Respiuadignl Enrc

PhoosyntHaesis Phoouu piua h0m Page No:

Dale

CBioGMERGETICS) MeTABoLISM
Nuclah'ou Malabolin
Caubohyduat mino aco
Muhbalit m
Mitabelis mm|Lipiou
Mtbbois v

1LARBOHYDRATE
LMETABOLIS
11Glucaniaqemesis i

yntuis ucasu nCaoolyaluat

CAmpAmal. 4mayoL
Swbs h r a t t
OR

Guwaqmi
CUdng
Lactat| CLicls
apienalu
Guyconel

Locotiam Mainy sytosal p mitnchenoluia.

T'sse Juveu kiolmu CRenal cauta

npautames i Glucau s mpauounk souuw oemu

O4 buoum RBC.

Gucos_is Hae mly ema soe

SKeluhul mul
A T s uhlizeo
SoucL uco ww staavahen_akte
elpdukiem ycag shauag.
 Phas p h a a s u
nt m3ym D G-6
Key
Conpou Euuctosed,6 Bis phaphaeuse Enroll
4
Pyuuvati Canboxylase: N
3
PEP cauboxyKinaset

phosphe enol pysuuveti)

4bsentin muselus
Absgt pope Hs
Guca
- 6 Phospihatu
Uye,kly) gucas -6-

Euucho -6-
Phosphaau

Fucte-1,6-Bis

NAD+2yeualatkyotu0 DHAP
NADT
NAD *H

AD P 3-6PG
Pi t ATP -
3phosphogyceuatL

2phosphogheunati
PEP
Hauvat
 DHAP- Dihudaoxy oon
Phospha
Page No:

Date
(

PEP yva

Pyuuvou cuuboxylasu
COA ATP, io Hn , Co
GTP
PEPCauboxykina Oxuleccutau

camiaqusis koem dockatu ,-

ackotu CReveusîblL Jlac Hon
Pyu
NADH NAD
H
GucamLagLnsis Aram_puopiOMai i
aopio nutTOA
Muty Maloy CoA
LuapisnytCon CauA-boxyladt
Coetsu i o Hn
P t t L o
Mutos CA Coemume)

Succinu Co AA
C1LA yelud inteumicliau)

Guycema Glyeeuskinas Glyteual -phos phau

tyceusl-s-dludugenas

DHAP

aMima aciel,-
o t h inteumidis
GAcagniuo amÁO asial_ kaums pywai
TLAg e d
ex pPt
SLecin upiw s Donot kulp ww
kornaheno Pywveit-
 Enroll
Page No:

Date

eguicemi@qtniseu b 4 Ky n3
P

Requlatiow
mutioneol lalieu

ulgulouhon
involmol i w thio
Michamis m
Indluction p Repusion
Lnsulin_inhibit _pyuuvelu Cauboxylase

COMbo*ylaL eMSYL
hsme wmhibYHow opyNa
alo inlaibih Has qucomaam
1 O mo n K

LAA *Guicagon_moliuer hu qhLconLAAtnAs

CpLOmo te)
haumo2

Cavalmt moiicAuhian aemumiY Phospholsb@n

M1 Gyctic AMP achyods pesohiem kinoa

CALasteuic gulaben Ac1yl Co A (chvere

Fuuchese -2,6 Bis phosphausa Cinhibihe)

Acty csA achivau pumwau aulbonyAA

T1T qnto puoolchon.

1,6Bsphesphalese
ekohales

COA
iuwal AUva PEP

Co boxulou AMI 6P G6e

Glute
fhosplabu6 PP
Kegulo em oocamo
Achvatg
LnhiLipu. Gueo
 Enrctl
Page N0

Date:

Enugtics a GucagNhe paiaasRy

GucOL +2NAD +2GDe
4AIP +2IP +6Hao
a puuuwatu t2NADHt +4ADP

Gluco
Guacas
AT
Cqce-6-Phaiplhal
Gucam-6-phosphodu

Euwchohe - 6 - Phosphot
Auckose-6-
phosphat

ATP
FunchoA 1, 6 8is phosphal
Euuchose 1h-Bis phosplhodu
2NADH

2NADH
Glycunaldrydu
3 ph0s phati
2ATP

2 ATP
3 Phosphoglytenoi
2 phospho qlyceuoii

2 PhosphneholpuUval
Phospho emel puLAUval
GTP_
ROxaroczkootu
ATK 2A DP
AATP N
2 Pywuvacte
uva
Net Alet
t2 ATP
-4A TP
+NADH -2GTP
d NADH
 Enroll

Page NO:

Date

GLLcaalaninu cyeli ~
toive
maiwuLk uam alammM
o tramspoiimg
musu Cvu.
NEogem fram

Glucos PywvoiL

yvvertt
AAamAni

Alan Btooo
SKELE TAL BLOOD IvERY
MUSCLE

12GLYCoGENMETABOLISM

0 Gyrgunsisi- dtumnadiom oyogn frem uueou 3 CLo0

site Cyos.ol, Tsu- uveu f mudu

uuuumnt ATP, UTe z Guucoe-

A smau frugmunt
apuime'
p- exiahiA gm_ oct a
GLeogenin Specitc paohim
witn
B0upt uco fremoliaosouuchuiols
UDP-G
chein.
Key enzume
trom gncose from sytosun symthasA
gtogun to koum up P-
Guucse h Non uclucaolAcive in_diphosphau
-Gyosiclic nkage. ueluciwo sati
 Enrot-
Page No:

Daie

Ca-4,6 enspuas
i Guicasyl
B u a m c l a i n g emiymt

anottusqucoe
guwo siclu to
L u a m s s S) to (8)
1,6 ytosiolic Unkag.
kee2 tu 40um

veu YCOGENESISPATHJAY

Suthasis of_UDP -gcgse Guuca

AT Guncokinas
achvaKii o{glruccts
ADP
Gucse-6-phosphale

MutAL

Gucose-1-phosphute

UTP Pyuaphosphauylu Kan

UDP- Gcose

UDP-GGlucose

2 Y G-GG-*-4-6eogmin

umiha Synth ast

ycogm
CLonaah'o L t m u » G - G - C - G - G G - h - G - G y c o g n i b

6dyrogm synnat
Bnch
- n a 4 G % - G - G - G G y q e o q n i n

Gucosy l-4,6) uamsLas

Gy-CnC--C7-G-67togmin

-1,6 Jn kag

GLYLOGEN
 Enroll
Page NO:

Date

yLVCOGENDLYSIS _ Key emum Glytoqn phacphouyloe

egoolatiom ashouol glycogm in veu

muscli

sit e Cusol

STEPS 0Achism a qlycogenphosphauylaw

Homeval atuuea úwH jaumauutou
1phosphaiu

Limit dixtin 8umaian

Achiom a dubuanchiuEB
Biumuhsmal em3yme
LuensRMAL Glucosiolou achity|
achi

myu o trisaccausols Buaking -116

wmit kcon bomchin
Point linuoy V.
clhoium
impoqu mallibuahen

)Linoqu cugun faumakism

Agaimw wmo val o qucou n
kawmo guncok 1-

OGuc0s4 faumahon Cmainy diven)

 Enrofl
Page No:

Date: /

qlycegnolysikpaitku

-L,4- Bonol

-1,trTkg
G--G-GG-6,-4-G-61-G-GGytoqunin

Cuguuuusl PLP
Gycoom Phosphaylon
Guuca - E
ww

G-1-G -9-G-G-G-- Gytogein

mit odtixhrin

G 4 4 G G - G - G - G 6 G u e o q e n i n

Debutinelumg ema4 qasieloe aciuik)

G -6-G-G-6-G-6-G-GlyLocmin

Phosphouylasu
Gucose-1- phosphats

Muwta emzum
Glhaco-6-Phosphau
Gcos-6-phosphaau Cüven)
 }Glyceasonsyisi.

canesia
Kugulatiam a

Attesteuo |Roummonat
RigulaliaRgulachia

Couy h i s wuhale
Basicaly,_emBYaL

ugulahgw

SynthasL Phosphoupss
lyengtmis) gytognalysis)-
HeumouL wquuel irm Hspuacs auLi
LNsULLN) EPI NE PHRINE
aLucAGON

0 De phosphozytectuot
2 shatu
Phosphaylteal

ALLOSIERIC REGULA1ON
Guuco-6-Phesphotu -
ATP
Allosteic inhibi tion ok
8ytonphesphosslas.
wne i will Llork 4lyro8t
Gues-6-PhosphatsAuashtac ariva hion ilusit
a
yengnSyntha
AAA=
 Enrcll
Page No:

Date:

HOmm@m_Jugulotidn

Gluragom tpixnphuin
imo 11TCAMe octivaiam at _aclunylatu yclosu
achvak Cus(Phosphoaua h87 oyeogn
PuO Ren kinau synhaeJeaytoynehit
Cinackn)

ackvoul

Phosphauy lost
kinas
achval

9uogum phosphauylos (OGlyuoqnaysiz

SGcose-1-phephale

CAckiin phosphaylatual sha

nsutm i muaAu phosphooliesteasL actiuiy-

oue, Hhe Jss_cAMP

Inach'ves fmmPMobem
ino ciuiig
ulihhuth uumlt jm blocko o
LDgAnlpu.

EleL quca.oam I e . oqyeaom oamalahom

levodu atuuin= In: o ycagen synthus

 Enroll
Paje No:

Date

+3
Ca
Ca igw activat phasphouylosu kiau

AcHvoe Clucaowm phasphauyor

wm M1 Gycaom dlugeroolotiaw

camSuA clusua -
Namt EnaumN oluket
0 Vom Gqieuke's disnase
Gluuca-6- veu__Kidmsy_
Pompe's_dos Adl altas ALL qans
Coi's disasu
Delbuonmeiug enaum veu
Anousads cdiuaue
Buameve em ve
5
Mandu'diua Melu qtytosp Mweu
6 Heuls dma
v
Phosphayosa
aayLnom phospha
Lvey
I ve
Taui'sdunom
Phosphoruchokinasu MAsLl's RAL
In,
aoupose
umemies Vpusae
duusom Mao o
st
 Enrc!
Page No:

1 , LIPID Daic:
MINO ACiD MeTABOLISM

Sumthu aluiacylalycunal : CTA)

Stuusl u acipacytu Cyoumumg glakulon structu)

0Live
SitsaAynthen TAG Aclipacyt
In tune
Struchuu
CH00C RL
CHO0CRz 3~abhy aciol
nbta&hiol
CH20:0C
Rz

Guyemal uut
Sn-yeunsl-3-Phosphali

pathuas eTAG Symtusis

Mameaeaeua
patuau
2Rqimmts jou sym#gi TAG
G-s-P
Faly acy CoA
FatyAcyCoR
Synnale
otty acid tATE+CaAc katty acyicoA tAM
monmkam +PP
GytenaL
kinam
Gye eual 3-P_
ATP ADP

In,
aaoipose. DHAP
NADH NADT
CHOH C HaOH
GLYCER0Gt-
yc enol-8-P NESIS
CHa0M _olajolugmas
ycewal-3-P
DHAP hyeny ackgmu phasphal
 Enroll
PT

) 1t

TAG Synthus
latyacl
Co'A CHROOR
CHO CHao OCRI _CoA
CHOH CHOOR2
cH0 H Rcyt ha T1 Au tra )s
CM20P
cHAOP
Gly-3-P Dio

Phos phoa rusa

H20

faty
A
CH2oloLA CH20CLR
éHoOCR2 CCuyttrurhosT CHaOCR2
L)
CHaoloCR CHAOH

Lncnel Faty acio

we a s a .

Tuanyt ueunalCTAG)
h
elndlAs a TA byipasss idsw
Lipalusi, Sunthus
Ctam
TAG im odipas Aim
L LCOmyeukesl umto r
katty acio msl umola
Hu_umkuume
hawmaws i e epinLphenint
tgco.qom , naupinephuine

TA pae hasmau semai

pass
GuelTAG PpaaL aLyeead ipaas
DAG

fA
LiPas 4ywns
Gyceusi
MA
|pas
oll

Entcssing olist
pios% salts in
0Emulsifcatiam af diuy kat by
t
smalu wmtushnu
wit imttsknal ipa
OLR2 Dqahiom a TA huakoausm puooduct a
F a t y auio anol attu conveuHal
i t e s i n a emuucosa
aasaloLol oy Hu
A
into TAG.
chylo miuoms.
dmmapauouol imh
Tac u
2 Chulamicuau nn@mm Huaug Hu Jupmphaiie f
bloood vasellau sustm to t s
mveudi
Lpopuohien uipas imcApillau
asiel Gluycus
chylamius Comveukal imte elhlomniums
Lmnamh d to_LmaWo a masA TA

E phkL s cylomuiusms aHnam b hupaic

sis.
s a uiveu y u p h t -mealiaus emdcsb

1A
nthsi Upo Apopopiohem Chaxamicuana
Factty cciod TA G
Chtwnme
- a mMonooeyqyanols
tfpiots

Plasnmau
MIMeuUnu

LPL HTGL
VLDL > IDL LDL
Veuy lo dumiy IntAmisliatt Clouo dtmty
WpopuaHen popolitn
popokem] LPL UpopaoH e
pat
HTGL hupaic au
Lipoa
 Mbeomaion Eoroll
Cncac

A1TY ALuD BIDsyNTHËSIS

Lacodiam- Cyhsal.
Site
Lac
AcekaLoA Shuttu sustumi
MITOCHONDXIA CYTOSoL
tronmspo4k
Bo
F
TA LCrat Synts

LiKat
A
AceHCOA Snhas
Aced eoA
Oxalauetotu TOnalaacehutu

Rie
malaiu
A
Buvas
P vdA
sep Ac
PAwautu
nsP6uku

Innumabchnuias
mumbwnu
CLptol bilayen)
A o Aoh coA
Caboxylas
A t y ton ATP Manamul-oA
TF

Bioin Cacj-
HO3- oz
 nrcl
Tage No:
Date

TAnthusism
palmatie Aiel.
Stbe a symthsis Cveu, imhestimt , iolnuy , Jumgs
Lactiug mamauy qlomol Mslipast tisuL

aei
Boai peunsou H spmthuss a koy
c y CoA).
dt hadluonasu
Pywvalu Complek Ary CoA +orolposin u

AT t ia

muaduol bu
* AAa y nthusstod by - onidatim 4fatty ariel un
Hhu mitochemoua.

Rquumimts : Aciky COA , NADPH,A TP

AcHvatiom a Acrh Lok

Acey Cok cMboxylosu Imp emyms
Acet tot
stpAeycoA CAuboxyasL Malamup CoA_
ATP, Giohn , Co1
LABC Coboxylss

PaTHLAY-ATM ansackiem t staruteal wumel

aiveuuon0shLough Ac PNGUMONIC&
IAcekyl o y.
MI Mnbomyl tomsknuyloe Keto.acul
Realderasl
SS Ketoocyl sqnthost
Delydua.dl.a
EREnay Ruoluuctnut TH Jhioesteuajt
 A c o y t tmm Enrol
hamsacylast
Acihyt
Melamyt ambaeutostoRMaloyl tuantugai

h
T
am 2 ulphiolal rduup
yacidl aymtaase
uw dh unchanal
Fa
Enz-upimyl- Sulphidhl ulinche
1) ottaclhtel o th emaumu
a+achmun [enz--sH] emaum
ACP-4- PhesplhapamtLhhuins-SH
CACP-4LPP-sH) Cm

Acchyl-Enz tlaASH
SR2 Aukyt_coA +Cnz-ys-SH
Swbwt
malamtt
S alenul CoA+ACP-SH ro d Malsmyt ACP + CoASH

CONDENSATION COA unacu Subumi

syn Hhal
Ca
B-KLtoacsl ALP{
NADPH
REDUCTiON Kehoaey
RLoludLast
SRe
NROP

-huyoluOKH CUY ACP

DEHYORATLON
DeysinaFas
RE DUCTLODN- H2o
NADP NADPH

Ihigteuo
But -ACP Enayt ACPT
¬nay
RLolilelosa

s poMuoy 4 oulaluoby 2 dmpeuton haun@nua

-Insuline
Olphasphouytakel] Cdphapuuylakd]
Long ttm fay Acid -

Camauchol bt tn
ugulohiom s
¬xpuwrsidm.
 Faty Acid sunthas CFAS)
Dimu fumeliomaly asRu

muulhumchamalmulh- has achniy o emyms

em3Ym caniu
L pnahitmwic. Auyl
em3y Pauohem. CALP)

# cnsdk a2 subumifs i

KSAT-MTDE-ER-KA-ALP Thio euasg

wit

Ruouuchom
SubumKt Condnsinq wwit
wwit v
SH
SH
SubumiZ s
4'P -AT-KS
-GR-DEMI
h -ACP KR

aky_tuciol
sumihai
mariouVuunu a
h A 2
veuEkuatu

I oumsl uw pelypuphels
FAS muulbijuonkiensdl

lomsst a
singlu Jamgu
uih demaim backeuia
plams
aumd im
FAS lmistT a mulipmelitnal

u t7 damains

puesimt iw
subdt
 phosphau
i n o u q u e Pyuo
CATI> Caumi hn. (pP

LFAO
ATTY AciD OxiDATION
Mitoehdmoluial -0miolotiow -

2
CooH FA.
CH2-CHA MaT CA2-
CH;
Suppau Y
mitthondia owa wwblu
B-niolatiam
- Dnidotiem CSuccusiuL eumakAM
nanER/miPteN
a acehl Cot)
OF Ddol etnain paty aciol amialatiamMinekonduo
Wnsahuuatud jat arioh auidatiom mi'hckenalio
LVeuyJgnng cnoin at aciol aaaidatiswpozom miachorl
FA
Boxidatiasw Thiokino ATP
AcHitin PP,
Ataotngttt
3 skps Tuampaut CoAsH
JAMP
(ru toA

Whchanduial mimkuame
impuummiass to Am COA s0sRLeial custimu
Hh s
Caunitinnshuttecystimm So
ACTIVATo
CAT-L launih
onspoLLh ecl innA
iloc honoluuiat
ith t hilp spcia
Laun Puhe" known CAT I
TRANSLOCASE
TRANSPORT CoumdHne
Au toA
CCtcttt
CEtttttttttrr1117777779?=
ttrrr1r117777772E