Faculty of pharmacy Mansoura University Pharmaceutics dep.

Credit hours system Program Dosage Forms 1 PT 224

Academic year 2019/2020 Second Semester final exam Level two

Question bank of Dosage Forms 1 (PT 224)

Question bank is in 7 pages

Answer the following questions:

Part I
1. What is the advantages of rectal therapy?
2. Enumerate the different factors affecting the drug absorption from rectal
suppositories.
3. What is the properties of an ideal suppository base?
4. Write short account on disadvantages of cocoa butter.
5. Enumerate only the types of suppository bases.
6. Write short account on the uses of suppositories (local and systemic effects).
7. What is the advantages of cocoa butter base?
8. What is the advantages of hydrogenated vegetable oils as suppository bases?
9. Write short account on multilayer suppositories
10. Write short account on coated suppositories.
11. Write the scientific term for each of the following;

The statement The scientific

term
It is the number of milligrams of potassium hydroxide that
would neutralize the acetic acid used to acetylate 1 g of fat.

The number of milligrams of potassium hydroxide required

to neutralize the free fatty acids and saponify the esters
contained in 1g of a fat.

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 Faculty of pharmacy Mansoura University Pharmaceutics dep.
Credit hours system Program Dosage Forms 1 PT 224

Academic year 2019/2020 Second Semester final exam Level two

It is the number of grams of I2 that reacts with 100 g of fat

or other unsaturated material.
It is the amount of water in grams that can be incorporated
in 100 g of fat.
It is the number of milligrams of KOH requires to
neutralize the free acid in 1g substance (fat).

Part II
Enumerate each of the following:-
12. The terms that can be used to describe the microcapsules.
13. The effects obtained by microencapsulated drug products.
14. The properties of coating materials for microcapsules
15. The properties of plasticizers which can be used in microcapsules.
16. The sides of differentiation between microcapsules and hard or soft gelatin
capsules.
Mention the drugs that:-
17- The flow properties of them can be improved by microcapsulation.
18- Are metabolized during absorption.
19- Have short biological half-life, so, they cannot prepare as microcapsules.
20- What is (are) the property (ies) of?
A- Drug swallowing in microencapsulated dosage form.
B- The release rate from damaged microcapsules.
C- The nature of core of microcapsules
21- Give reason (s) for the following:-
A- The decrease in particle size of suspended drugs of low water
solubility.

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 Faculty of pharmacy Mansoura University Pharmaceutics dep.
Credit hours system Program Dosage Forms 1 PT 224

Academic year 2019/2020 Second Semester final exam Level two

B- Addition of dispersed linear polymer to liquid cores

C- Smaller microcapsules have higher release rates than larger ones.
D- The addition of plasticizers to polymeric coating formers.

22- Give the name (s) of:-

A- A liquid mucolytic drug, its handling is improved by microcapsulation.
B- A drug when administered as microcapsules reduces gastric
irritation.
C- The site of absorption of vitamin B2?
D- A drug when administered with overdose in microcapsules, causes
accidental or intentional fatal poisonings
E- Two drugs that their volatility can be decreased by
microcapsulation.
F- Examples of the types of external plasticizers

23- Select the correct answer (Complete word not Symbol) of each of the
following
A- Ion-exchange resins contain ……………………………….. groups.
A- Non-ionizable B- Hydrophobic
C- Ionizable D- Hydrophilic

B- Which one of the following materials is used in the preparation of resin

copolymer?
A- Aluminum monostearate B- Glycerol tristearate
C- Divinyl benzene D- Hard paraffin

C- Which one of the following materials is weak cationic - exchange resins?

A- Sulfonic acid groups B- Carboxylic acid groups
C- Quaternary ammonium groups D-Tertiary amino groups

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 Faculty of pharmacy Mansoura University Pharmaceutics dep.
Credit hours system Program Dosage Forms 1 PT 224

Academic year 2019/2020 Second Semester final exam Level two

D- The insoluble ion-exchange resins may be supplied in the case of cation

exchangers as .................. salts.
A- Chloride B- Bromide
C- Sodium D- Iodide

E- The strength and permeability of the final resin is influenced mainly by

the degree of ………………… produced by the divinylbenzene content.
A- Separation B- Crosslinking
C- Breakdown D- Dissociation

F- The exchange capacity of ...................... exchange resin is pH dependent.

A- Weak cation B- Weak anion
C- Strong cation D- Strong anion

G- The insoluble ion-exchange resins may be supplied in the case of anion

exchangers as …………………………….. salts.
A- Chloride B-Sodium
C- Bromide D- Ammonium

H- Carboxylic acid type cation - exchange resins tend to have

approximately ………… the exchange capacity of sulfonic acid type.
A- Half B- One quarter
C- Twice D- Hundred

I- Sulfonic acid type cation - exchange resins tend to have approximately

…………………….. the exchange capacity of carboxylic acid type
A- Half B- One quarter
C- Twice D- Hundred

J- Exchange capacity of strong cation exchange resin is depending on

………………
A- Concentration of drug B- Solubility
C- Alkalinity D- Acidity

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 Faculty of pharmacy Mansoura University Pharmaceutics dep.
Credit hours system Program Dosage Forms 1 PT 224

Academic year 2019/2020 Second Semester final exam Level two

Part III
24- What is the different types of tablets?

25- What is the reasons of preparing multiple compressed tablets

26- What is the type of tablets used in oral cavity?

27- What is the type of tablets ingested orally?

28- What is the different types of diluents used in tablet production?

29- What is the different excipients used to manufacture of tablets?

30- Why the mannitol is widely used in chewable tablets?

31- What is the steps of wet granulation?

32- What are methods used for preparation of compressed tablet?

33- What is the importance of granulation process?

34- What is the importance of capsule coating?

35- What is the advantage of film coated tablets over that of sugar coated?
36- What is the reasons of tablet coating?
37- What is the properties of diluent that used in tablet production?
38- What is the disadvantages of capsules?
39- What is the raw materials used in production of capsules?

40- Choose the most correct answer:

1. Bitter tasting drugs can be formulated as;
(a) Chewable tablets (b) Coated tablets
(c) Compressed tablets (d) Molded tablets

2. What is the type of tablets that can be used in preparing the

multivitamin mineral combination?
(a) Multiple compressed (b) Layered
(c) Compressed (d) Sugar coated

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 Faculty of pharmacy Mansoura University Pharmaceutics dep.
Credit hours system Program Dosage Forms 1 PT 224

Academic year 2019/2020 Second Semester final exam Level two

3. Lozenges dissolves slowly over a period of .............. minutes.

(a) 10 (b) 30
(c) 60 (d) 120

4. Which one of the following tablets is the type of delayed action tablet?
(a) Enteric coated (b) Film Coated
(c) Chewable (d) Sugar coated

5. Which one of the following diluents is considered as a potential

instability source of moisture sensitive drugs?
(a) Lactose monohydrate (b) Microcrystalline cellulose
(c) Spray dried lactose (d) Calcium sulphate

6. Which one of the following fillers is an inorganic salt?

(a) Di Pac (b) Avicel
(c) Aerosil (d) Emcompress

7. What is the manufacture method of softgels that is based on the drop

formation phenomenon?
(a) Seamless (b) Punch
(c) Compaction (d) Slugging

8. What is the bloom strength of gelatin that is used for manufacturing of

hard capsule shells?
(a) 50-100 gm (b) 100 -150 gm
(c) 150 – 200 gm (d) 200-250 gm

9. What is the role of sodium lauryl sulphate during capsule shells manufacturing?
(a) Binding agent (b) Disintegrating agent
(c) Preservative (d) Wetting agent

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 Faculty of pharmacy Mansoura University Pharmaceutics dep.
Credit hours system Program Dosage Forms 1 PT 224

Academic year 2019/2020 Second Semester final exam Level two

10. Hard gelatin capsules are used to encapsulate the powdered material between
about;
(a) 65 mg to 1 gm (b) 100 mg to 1 gm
(c) 1 gm to 2 gm (d) 2 gm to 3 gm

11. Which one of the following materials is used with eutectic mixtures in capsules?
(a) Sodium lauryl sulphate (b) Magnesium stearate
(c) Magnesium carbonate (d) Silicon dioxide

12. Soft gelatin capsules are made of gelatin, water and .................................
(a) Disintegrant (b) Plasticizer
(c) Diluent (d) Lubricant

13. Coating capsules are used to...................

(a) Improved drug absorption (b) Reduce transparency
(c) Prevent drug release in the stomach (d) Retard microbial growth

14. What is the water-miscible liquid that may be encapsulated into soft gelatin
capsules?
(a) Chlorinated hydrocarbon (b) Polyethylene glycol
(c) Glycerin (d) Organic acid

15. Which one of the following methods is the first automatic softgels
encapsulation?
(a) Seamless (b) Punch
(c) Rotary capsule (d) Slugging

Examiners:
Prof. Dr. Abd El-Gawad H. Abd El-Gawad

Prof. Dr. Osama A. Soliman

Dr. Marwa S. El-Dahhan

With our best wishes

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