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Study information
Source details
Author Satoshi Ikeda
Title Corticosteroids for hospitalized patients with mild
to critically-ill COVID-19: a multicenter,
retrospective, propensity score-matched study
Year 2021
ID PMID: 34021229
Methodology
Study design retrospective study
Sample size 236
Sampling method all consecutive patients who met the inclusion
criteria
Intervention name Corticosteroid group
Participants Characteristics
Corticosteroid usual
Age ( n (%))
<40: 15 (12.7) 12 (10.2)
40-59: 44 (37.3) 49 (41.5)
60-79: 44 (37.3) 42 (35.6)
>80 15 (12.7) 15 (12.7)
Gender
Sex ( n (%))
84 (71.2) Male 80 (67.8) male
Race/ethnicity
Japanese 113 (95.8) 116 (98.3)
East Asians outside of Japan (China, Korea) 3 (2.5) 1 (0.8)
Sub-clinical (CRP, SpO2, Respiratory rates at
baseline…)
SpO2/FiO2 On Day 1
372.7 ± 112.7 383.3 ± 105.3
Outcome

Intervention groups
Intervention Group 1

Description as stated in report/paper Location in text or

source (pg &
¶/fig/table/other)

Group name Methylprednisolone

No. randomised to group
(specify whether no.
people or clusters)

Description (include Median—mg/day 80

sufficient detail for
Minimum–Maximum—mg/day 12-1000
replication, e.g. content,
dose, components)

Duration of treatment 11.0 [6.0, 15.8]

period

Timing (e.g. frequency,

duration of each episode)

Co-interventions (n)

Notes:

Risk of Bias assessment

Domain Risk of bias Support for judgement Location in text
or source (pg &
Low Hig Unclear (include direct quotes where available with
¶/fig/table/other
h explanatory comments)
)

Random sequence
generation (selection
bias)

Allocation
concealment
(selection bias)

Blinding of participants Outcome group: All/

and personnel
(performance bias)

(if separate judgement Outcome group:

by outcome(s)
required)

Blinding of outcome Outcome group: All/

assessment (detection
bias)
(if separate judgement Outcome group:
by outcome(s)
required)

Incomplete outcome Outcome group: All/

data (attrition bias)

(if separate judgement Outcome group:

by outcome(s)
required)

Selective outcome
reporting? (reporting
bias)

Other bias

Notes:

Outcomes
Outcome 1

Description as stated in report/paper Location in text or

source (pg &
¶/fig/table/other
)

Outcome name (1) death;

(2) hospitalized, on invasive mechanical ventilation or

ECMO;

(3) hospitalized, on noninvasive positive pressure

ventilation (NIPPV) or high-flow nasal cannula (HFNC);

(4) hospitalized, requiring low flow supplemental oxygen;

(5) hospitalized, not requiring supplemental oxygen,

requiring ongoing medical care;

(6) hospitalized, not requiring supplemental oxygen, no

longer required ongoing medical care; and

(7) discharged/not hospitalized.

Time points measured
(specify whether from
start or end of
intervention)

Time points reported

Unit of measurement (if

relevant)

Scales: upper and lower

limits (indicate whether
high or low score is
good)

Power (e.g. power & 0.034

sample size calculation,
level of power achieved)
Notes: