Name: SURATE, KYLA MELLICAH B.

Yr. and Section: BSN 3B

GENERIC NAME: MECHANISM OF ACTION: SIDE EFFECTS/ADVERSE

NURSING RESPONSIBILITY
Rifampin Rifampin acts via the inhibition of DNA- REACTION
dependent RNA polymerase, leading to a
The most common side effects of Examination and Evaluation
suppression of RNA synthesis and cell
Rifadin include:
death.  Assess ataxia or
 red discoloration of your incoordination that
BRAND NAME: INDICATION:
teeth, sweat, urine, saliva and might affect gait,
Isonarif, Rifadin, Rifamate, Rifater, For the treatment of Tuberculosis and
tears, balance, and other
Rofact Tuberculosis-related mycobacterial
 heartburn, functional activities.
infections, Rifadin is also a prescription
DRUG ILLUSTRATION:  upset stomach, Report balance
medicine used to treat the symptoms of
 loss of appetite, problems and
Neisseria Meningitidis Carriers. Rifadin
 nausea, functional limitations to
may be used alone or with other
 vomiting, the physician, and
medications.
caution the patient and
 diarrhea,
family/caregivers to
 fever,
guard against falls and
 headache,
trauma
 dizziness,
 Monitor signs of
 drowsiness,
thrombocytopenia
 tiredness, (bruising, nose bleeds,
CLASSIFICATION: CONTRAINDICATION:
 muscle weakness, and bleeding gums) or
Antitubercular Agents The following conditions are
 pain in your arms or legs, hemolytic anemia
contraindicated with this drug. Check with
DOSAGE/FREQUENCY/ROUTE:  problems with balance or (unusual weakness and
the physician if the patient have any of the
muscle movement, fatigue, dizziness,
following conditions:
600 mg, PO (orally), Daily  numbness, jaundice, abdominal
pain). Report these
 diabetes  confusion, signs to the physician.
 porphyria  changes in behavior, and  Assess any joint pain
 decreased blood-clotting from low  trouble concentrating or muscle pain to rule
vitamin K out musculoskeletal
Rifadin may cause serious side pathology; that is, try to
 alcoholism
effects including: determine if pain is
 liver problems
 abnormal liver function tests  hives, drug induced versus
 lightheadedness, pain caused by
 a yellowing of the eyes or skin from
 rash, anatomic or
buildup of bilirubin called jaundice
biomechanical
 wheezing,
problems.
 difficulty breathing,
 Monitor confusion,
 swelling in your face or
drowsiness, fatigue, or
throat,
weakness. Notify
 fever,
physician if these
 sore throat,
symptoms become
 burning in your eyes, problematic.
 skin pain,
 red or purple skin rash that Interventions
spreads and causes blistering  Always wash hands
and peeling, thoroughly and
 swollen glands, disinfect equipment
 muscle aches, (whirlpools,
 severe weakness, electrotherapeutic
 unusual bruising, devices, treatment
tables, and so forth) to
help prevent the spread
of infection. Use
universal precautions
 or isolation procedures
as indicated for specific
patients.
Patient/Client-Related
Instruction

 Advise patient about

possible discoloration
of tears, saliva, urine,
and other body fluids.
Instruct patient to notify
physician if
discoloration becomes
troublesome.
 Advise patient about
the likelihood of GI
reactions (nausea,
vomiting, diarrhea,
flatulence, abdominal
pain, heartburn).
Instruct patient to
report severe or
prolonged GI problems,
or signs of drug-
induced hepatitis (loss
of appetite, yellow skin
or eyes, severe nausea
and vomiting, fever,
sore throat, malaise,
 weakness, facial
edema).
 Instruct patient to
report other
troublesome side
effects such as severe
or prolonged headache
or flulike symptoms.

Reference/s:

Cunha, J. (2021). Rifadin. Retrieved from https://www.rxlist.com/rifadin-drug.htm

Medscape. rifampin (Rx). Retrieved from https://reference.medscape.com/drug/rifadin-rimactane-rifampin-342570
WebMD. Rifampin. Retrieved from https://www.webmd.com/drugs/2/drug-1744/rifampin-oral/details/list-contraindications
fadavispt.mhmedical.com. rifampin. Retrieved from https://fadavispt.mhmedical.com/content.aspx?bookid=1873&sectionid=139024547
GENERIC NAME: MECHANISM OF ACTION: SIDE EFFECTS/ADVERSE REACTION NURSING RESPONSIBILITY

Isoniazid The most common side effects of Assessment & Drug Effects
Isoniazid include:
BRAND NAME: INDICATION:  Monitor for therapeutic
 numbness and tingling in the effectiveness: Evident
Isonarif, Isotamine, Isotamine B, Isoniazid is used with other medications to extremities, within the first 2–3 wk of
Rifamate, Rifater treat active tuberculosis (TB) infections. It is  loss of appetite, therapy. Over 90% of
also used alone to prevent active TB  nausea, patients receiving
DRUG ILLUSTRATION:
infections in people who may be infected with  vomiting, optimal therapy have
the bacteria (people with positive TB skin  fatigue, negative sputum by the
test). Isoniazid is an antibiotic and works by  feeling unwell, sixth month.
stopping the growth of bacteria.  weakness,  Perform appropriate
 upset stomach, susceptibility tests before
 fever, and initiation of therapy and
 rash periodically thereafter to
detect possible bacterial
CLASSIFICATION CONTRAINDICATION: Isoniazid may cause serious side effects resistance.
including:  Lab tests: Monitor
Antituberculosis agents Isoniazid is contraindicated in patients who
 convulsions, hepatic function
develop severe hypersensitivity reactions,
DOSAGE/FREQUENCY/ROUTE: periodically. Isoniazid
including drug -induced hepatitis; previous  numbness or tinging in the
300mg, PO (orally), Daily extremities, hepatitis (sometimes
isoniazid-associated hepatic injury; severe
 painful or swollen joints, fatal) usually develops
adverse reactions to isoniazid such as drug
 irritability, during the first 3–6 mo of
fever, chills, arthritis; and acute liver disease
 memory loss, treatment, but may occur
of any etiology.
 difficulty concentrating, at any time during
therapy; much more
 involuntary movement,
frequent in patients 35 y
 fatigue,
or older, especially in
 depression, those who ingest alcohol
 pain and temporary vision loss, daily.
 blurred vision,  Monitor for visual
 sleeping too much or not enough, disturbance. An eye
 anxiety, examination may be
 suspiciousness, warranted.
 hallucinations,  Isoniazid-induced
 difficulty speaking, and pyridoxine (vitamin B6)
 suicidal thoughts depletion causes
neurotoxic effects. B6
supplementation (10–50
mg) usually accompanies
isoniazid use.
 Monitor BP during period
of dosage adjustment.
Some experience
orthostatic hypotension;
therefore, caution
against rapid positional
changes..
 Check weight at least
twice weekly under
standard conditions.

Patient & Family Education

 Note: Eating tyramine-

containing foods (e.g.,
 aged cheeses, smoked
fish) may cause
palpitation, flushing, and
blood pressure elevation.
Histamine-containing
foods (e.g., skipjack,
tuna, sauerkraut juice,
yeast extracts) may cause
exaggerated drug
response (headache,
hypotension, palpitation,
sweating, itching,
flushing, diarrhea).
 Withhold medication and
notify physician if S&S of
hepatotoxicity develop
(e.g., dark urine,
jaundice, clay-colored
stools).
 Avoid or at least reduce
alcohol intake while on
isoniazid therapy because
of increased risk of
hepatotoxicity.
 Withhold all drugs and
notify physician of
hypersensitivity reaction
 immediately; generally
occurs within 3–7 wk
after initiation of therapy.

References:

RxList. (2021). Isoniazid. Retrieved from https://www.rxlist.com/isoniazid-drug.htm

DRUGBANK. Isoniazid. Retrieved from https://go.drugbank.com/drugs/DB00951

robholland.com. ISONIAZID (ISONICOTINIC ACID HYDRAZIDE. Retrieved from http://www.robholland.com/Nursing/Drug_Guide/data/monographframes/I046.html