1

DRUGS INFLUENCE THE PERIPHERAL On the 2-3rd day after stomach resection intestinal E. Aethimizolum
peristalsis wasn't restored. What is to be 6. A doctor administered injection of galanthamine to a 63 years
NERVOUS SYSTEM old patient after ischemic insult of the brain for recovery of
CHOLINOMIMETICS. CHOLINESTERASE INHIBITORS administered for stimulation of gastrointestinal tract?
A *Proserin functions of the CNS. What is the mechanism of action of this
Patient with complaints of dryness in the mouth, drug?
photophobia and vision violation was admitted to the B Prasosin A. *Inhibition of acetylcholinesterase
reception-room. Skin is hyperemic, dry, pupils are C Cyclodole B. Inhibition of cholinacetylase
dilated, tachycardia. Poisoning with belladonna D Atropine sulfate C. Inhibition of catechol-O-methyltransferase
alkaloids was diagnosed on further examination. E Acetylcholine D. Inhibition of dopamin-beta-hydroxylase
What medicine should be prescribed? E. Inhibition of monoamine oxidase
1. In clinical practice quite often there are cases of poisoning by 7. A patient was paralyzed after insult. Indicate the drug which
A *Prozerin phosphororganic substances (insecticides, pest-Killers). Alloxim can be administered to him for recovery of movement function in
B Diazepam is the drug used to treat this poisoning. Specify the group of paralyzed extremities?
C Pilocarpine drugs to which it belongs. A. *Galanthamine
D Armine A. * Regenerators of cholinesterase B. Aceclidine
E Dipyroxim B. M-cholinoblockers C. Atropine
Analeptical remedy of reflective type from the H- C. Sympathomimetics D. Carbacholine
D. Adrenomimetics E. Mellictinum
cholinomimetics group was given to the patient for
E. N-cholinoblockers 8. Indicate the agents used for treatment of the poisoning by
restoration of breathing after poisoning with carbon 2. A patient with the diagnosis of glaucoma received proserinum phosphor-organic substances?
monoxide. What medicine was prescribed to the (neostigmine) in the form of eye drops. What compound is A. *Cholinesterase regenerators
patient? inactivated by proserinum that causes the decrease of intraocular B. Sympatholytics
A *Lobeline hydrochloride pressure? C. Adrenomimetics
B Atropine sulphate A. *Acetylcholinesterase D. M-cholinoblockers
В. Butyrilcholinesterase E. N-cholinoblockers
C Adrenalin hydrochloride
C. Cholinacetyltranspherase 9. A doctor administered Pilocarpine to the patient with
D Mesaton D. Pseudocholinesterase glaucoma. What is the main effect of this agent?
E Pentamin E. Acetylcholine A. *Decrease of intraocular pressure
A patient suffering from myasthenia has been 3. Proserinum (neostigmine) was introduced to the patient with B. Increase of the cardiac rhythm
administered proserin. After its administration the overdosage of tubocurarine. Due to what mechanism of action is C. Stimulation of GIT peristalsis
patient has got nausea, diarrhea, twitch of tongue proserinum effective in this situation? D. Increase of salivation
and skeletal muscles. What drug would help to A. *Inhibition of cholinesterase activity E. Increase of myometrium contructility
eliminate the intoxication? B. Blockade to the presinaptic membrane 10. A patient with complains of dryness of the oral cavity visited
C. Activation of M-cholinoceptors a dentist, who made the diagnosis: xerostomia. Which of the
A *Atropine sulfate D. The increase of cholinesterase concentration following drugs should the dentist prescribe?
B Physostigmine E. Blockade of adrenoceptors A. *Pilocarpine
C Pyridostigmine bromide 4. What drug is used in intestinal atony? B. Atropine
D Isadrine A. *Proserinum (neostigmine) C. Methacinurn
E Mesatonum B. Benzohexonium (hexomethonium) D. Ipratropium bromide
A patient in postoperative period was prescribed an C. No-spa (drotaverine) E. Halazolinum (xylomethazoline)
anticholinesterase drug for stimulation of intestinal D. Atropine 11. A dentist prescribed an agent stimulating salivation to a
E. Pirilenum fpempidinej patient with xerostomia. Indicate the drug.
peristalsis and tonus of urinary bladder. What drug is 5. A 5 years old boy with the diagnosis suffers from disorders of A *Aceclidine
it? movements coordination and muscular weakness (predominantly B. Dithylinum (suxamethonium)
A *Proserin in the right leg) after poliomyelitis. What drug should be C. Armin
B Dichlothiazide administered to improve neuromuscular transmission? D. Scopolamine
C Reserpine A. *Proserinum (neostigmine) E. Atropine
D Mannitol B. Coffeinum 12. Drugs from this group are used to decrease secretion of
C. Phenaminum (amphetamine) salivary and gastric glands, eliminate bronchospasm and
E Propanolol D. Extractus Eleutherococci bradycardia. Indicate the group of drugs.
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A. *M-cholinolytics C Nicotinic cholinoreceptor stumulation D. Armin
B. Myorelaxation drugs D Adrenoreceptor stimulation E. Galanthamine
C. M-cholinomimetics E Adrenoreceptor block 5. A patient suffering from bronchial asthma has accompanying
D. Cholinesterase inhibitors disease glaucoma. Indicate the group of drugs which is
Introduction of a pharmaceutical substance to an
E. Cholinesterase regenerators contraindicated for the patient.
13. An 8 years old child was poisoned by mushroom fly-agaric. experimental animal resulted in reduction of A. *M-cholinotytics
Which of the following drugs should be used as an antagonist? salivation, pupil mydriasis. Next intravenous В. Myotropic broncholytics
A. *Atropine introduction of acetylcholine didn't lead to any C. Alfa-beta-adrenomimetics
B. Pirenzepine significant changes of heart rate. Name this D. Glucocorticoids
C. Morphine substance: E. Beta-2-adrenomimetics
D. Ipratropium bromide A *Atropine 6. A dentist used a drug to inhibit salivation in a patient during
E. Aceclidine treatment. Indicate the group this drug belong to.
14. A 40 years old man was admitted to the toxicological
B Adrenaline A. *M-cholinolytics
department with poisoning by insectiside from the group of C Propranolol B. Beta-adrenoblockers
organophosphorous compounds. Which agent blocking peripheral D Proserin C. Beta-adrenomimetics
M-cholinoceptors is the most effective for the treatment of the E Salbutamol D. Astringent drugs
poisoning? E. M-cholinomimetics
A. *Atropine 1. A 48 year-old man had been admitted to the urology 7. A 6 years old child was delivered to the hospital with
B. Pirenzepine department with signs of renal colic. Indicate the drug which following symptoms: motor and psychical excitement, dry, hot
C. Plathyphylline main effect is associated with relaxation of smooth muscles and hyperemic skin, hyposalivation, difficulty of swallowing and
D. Benzohexonium (hexamethonium) A.* Platyphylllnum hoarse voice, dilated pupils and photophobia and tachycardia.
E. Amizylum (benactlzine) B. Analginum From the anamnesis it is known that the child has eaten some
15. Alloxim is used for treatment of poisonings with phospho- C. Morphine berries with dark-violet colour. Indicate an alkaloid which caused
organic insectiscides and strong choline esterase inhibitors. D. Omnoponum this poisoning
Indicate its mechanism of action. E. Promedolum A. *Atropine
A. *Regeneration of cholinesterase. 2. Indicate mechanism of broncholytic action of metacinium. B. Pirenzepine
B. Blockade of n-cholinoceptors. A. *Blockade of m-cholinoreceptors of bronchi. C. Ipratropium bromide
C. Stimulation of noradrenaline release B. Stimulation of m-cholinoreceptors of bronchi. D. Plathyphylline
D. Excitation of adrenoceptors. C. Stimulation of beta-2~adrenoreceptors of bronchi. E. Methacinum
E. Blockade of m-cholinoceptors. D. Blockade beta-2-adrenoceptors of bronchi. 8. In order to do eye inspection, it is necessary to widen the
E. Myotropic spasmolytic action. pupils. Choose the agent which can be used for this purpose.
3. A 50-year-old male farm worker was admitted to the A. *Atropine
M-CHOLINOBLOCKERS emergency room. He was found fainted in the orchard and since B. Amizylum (benactizine)
A stomatologist injected a patient with a certain drug then has remained unconscious. His heart rate is 45 and his blood C. Pilocarpine
in order to reduce salivation during tooth filling. What pressure is 80l40 mmHg. He is sweating and salivating profusely. D. Noradrenaline
drug is it? Which drug from the following should be prescribed? E. Acetylcholine
A. *Atropine 9. Pharmacological effects of this drug substance are midriasis,
A *Atropine sulfate B. Physostigmine decrease of exocrine glands secretion, tachycardia, dilation of the
B Adrenaline hydrochloride C. Proserine bronchi, inhibition of intestinal peristalsis. This drug does not
C Proserin D. Pentamine penetrate into the CNS. Determine the drug.
D Pilocarpine hydrochloride E. Norepinephrine A. *Methacinum
E Mesaton 4. The patient was admitted to a hospital with following B. Atropine
A patient with drug intoxication presented with the symptoms: general excitement, dry and hyperemic skin, dryness C. Adrenaline
of the oral cavity, disorder of vision, dilated pupils and D. Isadrinum (isoprenalinej
dryness of oral mucous membrane and photophobia, tachycardia. The doctor made the diagnosis: the E. Pirenzepine
mydriatic pupils. Such action of this drug is poisining by belladonna's alkaloids. Indicate the main alkaloid of 10. Atropine sulfate was administered to the patient for treatment
associated with the following effect: this plant? of intestinal colic. What accompanying disease confines usage of
A *Muscarinic cholinoreceptor block A. *Atropine the drug?
B Muscarinic cholinoreceptor stumulation B. Aceclidine A. *Glaucoma
C. Pilocarpine B. Bronchial asthma
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C. Sinus bradycardia B Succinate dehydrogenase B. Bemegridum
D. Hypotension C Carbanhydrase C.Dipiroximum
E. Dizziness D N-acetyltransferase D. Isonitrosinum
11. A 48-years-old man was admitted to the urologic department E Galanthaminum
E K-Na-adenosine triphosphatase
with symptoms of renal colic. What drug from mentioned below 4. A 53 year old man was admitted to a hospital in severe state
can be used for smooth muscles relaxation due to blockade of M- A patient with fracture of his lower jaw was admitted with complaints of headache, vertigo, nausea. BP 220/120 mm
cholinoceptors? to the maxillofacial department. It was decided to fix Hg. After injection of 1ml of 2,5% benzohexonium solution the
A. * Plathyphyllin his bones surgically under anaesthetic. After patient's state improved. Indicate the mechanism of action of this
B. Omnopone intravenous introduction of muscle relaxant there agent.
C. Morphin arose short fibrillar contractions of the patient's facial A. *Blockade of N-cholinoceptors of vegetative ganglions
D. Anaiginum muscles. What B. Blockade or M-cholinoceptors
E. Promedol muscle relaxant was applied? C. Blockade of beta1-adrenoceptors
12. The agent inhibiting vestibular centers is used for sea D. Excitation of alpha- adrenoceptors
sickness treatment. Determine this drug. A *Dithylinum E. Blockade of alpha1-adrenoceptors
A. *Scopofamine B Tubocurarin chloride 5. An agent from the group of ganglion blockers was
B. Atropine C Pipecuronium bromide administered to a patient with essential arterial hypertension.
C. Plathyphylline D Diazepam What effect underlies the decrease of BP?
D. Methacinum E Melictine A. * Sympathetic ganglions blockade
E. Homatropine A woman was delivered to a hospital for trachea B. Blockade of adrenal cortex
intubation. What of the following drugs should be C. Blockade of carotide sinuses
N-CHOLINOBLOCKERS D. Vasomotor centre blockade
applied in this case?
A patient with a limb fracture must be administered a E. Parasympathetic ganglions blockade
depolarizing drug from the myorelaxant group for the A *Dithylinum 6. Ganglion blocker benzohexonium (hexamethonium) was
purpose of a short-time surgery. What drug is it? B Nitroglycerine introduced to a patient with hypertensive crisis. What
C Metronidazole complication can develop in the patient after introduction?
A *Dithylinum A. *Orthostatic hypotension
D Atropine sulfate
B Tubocurarine chloride B. Withdrawal syndrome
E Gentamycin sulfate
C Cytitonum C. Inhibition of the CMC
D Atropine sulfate 1. Indicate the drug used for the treatment of pulmonary edema D. Disorder of gustatory sensibility
E Pentaminum caused by systemic arterial hypertension E. Diarrhea
During an operation a patient got injection of muscle A. * Benzohexonium 7. What neurotropic hypotensive agent belongs to the group of
ganglion blockers and is used to eliminate hypertensive crisis?
relaxant dithylinum. Relaxation of skeletal muscles B. Strophanthinum
C. Bemegridum A. *Pentaminum (azamethonium)
and inhibition of respiration lasted two hours. This B. Octadinum (guanethidine)
condition was caused by absence of the following D. Cordiaminum
E. Ethyl alcohol C. Anaprilinum lpropranolol)
enzyme in blood serum: D. Dopamine
2. During operation on the thyroid gland, to prevent excessive
A *Butyrylcholin esterase hemorrhage the doctor decided to use a method of controlled E. Reserpine
B Catalase hypotension with the help of trickling intravenous introduction of 8. 0,1% solution of hygronium was introduced intravenously in
C Acetylcholinesterase a drug. Specify it. drops to a 50-years-old patient with increased BP (220l110
A. * Hygronium mmHg). What is the mechanism of action of the drug?
D Glucose 6-phosphatase A. *Blockade of N-cholinoceptors
E Glutathione peroxidase B. Pirilenum
C. Pentaminum B. Blockade of M-cholinoceptors
A patient had to go through an operation. Doctors C. Blockade of adrenoceptors
D. Pachycarpinum
introduced him dithylinum (listenone) and performed D. Blockade of calcium channels
E. Dimecolmum
intubation. After the end of operation and cessation of 3. Injection of dithylinum (which had been introduced for E. Stimulation of alfa-adrenoceptors
anesthesia the independent respiration wasn't simplification of reposition of a dislocation in a shoulder joint) 9. Sings of tubocurarine overdosage appeared in a patient during
restored. Which enzyme deficit prolongs the action of evoked apnea in the patient. What is it necessary to introduce to operation. What drug should be used as an antagonist?
muscle relaxant? the patient for restoration of breathing? A. *Cholinesterase inhibitors
A. * Fresh citrated blood B. Alfa-adrenomimetics
A *Pseudocholinesterase C. M-cholinoblockers
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D. Ganglion blockers Patient with bronchial asthma was taking tablets acompanying disease?
E. beta-adrenomimetics which caused insomnia, headache, increased blood A. * Salbutamolum
10. A 45-year s-old man with dislocation of shoulder joint was pressure. What medicine can cause such B. Orciprenaline
admitted to the hospital. What drug can be used to relax skeletal C. Eohedrine
complications?
muscles and set the bone? D. Adrenaline
A. *Dithylinum (suxamethonium) A *Ephedrine E. Isadrinum
B. Dimedrolum (diphenhydramine) B Adrenaline 2. Expressed arterial hypotension had developed in the patient
C. Analginum (methamizole) C Chromolin sodium during an operation which had been carried out under
D. Promedolum (trimeperidine) D Euphyline phthorotanum-general anesthesia. Which- from the listed
E. Acetylsalicylic acid E Izadrine medicines below should be introduced to the patient to normalize
11. Peripheral myorelaxant was introduced to a patient with he's arterial blood pressure?
A patient suffers from diabetes melitus. After the
fracture of humeral bone to facilitate the bona reposition. A. *Mesatonum
Respiratory standstill developed in the patient. The respiration
regular insulin injection his condition grew worse: B. Strophanthin
restored after introduction of fresh citrate blood. What there appeared anxiety, cold sweat, tremor of limbs, C. Ephedrine hydrochloride
myorelaxant was introduced to the patient? general weakness, dizziness. What preparation can D. Noradrenatlnum hydrotartrate
A. *Dithylinum (suxamethonium) eliminate these symptoms? E. Adrenaline
B. Tubocurarine A *Adrenaline hydrochloride 3. Indicate mechanism of broncho-lytic action of salbutamol?
C. Pancuronium B Butamide A. *Stimulation of beta-2-adrenoceptors
D. Pipecuronium B. Inhibition of phosphodiesterase
E. Vecuronium
C Caffeine C. Activation of noradrenaline synthesis
12. Myorelaxant dithylinum (suxamethonium) was introduced to D Noradrenaline D. Blockade of H-f-histamine receptors
a patient with fracture of humeral bone to facilitate the bone E Glibutide E. Blockade of M-cholinoceptors
reposition. Respiratory arrest developed in the patient. An ophthalmologist used a 1% mesaton solution for 4. A 40 year old patient has been suffering from bronchial asthma
Proserinum (neostigmine) was introduced to a patient (it was the the diagnostic purpose (pupil dilation for eye-ground for 10 years accompanied with cardiac arrthymia (tachycardia).
doctor's mistake), but respiration didnTt restore. What drug can examination). What is the cause of mydriasis induced Indicate adrenomimetic agent which should be administered for
be used? by the drug? elimination of bronchospasm taking into account accompanied
A. *Fresh citrate blood heart disease.
B. Dipyroxime
A *Activation of alpha-1 adrenoreceptors A. *Salbutamolum
C. Isonitrosine B Activation of alpha-2 adrenoreceptors B. Adrenaline
D. Galanthamine C Block of alpha-1 adrenoreceptors C. Isadrinum
E. Bemegride D Activation of beta-1 adrenoreceptors D. Orciprenalinum
13. Dithylinum (suxamethonium) was introduced to a patient E Activation of M-cholinoreceptors E. Ephedrinum
with the aim to relax skeletal muscles during operation. It led to A patient ill with bronchial asthma didn't inform his 5. Salbutamol was administered to a 30 year old woman due to
myorelaxation during 6 hours instead of 5-7 minutes. This doctor that he had attacks of stenocardia. Doctor danger of having miscarriage as it causes decrease of contractile
situation can develop due to genetic deficiency of: ability of myometrium. Indicate mechanism of
administered him a medication, which taking resulted
A. *Blood plasma cholinestherase sympathomimetics.
B. Acetylation in less frequent attacks of bronchial asthma, but relaxing action upon the uterus of this drug.
C. Oxidative processes stenocardia attacks became more frequent. What A. *Stimulation of beta-2-adrenoceptors
D. Methylation medication was administered? B. Stimulation of aipha-2-adrenoceptors
E. Carboxylation A *Isadrin C. blockade of beta- f- adrenoceptors
14. Action of what agent is significantly prolonged in patients B Salbutamol D. Inhibition of monoaminooxydase
with genetic deficiency of buthyrilcholine estherase? E. Blockade of phosphodiesterase
C Aminophylline
A. *Dithylinum (suxamethonium) 6. A female patient was admitted to a hospital with
B. Adrenaline hydrochloride D Cromolyn sodium complaints of unpleasant sensations in the heart area, attacks of
C. Midantanum (amantadine) E Phenotherol acute weakness, sometimes loss of consciousness. Examination
D. Tubocurarine of patient revealed atrioventricular blockade. Indicate the group
E. Mesatonum (phenylephrine) 1. The patient of 40 years suffered from bronchial asthma for 10 of drugs that should be appointed in this situation.n
years. Acompanying this disease is cardiac arrhythmia A. *beta-adrenomimetics (Isadrinum)
(tachycardia). Specify the drug which may be used for elimina- B. Cardiac glycosides (Digitoxin)
ADRENOMIMETICS tion of bronchospasm with keeping into account the C. beta-adrenoblockers (Anapritinum)
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D. Calcium channel blockers (Verapamil) collapse for correction of blood pressure. What is the mechanism B. Adrenaline
E. Sympatholytics (Ornidum) of action of the drug? C. Isadrinum (isoprenaline)
7. Anaphylactic shock has developed in a patient after A. *Stimulation of alfa-adrenoceptors D. Atropine
novocainum (procaine) injection. What agent supresses B. Blockade of alfa-adrenoceptors E. Ephedrine
histamine release from mast ceils and eliminates main symptoms C. Blockade of beta-adrenoceptors 20. A patient with bronchial asthma has been taking isadrinum
of anaphylactic shock? D. Stimulation of α-β adrenoceptors (isoprenaline) inhalation for a long time. He notices the drug
A. Beclometasone E. Stimulation of b-adrenoceptors leads to tachycardia and headache. Which agent from listed
B. Euphillinum (aminophilline) 14. Collapse developed in a patient due to decrease of peripheral below can be used instead of isadrinum?
C. *Adrenaline vessels tone. What preparation is the most efficient in this A. *Salbutamol
D. Ketotifen situation? B. Mesatonum (phenylephrine)
E. Cromolin natrium (cromoglycic acid) A. *Mesatonum (phenylephrine) C. Anapriiinum (propranolol)
8. A doctor diagnosed hypoglycemic coma in a patient with B. Proserinum (neostigmine) D. Dobutaminum
diabetes mellitus and administered glucose solution IV to him. C. Isadrinum (isoprenaline) E. Cordiaminum (nikethamide)
Patient's condition improved. What drug can be used additionally D. Clophelinum (clonidine) 21. A patient with bronchial asthma did not tell doctor that he had
as the biochemical antagonist of insulin? E. Prazosine attacks of stenocardia sometimes. The doctor administered to him
A. *Adrenaline 15. What drugs should be used for bronchospasm treatment? the drugs. After a patient started to take this drug, attacks of
B. Mesatonum (phenylephrine) A. *beta2-adrenomimetics bronchial asthma became rare but attacks of stenocardia became
C. Dobutamine B. Sympatolytics more frequent. Indicate the drug which was administered by the
D. Isadrinum (isoprenaline) C. alfa-adrenomimetics doctor?
E. Dopamine D. Cholines terase inhibitors A. *Isadinum (isoprenaline)
9. A patient with chronic bronchitis has been taking ephedrine for E. M-cholinomimetics B. Salbutamol
a long time. What is the mechanism of the drug action? 16. Salbupart (salbutamol) was introduced to a 30-years-old C. Euphillinum (aminophilline)
A. *Stimulation of noradrenaline release into synaptic pregnant woman with threatened abortion. It reduced contractile D. Cromolin natrium (cromoglycic acid)
cleft activity of myometrium. Indicate the mechanism of action of E. Fenoterolum
B. Blockade of noradrenaline release into synaptic cleft salbutamol? 22. A patient with bronchial asthma had been taking tablets
C. Stimulation of a-adrenoceptors A. *Stimulation of beta2-adrenoceptors which caused insomnia, headache, increased blood pressure.
D. Blokade of b-adrenoceptors B. Blockade of beta f-adrenoceptors What medicine can cause such complications?
E. Direct influence on smooth muscles of bronchi C. Stimulation of alfa2-adrenoceptors A. *Ephedrine
10. Indicate the state which requires introduction of ephedrine? D. Inhibition of monoaminooxidase B. Isadrinum
A. *Arterial hypotension E. Inhibition of phosphodiesterase C. Cromolin sodium
B. Caffeine poisoning 17. Indicate broncholytic drug from the group of selective beta2- D. Euphyline
C. Tachycardia adrenomimetics. E. Oxprenololum
D. Arterial hypertension A. *Salbutamol
E. insomnia B. Methacinum
11. A patient with obstructive bronchitis has been taking C. Isadrinum (isoprenaline) ADRENOBLOCKER AGENTS
ephedrine for a long time without doctor's control. What side D. Euphillinum (aminophilline)
effect can be observed in the patient? E. Atropine 1. The patient suffering from idiopathic hypertensia, had the
A. *Excitation of CNS 18. An attack of bronchial asthma developed in 40-years-old acompanyng diseases: ciliary arruthmia, stenocardia, and chronic
B. Hypotension woman. Indicate the drug belonging to beta2-adrenomimetics bronchitis. The physician has decided to use a drug from the
C. Bradycardia which is effective for elimination of the attack group of beta-adrenoblockers. Which agent should be used ,
D. Apathy A. *Fenoterol taking into account the acompanyng diseases?
E. Sleepiness B. Ephedrine A. *Metoprololum
12. What drug can be used for treatment of hypotension due to C. Adrenaline B. Timololum
peripheral vascular insufficiency? D. Plathvphiiline C. Anaprinilum
A. *alfa-adrenomimetic E. Atropine D. Pindololum
B. b-adrenomimetic 19. A 40-years-old patient has been suffering from bronchial E. Oxprenololum
C. Analeptic asthma for 10 years, fie has also an accompanying disease cardiac 2. A patient who had been suffering from arterial hypertension
D. Colloidal plasma substitute arrhythmia (tachycardia). What adrenomimetic can be was treated with the drug which mechanism of action is
E. Salt plasma substitute administered for elimination of bronchospasm? connected with exhaustion of noradrenalin content in sympathetic
13. Mesatonum (phenylephrine) was introduced to a patient with A. *Salbutamol nerve endings. Indicate this drug.
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A. *Reserpinum E. Stimulation of atfa2-adrenoceptors E. Novocainamidum (procainamide)
B. Clopheinum 9. Аnарrilin was administered to a patient with arterial 15. Ischemic heart disease accompanied by cardiac arrhythmia
C. Anaprinilum hypertension accompanied by obstructive bronchitis. After that was diagnosed in a 50 years-old patient. Indicate the group of
D. Prazosine the attack of bronchospasm occurred in the patient. Indicate the drugs which should be administered?
E. Dibazolum reason of this side-effect. A. *Beta-adrenoblockers
3. A 40 year old patient suffers from arterial hypertension with A. *Blockade of beta 2-adrenoceptors of bronchi B. Alfa-adrenoblockers
hyperkinetic type of circulation and increased level of renin, B. Stimulation of beta 2-adrenoceptors of bronchi C. Beta-adrenomimetics
sternocardia, sinus tachycardia. Indicate the group of drugs C. Blockade of alfa 2-adrenoceptors of bronchi D. Alfa-adrenomimetics
which is more preferable for treatment of this patient. D. Blockade of beta1-adrenoceptors of bronchi E. Sympatholytics
A. *beta-adrenoblockers E. Stimulation of alfa 1-adrenoceptors of bronchi 16. An agent causing decrease of noradrenaline content in
B. Organic nitrates 10. Therapeutic effect of beta-adrenoblocker propranolol during vesicles of sympathetic nerve endings was administered to a
C. α-adrenoblockers the treatment of stenocadia is explained by: patient suffering from arterial hypertension. Indicate this drug ?
D. Sympatholytics A. *Decrease of myocardium oxygen demand A. *Reserpin
E. Ganglion blockers B. Inhibition of catecholamines' production B. Anaprilin (propranolol)
4. Indicate the drug which possesses hypotensive action exactly C. Dilation of coronary arteries C. Pirroxanum
due to decrease of vascular tone. What drug can be used? D. Increase of sensibility to catecholamines D. Dibazolum (bendazole)
A. *α-adrenoblocker E. Increase of peripheral arteries resistance E. Clophelinum
B. N-cholinoblocker 11. Examination of the 42-years-old women revealed stenocardia 17. A 50 years old woman suffering from hypertension has taken
C. α- β - adrenoblocker with following signs: BP = 170/100 mmHg, heart rate - 84lmin, a drug. In an hour BP was increased, but in 2 hours it started to
D. M-cholinoblocker on ECG -extrasystoles. Which drug from listed below is the most decrease. Indicate the drug.
E. β-adrenoblocker suitable for treatment? A. *Octadine (guanethidine)
5. Indicate the group of drugs to which prazosine belongs. A. *Anaprilinum (propranolol) B. Reserpine
A. *α-adrenoblockers B. Euphillinum (aminophilline) C. Prazosin
B. Cardioselective β-adrenoblockers C. Nitroglycerin D. Dibazolum (bendazole)
C. Nonselective beta-adrenoblockers D. Carbocromen E. Propranolol
D. Sympatholytics E. Papaverine 18. A patient with arterial hypertension has been treating with
E. Angiotensin converting enzyme inhibitors 12. Beta-adrenoblocker was prescribed to a patient for the reserpine for a long period of time. 2-3 weeks ago he began to
6. A 40-years-old patient suffers from cardiovascular diseases: treatment of ischemic heart disease but after some time cough and notice stomachache, heartburn, nausea. Indicate the group of
arterial hypertension of hyperkinetic type and high blood renin bronchospasm occured. Indicate the agent which was drugs which are able to eliminate these symptoms?
level, stenocardia and sinus tachycardia. Indicate the most administered? A. *M-cholinoblockers
expedient group of drugs for treatment of the patient? A. *Anaprilinum (propranolol) B. Astringent drugs
A. *beta-adrenoblockers B. Talinolol C. Antacids
B. Organic nitrates C. Atenolol D. Proton pump inhibitors
C. alfa-adrenoblockers D. Phenigidin (nifedipine) E. H2-histaminoblockers
D. Sympatholytics E. Metoprolol 19. Elongation of P-Q interval was revealed on ECG. Indicate the
E. Ganglion blockers 13. A patient suffers from arterial hypertension accompanied by drug which can cause this effect.
7. Indicate the state in which nonselective beta-adrenoblockers chronic obstructive bronchitis. Indicate hypotensive agent which A. *Atenolol
are contraindicated? is contraindicated for the patient ? B. Prazosin
A. *Bronchial asthma A. *Anaprilinum (propranolol) C. Reserpine
B. Thyrotoxicosis B. Prazosine D. Qctadinum (guanethidine)
C. Cardiomyopathy C. Nifedipin E. Phentoiamine
D. Myocardial infarction D. Dichfothiazidum (hydrochlorthiazide) 20. A patient who had been suffering from severe form of arterial
E. Arterial hypertension E. Captopril hypertension after examination received diagnosis of
8. Anaprilin (propranolol) was administered to a patient with 14. Which of the following antiarrhythmic drug is pheochromocytoma (tumor of adrenal medulla which is
hypertension that normalized BP fast. What is the mechanism of contraindicated for the patient with cardiac arrhythmia accompanied by increased synthesis of adrenaline). Indicate the
action of this drug? accompanied by bronchial asthma? group of drugs which should be administered to a patient before
A. *Blockade of beta1- and beta2-adrenoceptors A. *Anaprilinum (propranolol) surgical treatment.
B. Blockade of beta1- adrenoceptors B. Verapamil A. *alpha-adrenoblockers
C. Inhibition of phosphodiesterase C. Aimalin B. Calcium channel blockers
D. Blockade of alfa1-adrenoceptors D. Nifedipin C. Sympatholytics
 7
D. Ganglion blockers 7. Indicate the mechanism of action of local anesthetics. powder. What is this drug?
E. beta-adrenoblockers A. *Blockade of Na-channels A. *Anesthezinum (benzocaine)
B. Formation of albuminates with tissue’s proteins B. Novocainum (procaine)
LOCAL ANESTETICS, ADSORBING, COVERING, C. Blockade of M-cholinoceptors C. Pyromecaine
IRRITATIVE DRUGS D. Inhibition of non-specific excitatory systems of CNS D. Trimecaine
1. Agents, affecting the afferent innervation E. Blockade ot alfa-adrenoceptors E Sovcainum
1. A driver felt sharp pain in the eye. He was delivered to the 8. What morphological elements of skin and mucous membranes 15. What drug has to be added to lidocaine solution to prolong its
hospital. What local anesthetic may be applied for removal of a are involved in interaction with the drug in terminal anesthesia? action?
foreign body from the eye? A. *Sensitive nervous endings A. *Adrenaline
A.* Dicainum B. Epidermis B. Coffeinum
B. Novocainum C. Fatty tissue C. Analginum (methamizole)
C. Lidocainum D. Capillary wall D. Atropine
D. Trimecainum E. Derma E. Anaprilinum (propranolol)
E. Sovcainum 9. The patient needs an operation on soft palate. What method of 16. What is the mechanism of anti-inflammatory action of
2. As a result of the influence of terminal anesthesia which part of anesthesia is the most appropriate? astringent drugs?
the skin and mucus membranes are affected. A. *Infiltrative anesthesia A. *They form albumin film which decreases irritation
A. * Sensory nerve endings B. Local cooling of receptors
B. Epiderm C. Conductive anesthesia B. They inhibit excitability of membrane of the nerve fibers
C. Subcutaneous fatty tissue D. General anesthesia C. They are able to form colloid solutions
D. Walls of capillaries E. Psychotherapy D. They block prostaglandine synthase
E. Dermis 10. The patient needs Vishnevsky paranephric blockade. What E. They inhibit phosphorylase
3. Indicate the principle of action of covering drugs. concentration of novocainum (procaine) solution should to be 17. What is the mechanism of action of covering drugs?
A. *Creation of protective layer on the mucous membranes. used? A. Blockade of receptors of mucous membrane
B. Blockade of mucous membranes receptors. A. *0,25-0,5% B. Coagulation of proteins of superficial layer of mucous
C. Coagulation of proteins of superficial layer of mucous В. 1-2% membrane
membrane. C. 2-4% C. Binding to toxic substances with complexes formation
D. Formation of complexes with toxic agents. D. 4-5% D. *Formation of protective layer on mucous membranes
E. Stimulation of regenerative processes. E. 0.5-1% E. Stimulation of regenrative processes
4. Indicate the mechanism of action of local anesthetics. 11. What drugs from the group of local anesthetics are not used 18. What is the main indication for adsorbing drugs use?
A. *Block sodium channels. together with sulfonamides? A. *Intoxication
B. Create albuminates with plasma proteins A. *Novocainum (procaine) B. Hvpoacidic gastritis
C. Block M-cholinoreceptors B. Sovcainum C. Decrease in trypsin activity
D. Inhibit nonspecific activating systems of the CNS. C. Lidocaine D. Decrease in bile secretion
E. Block alpha adrenoreceptors. D. Trimecaine E. Diarrhea
5. Why not used Novocaine is terminal E. Ultracaine 19. A nurse used mustard plaster with water of more than 60oC
anesthesia? 12. Determine the drug which is used for all type of anesthesia. temperature and applied it on patient's back. In 30 minutes she
A. *Is poorly absorbed through normal skin surface and A. *Lidocaine found that patient's skin under the (sinapism, mustard poultice)
mucous membrane B. Anesthesinum (benzocaine) mustard plaster did not get red. What is the reason for absence of
B. Doesn't cause covering action. C. Novocainum (procaine) (sinapism, mustard poultice) mustard plaster effect?
C. Is rapidly absorbed and inhibits the CNS. D. Trimecaine A. *Inactivation of mirosine
D. Irritates mucous membrane. E. Dicainum (tetracaine) B. Inactivation of choline estherase
E. Activates m-cholinoreceptors. 13. Injection of a local anesthetic has to be given to a patient for C. Activation of mirosine
6. Indicate main effect of the local anesthetics. tooth extraction. What drug from listed below is to be chosen? D. Inactivation of monoaminooxydase
A. *Eliminate all kinds of sensibility due to blockade of A. *Lidocaine E. Activation of methyltranspherase
action potential creation B. Dicainum (tetracaine)
B. Selective relieve ot pain sensibility in local action. C. Anesthezinum (benzocaine)
C. Decrease of excitability of nerve endings D. Cocaine
D. Decrease of excitability and conductivity of the afferent E. Ketamine GENERAL ANESTHETICS. ETHYL ALCOHOL
E. Eliminates all kinds of sensibility due to paralysis of the 14. This agent is poorly soluble in water, so it is used for 1. A woman of 22 years had been admitted to the obstetric clinic
CNS. superficial anesthesia only in the form of ointment, paste and for delivery. Labor activity was satisfactory, but accompanied by
 8
severe pain. Choose a general anesthetic for labour pain relief, D. Natrii oxybutyras (oxybate sodium) E. Ether
without suppressing labor activity. E Hexenalum (hexobarbital) 12. Expressed bradycardia with endangered arrest of the heart
A.*Nitrous oxide 7. Indicate the emetic agent directly exciting vomiting centre was developed during phthorotanum (halothane) anesthesia.
B. Ether which is used in treatment of chronic alcoholism. What drug should be used to normalize the heart rate for
C. Thiopentalum-natrium A.*Apomorphine continuation of the operation?
D. Phthorotanum (halothane) B. Thermopsis grass infusion A. *Atropine
E. Hexenalum (hexobarbital) C. Ipecacuanha root infusion B. Coffeinum
2. In the orthopedic clinic the patient with a recent, D. Copper sulfate C. Adrenaline
uncomplicated dislocation of the shoulder joint was delivered. E. Zinc sulfate D. Camphor
Choose a general anesthetic with fast, but short-term action for 8. To anaesthetize the manipulation related to burn surface E. Isadrmum (isoprenaline)
out-patient reposition of dislocation of shoulder joint. treatment, a patient was intravenously injected a short-acting 13. An anaesthesiologist decided to introduce solution of
A.*Ketamine general anesthetic. A minute later, the patient showed increase of thiopental natrium intravenously to the 55-years-old patient for
B. Natrii oxybutyras (oxybate sodium) blood pressure, tachycardia, and increase of skeletal muscles general anesthesia before gastric resection. Indicate the
C. Ether tonicity and presence of reflexes. After awakening the patient had dangerous side effect of thiopental natrium.
D. Phthorotanum (halothane) disorientation and visual hallucinations. What medication was A. *Breathing standstill
E. Hexenalum (hexobarbital) introduced to the patient? B. Expressed stage of excitement
3. For treatment of patient suffered from chronic alcoholism the A.*Ketamine C. Drug tolerance
doctor has administered Teturamum (disulfiram) in combination B. Thiopental sodium D. Increased of blood pressure
with small doses of ethanol. What mechanism of action has the C. Nitrous oxide E. Drug dependence
given drug? D. Diethyl ether 14. A doctor administered thiopental natrium to a patient with a
A. *Oppression of activity of an enzyme acetaldehyde E. Sombrevin (Propanidid) fracture of mandibular for analgesia during operation. What is
oxidase 9. A patient was delivered to the surgical department in the principal of anaesthetic action of this drug?
B. Rising of activity of an enzyme alcohol dehydrogenase connection with acute appendicitis. A drug for general A. *Impairment of interneuronal impulse transmission in CNS
C. Blockade of dopamine receptors anaesthesia with expressed stage of excitement was used by the B. Interaction with opioid receptors
D. Excitation of the emetic center doctor. Determine this drug. C. Blockade of peripheral receptors
E. Blockade of central cholinoceptors A. *Ether D. Change of emotional attitude to pain
4. A sudden sharp decrease of blood pressure arose in a patient B. Nitrous oxide E. Inhibition of synthesis of prostaglandins
who was being operated under general anesthesia. The doctor C. Phthorotanum (halothane) 15.Thiopental natrium was introduced to the patient for the initial
introduced adrenaline, after that fibrillation of heart ventricles D. Hexenalum (hexobarbital) general anaesthesia that caused the development of laryngospasm
developed. Indicate the general anesthetic which was used and E. Natrii oxybutyras (oxybate sodium) and hypersalivation. Select a drug for the prevention of unwanted
with adrenaline might cause this complication. 10. General anesthesia with usage of volatile fluid was made to effects.
A *Phthorotanum (halothane) the patient during operation on the organs of abdominal cavity. A. *Atropine sulfate
B. Nitric oxide Surgical anaesthesia appeared in 5 minutes after the beginning of B. Adrenaline hydrochloride
C. Ether inhalation with non significant stage of excitement. Arterial C. Proserine
D. Thiopentalum-natrium hypotension and cardiac arrhythmia developed during operation. D. Alloxim
E. Hexenalum (hexobarbital) There was fast awakening after general anesthesia without E. Pirroxane
5. A patient was admitted to a neurosurgical department with a depression. Indicate the drug that was used for general 16. The patient suffers from cerebral trauma that caused brain
skull trauma. Due to progressive arising of neurological signs, the anesthesia. edema and hypoxic convulsions. Determine the drug possessing
diagnosis of brain edema was made. Indicate general anesthetic A. *Phthorotanum (halothane) anticonvulsive action.
which is also used as the drug for brain hypoxia. В. Nitrous oxide A. *Natrii oxybutyras (oxybate sodium)
A.*Natrium oxybutyras (oxybate sodium) C. Ether B. Anapriline (propranololJ
B. Ether D. Natrii oxybutyras (oxybate sodium) C. Corasole
C. Ketamine E. Hexenalum (hexobarbital) D. Piracetam
D. Propanidid 11. Acute affection of the liver (hepatitis) appeared after the E. Cordiamintlm (nikethamide)
E. Phthorotanum (halothane) repeated introduction of this drug for general anesthesia. What 17. Dentist extracted the tooth in a patient under general
6. Indicate the general anesthetic which causes long and drug can cause this pathology? anaesthesia. He used a drug with ultrashort anaesthetic action.
expressed stage of excitement. A. *Phthorotanum (halothane) Indicate this drug.
A.*Ether B. Nitrous oxide A. *Ketamine
B. Phthorotanum (halothane) C. Thiopental natrium В. Predione
C. Nitric oxide D. Propanidid C. Thiopental natrium
 9
D. Phthorotanum (haiothanej D. Enflurane D Diazepam
E. Nitrous oxide E Chloroform E Ethosuximide
18. General anesthetic with ultra short action (5 minutes) was 24. Expressed bradycardia, reducing of blood pressure appeared
introduced to a patient intravenously for analgesia of biopsy. It during phthorotanum anesthesia. What drug is contraindicated to 1. The patient of 70 years has appealed to the doctor with
caused muscular twitching, insignificant decreased of blood normalize the blood pressure and the heart rate for continuationcomplaints of superficial short-term sleep with often awakenings
pressure, stop of breathing for short period of time. Determine of the operation. caused by sense of internal tension, anxiety, fear. The diagnosis
this drug. A. *Adrenaline (epinephrine) has been made as: senile sleeplessness. Make a rational choice of
A. *Propanidid B. Atropine a hypnotic agent in the given situation.
В Natrii oxybutiyas (oxybate sodium) C. Mesatonum (phenylephrfne) A.* Nitrazepam
C. Predion D. Coffeinum(caffeine) B. Aethaminalum-natrium (pentobarbital)
D. Ketamlne E. Proserine (neostigmine) C. Phenobarbital
E. Phthorotanum (halothane) D. Bromisovalum
19. Propanidid is used very often in dentistry practice. Determine HYPNOTIC, ANTIEPILEPTIC, ANTIPARKINSONIC E. Chloral hydrate
the contraindication for use of this drug. AGENTS 2. The patient suffering from parkinsonism has been treating for
A. *Shock A patient who suffers from insomnia caused by a long time by the drug with central cholinolytic mechanism of
B. Reposition of jaw-bone fragments emotional disorder was prescribed a hypnotic drug action which efficiency has gradually decreased. Indicate drug
C. Reposition of dislocations of jaw with tranquillizing effect. What hypnotic was which should be administered instead of used one for improving
D. Taking out the stitches prescribed? of antiparkinsonic action?
E. Dissection of pulp cavity A. * Levodopa
20. The patient used solution of ethyl alcohol for warming after A *Nitrazepam
B. Cyclpdolum
supercooling. How does ethyl alcohol influence upon B Phenobarbital C. Mydocalmum
thermoregulation? C Chloral hydrate D. Tropacinum
A. *Increases heat emission D Sodium ethaminal E. Bellataminalum
В. Decreases heat emission E Bromisoval 3. A patient had been suffering from Parkinson's disease was
C. Increases heat production A 37 year old patient suffering from obliterating admitted to the neurological department. Indicate the drug
D. Decreases heat production inhibitting cholinergic influences which is used for treatment of
E. Decreases heat production and heat emission
vascular endarteritis of lower limbs takes daily 60
microgram/kilogram of phenylin. Because of this disease.
21. Teturam (disulfiram) was administered to the patient at the A.*Cyclodolum (trihexyphenidyl)
narcological department of psychiatric hospital. Determine the presentations of convulsive disorder (craniocerebral
B. Levodopa
indication for use of this drug. trauma in anamnesis) he was prescribed
C. Bromocriptin
A. .*Chronic alcoholism phenobarbital. Withholding this drug caused nasal D. Midantanum (amantadine)
В. Acute poisoning by ethyl alcohol hemorhage. What is this complication connected E Selegilin
C. Drug addiction with? 4. A patient with convulsions was delivered by the ambulance to
D. Acute poisoning by morphine the hospital where the diagnosis of status epilepticus was given.
E. Alcohol psychosis
A *Induction of enzymes of microsomal oxidation in
liver caused by phenobarbital Indicate the drug of the first choice in this situation.
22. In what concentration is ethyl alcohol used for antimicrobial A. *Diazepam
processing of skin: B Aliphatic hydroxylation of phenobarbital
B. Trimethinum (trimethadione)
A. *70% C Conjugation of phenylin with glucuronic acid C. Phenobarbital
B. 15% D Oxidative deamination of phenylin D. Dipheninum (phenytoin)
C. 60% E Inhibition of microsomal oxidation in liver caused by
E.Carbamazepine
D. 40% phenobarbital 5. An attack of generalized tonoclonic convulsions accompanied
E. 96%
A patient consulted a physician about muscle rigidity, by loss of consciousness and general suppression of the CNS
23. This drug for general anesthesia exerts stronger action upon developed in a patient after trauma. What drug should be
the liver and can affect the kidneys; it is used as the main constrained movements, permanent arm tremor. The
patient was diagnosed with Parkinson's disease. administered to this patient?
component for combined anesthesia. Phtor iones are formed A. *Phenobarbital
from this drug in the process of biotransformation. Determine What preparation should be administered?
B. Cyclodolum (trihexyphenidyl)
this drug. A *Levodopa C. Levodopa
A. *Phthorotanum (halothane) B Phenytoin D. Teturam (disulflram)
В. Ether C Phenobarbital E. Midantanum (amantadine)
C. Chlorethyl
 10
6. A 57-years-old woman was admitted to the hospital in coma vegetovascular distonia. Make the most rational choice of overloaded. Poisoning with what substance is the
with inhibition of breathing, decreased BF', signs of cardiac hypnotic drug. most likely?
insufficiency, decreased body temperature, inhibition of reflexes. A. *Nitrazepam
Due to anamnesis she had been suffering from insomnia and a B. Phenobarbital
A *Narcotic analgesics
doctor administered to her hypnotic agent. What drug can cause C. Chloral hydrate B Sedatives
this poisoning? D. Aethaminalum-natrium C Non-narcotic analgesics
A. *Phenobarbital (pentobarbital) D М-cholinergic antagonists
В. Sodium bromide E. Bromisoval E -
C. Valeriana tincture 12. A 65-years-old woman with Parkinson's disease has been A 4 year old child was admitted to the orthopaedic
D. Scopolamine treated with cyclodolum. Determine the mechanism of action of department with shin fracture together with
E. Promedolum (trimeperidine) this drug.
displacement. Bone fragments reposition requires
7. What agent should be administered to a patient in the case of A *Blockade of central cholinoreceptors
poisoning by barbiturates to normalize acid-base state? B. Stimulation of dopamine receptors
preliminary analgesia. What preparation should be
A. *NaHC03 C. Stimulation of serotonine receptor chosen?
B. Solution of arginine D. Blockade of histamine receptors A *Promedol
C. Vitamins E. Blockade of dopamine receptors B Analgin
D. Antibiotics 13. Determine the group of drug which can cause medicinal C Morphine hydrochloride
E. Physiological solution of Natrium Parkinsonism. D Panadol
8. A 68-years-old patient was addressed to the doctor in the A. *Neuroleptics
polyclinic with complaints of mental disorders after usage of B. Hypnotic drugs
E -
Phenobarbital for a long period of time accompanied by C. Antidepressants Examination of a patient revealed extremely myotic
insomnia. What drug will the doctor administer to this patient as D. Tranquilizers pupils, sleepiness, infrequent Chain-Stoke's
hypnotic E. Nootropic agents respiration, urinary retention, slowing-down of heart
A. *Nitrazepam 14. A patient took reserpinum for the treatment of hypertonic rate, enhancement of spinal reflexes. What
B. Cyclobarbital disease for a long period of time. One day the patient felt substance caused the poisoning?
C. Chloral hydrate muscles weakness, restriction of motion. Medicamentous
A *Morphine
D. Natrii oxybutyras (oxybate sodium) parkinsonism was diagnosed. What drug should be administered
E. Halopendol to eliminate these side effects? B Atropine
9. Determine the hypnotic drug which doesn't influence the A. *Cyclodolum (trihexyphenidyl) C Phosphacole
structure of sleep. B. Aminazinum (chlorpromazine) D Caffeine
A. *Nitrazepam C. Haloperidolu E Barbital
B. Phenobarbital P. Phenobarbital A patient suffering from initial hypertension has been
C. Barbital E. Tubocurarine taking an antihypertensive preparation for a long
D. Aethammalum-natrium (pentobarbital) time. Suddenly he stopped taking this preparation.
E. Bromisoval
After this his condition grew worse, this led to
10. The doctor administered a drug with a tranquilizing effect to NARCOTIC ANALGESICS
development of hypertensive crisis. This by-effect can
the patient with insomnia after emotional disorders. What drug A patient with hip fracture was prescribed a narcotic
was administered to the patient? be classified as:
analgetic. Its anesthetic action is determined by
A. *Nitrazepam interaction with the following receptors: A *Abstinence syndrome
B. Phenobarbital B Cumulation
C. Chloral hydrate A *Opiate receptors
C Tolerance
D. Aethammalum-natrium (pentobarbital) B Adrenoreceptors
D Sensibilization
E. Bromisoval C Cholinoreceptors
E Dependence
11. An 18-years-old patient complained of insomnia which D Benzodiazepine receptors
manifested by not being able to sleep that led to fatigue, 1. A synthetic analgesic agent which increases contractile activity
E GABA-ergic receptors of myometrium and relaxes the neck (cervix) of uterus was
weakness, difficulty in learning the following day. The clinical Patient in the unconscious state was admitted to the
examination revealed the following: the patient was easily prescribed to a woman in labour. Indicate this agent.
emergency room. Skin is cold, pupils are delayed, A.* Promedolum (trimeperidine)
irritated, emotionally unstable, heart rate and arterial pressure
were altered during conversations. The doctor determined that
breathing is heavy, with cycles of the Cheyne-Stokes B. Omnoponum
insomnia was associated with a neurosis-like state and type, blood pressure is decreased, urinary bladder is C. Analginum (methamizole)
 11
D. Morphine B. Promedolum (trimeperidine) the patient with arthritis of maxillofacial joint. What agent is
E. Fentanylum C. Pentazocin contained in the ointment?
2. A patient has signs of acute poisoning by morphine: sharp D. Omnoponom A. * Butadionum (phenylbutazone)
miosis, loss of consciousness, decrease of the arterial blood E. Codein B. Mefetmmic acid
pressure and Cheyne-Stokes respiration. Choose the proper С. Ibufrofenum
antagonist to be given. NON-NARCOTIC ANALGESICS D. Indomethacinum
A.* Naloxonum Signs of gastropathy develop in the patient with E. Diclofenac-sodium
B. Camphor rheumatoid arthritis who was treated with
C. Lobeline 17. Indicate the drug from the group of nonsteroid anti-
indometacin. With what activity of the drug can this inflammatory agents which exerts the most prominent anti-
D. Cytitonum complication be connected? inflammatory action in collagenoses?
E. Cordiaminum (nikethamide)
4. A 30 years old man was admitted to a hospital due to fracture A *Anticyclooxygenase A. *Iindomethacinum
of the crus with dislocation and expressed pain syndrome. B Antiserotonin B. Aspirin (acetylsalicylic acid)
Promedolum (trimeperidine) was introduced to eliminate pain. C Antihistamine С. Ibuprofenum
Indicate the mechanism of action of this drug. D. Butadionum (phenylbutazone)
D Antikinine
A.* Stimulation of the opioid receptors in the CNS. E. Ortophenum (diclofenac-sodium)
E Local irritating
B. Blockade of the opioid receptors in the CNS. 18. The 55 years old patient, developed gastric hemorrhage on
A female patient consulted a doctor about pain and
C. Stimulation of dopamine receptors in the CNS. the 7-th day of treatment with Indomethacinum. Indicate the
D. Blocade of GABA receptors in the CNS.
limited movements in the knee joints. Which of the
following nonsteroid anti-inflammatory drugs should pharmacological effect of the drug which explains this
E. Blocade of dopamine receptors in the CNS. complication.
5. Naloxone was introduced to a 25 years old woman because be administered taking into consideration that the
A. * Diminution of formation of Prostaglandin El
of intoxication by morphine. After injection the state of the patient has a history of chronic gastroduodenitis?
B. Diminution of formation of letuotrien
woman became better. Indicate the mechanism of action of this A *Celecoxib С Diminution of formation of Prostaglandin E2
drug. B Diclofenac sodium D. Diminution of formation of cyclic endoperoxides
A. *Blockade of the opioid receptors of the CNS. E. Diminution of formation of thromboxane
B. Blockade of GABA receptors of the CNS.
C Promedol
C. Blockade of the serotonin receptors of the CNS. D Acetylsalicilic acid 12. Nonsteroid anti-inflammatory agents are effective at
D. Blockade of benzodiazepin receptors of the CNS E Butadiounum treatment of rheumatic disease owing to ability to oppress:
E. Stimulation of the opiod receptors of the CNS. A. *Cyclooxygenase-2
19. Reduce of influence on which molecular substrate leads to
6. A drug addict was admitted to the emergency department in B. Phospholipase-A2
decrease of ulcerogenic action of nonsteroid anti-inflammatory
coma with signs of poisoning by opioid analgesics. What side C. Cyclooxygenase-1
agents?
effect of morphine contributed to the poisoning? D. Adenylatcyclase
A. *Cyclooxvgenase-1
A. *Tolerance E. Peroxidase
B. Kallikrein
В Euphoria 13. It is known, that nonsteroid anti-inflammatory drugs are
C. Lysosomal enzymes
C. Obstipation widely used for treatment of rheumatic disease. They influence
D. Cyclooxvgenase-2
D. Inhibition of breathing what of inflammatory process?
E. Adenylate cyclase
E. Reduction of diuresis
7. A 52-years-old patient who had been suffering from 20. The 63 years old patient with arthritis on a background of A. *Exudative
urolithiasis was delivered to the emergency department with treatment by aspirin (acetyisalicylic acid) has complained of B. Phase of alteration
renal colic. A doctor administered atropine together with opioid nausea, gravity in epigastrium. The doctor has abolished aspirin C. Phase of a proliferation
analgesic with spasmolytic activity to prevent development of the and has administered the antiinflammatory agent from the group D. All phases of an inflammation
pain shock. Choose this drug. of selective COX-2 inhibitors. Indicate this drug. E. Autoimmune
A. *Promedolum (trimeperidine) A. *Meloxicam' 14. The patient was treated by nonopioid analgesic due to
B. Tramadol B. Voltarenum (diclofenac-sodium) backache. In several days he started to complain of dyspeptic
C. Ibuprofen С. Indomethacinum disorders and stomachache (in anamnesis the patient had
D. Ketorolac D. Naproxenum hyperacidic gastritis). Indicate the reason of the arisen
E. Morphine E. Butadionum (phenylbutazone) complication.
15. Indicate the synthetic opioid analgasic which possesses A. * Inhibition of synthesis of prostaglandins in gastric
analgesic activity 100-400 times more than morphine. 16. The doctor has administered an ointment containing anti-
infiammatory agent from the group of pyrazolone derivatives to mucosa
A.*Phentanyl B. Stimulation of parasympathetic innervation by the stomach
 12
C. Inhibiton of mucous production by the gastric mucosa E. Toothache 11. A patient with respiratory disease with high temperature took
D. Inhibition of regeneratory activity of the gastric mucosa 3. A man of 26 years complaints of headache. Previously, the the drug from the group of non-opioid analgesics. This drug
E. Inhibition of organotrophic sympathetic influences upon the man suffered from peptic ulcer for the past 4 years. What drug is exerts predominantly anti-inflammatory action which excels the
stomach more preferable in this situation for the relief of his headache. salicilates and butadionum. It is highly absorbed in the intestine
A.* Paracetamolum and acts long. The side effects appear often. Determine this drug.
15. Following signs have developed at the patient after several
B. Diclofenac-sodium A. *Indomethacin
days of treatment by the drug with analgesic, antipyretic and
C. Acetylsalicylic acid B. Meloxicam
anti-inflammatory activity: headache, giddiness, sonitus, nausea,
D. Ibuprofenum C. Ortophenum (diclofenac sodium)
pain in epigastric area. Specify the drug which could produce
E. Indomethacinum D. Butadion
similar clinical pattern.
E. Ibuprofen
A. * Aspirin 12. A patient with various complaints addressed to the doctor.
B. Naphthyzinum (naphazoline) . In a 55 years old patient or the 4 ,h day of treatment with
After through clinical examination the following diagnosis was
C. Bromhexinum indomethacinum gastric hemorrhage developed due to
made: myositis, peptic ulcer of the stomach in remession,
D. Midantanum (amantadine) ulcering of gastric mucous membrane. By what is the
leukopenia. Determine the analgesic drug for the treatment of
E. Vitamin С ulcerogenic effect of the drug caused ?
myositis to this patient.
A. *Decrease of synthesis of prostaglandin E1
A. *Paracetamol (acetaminophen)
B. Decrease of synthesis of prostaglandin E2
B. Acetylsalicylic acid (aspirin)
5. Specify the most typical side-effects of butadionum, C. Decrease of synthesis of leucotriens
C. Amitriptyline
A. *Dispeptis disorders D. Decrease of synthesis of cyclic endoperoxydes
D. Morphine
B. Suppression of the CNS E. Decrease of synthesis of thromboxane
E. Butadionum (phenylbutazone)
C. Hypothermia 8. Nonopioid analgesic was administered to the patient with 3. After prolonged taking of a drug in relation with acute
D. Arterial hypotension neuritis of nervus trigeminus. This drug has fast effect, short time respiratory disease a patient began to complain of headache,
E. Allergic reactions of action, can cause allergic reaction of immidiate type. It may be vertigo, noise in ears, nausea, epigastric pain. Specify the drug
7. The patient with systemic lupus erythematosus was treated indicated in tablets and solution for injections. Determine this that might cause such clinical picture.
for a long time by non-steroid anti-inflammatory agents. drug. A *Acetylsalicylic acid
However, recently his condition has considerably worsened. A. *Analginum (metamizole) B. Vitamin С
Which drug is necessary to administer to the patient? B. Ibuprofen C. Naphthyzinum
A. * Prednisolone C. Mefenamic acid D. Bromhexinum
B. Analginum (Metamizole) D. Piroxicam E. Midantanum
C. Dimedrolum (Diphenhydramine) E. Indomethacin
D. Thymalinum 9. Pains in the small of the back developed after the lifting of NEUROLEPTICS, TRANQUILIZERS. SEDATIVES
E. Polyvitamins gravity (heavy loads). Radiculitis was diagnosed. It is known A patient who has been treated in a neural clinic and
from the anamnesis that the patient was suffering from ulcer of has been taking a sedative for a long time got the
Non-steroidal anti-inflammatory agent was administered to a the duodenal bulb for a long period of time. Make the most following complication: cough, rhinitis, epiphora. What
patient with rheumatic polyarthritis. In several weeks weakness rational choice of nonopioid analgesics :
drug caused these disturbances?
and indisposition were arisen. The clinical examination of the A. *Meloxicam
B. Ortophenum (diclofenac sodium) A *Sodium bromide
patient revealed necrotic quinsy and leucopenia. What drug
could cause this complication? C. lndomethacin B Diazepam
A. * Analginum (Metamizole) D. Butadion C Valerian
B. Paracetamolum E. Ibuprofen D Phenazepam
C. Nitrazepam 10. Gum bleeding arose in the patient after extraction of the E Reserpine
D. Omnopon tooth, rom anamnesis it was revealed that the patient suffered
A patient with myocardial infarction was admitted to
E. Morphine from rheumatic arthritis, and was treated with the anti-
inflammatory agent acetyl-salicylic acid(aspirin). Indicate the the cardiological department. For pain relief it was
13. Non-steroidal anti-inflammatory agents are used for the decided to potentiate fentanyl action with a
treatment of following pains, except: reason of arisen bleeding.
A. *Suppression of synthesis of thromboxane neuroleptic. Which of the following neuroleptics is the
A. * Fractures of bones
B. Headache B. Promotion ol thrombolysis most suitable for neuroleptanalgesia?
C. Arthritis C. Inhibition ot hemopoesis A *Droperidol
D. Neuritis D. Decreasing of blood coagulation
B Aminazine
E. Suppression of synthesis of uric acid
 13
C Triftazine B. Alfa-adrenoreceptors a patient with alcohol psychosis. Determine this drug.
D Haloperidol C. Beta-adrenoreceptors A. Aminazinum (chlorpromazine)
E Sulpiride D. M-cholinoceptors B. Sulpirid
E. N-cholinoceptors C. Diazepam
A 45-year-old patient suffers from neurosis
3. Impairment of movement co-ordination, shivering of the hands D. Triftazinum (trifluoperazine)
characterized by irritability, sleeplessness, motiveless and sleepiness developed in the patient had been suffering from E. * Haloperidol
anxiety. What drug would eliminate all the schizophrenia under the treatment by psychotropic drugs. 9. Neuroleptoanalgesia was made to a patient because of
symptoms? Indicate this group of drugs. myocardial infarction. What drug from the group of neuroleptics
A *Diazepam A. *Neuroleptics is used more often in combination with fentanyl?
B Valerian extract B. Analgesics A.* Droperidol
C. Tranquilizers B. Aethaperazinum (perphenazine)
C Pyracetam
D. Antidepressants C. Diazepam
D Caffeine sodium benzoate E. Psyco stimulants D. Chlozepidum (chlordiazepoxide)
E Levodopa 4. Introduction of aminazine(chlor-promazine), which was made E. Sulpind
The patient has taken the mixture prescribed by to a patient who had been suffering from chronic alcholism for 10. A patient had been suffering from schizophrenia accompanied
neuropathologist for neurasthenia for 2 weeks. elimination of agression and delirium, caused loss of by arterial hypertension. A doctor administered neuroleptic
Patient felt better but developed coryza, consiousness in this patient. Indicate the probable reason of this possessing expressed hypotensive activity. Indicate this drug.
conjunctivitis, rash, inertia, decrease of complication. A. *Aminazinum (chlorpromazine)
memory. Bromizm was diagnosed. What should be A. *Orthostatic collapse. B. Risperidone
prescribed to decrease symptoms? B. Inhibition of the reticular formation. C. Haloperidol
C. Impairment of coronary circulation. D. Diazepam
A *Natrium chloride D. Suppression of the limbic system. . E. Triftazinum (trifluoperazine)
B Glucose solution 5\% E. Impairment of oxidative processes in the brain tissue. 11. A 35-years-old woman was addressed to a doctor with
C Asparcam 5. Indicate the drug for elimination of the acute psychosis from complaints of temper tiredness, insomnia, internal tension. The
D Polyglucin the group of derivatives of phenothiazine. doctor had diagnosed neurosis and administered tranquilizer
E - A.*Aminazinum (chlorpromazine) (diazepam). Which of the effects of this drug is more important in
The patient was treated medically for psychosis for 2 B. Diazepam. this situation?
C. Haloperidol A. *Anxiolytic
weeks. Patient's condition improved but rigidity,
D. Amitriptylin B. Antiemetic
tremor, hypokinesia developed. Which of the drugs E. Natrii oxybutyras (oxybate sodium) C. Anticonvulsive
can cause such complications? 6. Determine the group of drugs which doesn't cause drug D. Myorelaxation
A *Aminazine dependence. E. Antipsychotic
B Diphenine A.* Neuroleptics 12. The majority of drugs from this group exert expressed
C Sydnocarb B. Tranquilizers sedative - hypnotic and myorelaxation action, that is why they
C. Barbiturates decrease concentration and reactions of the cured patients.
D Imipramine
P. Opioid analgesics Determine this group of drugs.
E Chlordiazepoxide E. Psychostimulants -phenylalkylamine derivatives A. *Tranquilizers
7. A doctor administered aminazinum (chlorpromazine) to the B. Salicylates
1. A 40 year-old patient was admitted to the psychiatric clinic in patient suffering from schizophrenia to eliminate delirium, C. Nootropic agents
an agitated state. He was aggressive, and delirated. Indicate the hallucinations, to decrease aggression and psychomotor D. Sedative
best drug to be given excitement. What is the mechanism of antipsychotic action of E. Ca channel blockers
A. *Aminazine (chlorpromazine) aminazinum? 13. A dentist introduced sibazonum (diazepam) to a 48-years old
B. Sodium bromide A. Excitation of M-cholinoreceptors in the CNS woman before extraction of tooth. Explain the mechanism of its
C. Diazepam B. Stimulation of opioid receptors anxiolytic action.
D. Tinctura Valerianae C. *Blockade of adrenoreceptors and dopamine receptors A. *Agonist of benzodiazepine receptors
E. Peserpinum in the CNS B. Stimulation of opioid receptors
2. A man with disorders of psychoemotional state and D. Excitement of adrenoreceptors and dopamine receptors C. Excitation of adrenoreceptors and dopamine receptors in the
sleeplessness, was treated with diazepamum. Upon which in the CNS. CNS.
receptors this drug influence? E. Inhibition of MAO D. Inhibition of α-adrenoreceptors
A.* Benzodiazepine receptors 8. A neuroleptic (butyrophenone derivative) was administered to E. Agonist of M-cholinoreceptors
 14
14. A patient was addressed to a doctor with complaints of An aged patient complains of headache, dizziness, situation ?
emotional unstability. feeling of psychoemotional tension and quick tiredness, worsening of memory. Anamnesis: A. *Phenaminum (amphetamine)
fear in meetings with the chief often accompanied by significant craniocerebral injury. Medicine of what group should B. Coffeinum
tachycardia, pain in the heart area, hyperemia of the face, C. Ginseng
be prescribed?
headache, hand tremor, sweating. Administer the necessary drug. D. Piracetam
A. *Chlozepidum (chlordiazepoxide) A *Nootropics E. Sydnocarbum (mesocarbe)
B. Aethaperazinum (perphenazine) B Somnific 7. What is the main mechanism of psycostimulant action of
C. Aethtmizolum C Neuroleptics coffeinum?
D. Analginum (metamizole) D Analgetics A.* Blockade of the adenosine receptors
E. Sulpirid E Sedatives B. Agonist of M-cholinoreceptors
15. What group of drugs is used for the treatment and prevention C. Stimulation of opioid receptors
of manias? 1. During the operation under general anesthesia the patient's D. Excitation of adrenoreceptors and dopamine receptors in the
A. * Lithium respiration was inhibited. Specify, which breathing stimulant CNS.
B. Sedatives should be used in this situation without pausing the general E. Inhibition of α-adrenoreceptors
C. Neuroleptics anesthesia This drug is used for the treatment of disorders of memory,
D. Tranquilizers A. * Aethimizolum cerebral atherosclerosis, after cerebral injuries, alcohol
E. Antidepressants B. Coffeinum encepholpathy, dementia. It improves the processes of
16. These drugs amplify and concentrate the inhibitory processes C. Bemeqridum memorizing and cognitively. Determine this drug.
in the brain cortex. They exert sedative action, relieve irritability, D. Cytitonum A. *Piracetam
and do not eliminate the feeling of fear, anxiety. Determine this E. Lobelini hydrochoridum B. Amitriptylinum
group. 3. The patient was admitted to the neurology department because C. Paracetamol
A.* Sedatives of complaints of decrease of memory, mental and work capacity, D. Bemegridum
B. Tranquilizers sleepiness and vertigo. His symptoms were connected to a brain E. Sibazonum (diazepam)
C. Antidepressants concussion, which took place 2 years ago as a result of an 12. A patient with traumatic encephalopathy was admitted to the
D. Neuroleptics automobile accident. What drug should be indicated to improve neurological department with complaints of disorders of
E. Psychostimulants his condition. memory, intellect, headache, vertigo. Choose the group of drugs
17. A patient was addressed to a doctor with complaints of A.* Pyracetamum (Nootropilum) for the treatment of the patient.
irritability, insomnia, fatigue. A doctor administered a sedative B. Natrii oxybutyras (oxybate sodium) A. *Nootropic agents (cognitive enhancers)
drug to him. In two weeks the patient began to complain of C. Sydnocarbum B. Analeptics
cough, sleepiness, decrease of memory, phenomena of rhinitis, D. Coffeinum C. Psychostimulants
conjunctivitis, dermatitis. What group of the drugs was E Cordiaminum (nikethamide) D. Antidepressants
administered by the doctor? 4. Specify indication for use of coffeinum. E. Adaptogens
A. *Bromides A. *Sleepiness. 13. Specify the characteristic side-effect of analeptics
B. Valeriana B. Arterosclerosis. A. *Convultions
C. Lithium C. Arterial hypertension. B. Bronchospasm
D. Tranquilizers D. Tachycardia. C. Hepatitis
E. Neuroleptics E Nausea. D. Arterial hypertension
17. A patient has been taking a mixture prescribed by 5.Indicate the drug which posseses analeptic and psycho E. Gastritis
neuropathologist for neurasthenia for two weeks. The patient stimulant activity. 14. Specify the main effect of Piracetam (Nootropil).
feels better but has developed coryza, conjunctivitis, rash, inertia, A.*Coffeinum A. *Improves the processes of memorising and cognitivity
decrease of memory. She is diagnosed with bromizm. What drug B. Bemegridum B. Tranqulizing effect
should be prescribed to decrease the symptoms? C. Aethimizoium C. Inhibition upon excitation in the CNS
A. *Natrium chloride (salty food) D. Cordiaminum (nikethamide) D. Stimulation of myocardium activity
B. Potassium chloride E. Strychnine E Deacreases the neuronal stability to hypoxia
C. Polyglucinum 6. The patient was addressed to a doctor with complaints of
D. Asparcam tiredness, decrease of capacity for mental and physical work, ANTIDEPRESSANTS. ADAPTOGENS.
E. Glucose solution 5% worsening of mood. In examination the doctor revealed arterial
hypertension and administered the drug from the group of 2. A woman tried to commit suicide, her psychiatrist made the
ANALEPTICS,. PSYCHOSTIMULANTS, NOOTROPIC psychostimulants. What agent is contraindicated in this diagnosis of endogenic depression. What drug should be given
AGENTS for her treatment?
 15
A. *Amitriptyllinum C. Barboval 1. After prolonged treatment of thyrotoxicosis with an
B. Nootropilum D. Nialamide antithyroid drug, suppressing synthesis of thyroid hormones in a
C. Sydnocarbum (mesocarbe) E. Natrium bromide thyroid gland, the patient complained of the dyspeptic disorders,
D. Aethimizoium appearance of a tumescence on the front surface of a neck.
E. Coffeinum Analysis of the blood revealed leukopenia and agranulocytosis.
HORMONAL DRUGS (1)
8. The patient addressed to a doctor with complaints of bad With what antithyroid drug was the patient treated?
mood, that was accompanied by expressed sedative action,
A 56-year-old patient with complains of thirst and
A. * Mercazolilum
feeling of fear, anxiety. The clinical examination revealed frequent urination was diagnosed to have diabete
B. Diiodotyrosine
psychical depression. What drug should be administered to this mellitus and butamin was prescribed. What is the С. Iodine
patient? mechanism of action of this medicine? D. Radioactive iodine
A. *Amitriptylinum A *It stimulates beta-cells of Langergans' islets E. Potassium perchlorate
B. Ammazinum (chlorpromazine) BIt helps to absorb the glucose by the cells of the
C. Coffeinum 2. The patient suffering from diabetes mellitus complained of
organism tissues flaccidity, apathy, difficulty of respiration. Investigation of the
D. Droperidolum
E. Ortophenum (diclofenac-sodium) CIt relieves transport of glucose through the cells' patient revealed: confused consciousness, paleness and dryness
9. A doctor administered amitriptyline to a patient with membranes of the skin and mucous membranes, sunken eyes, sharp pointed
endogenous depression. Explain the mechanism of action of this D It inhibits alpha cells of Langergans' islets features of the face. The blood pressure is 100/60 mmHg. Pulse
drug. E It inhibits absorption of glucose in the intestines is weak and frequent. Odour of acetone from the mouth. The
diagnosis of hyperglycemic coma was given. Which drug
A. *Inhibition of the neuronal reuptake of noradrenaline and Examination of a 70 year old patient rrevealed
serotonin should be introduced for the elimination of the given state?
insulin-dependent diabetes. What drug should be
B. Inhibition of the neuronal reuptake of serotonin A * Insulin
administered? B. Glibutidum
C. МАО inhibitor
D. Increase of release of noradrenaline and serotonin A *Glibenclamid С Bucarbanum
E. Inhibition of the neuronal reuptake of noradrenaline B Insulin D. Protamine-zinc-insulin
10. A man was addressed to the psychiatrist with complaints of C Mercazolilum E. Butamidum
dreary spirits, feeling of hopelessness and desperation, tendency D Parathyroidin 3. Hypoglycemic state arose in the patient who had been
to suicide. Determine the group of drugs for the treatment of this E Cortisone suffering from diabetes mellitus and was treated with insulin's
patient? Examination of a 60 y.o. patient revealed drug of prolonged action. Indicate the endocrine drug which
A.* Antidepressants should be introduce to eliminate this plate.
hyperglycemia and glucosuria. A doctor administered
B. Sedatives A. *Glucagonum
C. Neuroleptics
him a medication for internal use. What medication is
it? В Hydrocortisone
D. Tranquilizers
A Glibenclamid C. Triamcinolonum
E. Lithium
D. Noradrenaline
15. This group of drug includes psychotropic agents of plant B Furosemide
E. Prednisotonum
origin, These drugs are used in asthenic states after severe C Oxytocin
infectious diseases. They increase general vital tonicity of the D Pancreatine 4. Specify the hormonal agent which is used in diabetes
organism and its resistance to infectious diseases. These drugs E Corglycon insipidus.
are used in the form of tinctures or liquid extracts. Choose this An elderly female patient suffers from the type 2 A. *Adiurecrinum
group of drug. B. Oxytocin
diabetes mellitus accompanied by obesity,
A. *Adaptogens C. Insulin
B. Sedative atherosclerosis, coronary artery disease. Basal
D. L-thyroxin
C. Psychostimulants hyperinsulinemia is also present. What treatment
E. Prednisolonum
D. Antidepressants would be the most appropriate?
E. Nootropic agents A *Glibenclamid 8. In a woman during labor, weakness of labor activity is deter-
16. This drug has stimulating action promoting synthesis of mined. What hormone drug should be introduced for stimulation
B Insulin of myometrium contractions?
proteins and ATP, increases the capacity for physical and
C Retabolil
psychical work,. It is used for a long time and it shouldn't be A. *Hormone of n. supraopticus of the hypothalamus
taken before sleep. D Lovastatin (oxytocin)
A.*Tincture of Ginseng E Amlodipine В. Follicle stimulating hormone
B. Tincture of Valeriana С. Prolactin
 16
D. Luteinizing hormone A. *Oxitocin and Vasopressin A. * Oppression of release by pituitary body of thyrotropic
E. Hormone of n. paraventricularis of the hypothalamus B. Oxytocin and progesterone hormone
(vasopressin) C. Oxytocin and oestradiol В. Oppression of activity of the enzymes participating in
D. Vasopressin and oestradiol synthesis of iodine-containing hormones of thyroid
9. After removal of the thyroid in a patient the attacks of
E. Vasopressin and progesterone gland
convulsions are observed. What drug needs to be administered?
С. Activation of production by hypothalamus of
A. *Parathyreoidin 16. To the patient after a subtotal resection of thyroid gland the
thyroliberine
B. Somatotropin drug of replaceable therapy is administered. Specify this agent.
D. Inhibition of the process of iodation of hormones’
С. Insulin A. * L thyroxine sodium molecules
D. Prednisolonum B. Potassium perchlorate E. Destruction of tissue of thyroid glan
E. L-thyroxin C. Mercazolilum
22. Radioiodine (J 131) is administered to a 65 years old patient
D. Rifathyreline
12. A patient was treated for a long time by a glucocorticoid suffering from Basedow’s disease, considering inefficiency of
E. Potassium iodide
drug. After sharp stopping of taking a drug following complaints treatment by the basic drugs and impossibility of a surgical
were arisen: undue fatigability, emotional lability, sleeplessness, 17. Impairment of enamel and dentine formation is diagnosed in intervention. What is the mechanism of action of this agent?
headache, decrease of appetite, nausea. The syndrome was a child owing to the under content of calcium ions in blood. A. * Causes destruction of follicles of thyroid gland
diagnosed. What drug should be administered for correction of What hormonal drug can be administered to correct this state? B. Inhibits functions of thyroid gland
this state? A. *Calcitonin С Oppresses synthesis of hormones of thyroid gland
A. *ACTH B. Thyroxine D. Accelerates excretion of iodides from thyroid gland
B. Glucocorticoids C. Somatotropinum E. Blocks entering of iodine in thyroid gland
С. Adrenaline D. Prednisolone 23. Numbness of extremities and paresthesia were developed at
D. Corticosteroids E. Cortisone the 52 years old patient soon after the operation of
E. Mineralocorticoids thyreoidectomy, hypocalcemia is laboratory diagnosed. What
18. Mercazolilum (methimazole) had been administered to the
13. Specify the drug of posterior pituitary hormone applied to patient, suffering from thyrotoxicosis. What effect underlies hormonal drug is necessary for administering?
stimulation of labor activity of uterus. antithyroid activity of a drug? A. * Parathyroidin
A. *Oxytocin A. *Decrease of thyroid hormones production B. Thyreoidinum
B. Dinoproston B. Depression of production of thyrotropic hormone С. Calcitrinum
С. Pachycarpin С. Depression of uptake of iodine by thyroid gland D. Thyroxine
D. Dinoprost D. Destruction of cells of thyroid gland E. Triiodothyronine
E. Salbutamol E. Oppression of metabolism in thyroid gland 24. The patient after removal of thyroid gland suffers from
14. A 25 years old woman was delivered to a maternity home 19. Convulsions were developed at the patient after attacks of convulsions. What drug is necessary for administering
for delivery. Due to uterine inertia a doctor administered her thyreoidectomy. By usage of what drug is it possible to in this case?
hormonsil agent. Indicate this drug. eliminate this state? A. *Parathyroidin
A. *Oxytocin A. *Calcium chloride B. Insulin
B. Retabolilum B. Tubocurarine С. Prednisolone
С. Progesterone С. Calcitrinum D. Thyroxine
D. Gonadotropin chorionic D. Triiodothyronine E. Somatotropin
E. Testosterone E. Ergocalciferol 25. Insulin was introduced to the patient, suffering from diabetes
melliyus. What is the main mechanism of action of this agent?
20. At investigation of a sick woman hyperactivity of thyroid
60. A 19-year-old female suffers from tachycardia in resting A. * Activation of glucose transport from blood to tissues
gland is revealed. What drug should be administered to her?
condition, weight loss, excessive sweating, exophthalmos and B. Oppression of glycogenesis
irritability. What hormone would you expect to find elevated in A. * Mercazolilum (methimazole)
B. L-thyroxine C. Inhibition of transport of amino-acids
her serum? D. Activation of synthesis of triglycerides
С. Triiodothyronine
A. *Thyroxine E. Activation of glycogen synthesis
D. Lugol’s solution
B. Cortisol
E. Thyreoidinum 26. Hyperglycemic coma is developed at the patient, suffering
С. ACTH
D. Mineralocorticoids 21. A drug of iodine is administer, to the patient, suffering from from diabetes mellitus. What drug should be administered in this
E. Insulin hyperthyroidism of an initial stage. What effect underlies situation?
antithyroid activity of this drug? A. *Insulin of short action
15. Specify the hormones entering into composition of pituitrin.
 17
B. Insulin of long duration of action diabetes mellitus and is treated by insulin. 10 days ago his doctor C. Metforminum
С. Drug from the group of biguanide derivatives has administered to him hypotensive agent to treat arterial D. Gilipizid
D. Insulin of intermediate duration of action hypertension. In an hour after last introduction of this drug E. Chlorpropamide
E. Drug from the group of sulfonylurea derivatives hypoglycemic coma has developed. Which of the numbered
36. Specify a drug, which is suitable to be used in patients
drugs could cause this complication?
27. Which agent from listed below should be introduced for suffering from diabetes mellitus with lowered ability of pancreas
treatment of hyperglycemic coma? A.* Propranolol (anaprilinum) to produce insulin
B. Prazozin
A. *Insulin A. * Butamidum (carbutamide)
С. Verapamil
B. Metformin B. Insulin
D. Captopril
С. Protamin-Zincum-insulin С Adrenaline
E. Nifedipine
D. Chlorpropamide D. Glucagon
E Bytamidum (Carbutamide) 32. A 60 years old patient has been suffering within 9 years from E. Calcitrinum
diabetes mellitus and is treated by insulin. 10 days ago his doctor
28. To the patient, suffering from diabetes mellitus the nurse has 37. The patient of advanced age addressed to the doctor with
administered to him hypotensive agent to treat arterial
wrongly introduced almost double dose of insulin. In 2 hours complaints of dryness in a mouth, polyuria, weight loss. At
hypertension. In an hour after last introduction of this drug
sweating, tachycardia, convulsions and loss of consciousness has examination hyperglycemia and glycosuria are revealed. It is
hypoglycemic coma has developed. Which of the numbered
developed. Hypoglycemic coma is diagnosed. What drug should diagnosed: diabetes mellitus, II type (non insulin dependent), an
drugs should be used for treatment of this state?
be introduced to the patient? intermediate degree of gravity. Which of the numbered drugs
A. * Glucose should be administered to the patient?
A. *Glucose
B. Insulin В. Insulin
C. Noradrenaline A. *Butamidum (carbufamide)
С. Lydasum В. Insulin
D. Somatotropinum D. Natrii hydrocarbonas
E. Bemegride С. Acarbose
E. Noradrenaline D. Glucose
33. The state of the patient, suffering from diabetes mellitus was E. Adrenaline
29. A 60 years old patient has been suffering within 9 years from
worsened after the injection of insulin with long action duration:
diabetes mellitus and is treated by insulin. 10 days ago his doctor 38. At examination of 70 years old patient hyperglycemia is
general asthenia, cold sweat, tremor of extremities developed
has administered to him beta adrenoblocker propranolol revealed. What drug is expedient for treatment of this state which
hypoglycemic coma was diagnosed. Intravenous injection of
(anaprilinum) due to arterial hypertension. In an hour after last is used oraly?
glucose solution didn’t cause improvement of the state. What
introduction of propranolol hypoglycemic coma has developed. A. *Glibenclamide
drug should be used in this situation?
Indicate a reason of arising of hypoglycemia in this case? B. Mercazolllum
A. * Adrenaline
A. * Oppression of glycogenolysis C. Parathyroidin
B. Insulin
B. Prolongation of action of insulin D. Iinsulin
C. Isadrinum (isoprenaline)
C. Decrease of release of glucagon E. Cortisone
D Dobutamine
D. Magnification of bioavailability of insulin
E. Dopamine 39. Indicate the synthetic antidiabetic drug from the group of
E. Diminution of absorption of glucose
34. The 56-years patient complained of thirst and frequent biguanide derivatives.
30. A 60 years old patient has been suffering within 9 years from A. *Metformin
emiction. After investigation in endocrinology the diagnosis of
diabetes mellitus and is treated by insulin. 10 days ago his doctor B. Acarbose
diabetes mellitus was established, and Butamidum (carbutamide)
has administered to him beta- adrenoblocker propranolol С Butamidum (carbutamide)
was administered to him. Determine the mechanism of action of
(anaprilinum) in connection with arterial hypertension. In an D. Glibenclamide
this agent.
hour after last introduction of propranolol he has felt asthenia, E. Glipizid
darkening in eyes, arterial pressure was depressed and in some A. * Stimulates beta-cells of pancreatic islets of Langerhans
minutes the patient has lost consciousness. Indicate the condition B. Promotes utilization of glucose by tissues of an organism 40. The patient of 45 years complains of constant thirst and
which has developed at the patient. С. Facilitates glucose transport through cellular membranes expressed polyuria. The level of glucose in blood plasma is
D. Oppresses beta-cells of pancreatic islets of Langerhans normal, and in urine glucose misses. What drug should be chosen
A. * Hypoglycemic coma
E. Increases a level of glucose in a blood for his treatment?
B. Hyperglycemic coma
C. Cardiogenic shock 35. What drug stimulating release of endogenic: insulin is a A. *Adiurecrinum
D. Sharp impairment of cerebral circulation derivative of sulfonylurea with average action duration (8-24 B. Desoxycorticosterone
E. Allergic reaction hours)? С Insulin
D. Hydrocortisone
31. A 60 years old patient has been suffering within 9 years from A. * Butamidum (carbutamide)
E. Prednisolone
B. Buforminum
 18
41.What drug oppresses absorption of glucose in small intestine? A patient ill with neurodermatitis has been taking disorder of menstrual cycle. What drug the patient took?
A. * Acarbose prednisolone for a long time. Examination revealed A. * Prednisolone
B. Insulin high rate of sugar in his blood. This complication is B. Indornethacin
С. Butamidum (carbutamide) C. Butadionum (Phenylbutazone)
caused by the drug influence upon the following link
D. Metformin D. Synaflanum (Fluoclnolone)
E. Glucose
of carbohydrate metabolism:
E. Beclomethasone
A *Gluconeogenesis activation
42. Acute bronchitis is arisen in a patient suffering from diabetes 9. The 60 years old woman who had been suffered from arthritis
B Glycogenogenesis activation
mellitus. What antimicrobial drug is undesirable for of knee joint was treated for a long time by Dexamethasone.
administering to this patient? C Intensification of glucose absorption in the bowels
Indicate the mechanism of anti-inflammatory action of this drug?
A. *Biseptol (co-trimoxazole -combined sulfonamide)
D Inhibition of glycogen synthesis
A. *Blockade of phosphlipase A2
B Amptcillin (antibiotic) E Activation of insulin decomposition В Blockade of cyclooxygenase-1
С. Tetracycline (antibiotic) Continious taking of a drug can result in С. Blockade of cyclooxygenase- 2
D. Azithromycin (antibiotic) osteoporosis, erosion of stomach mucous membrane, D. Blockade of folate synthase
E. Cefotaxim (antibiotic) hypokaliemia, retention of sodium and water, reduced E. Blockade of folate reductase
content of corticotropin in blood. Name this drug:
10. The patient suffering from arthritis has been treating for
HORMONAL DRUGS (I1) A *Prednisolone
several months by glucocorticoid agent Dexamethasone.
A patient ill with collagenesis has been taking B Hydrochlorothiazide Recently he has begun to complain of nausea, frequent stomach
prednisolone for a long time. Hypokaliemia C Digoxin aches. Clinical examination has revealed ulcer of the stomach.
development caused spastic pain of skeletal muscles. D Indometacin What is the mechanism of ulcerogenic action of
What medication should be used in order to correct E Reserpine glucocorticoids?
A *Impairment of microcirculation in gastric mucousa
potassium exchange?
B. Blockade of prostaglandin synthase
A *Panangin 31. Treatment by anti-inflammatory drugs was administered to C. Inhibition of protein synthesis due to activation of
B Dithylinum the patient with rheumatic endocarditis. After a while gluconeqgenesis
C Diazepam hyperglycemia was him. What group of drugs is capable to D. Initiation of n. vagus
D Noshpa provoke such side-effect? E. Blockade of gastrin synthesis
E Thyrocalcitonin A. * Glucocorticoids
11. A patient suffers from systemic inflammatory affection of
Patient was on glucocorticoids for a long time, B. Antibiotics of the group of Penicillins connective tissue. Indicate the drug inhibiting all phases of
discontinuation of usage caused exacerbation of the C. Ascorbic acid inflammation which should be administered to the patient?
D. Sedatives
illness, decreased BP, weakness. How can you E. Nonsteroid anti-inflammatory agents
A. *Dexamethasone
explain it? В. Butadionum (Phenylbutazone)
Many kinds of pathological states (inflammation, pulmonary С. Contrycal (Aprothtin)
A *Insufficiency of adrenal glands
edema, shock of different origin) are accompanied by violation D. Indomethacine
B Adaptation to the medicine of permeability of vessels. Which of the listed below drugs can E. Diclofenac-sodium
C Sensitization be used for elimination of this reaction at any of the termed
D Hyperproduction of ACTH 5. Specify a synthetic analogue of glucocorticoid hormones.
states?
E Cumulation A *Prednisolonum
A. * Prednisolone
Testosterone and it's analogs increase the mass of В. Adrenaline
B. Indomethacinum
C. Pituitrinum
skeletal muscles that allows to use them for treatment C. Dimedrolum (diphenhydramine)
D. Cortisone
of dystrophy. Due to interaction of the hormon with D. Aspirin (acetylsalicylic acid)
E. Testosterone
what cell substance is this action caused? E. Beclomethasone
6. A patient, 42 years old, took glucocorticoids in relation with
A *Nuclear receptors
rheumatoid arthritis. In 3 weeks the signs of arthritis were almost
B Membrane receptors The woman of 33 years on a phone of long-lasting eliminated and the patient stopped taking Им drugs. But a day
C Ribosomes medicamental therapy of chronic polyarthritis, began to mark after there was a relapse, and the new attack was significantly
D Chromatin herself increase of arterial pressure, change of allocation of fatty more severe than at the beginning of the disease. What's the
E Proteins- activators of transcription tissue (accumulation mainly in the area of the face and neck), reason of the developed complication?
 19
A. *Decrease of release of glucocorticoids D. Inhibition of translation E. Butadionum (phenylbutazone)
B. Increase of methabolism of glucocorticoids E. Stimulation of COX activity
51. Specify a drug from the group of glucocorticoids, which is
С. Slowing down of transport of glucocorticoids
45. A doctor had administered several drugs (anti-inflammatory, poorly absorbed into the blood in application to the skin.
D. Speeding-up of elimination of glucocorticoids
antibacterial and so on) to a patient who suffered from rheumatic A. *Synaflanum (fluoclnolone)
E. Increase of glucocorticoids' receptors adaptation
carditis. After a while hyperglycemia has arisen at him. What B. Dexamethasone
7. A woman, 28 years old, was admitted to a hospital in relation group of drugs is (capable to cause such side-effect? C. Triamcinolone
with danger of miscarriage. Earlier she had two cases of A. * Glucocorticoids D. Desoxycorticosterone
preliminary labor. Specify the drug of the hormone of corpus B. Nonsteroid anti-inflammatory drugs E. Prednisolone
luteum that needs to be introduced in this case. С. Antibiotics of Penicillin group 52. The doctor has administered an ointment containing
A. *Progesterone D. Ascorbic acid glucocorticoid to the patient suffering from allergic dermatitis.
B. Praegninum E. Sedatives The advantage of this drug is - it is not absorbed into the blood
С. Diazepam from the skin. Specify this drug.
46. Specify synthetic analogue of glucocorticoid hormones.
D. Magnii sulfas
A. *Prednisolone A. *Flumethasone
E. Tocopherol
В. Pituitrine B. Dexamethasone
10. A patient had been taking glucocorticoids for a long time. С Adrenaline С. Becfomethasone
When the drug was withdrawn he developed the symptoms of D. Cortisone D. Hydrocortisone
disease aggravation, decreased blood pressure arid weakness. E. Testosterone E. Prednisolone
What is the reason of this condition?
47. The patient suffering from severe form of diabetes mellitus is 53. Glucocorticoid agent (Prednisolone) had been administered to
A. *Appearance of adrenal insufficiency netted by insulin. Now his condition requires administering of the patient of 42 years who suffered from rheumatoid arthritis, in
B. Sensibilization antiinflammatory agent. Specify the drug which can demand 3 weeks patient’s state had improved and he had discontinued
С. Habituation (tolerance) correction of a dose of insulin? taking of the drug. However in a day his condition was worsened.
D. Hyperproduction of ACTH What was the reason of this complication?
A. * Prednisolone
E. Cumulation
В Diclofenac-sodium A. * Production of glucocorticoids had dropped
11. A patient with severe inflammatory disease had been treated C. Ibufrofen B. Transport of glucocorticoids was inhibited
by prednisolone during 10 months. Due to improvement of D. Indomethacin С. Elimination of glucocorticoids had been accelerated
patients state the doctor has reduced a dose of prednisolone and E. Butadionum (phenylbutazone) D. Adaptation of receptors to glucocorticoids had strengthened
added corticotropin. What purpose has he pursued, 48. The man of 50 years suffers from tuberculosis of the skin. E. Metabolism of glucocorticoids had strengthened
administering corticotropin? Which of numbered drugs, used for treatment of dermal 54. After long-term treatment by glucocorticoid agent this drug
A. *Stimulation of suprarenal glands activity diseases, is contra-indicated to this patient? was abolished, but patient’s state was worsened: exacerbation of
B. Potentiotion of drugs effects A. * Prednisolone the current disease, decrease of arterial pressure; asthenia had
C. Replacement of prednisolone B. Tetracycline developed. Indicate a reason of the arisen condition.
D. Decrease of side-effects of prednisolone С. Sulfur ointment
E. Prophylaxis of tolerance to prednisolone A. * Insufficiency of suprarenal glands
D. Ergocalciferol B. Drug tolerance
43. The patient's state requires introduction of glucocorticoids. E. Retinol acetate С. Sensibilization
How is t necessary to administer them taking into account 48. What drug cannot be used at infectious affections of skin? D. Hyperproduction of ACTH
physiological change of these hormones' content in a blood? E. Cumulative action
A. * Prednisolone ointment
A. *2/3 of the dose in the morning, the rest in the afternoon
B. Gentamvcin ointment 55. The patient of 60 years has tolerated mastectomy. After a
B. All dose in the evening
С Tetracyclin ointment course of radiation therapy the doctor has administered a
С. All dose in the morning D. Yellow mercury ointment synthetic drug of nonsteroid structure which eliminates
D. Evenly within day E. Brilliant green stimulatory influence of oestrogens on tumoral growth. Specify
E. 2/3 of the dose in the evening, the rest in the morning this drug.
50. The daily dose of what drug should be parted on unequal
44. Indicate the mechanism of antiinflammatory action of portions according to phases of a circadian rhythm? A. *Tamoxifen
Prednisolone. A. *Dexamethasone B. Fosfestrol
A. * Inhibition of phospholipase A2 activity B. Indomethacin C. Rubomvcin
B. Inhibition of transcription С. Ibufrofen D. Diethylstiibestrol
C. Inhibition of COX activity D. Diclofenac-sodium E. Cisplatin
 20
56. The woman of 28 years was admitted to the department of foodstuffs. Their consumption causes an allergic D Ambroxol
pathology of pregnancy due to threat of abortion. In her reaction in form of itching skin eruptions. What E Losartan
anamnesis there are two events of premature birth. Specify a drug antihistaminic drug should be admistered so that the
of the yellow body hormone which should be administered in this 1. A 40 year-old patient working as a driver suffers from chronic
child could attend school?
case. conjunctivitis of an allergic genesis. Which antihistamine drug'
A. * Progesterone A *Loratadine should be administered to a patient, taking into account his
B. Praegninum B Dimedrol profession?
С. Diazepam C Diclofenac A. * Diazolinum
D. Magnesium sulfate D Aminophylline B. Dimedrolum
E. Vitamin E. E Ephedrine С. Diprazinum
57. Cancer of mammary gland is diagnosed at the woman of 6 A woman works as railway traffic controller. She D. Suprastinum
years. What hormonal drug should be administered? suffers from seasonal vasomotor rhinitis and gets E. Ketotifenum
A. *Testosterone treatment in the outpatient setting. She was 6. Which drug is the most preferable to local treatment of allergic
B. Synoestroium prescribed an antihistamine that has no effect upon dermatitis?
C. Phenoboline central nervous system. What drug is it? A. *Hydrocortisone ointment
D. Progesterone
A *Loratadine B. Hippophea oil
E. Insulin
C. Furacilinum solution
B Dimedrol D. Afethyisalicylate liniment
58. Indicate the drug which stimulates synthesis of proteins,
exerts positive influence on calcium and nitrogen exchange and
C Promethazine E. Ichthyolum ointment
also promotes increase of appetite and body weight. D Suprastin
E Tavegil 21. Dimedrolum (diphenhydramine) is administered to a patient
A. * Retabolilum (nandrolone decanoate) with urticaria to reduce itching rashes on the skin. What
B. Prednisolone A 45-year-old woman suffers from allergic seasonal
mechanism provides its efficiency in this case?
C. Dexamethasone coryza caused by the ambrosia blossoming. What A. * Competitive blockade of HI-histamine receptors
D. Progesterone medicine from the stabilizer of the adipose cells B. Inhibition of synthesis of histamine
E. Corticotropin group can be used for prevention of this disease? С. Suppression of release of histamine
59. The doctor has administered Retabolilum (nandrolone A *Ketotifen D. Acceleration of histamine destruction
decanoate) to a female patient after consolidation of fracture of a B Diazoline E. Blockade of H2-his famine receptors
bone for acceleration of recovery, Indicate characteristic C Phencarol 22. What drug should be administered to the patient who suffers
undesirable effect of this drug at women. D Tavegyl from rashes due to allergic reaction accompanied by reddening,
A. * Masculinization E Dimedrol edema, and strong itch of skin which causes sleeplessness?
B. Decrease of body weight A doctor administered a patient with allergic A. *Dimedrolum (diphenhydramine)
С. Catabolic effect B. Nitrazepamum
dermatitis a H1-histamine blocker as a part of
D. Feminization C. Chlorall hydrate
E. Asthenia complex treatment. Name this medication:
D. Natrii oxybutyrate (oxybate sodium)
4. In a woman, 33 years old, after long-term pharmacotherapy
A *Loratadine E. Phenobarbitalum
of chronic polyarthritis arterial hypertension, redistribution of B Cromolyn sodium
23. The patient with allergic rhinitis s taken antihistamine drug
fatty tissue, menstrual disorders were observed. What drug did C Prednisolone
PO. In an hour the patient felt dryness in mouth, retardation and
the patient take? D Adrenaline sleepiness. Indicate this drug.
A. *Prednisolonum E Hydrocortisone A. *Dimedrolum (Diphenhydramine)
B. Indomethacinum A student came to see a doctor and asked to B. Diazolinum (Mebhydrolin)
C. Butadionum administer him a drug for treatment of allergic rhinitis C. Phenobarbitalum
D. Synaphlanum that occurs in the period of linden flowering. What D. Diazepamum
E. Beclomethasonum
drug may be used? E. Paracetamolum
A *Loratadine 24. Indicate "day time" antihistamine agent (with the least
ANTIALLERGIC AND IMMUNOTROPIC
B Noradrenaline hydrotartrate expressed sedative and hypnotic activity).
AGENTS
C Propanolol A. *Diazofinum (Mebhydroline)
A 12 year old child has intolerance to some
 21
B. Dirnedrolum (Diphenhydramine) numbered drugs is necessary to introduce first of all as first aid? 40. The patient took Levomycetinuin (chloramphenicole) for a
C. Diprazinum (Promethazine) A. *Adrenaline long time without doctor’s permission. Now the patient’s
D. Tavegilum (Clemastine} B. Dimedrolum (diphenhydramine) examination revealed leucopnia. What drug should be
E. Suprastinum (Chloropyramine) С. Chromoglicic acid administered for stimulation of leucopoiesis.
2 5 . A 40 years old outpatient (driver) suffers from chronic D. Salbutamol A.* Pentoxytum
conjunctivae, of allergic genesis. What antihistamine drug is E. Ephedrine В. Methotrexate
necessary to administer taking into account his occupation? C. Mercaptopurine
34. Anaphylactic shock was developed at the patient after
A. *Diazolinum (Mebhydroline) D. Cyancobalamine
intracutaneous test on sensitivity to Penicillin. The doctor had
B. Diprazinum (Promethazine) E. Prednisolone
administered a drug which eliminated bronchospasm and arterial
C. Suprastinum (Chloropyramine) hypotension, indicate this drug. 41. The patient with chronic infection disease requires treatment
D Dimedrolum (Diphenhydramine) A. * Adrenaline with specific immunostimulant agent. Indicate this drug.
E. Ketotifenum B. Noradrenaline A. *Pentoxylum
27 It is necessary to administer antihistaminic agent to a woman С. Mesatonum (Phenylephine) B. Methotrexate
suffering from seasonal vasomotor rhinitis, who works as a D. Atropine C. Mercaptopurine
dispatcher on the railway. Indicate the drug from this group E. Salbutamol D. Actinomycin
which doesn’t possess sedative and hypnotic properties. 36. Indicate the drug which is the most expedient for using for E. Cyclophosphanum
A.* Diazolinum (Mebhydroline) topical treatment of allergic dermatitises? 42. 48 years old woman who is from exacerbation of chronic
B. Dimedrolum (Diphenhydramine) A. *Hydrocortisone ointment pneumonia requires treatment with stimulant agent. Indicate this
C. Diprazinum (Promethazine) B. Solution of furacilinum (nitcofural) drug.
D. Suprastinum (Chtoropyraine) C. Liniment of n>ethylsalicylate A. *Thymalinum
E. Tavegilum (Clemastine) D. Ointment of ichthyolum (ichthammot) B. Sulfocamphocainum
28. A girl was treated with antibiotic from the group of E. Sea buckthorn oil (Oleum Hippophae) C. Biseptol (co-trimoxazole)
semisynthetic Penicillins due to acute bronchitis. On the 3rd day D. Dimedrolum (diphenhydramine)
37. The patient with chronic relapsing dermatitis of allergic
of treatment allergic dermatosis has developed. Indicate an E. Levamisole
genesis requires treatment by a glucocorticoid agent. Indicate the
antiallergic drug which should be administered to the patient. drug from this group which exerts only local action on skin and 43. Indexes of immune response are worsened in a patient during
A. * Suprastinum (Chloropyramine) does not cause systemic side-effects. chemotherapy of malignant tumour. What drug should be
B. Levamisole A. * Synaflanum (fluocinolone) administered in this state?
С. Aspirin (Acetylsalicylic acid) B. Prednisolone A. * Thymalinum
D. Biseptol (Co-trimoxazole) C. Hydrocortisone B. Cyancobalamine
E. Mefenamic acid D. Dexamethasone C. Iron preparations
29. Allergic dermatitis has been diagnosed at the patient of 43. E. Triamcinolone D. Prednisolone
The doctor has administered to him complex therapy including E. Acetylsalicylic acid
38. A doctor administered chromoglicic acid to the patient
the blocker of HI-histamine receptors. Indicate this drug. suffering from bronchial asthma to prevent attacks. Indicate the 44. A drug from the group of immunostimulant which is an
A. *Diprazinum (promethazine) principle of action of this drug. analogue of natural biogenic substrate and almost doesn’t exert
B. Cromolin sodium (cromoglicic acid) A. *Stabilization of membranes of mast cells side effects is administered to a 4 years old child. Indicate this
C. Prednisolone B. Binding of free histamine drug.
D. Adrenaline C. Decrease of concentrations of immunoglobulins A. * Interferon
E. Hydrocortisone D. Inactivation of histamine B. Prodigiosanuin
30. Indicate the group of antiallergic agents which loratadine E. Blockade of histamine receptors С. Thymalinum
belongs to. 39. A 45 years old patient suffers horn seasonal allergic rhinitis D. Pyrogenatum
A. * Blockers of histamine receptors related lo blooming of ragweed. What agent should be used for E. Levamisole
B. Membrane stabilizers prevention of this disease? 45. Indicate the immunostimulant drug which is also well
C. Antagonists of leucotriene receptors A. *Ketotifenum known as anthelmintic agent.
D. Glucocorticoids
В. Phencarolum (quifenadine) A. * Levamisole
E. Blockers of serotonine receptors
С. Diazolinum (mebhydroline) B. Interferon
32. The patient of 35 years, suffering from bronchial asthma, is D. Tavegilum (clemastine) С. Methyluracil
hospitalized in a state of anaphylactic shock. What of the E. Dimedrolum (diphenhydramine) D. Pyrantelum
 22
E. Natrium nucleinate D Tachyphylaxis B Rectal
46. A patient suffering from chronic generalized parodontics E Cumulation C Subcutaneous
requires the treatment with immunostimulant agent which Proserin increases skeletal muscle tone when given D Peroral
possess anthelmintic activity. Indicate this drug. systematically. Halothane induces relaxation of E Inhalation
A. *Levamisole skeletal muscles and reduces proserin effects. What
B. Seeds of pumpkin is the nature of proserin and halothane interaction? A patient who has been suffering from cardiac
С. Pyrantelum insufficiency for several months has been taking
A *Indirect functional antagonism
D. Chloxile digoxin on an outpatient basis. At a certain stage of
E. Piperazine adipate B Direct functional antagonism
C Competitive antagonism treatment there appeared symptoms of drug
47. Indicate the drug which significantly increases body D Independent antagonism overdose. What phenomenon underlies the
temperature. development of this complication?
E Noncompetitive antagonism
A. *Pyrogenatum
B. Acetylsalicylic acid A patient with frequent attacks of stenocardia was A *Material cumulation
C. Methyluracil prescribed sustak-forte to be taken one tablet twice a B Habituation
D. Aminazine (Chlorpromiazine) day. At first the effect was positive but on the second C Sensibilization
E. Molgramostim day stenocardia attacks resumed. What can explain D Functional cumulation
48. A 45-year-old woman suffers from allergic seasonal coryza inefficiency of the prescribed drug? E Tachyphylaxis
caused by Ambrosia blossoming. What drug from the group of A *Tachyphylaxis A patient ill with chronic cardiac insufficiency was
stabilizers of mast cells can be used for prevention of the B Cumulation prescribed an average therapeutic dose of digoxin.
disease? C Sensibilization Two weeks after begin of its taking there appeared
A. *Ketotifen D Idiosyncrasy symptoms of drug intoxication (bradycardia,
В. Phencarol extrasystole, nausea). Name the phenomenon that
E Dependence
C. Tavegil caused
D. Dimedrol A patient taking clonidine for essential hypertension
treatment was using alcohol that caused intense accumulation of the drug in the organism?
E. Diazoline
inhibition of central nervous system. What may it be A *Material cumulation
GENERAL PHARMACOLOGY connected with? B Functional cumulation
A patient with chronic cardiac insufficiency has been A *Effect potentiating C Tolerance
taking foxglove (Digitalis) preparations for a long B Effect summation D Tachyphylaxis
time. Due to the violation of intake schedule the C Cumulation E Idiosyncrasy
woman got symptoms of intoxication. These D Intoxication Mother of a 2 year old child consulted a
symptoms result from: E Idiosyncrasy stomatologist. In the period of pregnancy she was
A *Material cumulation Continuous taking of some drugs foregoing the irregularly taking antibiotics for an infectious disease.
B Tachyphylaxis pregnancy increase the risk of giving birth to a child Examination of the child revealed incisor destruction,
C Idiosyncrasy with genetic defects. What is this effect called? yellow enamel, brown rim around the dental cervix.
D Antagonism What drug has apparent teratogenic effect?
A *Mutagenic effect
E Sensibilization B Embryotoxic effect A *Doxacycline
A man who has been taking a drug for a long time C Teratogenic effect B Furosemide
cannot withhold it because this causes impairment of D Fetotoxical effect C Ampiox
psychic, somatic and vegetative functions. Name the E Blastomogenic effect D Xantinol nicotinate
syndrome of different disturbances caused by drug A 36 y.o. man has a craniocerebral trauma. E Octadine
discontinuation: Objectively: diminished breath sounds, thread pulse, 9. During examination in out-patient department a physician
A *Abstinence no reflexes. What way of pyracetam introduction will identified pneumonia and- prescribed in-patient treatment by
B Sensibilization be the most apropriate in this case? ampicillin and cefalexin. However, the patient started treatment
C Idiosyncrasy at home with the same antibiotics, dosage and timing prescribed
A *Intravenous
by the doctor. Within three days the sick person felt better, fever
 23
and cough reduced. The treatment was discontinued and the
patient turned back to work. Next day he/she felt much worse,
fever and cough were developed again, that is why the patient
had to be examined by the physician, indicate please which
principle of chemotherapy was disobeyed by the patient:
A. *Duration of treatment
B. Combined usage of agents
C. The earliest chemotherapy beginning
D. Effective agent choice based on clinical and
bacteriological diagnosis
E. Optimal selection of dosage, timing and
introduction ways of agent
10. Patient with pneumonia was treated by injections of
antibiotic. Determine the type of chemotherapy:
A. *Causal treatment
B. Substitute treatment
C. Preventive treatment
D. Symptomatic treatment
E. Pathogenic treatment