Professional Documents
Culture Documents
Female Male
Gonad
Female: Ovary
Male: Testes
Week 5:
Mesonephric (Wolffian duct)
Paramesonephric (Mullerian duct)
Week 7-8: (Males)
early gonadal tissue begins formation of
testosterone
Testosterone- mesophrenic duct develops into
reproductive organs
Week 10: (Females)
Paramesophrenic duct becomes dominant and
develops into reproductive organs
When Ovaries form, all of the oocytes (cells 2. low Estrogen level in the blood
that'll develop into eggs throughout the 3. Hypothalamus (GnRH - FSHRF)
woman's matuer years) are already present. 4. Anterior Pituitary Gland (FSH)
Pubertal Development 5. Ovaries (Estrogen)
- Puberty is the stage at which secondary sex changes prepares the endometrium to be thickened
begin facilitates growth of primodial follicle to
FEMALES: become graafian follicle
- Hypothalamus SECRETORY/ PROGESTATIONAL/ LUTEAL/
- GnRH (Gonadotropin RH) PREMENSTRUAL PHASE (DAY 15-26)
- Anterior Pituitary Gland 1. 13th day of menstrual cycle
- FSH & LH 2. high estrogen, low progesterone
3. Hypothalamus (GnRH - LHRF)
Androgen 4. Anterior Pituitary Gland (LH)
muscular development follicle cells to produce lutein - rich in
physical growth progesterone
Male: testosterone is low until puberty (12-14) 5. Ovaries (Progesterone)
Female: testosterone influences enlargement of further thickens the wall
labia majora, clitoris and formation of axillary and nourishes uterine wall
pubic hair hormone of ovulation and pregnancy
Estrogen fluid retention and decrease GI motility
development of uterus, fallopian tubes and vagina 6. 14h day of menstrual cycle
7. high estrogen, high progesterone
Secondary Sex Characteristics 8. Rupture of Graafian follicle
Female: 8a1. Degenerate and becomes corpus luteum
o GROWTH SPURT 8a2. 24th day: Corpus Albicans
o INCREASE IN TRANSVERSE DIAMETER OF THE PELVIS 8b1. Release of ovum (fertile)
o BREAST DEVELOPMENT Ischemic Phase (Day 26)
o GROWTH OF PUBIC HAIR 1. 26th day of menstrual cycle
o ONSET OF MENSTRUATION 2. low progesterone
o GROWTH OF AXILLARY HAIR 3. endometrium begins to degenerate
o VAGINAL SECRETIONS 4. endometrium sloughs off
Male: Menstrual Phase
o INCREASE IN WEIGHT
o GROWTH OF TESTES Family Planning Methods
o GROWTH OF FACE, AXILLARY AND PUBIC HAIR A. Natural Family Planning Methods
o VOICE CHANGES 1. LAM (Lactating Amenorhea Method)
o PENILE GROWTH 1% to 5% Failure Rate
o INCREASE IN HEIGHT When a woman is breastfeeding, there is
o SPERMATOGENESIS (PRODUCTION OF SPERM) suppression of both ovulation and
Menstruation.
Menstruation Mens will return 6mos PP
4 Major Organs: If Not lactating 2-3mos PP
HYPOTHALAMUS 2. BBT (Basal Body Temperature) Method
ANTERIOR PITUITARYGLAND Just before the day of Ovulation, a woman’s
OVARIES basal body temperature falls to about 0.5°F.
UTERUS (ENDOMETRIUM) At the time of ovulation, her BBT rises a full
Normal Menstrual Cycle: 0.2°C because of the rise in progesterone with
INTERVAL: 28 DAYS ovulation.
DURATION: 4-6 DAYS Watch out for a slight dip and a sudden
AMOUNT: 30-80 ML PER MENSTRUAL PERIOD increase.
(SATURATED PAD AFTER 1 HR IS HEAVY BLEEDING) 3. Billing’s (Cervical Mucus Method)
COLOR: DARK RED (BLOOD, MUCUS, ENDOMETRIAL predicts ovulation using the changes in
CELLS) cervical mucus that occur naturally with
ODOR: SIMILAR TO MARIGOLD ovulation.
Before Ovulation: Mucus is thick and does not
Physiology of Menstruation stretch when pulled between the Thumb and
PROLIFERATIVE/ ESTROGENIC/ FOLLICULAR/ Finggers.
POSTMENSTRUAL PHASE (DAY 1-14) On the day of Ovulation, it becomes thin,
1. On the 3rd day of menstrual cycle
copius, watery and transparent. Feels slippery
like egg white and stretches for about 1 inch 1. Coitus Reservatus (Sex S Ejaculation)
before breaking. C. Artificial Methods
1. Mechanical/Chemical Barriers
A. Condom
• Made of latex
• <sexual satisfaction
• Checks Holesm Protects from STI 99.9%
b. IUD
• Best time to insert, during menstruation or
After placental delivery
• Long term effect 5-10yrs
• Economical
• Insertion: Sever Cramping
• Monogamous Relationship
• Copper – Spermicidal
• If mother becomes pregnant, IUD must be
4. Symptothermal Method removed
Combination of BBT Method and Billing’s C. Artificial Family Planning Methods
Method a. Mechanical/Chemical Barriers
Checking of Temp in am to detect BBT. 1. Condom
Assessing for Spinnbarkeit property of • Is a latex rubber or synthetic sheet that is
Cervical Mucus. placed over the erect penis before coitus to
5. Calendar Rhythm Method trap sperm.
Continuous monitoring of Menstrual Cycle. • Protects from STI – 99.9%
Needs 6mos data. Applicable only for women • Has 2% of Failure Rate
with regular menses. 28-32 days MC. 2. IUD (Intra-uterine Device)
Formula: • An intrauterine device, is a small, often T-
Longest = -11 shaped birth control device that is inserted
Shortest = -18 into a woman's uterus to prevent pregnancy.
DOO= No. of Days of the Menstrual Cycle – Among birth control methods, IUDs, along
14 with contraceptive implants, result in the
Family Planning Methods greatest satisfaction among users.
A. Natural FPM
1. LAM
• Mens will return 6mos PP
• If Not lactating 2-3mos PP
2. BBT
• Early in am b4 arising in bed, b4 doing anything
Contrain in:
1. Insomnia
2. Stress
3. On Diet
4. Infxn
3. Billing’s Method (Cervical Mucus Method)
• Spinnbarkeit test, clear, thin, stretchy, copious =
Fertile
• Cloudy, sticky, thick = infertile
Types of Infertility:
1. Primary = No preg at all
3. Diapragm
2. Secondary = difficult to conceive again
DOC: CLOMIPHENE CITRATE (CLOMID) A diaphragm is a circular rubber disk that is
-Induces Ovulation placed over the cervix before intercourse to
B. Social Family Planning Methods mechanically halt the passage of sperm.
1. Abstinence Combination of a spermicidal gel increases
2. C. Interruptus rate of effectivity.
3. C. Reservatus
Family Planning Methods
B. Social Methods
• Least effective Method
1. Coitus Interruptus (withdrawal)
Clitoris increases in size
Appearance of mucoid fluid on vaginal wall
Vagina widens and increases in length
Breast nipples become erect.
Boys
Penile erection
Scrotal thickening and elevation of testes
Plateu
Just before orgasm
Girls:
Clitoris is drawn forward
Lower part of the vagina becomes extremely
4. Cervical Cap congested
Is made of soft rubber shaped like a thimble, Increased nipple elevation/ erection
which fits snugly over the uterine cervix. With Boys:
high failure rate the same as of the Further distention of penis
Diaphragm. Orgasm
Shortest stage
Intense pleasure
“Climax”
Resolution
30-minute period during which internal and
external organs return to unaroused state.
Boys: refractory period
Girls: none
5. Spermicidal Gel
Spermicide is a contraceptive substance that
destroys sperm, inserted vaginally prior to
intercourse to prevent pregnancy.
Contains Non-Oxinal 9 (Highly Acidic)
2. Physiologic Method
1. Depo-provera
Depot medroxyprogesterone acetate
• Given IM, do not massage
• Q 3mos
Lunelle
• Q 1 mos.
Ovulation will resume 6-12mos after D/C
2. Norplant
• 6 match like capsules containing progesterone
• Protects from pregnancy upto 5yrs
• +keloids the skin
• Ovulation will resume after removal
3. Pills
Missed Pills –
1st Day = 2 now, 1 tom
2nd Day = 2 now, 2 tom
Influence of Menstrual Cycle on Sexual Response
3rd Day = Throw Pack, restart cycle with new set
During luteal phase – plateau stage is reach more
quickly – achieving orgasm more readily
Sexual Response Cycle
Women may initiate during this time of the month
Excitement
Influence of Pregnancy on Sexual Response
Stimulation
Pregnancy - vasocongestion
Foreplay
Orgasm don’t cause a spontaneous miscarriage
Parasympathetic nerve stimulation
If with Hx of premature labor, sucking or massaging
Vasoconstriction and arterial dilatation
breast is contraindicated
Muscular tension
Girls
Types of Sexual Orientation - reflects insecurity or the inability to feel
Sexual gratification can be experienced in many confident enough
ways D. Sadomasochism
Heterosexuality (opposite sex) - inflicting or receiving pain for sexual
Safe sex practice pleasure
Abstinence (100% guarantee) E. Exhibitionism
Choose your partner and ask his/her - exposing one’s own genitals to an
lifestyle unsuspecting person
Inspect your partner F. Frotteurism
Condom (best for prevention of infection) - touching or rubbing against unconsented
Homosexuality person
WWW G. Bestiality
If partner is bisexual, higher chances of - sexual relations with animals
getting infected H. Pedophilia
MWM - interested in sexual encounters with children
Counselling for prevention of HIV and STIs Sexual Harassments
Bisexuality (either) - unwanted, repeated sexual advances, remarks or
Bisexual x others = HIGHER RISK behaviour toward another that is offensive to the
Transsexuality recipient
Feels as if he/she is of the opposite gender - present to both genders
Gender affirmation surgery (synthetic vagina - distressing that can lead to short-term or long-
and penis) = decreased over years term psycho consequences to the victim and its
Operations doesn’t change chromosomal family
structure - Nurses should be aware of harassments
Types of Sexual Expressions 1. Quid pro quo (equal exchange)
1. Celibacy (abstinence) 2. Hostile work environment – employer makes
- religious orders employee feel uncomfortable (honey, babe)
- way of life for many adults Disorders of Sexual Functioning
- fashionable among growing numbers of young A. Failure to achieve orgasm
adults Women: poor sexual technique, concentrating
- focus on giving and receiving love other than too hard or negative attitude toward partner.
through sexual expression; prevents pregnancy and DOC: Female Viagra (Pink Viagra)
STD B. Erectile Dysfunction (Impotence)
2. Masturbation inability to produce or maintain erection
- Self-stimulation Causes: aging, atherosclerosis, or diabetes, S/E of
- Mutually done drugs (antidepressants) or after discontinuance of
- Sexual and anxiety release Finasteride (BPH)
- Women find masturbation to orgasm most C.Premature Ejaculation
satisfying and use it more commonly than men - ejaculation before partner’s satisfaction has been
- Pre-schooler masturbation (without any attempt) achieved.
*Autoerotic asphyxia – extreme masturbation - unsatisfactory and frustrating
associated with hanging for extreme sexual Causes: psychological, masturbating to orgasm,
experience = FATAL doubt of masculinity and fear of impregnating
Erotic Stimulation partner
Use of visual materials for arousal D. Persistent Sexual Arousal Syndrome (PSAS)
- Adolescents: developmental and normal Women: excessive and unrelenting arousal in the
NI: respect this type of material when seen on pt’s absence of desire
room. Factors: psychological, restless leg syndrome,
Paraphilias overactive bladder
- sexual arousal to objects, situation or individual Ask pt’s if they are taking gingko biloba or
A. Fetishism Finasteride (sex booster)
Arousal from certain objects (leather, rubber, Restless Leg Syndrome
shoes, feet) Uncontrollable desire/urge to move your leg/s
B. Transvestism (hetero, homo or bisexual) Common sensations:
Cross-dressing is sexually arousing for them Crawling
C. Voyeurism Creeping
- Peeking tom Pulling
- almost all children and adolescents pass Throbbing
through this sexual expression Aching
Itching - Prevents bone loss and the risk for bone
Electric fracture
Characteristics: Bisphosphonates (Alendronate, Zoledronic Acid)
Starts after rest - Reduces bone thinning and risk of fracture
Relieves with movement Contraception
Commonly at night (nigh time leg twitching) Note:
Pain Disorder Personal values
Vaginismus – involuntary contraction of the Ability to use method correctly
muscles (vagina) when coitus is attempted, which If method will affect sexual enjoyment
prohibits penile penetration. Financial factors
Factors: If relationship is short term or long term
Rape Hx Prior experiences with contraception
Early learning pattern (bad/ sinful) Future plans
Dyspareunia – pain during coitus Ideal Contraceptive should be:
Factors: Safe
Endometriosis – abnormal placement of Effective
endometrial tissue Compatible with religious beliefs and personal
Vestibulitis – inflammation of the vestibules preferences
Vaginal infection Free of bothersome side effects
Hormonal changes (menopause) Convenient and easily obtainable
Menopause Affordable and needing few instructions
“Change of life” Do’s before using new method of contraception
Cessation of menstrual cycle (40-55 yrs old) Subjective assessment
Smokers tend to have earlier menopause than Vital signs
others Pap smear
Perimenopausal – period which menopausal Pregnancy test
changes is occurring (transition of 1-2 yrs) Gonococcal and Chlamydial screening
Menopause – 12 months amenorrhea Obstetric history (STIs, past pregnancies, failure
Postmenopausal – period after the final menses (12 of previously used method and compliance
months) history)
Maturation of Oocytes Sexual practices
From utero: 5-7 million (most never develop and Hormonal Contraception
atrophy) Hormonal contraceptives are, as the name
At birth: 2 million implies, hormones that are taken orally, transdermally,
7 yrs old: 500,000 intravaginally, or intramuscularly.
22 yrs old: 200,000 Combination of Oral Contraceptive
The point at which no functioning oocytes Commonly known as pills, OCs, or COCs, are
remain in the ovaries composed of varying amounts of natural estrogen
Due to follicular attrition, ovaries atrophy or synthetic estrogen combined with a small
resulting to decrease of estrogen level amount of progesterone
Physiological Changes: If taken religiously, 99.9% effective
1. Breast and genital organs atrophy If occasionally forgotten, and due to physiologic
2. Vaginal dryness (NI: Vaginal lubricant) differences there’s 5% failure
3. Osteoporosis (NI: Exercise (Weight-bearing, Estrogen - accts to suppress FSH and LH to suppress
strength training and aerobics)) ovulation.
4. Hot flashes (NI: relaxation technique) Progesterone – decreases permeability of cervical
5. Urinary incontinence (NI: provide pads, kegel mucus and so limits sperm motility and access to
exercise) ova.
6. Decrease in libido COC
7. Sleep disturbances Typical pills are supplied with 28-pill dispensers (21
8. Headache active and 7 placebo pills) labelled with the day of
Medical Management the cycle.
Hormone Therapy Not effective for the first 7 days
- Used to be miracle drug that promotes Caution women to take only pills in order or the
youthfulness progesterone level could be inaccurate and
- Pills, injectable or surgery ineffective for that day.
S/E: Increase risk of breast CA and blood clots Prescribed by physician after examination
Selective Estrogen receptor Modulator (SERMs) Oral Contraceptive Decreases:
Dysmenorrhea (lack of ovulation)
Premenstrual dysphoric syndrome and acne ● Failure rate is lesser than oral contraceptives. 1%
(increase in progesterone level) ● Won’t affect during breastfeeding
Iron deficiency anemia (reduced amount of ● Con’s:
menstrual flow) ○ Weight gain
Acute pelvic inflammatory disease (PID) ○ Irregular menstrual cycle
Endometrial and ovarian cancer, cysts and ectopic ○ Possible infection to insertion site
pregnancies ● Contraindicated to women with undiagnosed
Fibrocystic breast uterine bleeding
Endometriosis, osteoporosis, rheumatoid arthritis IM Injection
When to Take Pills: ● Medroxyrogesterone acetate (Depo-Provera)
1. Sunday start: Take the first pill on the first Sunday ● IM every 3 months. Contains only progesterone
after the beginning of menstrual flow ● Educate to never massage the site after
2. Quick start: Begin pills as soon as they are administration to allow slow absorption from
prescribed (increase compliance) muscles.
3. First day start: begin pills on the first day of menses ● Not advisable for long term use (not over 2 yrs)
4. After childbirth: on any day (or Sunday) closest to 2 ● Cons:
wks after birth; after an elective termination of ○ Weight gain
pregnancy, she could begin on a chosen day after ○ headache
the procedure. ○ Depression
Progestin-only Pills ○ Irregular menstrual cycle for 1 yr
Mini-pills ○ No menstrual bleeding after the 1st yr.
Doesn’t allow development of endometrium, or ○ Higher risk for osteoporosis
sperm to freely access the cervix, fertilization and Emergency Postcoital Contraception
implantation won’t take place ● Morning-after pill
Ovulation may occur ● Unprotected voluntary coitus or involuntary
Side Effects of Oral Contraception situations such as rape
Nausea ● Types:
Weight gain ○ High-dose progestin base
Headache ○ IUD
Breast tenderness ● 75% effectiveness is taken within 72 hrs
Breakthrough bleeding
Monilial vaginal infections (Candida albicans) Surgical Methods (Irreversible Procedure)
Mild hypertension Vasectomy
Depression ● The vas deferens on each side are pulled forward,
Symptoms of MI, Thromboembolic Complication: cut or tied and cauterized, blocking the passage of
Chest pain (MI or pulmonary embolism) spermatozoa
SOB ● Under local anesthesia
Severe headache (CVA) ● Special consideration:
Severe leg pain (thromboembolism) ○ 2 negative sperm reports (6-10 wks)
Eye problem (HTN, CVA) ○ 10-20 ejaculations
Hormone Transderm patch ● COmplications:
● Efficiency is equal to COCs ○ Hematoma
● Applied each week for 3 weeks ○ Postvasectomy pain sydorme
● 4th week, patch free week, menstrual flow will
occur
● May be applied to ff areas:
○ Upper outer arm
○ Upper torso (front or back, excluding breast)
○ Abdomen
○ Buttocks
● Dont’s: Tubal Ligation
○ Areas where makeup, lotion or creams are ● Fallopian tubes are occluded by cautery, crushed,
applied clamped or blocked, preventing the passage of both
○ Waist (may lossen when bending) sperm and ova
○ Irritated skin or/with open lesions ● This is done after menstrual flow and before
Subdermal Hormone Implants ovulation
● Norplant ● s/sx S/P ligation
● 6 matchsticks like that contains progesterone ○ Abd discomfort
● 5 yrs of protection from pregnancy ○ Abd bloating (24 hrs)
○ Diaphragmatic & shoulder pain ● Current illness
● Extensive obesity may require full laparotomy ● Sexual practices
● Contraceptives used
Elective Termination of Pregnancy ● Past pregnancies, miscarriages or abortions
Elective Termination ● Hx of contraceptive use
● A procedure performed by a knowledgeable HCP to ● Reproductive infections
end pregnancy before fetal viability. ● Operations performed
● AKA therapeutic, medical, or induced abortions. ● Hx of cancer and treatments
● Reasons: ● Menstrual cycle
○ Threatens a woman’s life (Class IV heart dse) Factors of Subfertility in Men
○ Chromosomal defect in fetus ● Disturbance in spermatogenesis
○ Unwanted ● Inadequate FSH and LH in the pituitary
Medically Induced Termination ● Obstruction in the seminiferous tubules, ducts, or
● Mifepristone vessels, which prevent the movement of
● Methotrexate (DOC for ectopic pregnancy) spermatozoa
● Misoprostol ● Qualitative or quantitative changes in the seminal
Contraindications: fluid
● Ectopic pregnancy ● Development of autoimmunity
● IUD in place ● Problems in ejaculation or deposition
● Serious medical conditions (Chronic adrenal ● Chronic or excessive exposure to X-ray or
failure) radioactive substance
● Long-term systemic corticosteroid therapy Limited Sperm Count
● Hemorrhagic d/o ● The number of sperm in a single ejaculation or in a
Surgical Elective Termination milliliter of semen. The minimum sperm count
● Dilatation and Curettage consider normal has:
○ Cervix is dilated and uterus is scraped clean with ○ 33 t0 46 million sperm per milliliter of seminal
a curette fluid, or 50 million per ejaculation
● Hysterotomy ○ 50% of sperm that are motile
○ Similar to cesarean birth ○ 30% that are normal in shape and form
○ 20-24 weeks AOG Testing for Sperm Number
Subfertility ● Analysis of Pituitary Hormones
● the failure to achieve a clinical pregnancy after 12 ○ Whether adequate levels of FSH and LH
months or more of regular unprotected sexual ● Semen Analysis
intercourse. ○ After 2-4 days of sexual abstinence, a man
● The major clinical challenge is to assess the ejaculates by masturbation in a clean specimen
reproductive aging status of a given woman. collector.
● Types: ○ Specimen is examined for 1 hr
○ Primary subfertility - no previous conception ○ Average specimen 1.4-1.7 mL and should contain
○ Secondary - Previous viable pregnancy but 33-46 million of sperms.
unable to conceive at present. ○ Required after 2-3 months (spermatogenesis)
● Sterility - inability to conceive ○ 30-90 days before sperm matures
Fertility Assessment Therapy for Increasing Sperm Count and Motility
● Educate couples regarding variety of tests and ● If sperm are present but the total count is low, a
procedures man may be advised to
● Help client identify and express their feelings, how ○ Abstain from coitus for 7 to 10 days at a time to
far they are willing to go on in testing and increase the count.
procedures ○ Ligation of a varicocele (varicosity in spermatic
● Counsel clients about available vein, if present)
resources/alternatives when pregnancy cannot be ○ Changes in lifestyle:
achieved. ■ such as wearing loose clothing
Health History ■ avoiding long period of sitting
● His general health ■ avoiding prolonged hot baths
● Typical 24-hr food intake, drugs, herbs, alcohol and Therapy for Sperm Disorders
tobacco use ● If the sperm are not able to pass through the vas
● Congenital health problem (hypospadias or deferens because of obstruction, surgery to relieve
cryptochidism) the obstruction is extensive, costly, and may not
● Previous exposure of his testes to radiation therapy, have a positive outcome.
xray or industrial accidents
● Previous operation done
● Extracting sperm from a point above the blockage human chorionic gonadotropin (hCG) to produce
and injecting it into the vagina or uterus of the ovulation.
man’s partner by intrauterine insemination. ● If increase prolactin levels are identified,
Ejaculation Problems bromocriptine (Parlodel) is added to the medication
● Erectile Dysfunction or the inability to achieve an regimen to reduce prolactin levels and allow for the
erection, which may occur from psychological rise of pituitary gonadotropins.
problems, diseases such as a cerebrovascular
accident, diabetes, as well as the discontinuation of Assisted Reproductive Techniques
finasteride, a drug used for male pattern baldness Alternative Insemination
may result in erectile dysfunction. This condition is ● Installation of sperm from specimen collected (male
primary if the man has never been able to achieve partner or donor) into female reproductive tract.
ejaculation and secondary if the man was able to ● Sperm can be cryopreserved (frozen) in a sperm
achieve ejaculation in the past but now has bank
difficulty. ○ D/A: slower motility
Premature Ejaculation ● In preparation, Clomiphene or FSH is given 1 month
● Another factor that may interfere with the proper prior to stimulate ovulation.
deposition of sperm. ● It takes 6 months or more to achieve
● It is another problem often attributed to In Vitro Fertilization
psychological causes. ● Fertilizing sperm and egg in a tube for 40 hrs, once
● Adolescents may experience it until they become successful, the zygote (laboratory-grown fertilized
more experienced in sexual techniques. ova) is inserted to woman’s uterus.
Testing for Ejaculation Concern ● Overall pregnancy rate of IVF is as low as 30%-35%
Ejaculation concern are identified by a sexual for ages 35 and below, and 6%-10% for women
history. It may be difficult for a man to discuss his area above 40 yrs old.
of his life, especially if a nurse is female, so skillful ● Expensive and complication of infection can occur.
patient interviewing technique is required.
Solution for erectile dysfunction include Alternatives to Childbirth
psychological or sexual counseling as well as the use of 1. Surrogacy
phosphodiesterase inhibitor, such as sildenafil (Viagra) 2. Adoption
or tadalafil (Cialis). 3. Child-free living
Factors that Cause Female Subfertility
● Limited production of FHS or LH, which interfere Genetic Pattern
with ova growth Genetic D/O
● Anovulation (failure or inadequate expulsion of ova) ● Incest
● Uterine factors, such as rumors or poor endometrial ● Occupational hazards
development Genes
● Problems of ova transport through the fallopian ● Basic unit of heredity that determine both the
tubes to the uterus physical and cognitive characteristics of people.
● Cervical and vaginal factors, which immobilize ● Human cell is composed of 23 pairs or 46
spermatozoa chromosomes (44 autosomes and 2 sex
● Poor nutrition, increased body weight, and lack of chromosomes)
exercise, which may compound these problems. Terminologies
Ovulation Monitoring ● Allele - variant form of a gene
The fastest way to investigate if ovulation is ○ Dominant - exerts effects whenever present
occurring is to measure the woman’s serum ○ Recessive - masked out when dominant is
progesterone level during the luteal phase of her present
menstrual cycle (about day 21 to day 28 of a typical ● Phenotype - outward appearance or the expression
cycle). If this is elevated, it implies a corpus luteum has of genes (observable)
formed or ovulation has occurred. ● Genotype - genetic makeup or composition
Anovulation Therapy ○ Homozygous - two healthy genes (HH) or 2
● Administration of GnRH is a possibility (this will unhealthy genes
stimulate the pituitary to secrete more FSH and LH). ○ Heterozygous - one unhealthy, one healthy (hH)
● Therapy with clomiphene citrate (CLomid, Genetic Pattern
Serophene) may also be used to stimulate 1. Autosomal Dominant Inheritance
ovulation. a. h - healthy allele
● In other women, ovarian follicular growth can be b. D - dominant D/O
stimulated by the administration of combination of Characteristics in genogram:
FSH and LH in conjunction with administration of - Sex is not important
- There’s a hx in other family member (vertical)
2. Autosomal Recessive Inheritance - Through sonogram (11-13 wks) detects unusual
a. h - healthy allele fat or fluid deposit at the back of the fetal neck.
b. d - recessive D/O (DOwn and Turner Syndrome)
Characteristics in genogram: 2. Karyotyping
- Both parents of a child with a d/o are free - Process of pairing and ordering all chromosomes
- Fam hx of the disorder is not present (horizontal) 3. Maternal Serum Screening
- Sex is not important a. AFP (alpha Fetoprotein) - glycoprotein produced
3. X-linked Dominant Inheritance by the fetal liver.
a. X - Dominant D/O i. Elevated - Neural tube defects
b. x & y - healthy alleles ii. Decreased - chromosomal d/o
Characteristics in genogram: b. Unconjugated estriol - protein produced in the
- All are affected placenta and in the liver
- All female children of affected men are also i. Decreased - High risk for Down Syndrome
affected; men are not c. HCG (human chorionic gonadotropin) - hormone
- Present in every generation (vertical) produced by the placenta
- All children of homozygous affected women are i. Elevated - presence of midline closure
affected. anomaly
- 50% of the children of heterozygous affected 4. Chorionic Villi Sampling (CVS)
women are affected - Diagnostic technique that involves the retrieval
4. X-linked Recessive Inheritance and analysis of chorionic villi from growing
a. x - recessive D/O placenta.
b. x & y - healthy alleles - Highly accurate but invasive.
Characteristics in genogram: - NI: Instruct signs of infection and abnormal
- Only males in the family have the disorder occurrence of bleeding (miscarriage).
- Sons of the affected man are not affected. 5. Amniocentesis
- The parents of affected children are not affected - Withdrawal and analysis of amniotic fluid.
(horizontal) - NI: Instruct signs of infection and abnormal
5. Y-linked Inheritance occurrence of bleeding (miscarriage).
Characteristics in genogram: - Lower risk of miscarriage than CVS.
- Only males in the family have the disorder 6. Fetal imaging
6. Mitochondrial Inheritance - MRI and UTZ are used to assess fetal size and
Characteristics in genogram: structural d/os.
- Females only pass mitochondrial d/os 7. Fetoscopy
Chromosomal Disorders - endoscopic procedure during pregnancy to allow
1. Nondisjunction D/O surgical access to the fetus, the amniotic cavity,
- Cell division is uneven the umbilical cord, and the fetal side of the
- Ex. Down Syndrome (Trisomy 21) placenta.
2. Deletion D/O 8. Newborn Screening
- Part of chromosome breaks during cell division - Newborns are tested for a number of d/os
- Ex: Cri-du-chat Syndrome (chromosome 5) 1. Congenital Hypothyroidism
3. Mosaicism 2. COngenital Adrenal Hyperplasia
- Nondisjunction d/o occurs after fertilization 3. Phenylketonuria
- Causes: exposure to radiation 4. G6PD (glucose 6- phosphate dehydrogenase
- Ex: Down Syndrome (near-normal intelligence) deficiency)
4. Isochromosomes 5. Galactosemia
- Horizontally separated. 6. Maple syrup Urine Dse
- Ex: Turner syndrome.
Female Reproductive System
Genetic Counselling and Testing
Counselling
● Provide concrete and accurate information about
the process of inheritance and inherited d/os.
● Allow them to have choices about future
reproduction.
● Allow families to begin preparation for a child with
special needs.
Diagnostic Test
1. Nuchal Translucency Screening
External Structures
1. Mons Veneris- A pad of adipose tissue located 7. Hymen – is a tough but elastic semicircle of
above the symphysis pubis, pubic bone joint. tissue that covers the opening to the vagina
Covered by a triangle of coarse, curly hairs. Protects during childhood.
the pelvis from trauma.
2. Labia Minora
- Two hairless folds of connective tissue.
- The folds are normally pink in color. The internal
surface is covered with mucous membrane and the
external surface is covered with skin.
3. Labia Majora
- Two folds of tissue, fused anteriorly but separated Excision of an imperforate hymen- to allow menstrual
posteriorly, positioned lateral to the minora and blood to escape in a female who has reached puberty
composed of loose connective tissue covered by
epithelium and pubic hair. Female Internal Structure
- Shields the outlets to the urethra and vagina Ovaries
Approx. 3cm long and 2cm in diameter and 1.5cm
thick. Equivalent to the size and shape of an
Almond. They are grayish-white and appear pitted,
with minute indentions on the surface.
Are solid, avoid structures positioned in the upper
pelvic cavity on both sides of the uterus. They are
slightly larger than an almond
Normally, they lie so low they cannot be located by
abd palpation. Only if an abnormality exists, such as
an enlarging ovarian cyst, can the resulting
4. Other external organs
tenderness and enlargement be evident on the LLQ
1. Vestibule – flattened, smooth surface inside the
or RLQ.
labias. The orifice of the Urethra and vagina arise
-Function: To produce, mature, discharge ova.
from this membrane.
Produce Hormones and regulate Menstrual Cycle.
2. Clitoris- small rounded organ of erectile tissue at
the forward junction of the labia Minora. The The Ovaries are held suspended by three strong
Center of sexual arousal and orgasm in a woman ligaments to both the uterus and pelvic wall.
3. Skene Glands – located on each side of the
urinary meatus. Their ducts open into the
urethra.
4. Bartholin’s Glands – located on each side of the
vaginal opening. Their ducts open into the
proximal vagina near the labia minora and
hymen. Both glands help lubricate the vagina
during coitus and maintains alkalinity.
5. Fourchette – is the ridge of tissue formed by
the posterior joining of the L.Min. & L.Maj. This
Because they are suspended and not firmly fixed, an
is the structure that sometimes lacerates during
abnormal tumor or cyst growth that can easily
birth or is cut during Episiotomy.
enlarge twice its size before pressure on the
6. Perineum – a muscular area that stretches
surrounding organs leads to signs and symptoms.
during childbirth to allow enlargement of the
Fallopian Tubes
vagina and passage of the fetal head.
Approx. 10cm long in a mature woman. Their
function is to convey the ovum from the ovaries to
the uterus and to provide a place for fertilization of
the ovum by the sperm.
Parts of the Fallopian Tubes
1. Interstitium – part of the tube that lies within
the Uterine Wall.
2. Isthmus – Site for Tubal Ligation
3. Ampulla – Longest Part. Site of Fertilization
4. Infundibulum – Funnel Shaped. Covered by
Fimbria that helps guide the ovum into the
fallopian Tube.
Because the fallopian tubes are open at their distal b. Glandular Layer – Dramatically
ends, a direct pathway exists from the external influenced by Estrogen &
organs to the peritoneum. This can lead to infection Progesterone. Becomes so
of the Peritoneum. For this reason, clean technique thickened each month under
must be used during pelvic exams. And Sterile the influence of hormones that
Technique during vaginal exams, labor and birth. it becomes capable of
Uterus supporting pregnancy. This is
Is a hollow, muscular, pear shaped organ located in the layer that sheds off as
the lower pelvis, posterior to the bladder and menstrual flow.
anterior to the rectum. - The layer that later on
5-7cm long, 5cm wide, 2.5cm deep. Weighs 60g in becomes the Decidua during
non-pregnant women. Pregnancy.
Function – to receive ovum from FT, provide place Decidua - the thick layer of
for implantation and nourishment, furnish modified mucous membrane
protection to a growing fetus, and at maturity of the which lines the uterus during
fetus, expel it from the woman’s body. After pregnancy and is shed with
pregnancy, the uterus never returns exactly to its placenta afterbirth.
non-pregnant state but remains 80g in weight. 2. Myometrium – The Layer of Muscle Fibers.
Is a thick-walled muscular organs shaped like an Responsible for Uterine Contractions.
inverted pear. It is where an egg normally implants 3. Perimetrium – outer layer of connective Tissue.
Provides a site for implantation of the pre-embryo, Adds further strength and support to the organ
nourishes the developing embry/fetus, expels the 3 Major Types:
fetus at birth and sheds its inner lining every month 1. Shape
if pregnancy does not occur 2. Position
Division of the Uterus 3. Flexion
1. Fundus – The Portion that can be palpated When a woman lies on her back, the course of the
abdominally to determine the amount of uterine vagina goes inward and downward. The Posterior
growth during pregnancy, to measure the force Fornix serves as a place for the pooling of semen
of uterine contractions during labor, and to after coitus. This allows for a large amount of sperm
assess if the uterus is returning to its non- to remain close to the cervix.
pregnant state.
Bartholomew’s Rule Stages of Fetal Development
To determine the AOG base on the fundic Terms to Describe Fetal Growth
height 1. Ovum – Ovulation to Fertilization
Tape measure is placed in the fundus of the 2. Zygote – Fertilization to Implantation
Uterus 3. Embryo – Implantation to 5-8 weeks
3mos: Above SP 4. Fetus – 5-8 weeks to term
5mos: Level of Umb. 5. Neonate – 1st 28 days
6. Infant – 29th days to 1 year
8mos: Level of Xyphoid Process
In 38 weeks, a fertilized ovum matures from a single
9 mos: Below Xyphoid Process
cell to a fully developed fetus.
2. Corpus/Body – Forms the Bulk of the organ.
3 Periods of Fetal Growth & Development
The portion of the uterus that expands to
1. Pre-Embryonic Stage
contain the growing fetus.
o From fertilization to 2 weeks
3. Isthmus – The portion of the uterus where
2. Embryonic Stage
incision is made during caesarean birth.
o From week 3 to week 8
4. Cervix – The lowest portion of the uterus.
3. Fetal Stage
Contains Different Parts:
o From Week 8 to birth
a) Cervical Canal – The Central Cavity
b) Internal Cervical Os – the internal opening at
Fertilization: The beginning of Pregnancy
the junction of the Isthmus of the Uterus
Fertilization
c) External Cervical Os – Distal opening to the
o conception or impregnation
vagina
o Is the union of an ovum and a spermatozoa.
Uterine & Cervical Coats
o The ovum is extruded from the Graaffian Follicle of
The uterine wall consists of three different layers:
an ovary and is surrounded by a ring of
1. Endometrium – Inner layer of mucous
mucopolysaccharide fluid (zona pellucida) and a
membrane. The one that sheds off during
circle of cells (corona radiata)
menstruation
a. Basal Layer – remains stable, uninfluenced by
Hormones.
o Hyaluronidase is released by sperm and dissolves Theoretically, there is no exchange of blood cells
the corona radiata and zona pellucida that protects between the embryo and the mother during
the ovum. pregnancy. However, fetal cells do cross into the
o Immediately after penetration of ovum, the maternal blood stream as well as fetal enzymes
chromosomal material of the ovum and such as Alpha-fetoprotein (AFP) produced by the
spermatozoa fuse to form a zygote. fetal liver. This allows testing of fetal cells for
o Bec. Sperm and ovum each carry 23 chromosomes genetic analysis as well as the level of AFP in
(22 autosomes and 1 sex) chromosome the zygote maternal blood.
has 46 chromosomes in total. If an x carrying sperm Braxton Hicks contractions, the barely noticeable
penetrates the ovum = 2 X chromosomes = assigned uterine contractions present from about the 12th
female at birth. If a Y carrying sperm penetrates the week of pregnancy.
ovum = 1 X and 1 Y chromosome = assigned Male at Uterine perfusion and placental circulation are most
birth. efficient when the mother lies on her left side. This
Fertilization depends on 3 separate factors: position lifts the uterus away from the inferior vena
1. Equal Maturation of both sperm and ovum cava.
2. Ability of sperm to reach ovum
3. Ability of sperm to penetrate the ovum cell Endocrine Function in Pregnancy
membranes The outer layer of the Chorionic Villi develops into a
Implantation separate and important hormone-producing
Mitotic cell division begins. system.
First division occurs about 24 hrs, then succeeding Hormones produced by the Chorionic Villi.
division continuous every 22 hrs 1. HCG
Over the next 3 or 4 days, Blastocyst is formed. 2. Progesterone
Cells in the outer ring is termed as Trophoblast. This 3. Estrogen
will later form the placenta and membranes 4. HPL
The cell inner mass, embryoblast, is the portion of HCG (Human Chorionic Gonadotropin)
the structure that will later form the embryo. The 1st placental hormone produced.
Can be found in maternal blood and urine as early
Embryonic and Fetal Structures as the first missed menstruation
Umbilical Cord See Pregnancy Test Kits.
Develops from amnio - The pregnant woman’s blood will be completely
Body stalk attaches embryo to yolk sae, fuses negative for HCG within 1 to 2 weeks after birth.
with embryonic portion of placenta Finding no serum HCG after birth can be used as
Provides pathway from chorionic villi to embryo proof that placental tissue is no longer present
Contains two arteries and one vein; surrounded by in-utero.
Wharton’s jelly to protect vessels
Wharton’s jelly: specialized connective tissue The purpose of HCG is to act as a fail-safe measure
Protects blood vessels to ensure that the corpus luteum of the ovary
Function of umbilical cord: provides circulatory continues to produce progesterone and estrogen so
pathway to embryo the endometrium of the uterus is maintained.
Placenta Progesterone
Placental development The Hormone of pregnancy
Begins at third week of embryonic development Necessary for maintaining the endometrial lining of
the uterus during the entire duration of gestation.
Develops at site where embryo attaches to
Estrogen
uterine wall
Primarily Estriol
Function: metabolic and nutrient exchange between
Contributes to the woman’s mammary gland
embryonic and maternal circulations
development in preparation for lactation
Placenta has two parts
Stimulates uterine growth to accommodate the
Maternal
developing fetus.
Fetal
Human Placental Lactogen
Maternal portion
Promotes Mammary Gland (breast) growth in
Consists of deciduas basalis and its circulation preparation for lactation in the mother.
Surface appears red and flesh-like Serves an important role in regulating the maternal
Fetal portion glucose during pregnancy.
Consists of the chorionic villi and their circulation
The fetal surface of the placenta is covered by The Amniotic Membranes
the amnion - The Chorionic Villi on the medial surface of the
Appears shiny and gray thropoblast gradually thin until they become the
Chorionic Membrane, the outermost fetal o Two embryos develop with separate amniotic
membrane. sacs
- The Amniotic Membrane, forms beneath the o Sacs will eventually be covered by a common
chorionic membrane chorion
- Is a dual walled sac composed of the Chorion and o Monochorionic-diamniotic placenta
the Amnion. If amnion already developed, division approximately
- The two fuse together as the pregnancy continues, 7 to 13 days after fertilization
and by term, they appear to be a single sac. o Two embryos with common amniotic sac and
- The Amniotic membrane not only offers support to common chorion
the amniotic fluid but actually produces fluid. o Monochrionic-monoamniotic placenta
The Amniotic Fluid o Occurs about 1% of the time
- The Amniotic fluid never becomes stagnant because Fraternal Twins
it is constantly being newly formed and absorbed by Also referred to as dizygotic
direct contract with the fetal surface of the o Arise from two separate ova fertilized by two
placenta. separate spermatozoa
- N Color: Clear Straw Colored o Two placentas, two chorions, and two amnions
Yellow: RH Incom o Sometimes placentas fuse and appear to be one
Brown: Infxn Fraternal twins
Green: Meconium Stained o No more similar to each other than singly bom
Red: Abruptio Placenta siblings
- N PH = 7.25 slightly alkaline o May be of same or different sex
- N Odor: Odorless, Slightly sweet, bleach like smell
- Nitrazine Paper Test Origin and Development of Organ Systems
Results: Zygote Growth
if paper turns blue= Amniotic Fld Development proceeds in a cephalocaudal
If paper turns red/yellow=URINE direction.
- Fern’s Test Primary Germ Layers
+ Ferning Image Body organ systems develop from specific tissue
- N Volume: 500 – 1000ml layers called germ layers.
<500 = oligohydramnios Ectoderm - gives rise to the skin, hair, nails, the
o Fetus cannot urinate nervous system, sense organs, mucous
o Renal Anomaly membranes of anus, nose and mouth, mammary
>1000ml = polyhydramnios glands.
o Fetus in unable to swallow Mesoderm - specifies the development of
o S/ of trachea-esophageal Fistula several cell types such as bone, muscle, and
- 3cs of TEF connective tissue. Reproductive system,
Choking cardiovascular system, upper portion of urinary
Cough system
Cyanosis Endoderm - cells become the linings of the
Functions of Amniotic Fluid digestive and respiratory system, and form
- Cushions the baby, protects from trauma organs such as the liver and pancreas. Lower
- Maintains Temp urinary system.
- Promotes Fetal Movement Cardiovascular System
16th day of life - blood vessels and single heart tube
Twin Pregnancies is already present and beats as early as the 24th
Identical Twins day,
Develop from single fertilized ovum 6th-7th week - septum that divides the heart
Of same sex and have same genotype chambers develop
Identical twin usually have common placenta; 7th week - heart valves develop
monozygosity is no affected by environment, race 10th-12th week - heart sound can be heard with a
physical characteristics, or fertility doppler instrument
Both fetus are same sex with same characteristics 20th week - accurate ECG conduction can be
Single placenta recorded
28th week - consistent heartbeat of 110-16-bpm
Number of amnions and chorions present depends
Fetal Circulation
on timing of division
Placenta - umbilical vein - ductus venosus - inferior
Division within 3 days of fertilization; two embryos,
vena cava - right side of the heart - right atrium -
two amnions, and two chorions will develop
foramen ovale - left atrium - left ventricle -
Division about 5 days after fertilization
ascending aorta - other parts of the body
Placenta - umbilical vein - ductus arteriosus - Trimesters: 3 Trimesters
inferior vena cava - right side of the heart - right Calendar Months: 9 Months
atrium - right ventricle - pulmonary artery - lungs Calendar Weeks: 38 Weeks
(small amt) and ductus arteriosus - descending Calendar Days: 266 Days
aorta - umbilical arteries – placenta End of 4th Week AOG
Respiratory System Spinal Cord is Formed and fused at midpoint
3rd week - respiratory and GI tract exist as one tube Rudimentary Heart appears as a prominent bulge
End of 4th week - septum divides the two and lung on the anterior Surface
buds appear. Arms and Legs are bud-like structures; Rudimentary
24th week - surfactant is formed and excreted by eyes, ears, and nose are discernible.
the alveolar cells of the lungs. With Marked C-Shape and Rudimentary Tail
Surfactant - prevents alveolar collapse and improves Fetus Growth and Development
infant’s ability to maintain respiration once 4 weeks 4-6 mm, brain formed from anterior
delivered in the outside environment. neutral tube, limb bud seen, heart beats, GI system
Has two components: begins
Lecithin (L) 6 weeks: 12 mm, primitive skeletal shape, chambers
Sphinogomyelin (S) in heart, respiratory system begins, ear formation
Ratio: 2:1 begins
Nervous System End of 8th Week AOG
8th week - brain waves can be detected thru Organogenesis is Complete
Electroencephalogram The Heart beats rhythmically
24th week - ear is capable of responding to sound. Facial Features are discernible
Food intake of the mother is important for brain External Genitalia are forming but sex is not yet
development (Folic acid) distinguishable
Lack of folic acid - neural tube defects The Abd bulges forward because of intestinal
(meningocele, spina bifida) growth
Digestive System Sonogram shows gestational Sac
4th week - separation of GI and respiratory tract Fetus Growth and Development
6th-10th week - intestines becomes too large that it 12 weeks: 8 cm, ossification of skeleton begins, liver
is pushed into the base of the umbilicus. produces red cells, palate complete in mouth, skin
Meconium - collection of cellular waste, bile, fats pink, thyroid hormone present, insulin present in
and etc. Sticky and appears black or dark green. pancreas
GI tract is sterile. There is no presence of good 16 weeks: 13.5 cm, teeth begin to form, meconium
bacteria inside the intestine that’s why Vit. K is begins to collect in intestines, kidneys assume
routinely given at birth. shape, hair present on scalp
Musculoskeletal System End of 16th Week AOG
First 2 weeks - cartilage prototypes provide support Fetal Heart Sounds are audible by ordinary
to the growing fetus. stethoscope
11th week - fetus can be seen to move thru UTZ Lanugo is well formed
20th week - Quickening (fetal movement) Both Liver and pancreas are functioning
Reproductive Sytem Fetus actively swallows amniotic fluid showing
8th week - sex can be determined thru uncoordinated swallowing reflex
chromosomal analysis Urine is present in amniotic fluid
Testes first form in the abdominal cavity until 34- Sex can be determined thru UTZ
38th weeks. End of 20th Week AOG
Cryptochidism (undescended testes) - surgical Spontaneous Fetal movements can be sensed by
intervention the mother
Urinary System Antibody Production is Possible
End of 4th week - kidney is present Hair including eyebrows begin to form on the head;
12th week - urine is formed vernix caseosa begins to cover the skin
16th week - excretion of urine in amniotic fluid. Meconium is present in the upper intestine
Integumentary System Brown fat begins to form
36th week - subcutaneous fat begins to deposit Sleeping patterns are distinguishable
underneath the skin End of 24th Week AOG
Lanugo - soft downy hair (preserves warmth) Active Production of Lung Surfactant Begins
Vernix Caseosa - cream-cheese like (lubrication and Eyelids begin to open and pupil is now reactive to
prevents maceration) light
Hearing can be demonstrated by response to
Milestones of Fetal Growth and Development sudden sound
If fetus reaches 500-600g they have achieved low- o 8mos: Level of Xyphoid Process = 32 - 36
end AOV and can be cared for in a NICU. weeks
End of 28th Week AOG 9 mos: Below Xyphoid Process = 36 - 38 weeks
Lung Alveoli are almost mature; surfactant can be - McDonald’s Rule
demonstrated in amniotic fluid Months:
Testes begin to descend into the scrotal sac from = FH (cm) x 2
lower abd cavity 7
The blood vessels of the retina are formed but thin Weeks:
and extremely susceptible to damage from high = FH (cm) x 8
oxygen concentrations 7
End of 32nd Week AOG
Sub-Q Fats begin formation, Little old man Obstetric History
appearance is Lost Terms Related to Pregnancy Status
Fetus responds by movement to sounds outside the 1. GRAVIDA – The number of Pregnancies regardless if
mother’s body Delivered and Regardless if Dead or Alive
Active Moro Reflex is present 2. PARITY – The No. of Deliveries that have reached
Fingernails reach the end of fingertips viability, regardless if dead or alive
End of 36th Week AOG 3. PRIMIGRAVIDA – A Woman who is pregnant for the
Most Fetuses turn into a vertex (Head Down) first time
presentation during this month 4. PRIMIPARA - A woman who gave birth to one child
Types of Presentations past age of viability
1. Cephalic 5. MULTIGRAVIDA – A Woman who has been
Vertex pregnant previously
Sinciput 6. GRANDMULTIGRAVIDA – A woman who has been
Occiput pregnant many times
Mentum (Chin) 7. MULTIPARA – A Woman who has carried two or
Face more pregnancies to viability
Brow 8. NULLIGRAVIDA – A Woman who has never been
2. Breech and is not currently pregnant
Footling (feet) Classification of Para
Frank Breech T – Term: 38Weeks
Complete Breech P- PreTerm: <38 Weeks
Incomplete Breech A- Abortion: <20 Weeks
Transverse L- Living: Alive
1. Acromion (Shoulder) M: Multiple: Twins
End of 40th Week AOG Pre-Natal Visits
Fetus kicks actively, sometimes strong enough to At Least 4 visits in Total
cause considerable discomfort 1st- Anytime on 1st Trimester
Fingernails extend over fingertips 2nd- 20 – 24 weeks (Age of Viability)
Vernix starts to decrease and is more prominent in 3rd- 28 - 32 weeks
body creases 4th- 36 weeks