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ReVISION1eT-V

AeClaxohos lovmone (a)Bayed o Mexboris

cko
Mechanicu o Achio
BTuck Ho ufsacelleulax receptovc
urocorhcod
Mirrexalo tate
Binds oit cell suvface

w
eceplors ACTH,Glua gr
esen qex-C AMP w

Binde Binde oit cell cunaae ANF No (n

e ceptovY
01d
meecengescGMPum
8 ircs wfh ceel cuore 1RH, GnRH
TecepBons
mescorgey -CaPP2 Onyin
CPIPa-Plosphatidy) fongitol)
Bindc wHt ceel susace
ecopfos Pnculin 36t
ww
Mociafed Hxoug Turok inase u

Binds oH
aCunface
yeceptov INE PRL
Me enqer
ihaelphospha fod
Cascade
 Cudie A asCemdasy mesoR
poe has 3sub-unik , P,
Pofeiu when bound uwt
GDP ?inacv

aihen G -d cub unit detathe he HR touuplax

kun binds f GIP and achiyalee adenylake curiate

denlate elaR COnneck ATP +o CAMP

Profein ina ce hovinq calalyhe ite Cc) ac egla ong

unik C) whenatfache.d in achve

CAMP bincing wit Requlatoo unik cek calalyhe unik

face No w Proeiy irate i arhe

Protein kirase phospkovlate enzym pxoein Cinase

Ophotpho Peinc

ATP
acives
tdnlae E Phoeiy
Cyaie CO tinase

cHMP-
(cAM

Eny Paophe ylabes

CPoteie) IP ntu

gndaton oc
ptioclod ccfauae
6 AMP
9-5 lie AMP
(cad)
 Turosloe Einse)
Machonigm Hrone Acbio
+Homonee nculin
*
Intalin 2 P cubunile
cceptos ha

ncalin bindt oik Cubunile achiuahirg rosine Lin

acfih o un
Alo phesphoniaion -ni farer placa 2 phosphonyaa
inceuln ecëp tos cubchabe Ges)

62s- acvaboo e&ul t n p?-3 CinaR ac vaion

ac5vaion
wich acfivatau auou potin inasa4 lit Ptc, PAB

Resull in tiancciphion of speke qeneg for Ce eeye

gurolysi i te ucokinace i'nculin_binds
bunit tsanthi Es ianals
subunt - subuniE

PPFIFRATPITO
Jo
hen incclin binds
Cinose achvihy siaxe

necine Tesiduns ae
phocpbenyhfe
Auated p-unit phocptomyae
(R) an kadg to cellu oy Yeaponst
 Niticoxide ac otent Vaxodulafov inAng
Angina
Acekkholine alfaches coit acceplo, gnas
sant nitted fnotitol phosphate

Thit esulk in olease oP co _ions and ocHvate

NER oxide cynCase (Nos)

-NO diPP to adjaant mocth Muscle bves ure and

activatu a r y lale Cyelaxe

Guanfate yelae achvales potio Cinasen moo musclag

slk n aphospholakion e i n liah chait oheh

Cauee Telarirgdmusd

lence vuulk o dila Kon o Covona auteaies cund

ack aS potent Vacodilatos
Angira Pectovi

nAnt imay
A Hypottpidicm aloysigeies
TcH in blood ncsea ecd

T3 auud T in Bloood Decxeased

Respose Fo TP H txagoattt esponse

soda y lypev tupoicdec

Causeg

Diseasto iufay qlan 0 hotualamus

 se cre fing pittan aderoma
chroni gonodotpphint Secveia humoss
fuynotoxco tir
Gqestatom

Ciigeadue
BMR trCYeage nceased hea ppdue Hoo
hloightlotu h los
Mucele weaKnes s qulon mendhu o Cy
Radness oP Palms Amotence in Maler
Tachy cavdig Cobe
Charge ETg and
FT ad FTy ase decreo sed in hyperHtuyrpidlium

F aud Fly a increased in

pen teidicm
3An
A ic hemica function Gpe bmone
- Gpeot o long bone mediated b 2GF-4
ncseaea uptake o Amino acid ocelts
Huve by helpinq ve) Nihoen Balane
potein
lpolrit Arti-2ntutin ffecf
poi e sept fissuea, Covtiloqen aud Bone

Gowi omone hos Anobolie ed

 Ahromahe Ggt omere
Abooouy
HCvomeq oly PncveasedG ishquemmb o
in adeulls
Paainl atve
Hbroamal chape
hands and eet
6iganien Jncreased GH Exheme atl dakuxe
in childhood large handt and Pee
Dcay Fim -Decreaced G iy Bowed le
Childhood chort abure
slo Gout
4A Adbre nal Cohcal Hosmoreg
Glutocosheoids
-Covhio
Minre salocotroicle
Hdoctevore
Deovy coshcoteione
Cex co shcoid
shoqerc Clesey exten
Cchig pme
Cau e Hpesece hom of adnocohcal homonea
ueto
hpercfioning of Adve na covBex
-lumor (ovte Pihuty yhrd
o advea
 Ne

Ratuse
Roundd ace meon oe
Bufalo hum Cvunea obeiaty
Fafique
muccle wea Cneig
Hepevfentio
-pey alucenia
bwea boneg

Pol ura and polydqpcio