Scribd Logo
Upload

Welcome to Scribd!

  • Patho Final

    Uploaded by

    P B
    9 views2 pages
    This document outlines the pathophysiology of COVID-19. It shows that modifiable risk factors like smoking and non-modifiable factors like old age and male sex can increase risk of exposure to SARS-CoV-2 through respiratory droplets or contact with contaminated surfaces. The virus then attaches to ACE2 receptors in cells and starts replicating, causing destruction of cells in the lungs, heart, kidneys and other organs. This leads to symptoms like fever, cough, shortness of breath and chest pain as the body mounts an inflammatory response with the release of cytokines that can cause further organ damage.

    Original Description:

    Original Title

    patho-final

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document outlines the pathophysiology of COVID-19. It shows that modifiable risk factors like smoking and non-modifiable factors like old age and male sex can increase risk of exposure to SARS-CoV-2 through respiratory droplets or contact with contaminated surfaces. The virus then attaches to ACE2 receptors in cells and starts replicating, causing destruction of cells in the lungs, heart, kidneys and other organs. This leads to symptoms like fever, cough, shortness of breath and chest pain as the body mounts an inflammatory response with the release of cytokines that can cause further organ damage.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    9 views2 pages

    Patho Final

    Uploaded by

    P B
    This document outlines the pathophysiology of COVID-19. It shows that modifiable risk factors like smoking and non-modifiable factors like old age and male sex can increase risk of exposure to SARS-CoV-2 through respiratory droplets or contact with contaminated surfaces. The virus then attaches to ACE2 receptors in cells and starts replicating, causing destruction of cells in the lungs, heart, kidneys and other organs. This leads to symptoms like fever, cough, shortness of breath and chest pain as the body mounts an inflammatory response with the release of cytokines that can cause further organ damage.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    PATHOPHYSIOLOGY

    MODIFIABLE NON-MODIFIABLE
    LIFESTYLE (smoking) OLD AGE
    MALE

    Respiratory droplet production (person who


    are infected)

    Droplet contact with mucus membrane Adherence to fomites (objects or materials


    which are likely to carry infection)

    Exposure to SARS-COV-2 (Causative Agent)

    Attachment to the ace-2 receptor in body


    cells

    Gain access, SARS-COV-2 starts to replicate

    INCUBATION PERIOD

    COVID-19 INFECTION

    Destruction of cells in the lung alveoli,


    NASAL OBSTRUCTION endothelial cells, kidneys, HEART and GIT

    Loss of Olfactory Receptor Damage to gustatory


    Neurons (ORNS) receptors

    Loss of smell
    Loss of taste
    Destruction of cells in the lung alveoli,
    endothelial cells, kidneys, HEART and GIT

    Neutrophils migrates to the lungs

    Fluid accumulation in Shortness of breath Neutrophils migrates to the heart


    interstitial and alveoli
    Fluid builds up
    Chest pain (4/10)
    Opacity in lungs/infiltration
    in chest x-ray Pericardial effusion
    Release of cytokines

    CARDIAC TAMPONADE

    Increased skeletal Prostaglandin release


    muscle cell damage (hypothalamus) Chamber of the heart are
    compressed

    Fever (high
    Muscle pain temperature) Chamber of the heart
    unable to relaxed

    Muffled heart
    sound Decrease venous return,
    filling, cardiac output

    Increased retrograde venous


    pressure in the veins Hypotension
    tachycardia
    Narrowed pulse pressure
    tachypnea
    Jugular vein distension

    Chest pain

    You might also like