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Ghoul 2020
Ghoul 2020
The study was supported in part by GC, Dental Products Company. Prodent and CADent Dental Laboratory provided CAD-CAM supports.
a
Chief of clinical services, Department of Prosthodontics, School of Dentistry, Lebanese University, Beirut, Lebanon.
b
Professor, Department of Dental Materials, School of Dentistry, University of Zurich, Zurich, Switzerland.
c
Professor, Department of Endodontics, School of Dentistry, Lebanese University, Beirut, Lebanon.
d
Department of Prosthodontics, School of Dentistry, Saint Joseph University, Beirut, Lebanon.
e
Professor, Department of Research, Department of Prosthodontics, School of Dentistry, Lebanese University, Beirut, Lebanon.
All prepared specimens were scanned with an 2-mm-thick specimens was segmented from every piece
intraoral scanner (TRIOS 3; 3Shape A/S). The digital with parallel walls to obtain a vertical perpendicular view
scans were saved as 40 standard tessellation language on the stereomicroscope stage.
(STL) files for the 40 specimens. The appropriate design The discrepancy between the tooth and the endo-
software (2017; 3Shape Dental System) was used to crown was represented by the pink-colored light layer,
design the endocrowns on the virtual model. The oper- which was examined at ×70 magnification using a digital
ator determined design parameters as the thickness of trinocular stereomicroscope (AmScope 3.5; Irvine) with a
the spacer, which was set to be 10 mm on the marginal corresponding digital camera and software. For better
discrepancy and 40 mm on the internal discrepancy; all comparison, each slice was divided into 4 areas of in-
restorations were designed to have similar occlusal terest: marginal gap, cervical area, axial wall, and pulpal
anatomy and the same occlusogingival height. The floor according to previous publications.12,13,39 Eight
virtual endocrowns were converted to 40 STL files; they measurements were selected on each slice: 1 measure-
were milled under wet processing with a 5-axis milling ment on the marginal gap, M1; 2 measurements on the
machine (Coritec 250i; imes-icore GmbH) and CAD- cervical area, C1 in the center and C2 on the cervico-axial
CAM materials: Cerasmart (block: A2 HT/14L), Trilor angle; 3 measurements on the axial wall, A1, A2, and A3
(disk: diameter=98 mm, height=14 mm), IPS e.max CAD which divided the axial wall into 3 equal parts; and 2
(block: LT A2/C14), and Vita Suprinity (block T A2/LS14). measurements on the pulpal floor, P1 on the axiopulpal
The milling rotary instruments were changed for each angle and P2 in the center of the pulpal area of the
group, and the size of the smallest was 0.6 mm. sectioned replica (Fig. 1). M1 was the AMD, that is, the
Following the manufacturer instructions, specimens in distance between the most extended point of the endo-
group E (IPS e.max CAD) and group V (Vita Suprinity) crown margin and the external marginal line of the
were subjected to the crystallization process (Vita Vacu- prepared tooth. C2 was the bisector of the angle between
mat 6000 M; VITA Zahnfabrik GmbH), while specimens the cervical area and the axial wall. P1 was the bisector of
in group C (Cerasmart) and group T (Trilor) did not need the angle between the pulpal floor and the axial wall. C1,
any crystallization firing. All endocrowns were seated on A1, A2, A3, and P2 were the perpendicular distance from
the corresponding teeth and evaluated with an explorer the inner surface of the endocrown to the abutment
and a silicone indicator paste (Fit Checker; GC Corp) for tooth. M1 represented the marginal fit, whereas C1, C2,
adaptation. Some restorations, mainly in group T, A1, A2, A3, P1, and P2 represented the internal fit of the
needed adjustments to enhance the fit. endocrown. Discrepancy thicknesses at marginal sites
The marginal and internal fit of the restorations in the 4 and internal sites were analyzed. A total of 1280 mea-
groups were assessed by a RT. Each endocrown was filled surements were made for the 4 groups (8 measure-
with a pink light-body vinyl polyether silicone impression ments×4 sections×10 endocrowns×4 groups). All data
material (EXA’lence; GC Corp) and seated along the long were saved in a spreadsheet (Microsoft Excel 2007;
axis of the corresponding tooth under a constant force of Microsoft Corp).
50 N for 5 minutes.38 After 5 minutes (setting time of the The Shapiro-Wilk test of normality confirmed that the
light-body material), the restoration was removed from data were normally distributed (P>.05). Failure to meet
the corresponding tooth. The layer of the light body the assumptions required for a 2-way mixed ANOVA
adhered to the intaglio surface of the tooth. A green necessitated separate testing of the effects of the
heavy-bodied material (EXA’lence; GC Corp) was injected between-subjects factor (group) and of the within-
into the tooth to adhere and stabilize the light-body subjects factor (region), followed by Bonferroni correc-
material. After polymerization, a sharp surgical blade tions for the multiple testing of 2 separate hypotheses.
was used to cut each replica into 4 pieces from the center One-way ANOVA tests were performed to assess dif-
in a buccolingual and mesiodistal direction. A slice of ferences in marginal, cervical, axial, pulpal, and average
DISCUSSION
The results of this study led to the rejection of the 2 null
Figure 1. Schematic representation of measurement positions for hypotheses tested: no difference would be found be-
marginal and internal fit in cross-sectional cut of replica. Pink light layer tween cervical, axial, pulpal, and marginal fit of endo-
represents cement analog layer; M1: absolute marginal discrepancy. C1 crown restorations within each group and no difference
and C2: cervical discrepancies. A1, A2, and A3: axial discrepancies. P1 and would be found between internal fit (cervical, axial, and
P2: pulpal discrepancies.
pulpal) and marginal fit of endocrown restorations
among the 4 groups.
Several destructive and nondestructive methods have
internal gaps among the 4 groups, followed by the Tukey
been used to measure marginal and internal gaps, including
post hoc test for multiple comparisons. The Welch
a dental explorer,17 visual examination,17 across section
ANOVA and Games-Howell post hoc tests were applied
technique after cementation,17 and an impression tech-
when the assumption of homogeneity of variances was
nique (RT).28 Recently, microcomputed tomography has
violated. Repeated measures ANOVA tests were then
been introduced to provide 3D analysis of marginal and
carried out to test for differences among marginal, cer-
internal discrepancies in dentistry.14 The RT has been
vical, axial, and pulpal gaps for each of the assessed
chosen by previous studies15,32,37,39 to evaluate marginal
groups separately and were followed by post hoc pair-
and internal gaps and was also used in this study because it
wise comparisons with Bonferroni adjustment. Finally,
is straight forward, accurate, reliable, less costly, noninva-
paired t tests were used to assess the differences between
sive, and can be repeated quickly without loss of precision.
marginal and internal gaps separately for each of the 4
In addition, light-body vinyl polyether silicone impression
tested groups.
material was used in this study because it demonstrated
All measurements were repeated twice at least 1
excellent dimensional stability.38 However, a disadvantage
month after the initial assessment, and intraobserver
of this technique is that it is a 2-dimensionalebased method.
reliability was evaluated with the 2-way mixed effects
In the present study, 4 segments with 32 landmarks per
intraclass correlations for absolute agreement on single
abutment were measured, and this may not represent the
measures. All data were processed using the statistical
complete marginal and internal fit.18
software (IBM SPSS Statistics, v20; IBM Corp) (a=.05
To standardize the measurement and to provide high
except when assessing the outcomes of the ANOVA
clinical relevance despite using natural human teeth, all
tests, where a=.025 to account for the multiple testing of
the teeth chosen were of similar size, all preparations
2 separate hypotheses).
were standardized using 1 type of diamond rotary in-
strument on a surveyor, a precise CAD-CAM scanner
RESULTS
and milling machine were used to eliminate manual
The intraclass correlations ranged between 0.904 and errors, and all replicas were sectioned in the same
0.998 for intrarater reliability, demonstrating very high position to observe the discrepancies from a directly
correspondence. All regions tested displayed statistically perpendicular perspective. Therefore, it was possible to
significant differences in fit among the 4 assessed groups compare the marginal and the internal fit focused only on
(P<.001). Group T consistently displayed the largest the different tested materials.
values among the groups for all tested regions, whereas Marginal and internal discrepancies are the main
group E displayed the smallest gap for all regions except concern of CAD-CAM endocrown restorations.12 A gap
for the axial region, where the smallest gap was observed between 75 and 160 mm has been considered acceptable
for group V (Table 2). When the adaptation was for internal and marginal adaptation.19,26 In this study,
compared across the regions, all the tested groups dis- the mean 2-dimensional internal gap of the 4 groups
played statistically significant differences in fit (P<.001). (C, T, E, and V) was in the range of 105.3 to 161.6 mm,
Table 2. Mean values, standard deviations, and group comparison of gap thickness (values in micrometer) at various regions across 4 tested groups
(n=40)
Group Group Comparison
C (n=10) T (n=10) E (n=10) V (n=10) One-Way ANOVA Pa
Region Mean ±SD Mean ±SD Mean ±SD Mean ±SD F P C/T C/E C/V T/E T/V E/V
Marginal 143.0 ±21.7 196.7 ±33.7 104.8 ±14.1 114.7 ±21.5 23.239a <.001b .003b .001b .04 <.001b <.001b .631
Cervical 119.9 ±22.0 168.0 ±24.7 83.8 ±11.7 92.8 ±13.1 40.979 <.001b <.001b .001b .013b <.001b <.001b .013
Axial 83.9 ±15.4 92.0 ±18.8 90.5 ±18.9 60.7 ±7.8 8.314 <.001b .667 .792 .012b .996 .001b .001b
a b b b b
Pulpal 144.5 ±22.0 224.7 ±51.1 141.6 ±20.1 179.1 ±23.0 11.186 <.001 .003 .99 .014 .002 .096 .006b
a b b b b
Internal 116.1 ±14.3 161.6 ±23.6 105.3 ±14.9 110.9 ±12.4 13.805 <.001 .001 .374 .818 <.001 <.001 .8
C, Cerasmart; E, IPS e.max CAD; SD, standard deviation; T, Trilor; V, Vita Suprinity. aWelch ANOVA and Games-Howell post hoc P value reported when assumption of homogeneity of variances
violated. bStatistically significant at P<.025.
Table 3. Mean values, standard deviations, and region comparison of gap thickness (values in micrometer) within each of 4 groups across various
regions (n=40)
Region Region Comparison
Marginal (1) Cervical (2) Axial (3) Pulpal (4) Repeated-
(n=40) (n=40) (n=40) (n=40) Measures ANOVA Pairwise Comparison P
Group Mean ±SD Mean ±SD Mean ±SD Mean ±SD F P 1/2 1/3 1/4 2/3 2/4 3/4
C 143.0 ±21.7 119.9 ±22.0 83.9 ±15.4 144.5 ±22.0 22.122 <.001* .283 .002* 1 .002* .078 <.001*
T 196.7 ±33.7 168.0 ±24.7 92.0 ±18.8 224.7 ±51.1 46.209 <.001* .007* <.001* .085 <.001* .002* <.001*
E 104.8 ±14.1 83.8 ±11.7 90.5 ±18.9 141.6 ±20.1 40.695 <.001* .004* .594 .003* 1 <.001* <.001*
V 114.7 ±21.5 92.8 ±13.1 60.7 ±7.8 179.1 ±23.0 173.533 <.001* .001* <.001* <.001* <.001* <.001* <.001*
C, Cerasmart; E, IPS e.max CAD; SD, standard deviation; T, Trilor; V, Vita Suprinity. *Statistically significant at P<.025.
which was close to the clinically acceptable range of 75 Table 4. Differences in marginal and internal gap adaptation (values in
to 160 mm.19,26 The mean 2-dimensional marginal gap micrometer) within each of 4 groups (n=40)
of the 3 groups (C, E, and V) were in the range of 104.8 Marginal Internal Change
(n=40) (n=40) (T2-T0) Paired t Test
to 143.0 mm, which was in the clinically acceptable Group Mean ±SD Mean ±SD Mean ±SD Test Statistic P
range.19,26 But, the mean marginal gap of group T was C 143.0 ±21.7 116.1 ±14.3 26.9 ±25.7 3.317 .009*
196.7 mm, above the clinically acceptable range.19,26 T 196.7 ±33.7 161.6 ±23.6 35.2 ±17.2 6.478 <.001*
Group T displayed the largest gaps, followed by group E 104.8 ±14.1 105.3 ±14.9 -0.5 ±18.4 -0.083 .936
C and then group V, whereas group E displayed the V 114.7 ±21.5 110.9 ±12.4 3.8 ±13.4 0.891 .396
smallest gaps. Significant differences were observed C, Cerasmart; E, IPS e.max CAD; SD, standard deviation; T, Trilor; V, Vita Suprinity.
between the ceramic-based and resin-based blocks, *Statistically significant P<.05.
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