Blood Rouleaux formation- ability of RBC to pile of

coins. Adhere to one another along its

Came from mesoderm concavity
It is a specialized connective tissue Life span- 120 days
Breakdown RBC stored in the bone marrow
8% of the total body weight then in case of emergency, RBC are called
again to be produce outside the bone
Female 4-5L
marrow to produce new RBC
Male 5-6L
Terms
Consist of 2 Anisocytosis- variation in the size

a. Formed elements (RBC, WBC, platelets)

b. Fluid intercellular substance (plasma)

Function
Poikilocytosis- variation in shape
- For transport of gases (O, CO2), nutrients need
by the body, waste products in and out
- Protect from blood lost (responsible platelets),
toxins and infections ( WBC)
- Regulate pH through buffering system, making
our body temp normal (37.5) Hypochromic- in terms in color less red.
Less iron than normal
Came from the yolk sac- first cell to produce blood

2nd trimester fetal life- liver, spleen, thymus, lymph

nodes

4yrs of life- bone marrow

Yellow bone marrow help to produce blood in case

of emergency Normochromic-

Hemopoiesis

- Lymphoid tissue- thymus, spleen, lymph node

 Two particular cells that are produced
 Lymphocyte and monocyte- agranular
(makinis) Hyperchromic- more iron
- Myeloid tissue- bone marrow
 Erythrocytes- RBC
Highly specialized and highyly differentiated
cells
Biconcave in shape
Contains hemoglobin- heme and protein
Heme= iron responsible for color
Has the property to bind the oxygen
Responsible to transport oxygen
 Polycythemia- more RBC U shaped nucleus.
Normal blood- normal Activated when there is a chronic inflammation
Anemia- less RBC
Macrophage- transform when it migrates to the
inflamed tissue

Granulars

Neutrophils- more than 1 nucleus

multilubulated
Leukocytes- WBC, white blood corpuscles
Contain nucleus 60-70% of 100% WBC
Involve in cellular
The most abundant among the 5 WBC
Life span 24hrs
2 types Madaming butlig- fine lilac granules (butlig)
1. Agranular- does not have any granules
Lymphocytes First line of defense against invading microorganisms
monocytes
The most active is neutrophils followed by monocytes
2. Grnualar- have granules either pink,
the basophil
lilac
Neutrophil Increasing in number during acute inflammation
Eosinophil
Basophil Eosinophil- 2-4% of 100% WBC]

Terms Contains granules in bright pink

2 nucleus

2 particlar episodes, when there is allergic reaction and

parasitic infection when it activated

Basophil- less than 1% of 100 % WBC

Nucleus not so markedly define because odf the

granules that are dark blue in color, but said to be
having S shape nucleus
Leukocytosis- more than the number of normal WBC Produces:
Leukopenia- less than the number of normal WBC Heparin- anti coagulant
Lymphocytes- 20-30% of 100% WBC Histamine- baso dilating agent
Has round large nucleus with a small indentation on one Serotonin
side with a narrow rim of cytoplasm because of the big
nucleus Prostaglandin

Activated when there is a chronic inflammation

Monocytes- 3-8% of 100% WBC PLATELETS- thrombocytes

Largest WBC
Smallest formed elements of the blood
non- nucleated same as the RBC
main function is to assist in hemostasis

How: if there is injury or there is a flow of blood

It will produce serotonin that is known to be the vaso

constrictor

Blood clotting- platelets will release

thromboplastin( enzyme that will help the prothrombin
to become thrombin)

Thrombin- particular enzyme that is needed by the

fibrinogen to transform into fibrin

Fibrin- mesh work (fibrous) holds the blood cells from

coming out para magka clot.

Terms

Thrombocytosis- more platelets

If there is increase in number of platelets

Thrombocytopenia- less platelets

Little or no platelets

PLASMA- intercellular fluid

Helps transport all the nutritive materials

Hematocrit