26 Important MCQs

Unit –V (Drug Stability)

(With Solutions)
Physical Pharmaceutics-II
BP 403T
By
Dr. Mahendra Pratap Singh
Assoc. Prof. & Vice Principal
Krishnarpit Institute of Pharmacy
Prayagraj, India
Question.1:- Which of the following is
cause of physical degradation of drug?
a) Volatilisation of components during storage
b) Changes from one state to another
c) Change in colour
d) All of the above

Answer: d) All of the above

Question.2:- The accelerated stability studies are
primarily used to determine:

a) Energy of the activation of the reaction

b) k value at elevated temperatures
c) k value at the room temperature
d) shelf life of the product

Answer: d) shelf life of the product

Question.3:- Which of the following factors affect the
rate of reaction?

a) Temperature
b) Catalysis
c) Dielectric constant
d) All of the above

Answer: d) All of the above

Question.4:- The effect of temperature on rate of
reaction is explained by

a) Arrhenius equation
b) Nernst equation
c) Noyes Whitney equation
d) Fick's first law

Answer : a) Arrhenius equation

Question.5:- Identify the equation that is NOT of
Arrhenius:

Answer: A
Question.6:- The unit of activation energy is

a) kJ/mol
b) J
c) N/m
d) mm

Answer: a) kJ/mol
Question.7:- The dielectric constant is used to
measure
a) Viscosity of solvent
b) polarity of the solvent
c) temperature of solvent
d) flowability of solvent

Answer: b) polarity of the solvent

Question.8:- ............is the time necessary for the
concentration of the reactant to decrease to 90% of
its original concentration.

a) Product life
b) Shelf life
c) Half life
d) None of the above

Answer: b) Shelf life

Question.9:- Generally, Stability testing is
employed for-
a) Delivering evidences of the change in quality of
the drug product with time.
b) Confirming shelf life for the drug product.
c) Determining container closure system suitability.
d) All of the above

Answer: d) All of the above

Question.10:- in a zero-order reaction the rate of
reaction is _________ to concentration of Reactant.
a) Dependent
b) Partially dependent
c) Independent
d) None of the above

Answer: c) Independent
Question.11:- In a second-order reaction, the sum of
the exponents in the rate law is equal to-

a) Zero
b) One
c) Two
d) Three

Answer: c) Two
Question.12 Stability Data for Climatic zone III
& IV comes under___________ICH guideline
a) Q1C
b) Q1E
c) Q1F
d) Q1D

Answer: c) Q1F
Question.13:- Climatic zone- II is-

a) Moderate climate
b) Subtropical and Mediterranean climate
c) Hot/dry climate
d) Hot/humid climate

Answer: b) Subtropical and Mediterranean

climate
Question.14:- Penicillin G is prepared as a salt of
procaine penicillin G. Now the rate ofdecomposition
of penicillin G will be-
a) Increased
b) Reduced
c) Unchanged
d) Unpredictable

Answer: b) Reduced
Question.15:- Which of the following mechanisms is
most frequently responsible for chemical degradation-
a) Oxidation
b) Reduction
c) Hydrolysis
d) Decarboxylation

Answer: c) Hydrolysis
Question.16:- For first order degradation-

a) C vs T- Straight line
b) logC vs T – Straight Line
c) C vs logT - Straight Line
d) logC vs T – Curved line

Answer: b) logC vs T – Straight Line

Question.17:- The modern definition of oxidation is-

a) Loss of oxygen
b) Gain of oxygen
c) Loss of one or more electrons
d) Gain of one or more electrons

Answer: c) Loss of one or more electrons

Question.18:- Hausner Ratio is

a) Tapped density / Bulk density

b) Bulk density / Tapped density
c) Bulk volume / Void volume
d) Void volume / Bulk volume

Answer: A) Tapped density / Bulk density

Question.19:- the accelerated stability studies are
valid only when Ea of the chemical reaction is-
a) Less than 10 kcal/mol
b) 10 to 30 kcal/mol
c) 30 to70 kcal/mol
d) More than 70 kcal/mol

Answer: b) 10 to 30 kcal/mol
Question.20:- Photodecomposition of drugs usually
follow
a) Zero
b) First
c) Second
d) Third
Answer: a) Zero
Question.21:- A second order reaction
behaves as a pseudo first order reaction
when concentration of-
a) One reactant is significantly higher than other
b) The concentration of both reactant is high
c) The concentration of both reactant is low
d) The concentration of both reactant is equal

Answer: a) One reactant is significantly

higher than other
Question.22:- Which of the following can be
designated as the molecularity of a reaction-

a) Zero
b) Half
c) One
d) One and Half

Answer: c) One and Half

Question.23:- Which one of these methods is the
MOST effective in preventing the rateof hydrolysis?
a) Buffer
b) Complexation
c) Removal of water
d) Suppression of solubility

Answer: c) Removal of water

Question.24:- The storage directions on a parenteral
solution specify ‘store in a coolplace’. Thismay be stored in-

a) an air-conditioned area at 10°C

b) a refrigerator at 15°C
c) a place whose temperature is set at 5°C
d) room temperature, at 25°C

Answer: b) a refrigerator at 15°C

Question.25:- Which one of the following is
primarily NOT a chemical decomposition?

a) Isomerisation
b) Hydrolysis
c) Oxidation
d) Volatilization

Answer: d) Volatilization
Question.26:- The expiry date for a tablet is not
mentioned on the label. It means that the expiry
time in years is:
a) two years
b) three years
c) five years
d) Nil
Answer: c) five years