or accept the default settings.
MEMORY
GIVES RISE TO HELPER T GIVES RISE TO
Privacy Policy CELLS

Marketing STIMULATES STIMULATES

STIMULATES

Personalization ANTIGEN (2nd EXPOSURE)

Analytics PLASMA MEMORY STIMULATES MEMORY
ACTIVE
CELLS B CELLS CYTOTOXIC T
T CELLS
CELL
Save Accept All
SECRETE ANTIBODIES
 

SISTEM KOMPLEMEN

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

Dua aspek penting dalam

regu
gula
lasi
si res
espo
pons
ns im
imun
un::

This website stores data such as

1. Pada saat
saat ter
erben
bentuk
tukn
nya imuno
imunok
cookies to enable essential site kompe
functionality, as well as marketing,
ompettensi.
ensi.
personalization, and analytics. You
may change your settings at any time
2. Peng
engen
endal
dalia
ian
n respon
espon limf
limfos
or accept the default settings.osit
it yang
ang mat
matang
Privacy Policy
ter
erha
hada
dap
Marketing p Ag.
Ag.
Personalization

Analytics

Save Accept All

 

Secara umum
mum respons imun di
dip
peng
nga
aruhi oleh:
leh:

• Genetik
• Umur
This website stores data such as
• Nutrisi
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default • Mole
Molek
kul MHC
settings.

Privacy Policy
•
Marketing Efek sito
sitoki
kin
n
Personalization

Analytics
• Antigen
Save Accept All
•

Antibodi
 

Pengaturan oleh Ag

Dos osis is bebesa sarr Dosiss kecil

Dosi ecil
This website stores data such as
diber
di
cookies toberik ikan an
enable essential siteberul
berulang
functionality, as well as marketing,
ang diber
diberik
ikan
an berul
berulan
ang
g
personalization, and analytics. You
may change your settings at any time
or accept the default settings.
Toleransi Toleransi
Privacy Policy

Marketing

Personalization

Analytics

Save Do
Dosi
siss se
seda
dang
ng
Accept All Imunitas
 

Pengaturan oleh Ag

Sifat Ag:
Makin kompleks

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
Makin
Makin banya
banyak
k epito
epitop
p
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Mempe
emperrbesa
Personalization
besarr in
intter
erak
aksi
si an
anttar se
sell
Analytics

Save Accept All

 Merangsang respons imun
 

Pengaturan oleh Ag

Meta
Metabo
bolilism
sme
e Ag:
Ag:

Substansi yang tidak dapat dimetabolis

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.
Resi
Resist
ste
en te
terh
rha
adap dig
digesti
sti enzim
zimatik
tik
Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

Tidak dapat diproses ol

oleh
eh APC
 Tidak dapat diproses ol
oleh
eh APC
 

Pengaturan oleh Ag

 Ag sequestration:
sequestration:   •protein lensa
This website stores data such as
•protein sperma
cookies to enable essential site
functionality, as well as marketing,  Ag tulang rawan
•

personalization, and analytics. You

may change your settings at any time
or accept the default settings.

Privacy Policy

Terlin
Terlindung
dung barrie
barrierr ana
Marketing anatom
tomik
ik
Personalization

Tidak terpapar pada sistem imun

Analytics

Save Accept All

 

Cytokines

B Th
Antigen Cytokines Tc LG
This website stores data such as
presentation
cookies to enable essential site
functionality, as well as marketing, Activation
personalization, and analytics. You
may change your settings at any time Cytotoxicity
or accept the default settings.

Privacy Policy APC

Marketing

Personalization
Intracellular Virally infected
Analytics
Organism in Cells & some
Save Accept All
tumor cells
Antibody production macrophage
 

MODEL DIFERENSIASI SEL MEMORY

Ag
+
costimulation

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
Activated cells + factor / Effector cells
personalization, and analytics. You environment X
may change your settings at any time
or accept the default settings. Ag

Privacy Policy

Marketing

Personalization

Analytics Activated cells + factor

Memory cells
Save
environment Y
Accept All
 

MODEL DIFERENSIASI SEL MEMORY (3)

Ag
+ Apoptotic death
costimulation Ag >95%

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.
Naieve cell Activated cell Effector cell
Privacy Policy

Marketing

Personalization

Analytics
Memory cell
Save Accept All
 

Pen
eng
gatur
uran
an ol
oleh
eh Ab

Feedback inhibition
Produksi Ab
• pro
produ
duk
ksi Ab
This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.
Produksi IgG
Privacy Policy

Marketing

Personalization

Analytics Meng
Mengha
hamb
mbat
at pr
prod
oduk
uksi
si Ig
IgM
M
Save Accept All
 

CYTOKINE
SOURCE

REC CELLS

AUTOCRINE
This website stores data such as
cookies to enable essential site
functionality, as well as marketing,

NDO
personalization, and analytics. You
BIOLOGIC
may change your settings at any time
ACTION CYTOKINE
CRINE
or accept the default settings.
EFFECTS
Privacy Policy

Marketing

Personalization
PARACRINE
Analytics

Save Accept All

REC CELLS
 TARGET
 

SOURCE

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time• MACROPHAGE
or accept the default settings.
• T LYMPHOCYTE
Privacy Policy • EPITHELIAL CELL
Marketing • DENDRITIC CELL
Personalization
• FIBROBLAST
Analytics

Save Accept All

 

CELLS

ANTIGEN MITOGEN

This website stores data such as

CYTOKINE
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You • LYMPHOKINE
may change your settings at any time
or accept the default settings. • MONOKINE
• INTERLEUKIN
Privacy Policy

Marketing MEDIATE
and
Personalization
REGULATE
Analytics

Save IMMUNE
Accept All INFLAMMATORY
REACTION
 

CYTOKINE

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

CD4+ T cells
• T cells with CD4 marker (glycoprotein)
(glycoprotein)
• 70% of T cells in the periphery
pe riphery
•
This website T helper cells
stores data such as
cookies to enable essential site
functionality,
• Play central
central role in modulating cellular immunity
as well as marketing,
personalization, and analytics. You
via secretion of cytokines that modulate:
may change your settings at any time
or accept the default settings.

 – B cell activation
Privacy Policy
 –

Marketing Immunoglobulin secretion (quality)

PersonalizationMacrophage and dendritic cell activation
 –

Analytics  – Cellular chemota

chemotaxis
xis and iinflamma
nflammation
tion
Save
• Th1Accept
versusAll
Th2 cells
 

Th1 and Th2 cells

CD4+ T helper cells can be classified into two
based on their cytokine profiles: T helper cell type
1 (Th1) and T helper cell type 2 (Th2).
This website stores data such as
cookies to enable essential site
 Cytokine profile is influenced by several factors:
functionality, as well as marketing,
personalization, and analytics.
Nature You and dose of antigen
may change your settings at any time
Route of infection
or accept the default settings.

Initial cytokine environment

Privacy Policy

Marketing Type of antigen presenting cell/costimulation

Genetic background
Personalization

Analytics
 The cytokine profile determines the effector function of
Save Accept All
the helper cell
 

Differences b/w Th1 and Th2 cells

Th1 cell Th2 cell

This website stores data such as
Produces type 1
cookies to enable essential site
functionality, as well as marketing,
Produces type 2
cytokines
personalization, and analytics. You cytokines
may change your settings at any time
or accept the  IL-2, IFN-g, TNF-a,
default settings.  IL-4, IL-5, IL-10, IL-
Privacy Policy
TNF-b 13
 Activates macrophages
Marketing macrophages Provides help to B cells
and DCs for intracellular
Personalization in antibody response
Analytics
killing of pathogens Mediates allergy and
Save Accept All
Mediates CMI immunity to
 extracellular pathogens,
including parasites
 

Fungsi efektor 
Sel T helper 1

Fungsi efektor 
Sel T helper 2
This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

 

Pera
Perana
nan
n si
sito
toki
kin
n

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

 

MEDIATOR REGULATOR

INNATE
This website stores data such as
IMMNUNITY
cookies to enable essential site
TNF, IL-1
TNF,
functionality, as well as marketing,
personalization, and analytics. You
IL-1,, IL-1
IL-12,
2, IFN ,
IL-10. IL-6, IL-15, IL-18
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing ADAPTIVE
Personalization IMMNUNITY
Analytics

Save Accept All

IL-2, IL-4, IL-5, IFN 
LT,, TGF , IL
LT IL-1
-133
 

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 29

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

ACTIVATED MN PHAGOCYTE
ANTIGEN STIMULATED T CELL
NK CELL
MAST CELL

This website stores data such as

cookies to enable essential site
LPS
LPS (G
(GR
RAM NE
NEG)
G)
functionality, as well as marketing, MICROBES
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing TNF
Personalization

Analytics
• POTENTIAL MEDIATOR OF ACUTE
Save
INFLAMMATORY RESPONSE
Accept All

•
 RESPONSIBLE FOR SYSTEMIC
COMPLICATION OF SEVERE INFECTION
 

CLASSIFICATION
CLASSIFICATION OF
O F IFN

SOURCE
This website stores data such as
cookies to enable essential site
TYPE I
functionality, as well as marketing, LEUCOCYTE IFN IFN
personalization, and analytics. You FIBROBLAST IFN IFN
may change your settings at any time
TYPE II
or accept the default settings. IMMUNE IFN IFN g
Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

BIOLOGIC ACTION OF IFN

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

BIOLOGIC ACTION OF IFN g

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

BIOLOGIC EFFECT OF TNF

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 Cytokines imbalance between effector
effector and T regulato
regulatory
ry cells in Autoimmune disease

ROLE OF CYTOKINE
IN HEMATOPOIESIS

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

Personalization

Analytics

Save Accept All

 

CELLS

INFLAMMATORY
STIMULI
This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time CHEMOKINE
or accept the default settings.

Privacy Policy CHEMOTACTIC

CHEMOTACTIC CYTOKINE
Marketing

Personalization

Analytics
• STIMULATE LEUCOCYTE MOVEMENT
Save Accept All
• REGULATE MIGRATION
MIGRATION LEUCOCYTE
LEUCOC YTE
 FROM BLOOD TO TISSUE
RECRUIT LEUCOCYTES TO THE SITE OF INFLAMMATION
 

TISSUE
NORMALLY/INJURY

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You CHEMOKINE
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing

PROMOTING MIGRA
Personalization
MI GRATION
TION LYMPHOCYTE
Analytics
TO DIFFERENT REGION OF PERIPHERAL
Save Accept All LYMPHOID ORGAN
 REGULATE THE TRAFFIC OF LYMPHOCYTES
THROUGH PERIPHERAL LYMPHOID TISSUE

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings. REGUL SI D L M
Privacy Policy TOLER NSI IMUNOLOGIK
Marketing

Personalization

Analytics

Save Accept All

 

Sistem imun normal


membedakan self dari nonself 

This website stores data such as

cookies to enable essential site
self tissue/
antigen
functionality, as well as marketing,
personalization, and analytics. You
self
antigen
tissue/
may change your settings at any time
or accept the default settings.

Privacy Policy
immune
tolerance response
Marketing

Personalization
  autoimmune
Analytics

Save Accept All

SISTEM IMUN
 

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
Sentral
diinduksi oleh pengenalan
self-Ag oleh limfosit immature
di organ limfoid generative
generative..

Self tolerance
may change your settings at any time
or accept the default settings.

Privacy Policy Perifer 

Marketing
diinduksi oleh pengenalan
Personalization

Analytics
self-Ag oleh limfosit mature
di organ limfoid perifer .
Save Accept All
 

Toleransi Limfosit T

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

 

ANERGI

 Akibat pengenalan Ag tanpa adanya

ko-stimulasi yang adekuat.

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

 

Delesi

apoptosis

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

 

Supresi oleh sel T regulator

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

 

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
KOOPERASI ANT
or accept the default settings.
ANTAR SEL
Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

 

Complex network

This website stores data such as

cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All

This website stores data such as
cookies to enable essential site
functionality, as well as marketing,
personalization, and analytics. You
may change your settings at any time
or accept the default settings.

Privacy Policy

Marketing
Personalization

Analytics

Save Accept All