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DIURETICS AND
ANTI DIURETICS
► Urine formation:
1. Glomerular filtration rate = 180L/day
2. Tubular re-absorption (around 98%)
3. Tubular secretion
► How could urine output be increased ?
↑ Glomerular filtration Vs ↓ Tubular reabsorption
(the most important clinically)
o If you increase the glomerular filtriation Æ increase
tubular reabsorption (so you cant use glomerular
filtiration)
The
filtirate
here is
isotonic
The filtirate
here is
hypertonic
Classification of Diuretics
► The best way to classify diuretics is to look for their Site of
action in the nephron
It prevents
the
reabsorption
of HCO3 and
Na
•In glaucoma :
9The ciliary process absorbs HCO3 from the blood.
9 ↑HCO3 Æ ↑aqueous humor.
9Carbonic anhydrase inhibitors prevent absorption of HCO3 from the blood.
•Urinary alkalinization : to increase renal excretion of weak acids e.g.cystin and uric acid.
3. Therapeutic Uses
a) Edema (in heart failure, liver cirrhosis, nephrotic syndrome)
b) Acute renal failure
c) Hyperkalemia
d) Hypercalcemia
Loop
diuretics