Loknete Hanmantrao Patil Charitable Trust’s,

Adarsh Institute of Pharmacy (D.Pharm), Vita

Bhavaninagar, Kundal Road, Vita

QUESTION BANK OF EACH TOPIC

Subject – Pharmaceutics – I (0805)

1. Dosage Forms
a. Define drug. Give the importance of dosage form.
b. Classify dosage forms with examples.
c. Define emulsion. Give the identification tests for it.
d. What are the precautions required for eye drops.
e. Enlist NDDS. Explain any two.

2. Pharmacopoeia
a. Give the history of I.P.
b. Discuss salient features of seventh edition of I.P. 2014.
c. Discuss salient features of sixth edition of I.P. 2010.
d. Enumerate the different pharmacopoeias.

3. Metrology
a. Define Isotonic solution. Give the principles for adjustment to isotonicity.
b. Give the various methods of calculations of solution for iso-osmotic.
c. Conversions in imperial and metric systems.
d. Find the volume of 20%, 15%, 10% and 8% alcohol should be mixed to get 12% alcohol
500 ml.
4. Packaging of Pharmaceutical
a. Define Pharmaceutical containers. Write the qualities of good container.
b. Enlist types of containers on the basis of their utility. Explain any two.
c. Give the materials used for making of containers with advantages & disadvantages.
d. Give the composition of glass.
e. What are the advantages and disadvantages of glass as container?
f. Why hydrolytic resistance test is carried out on glass container?
g. What are the composition of plastic container?
h. Define closures. Enlist materials used for making of closures. Explain rubber.
i. What is aerosol? Give an account of container used for aerosol packaging.
j. Give the methods used for packaging of aerosol product.
k. Write a note on modern unit dose packaging.

5. Size Reduction
a. Define size reduction. State the importance of size reduction.
b. Enlist factors affecting on size reduction. Explain any four.
c. Give construction, working of any one equipment comes under impact and attrition
mechanism.
d. Fluid energy mill.
e. Write a note on levigation and elutriation.
f. Give the various methods of size reduction.
Page 1 of 5
 Loknete Hanmantrao Patil Charitable Trust’s,
Adarsh Institute of Pharmacy (D.Pharm), Vita
Bhavaninagar, Kundal Road, Vita

QUESTION BANK OF EACH TOPIC

Subject – Pharmaceutics – I (0805)

6. Size separation
a. Define size separation. Write a note on various grades of powder.
b. What is sieve number? Explain various standards for sieves.
c. Explain in detail the sieve shaker.
d. Write construction, working and uses of cyclone separator.
e. Give an account of multistage elutriator with is advantages.

7. Mixing and Homogenization

a. What is perfect mixing? Give its objectives.
b. Define i) Positive mixture ii) Negative Mixture iii) Neutral Mixture
c. What are the factors affecting on powder mixing?
d. How will you mix the three powders by the use of double cone blender?
e. What is vortex? How will you avoid the vortex formation?
f. What is the construction, working and uses of planetary mixer?
g. Silverson Mixer Homogenizer.
h. Define Viscosity and Homogenization.
i. What are the equipments used for mixing of liquids? Give in detail about ‘Propeller Mixer’.

8. Clarification and Filtration

a. Differentiate between filtration and clarification.
b. Explain the factors affecting on rate of filtration.
c. What is filter media? Enlist filter media’s used in pharmaceutical industry.
d. Define filter aids. What are qualities must possess the filter aid?
e. Give construction, working, advantages and disadvantages of
i) filter press ii) Meta filter iii) Filter leaf iv) Filter candle

9. Heat Processes-Evaporation
a. What are the various methods of heat transfer?
b. What is desiccation? Name the dehydrating agents used in desiccation.
c. Define sublimation. Give the mechanism behind it.
d. Define evaporation. Write the factors affecting on rate of evaporation.
e. Write a note on evaporation under reduced pressure.
f. Give construction, working of any one evaporator comes under film evaporator.
g. State the meaning of natural evaporation. Write construction, working and uses of
evaporating still.
h. Write construction, working and uses of evaporating Pan.

Page 2 of 5
 Loknete Hanmantrao Patil Charitable Trust’s,
Adarsh Institute of Pharmacy (D.Pharm), Vita
Bhavaninagar, Kundal Road, Vita

QUESTION BANK OF EACH TOPIC

Subject – Pharmaceutics – I (0805)

10. Distillation
a. Define distillation. Enlist the types of distillation processes.
b. How will you prepare purified water IP and WFI by distillation?
c. Write the applications of distillation in pharmacy.
d. Define i) Purified water ii) WFI iii) SWFI
e. What do you mean by steam distillation? Explain with the help of neat sketch the working
of apparatus used for the distillation on laboratory scale. Add its applications in Pharmacy.
f. Write a short note on i) Fractional distillation ii) Vacuum still
iii) Destructive distillation iv) Florentine receiver
g. How will you separate two immiscible liquids in pharmacy?
h. Name and draw a well labelled sketch of apparatus used for separation of two immiscible
liquids.

11. Drying Processes

a. What do you mean by Drying? Write the applications and explain in details the theory of
drying.
b. Differentiate between thermal and non-thermal drying.
c. Discuss the theory, construction and working of FBD.
d. Give the theory, construction and working of freeze drying apparatus. Write the advantages
and disadvantages of freeze drying process.
e. Give the theory, construction, working, merits and demerits of any one apparatus used
for liquid drying.
f. Write a note on microwave drying.

12. Sterilization
a. Differentiate between sterilization and disinfection.
b. Explain in detail about thermal resistance of microorganisms.
c. Define sterilization. Add the factors affecting on thermal destruction of microorganisms.
d. Classify various methods of sterilization with their instruments.
e. Write a note on gaseous sterilization.
f. Give the construction of autoclave with well labelled sketch.
g. Define aseptic techniques. How to design aseptic Room?
h. How will you perform test for sterility?
i. Explain in detail about mechanical sterilization. Give merits and demerits.
j. What precautions must be taken while working in aseptic room?
k. Define- i) Antiseptic ii) Bactericide iii) Sterility iv) Disinfection v) Bacteriostatic

13. Processing of Tablets

a. Define tablet. Add its advantages and disadvantages.
b. Classify tablet according to their routes of administration.

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 Loknete Hanmantrao Patil Charitable Trust’s,
Adarsh Institute of Pharmacy (D.Pharm), Vita
Bhavaninagar, Kundal Road, Vita

QUESTION BANK OF EACH TOPIC

Subject – Pharmaceutics – I (0805)
c. Explain the steps involved in manufacturing of tablet.
d. Differentiate between granules and fine powder.
e. Discuss in detail the excipients used in formulation of tablet.
f. Explain the methods for preparation of granules.
g. Give the construction and working of Single Punch Tablet Machine with the help of well labelled
diagram.
h. Rotary Tablet Machine.
i. Write a short note on Drycota Tablet Machine.
j. What are the various manufacturing defects of tablet? Give the Reasons and remedial measures for
that.
k. Why coating of tablet is done? What are the different methods of coating?
l. State the meaning of Sugar coated tablet. Discuss the various stages of sugar coating process.
m. Write a short note with advantages and disadvantages on- i) Film Coating ii)Enteric Coating.
n. State the meaning of Microencapsulation. Discuss the various techniques used in
microencapsulation.
o. Explain in detail the various evaluation tests of tablet.

14. Processing of Capsules

a. Define capsules. Write its advantages and disadvantages.
b. Differentiate between Hard and soft gelatin capsule.
c. Discuss in detail the excipients used in the manufacturing of capsules.
d. Explain in detail the filling process of hard gelatin capsule. (Hand operated)
e. Explain in detail the filling and sealing process of soft gelatin capsule. (Rotary Machine)
f. Define angle of repose. Write its significance.
g. Write a note on capsule number.
h. Explain in detail the various evaluation tests of capsule.
i. What are the special applications of capsule?

15. Extraction Processes

a. What is extraction? Give the various processes of extraction.
b. Define menstruum. Add the merits and demerits of water and alcohol used as a mentruum.
c. Classify Extraction processes.
d. How to differ infusion and decoction processes.
e. What is maceration? Explain simple maceration.
f. Discuss in details of maceration with adjustment.
g. Explain in detail the multiple maceration process.
h. Differentiate between Maceration with adjustment and multiple maceration process.
i. Differentiate between double and triple maceration.
j. Define percolation. Give the percolation methods for concentrated preparation.
k. Enlist the various types of percolators. Give the various stages involved in percolation process for
tinctures (Simple percolation).

Page 4 of 5
 Loknete Hanmantrao Patil Charitable Trust’s,
Adarsh Institute of Pharmacy (D.Pharm), Vita
Bhavaninagar, Kundal Road, Vita

QUESTION BANK OF EACH TOPIC

Subject – Pharmaceutics – I (0805)
l. Write in detail about continuous hot percolation/ soxhelation/ soxhlet extraction method with
the help of well labelled diagram. What are the limitations of this method?
m. What factors which are considered while selecting the extraction process.
n. Write a note on Ayurvedic dosage form.

16. Immunity and Immunological Products

a. Define immunity. Give the types of immunity.
b. What are the factors responsible for immunity?
c. What is immunological product? Classify them with example.
d. Give the full form of BCG. Add a short note on BCG.
e. Write in detail- i) Small pox vaccine ii) Pertussis vaccine iii) Cholera vaccine
iv) Poliomyelitis Vaccine v) Rabies Vaccine
f. Write a note on passive immunization.
g. Discuss the term immunological products as diagnostic agent. Add a note on SCHICK Test.

(Name and Signature of Faculty)

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