Peripheral HydroCoil® Embolization System

Expanding your capabilities

The New Generation of Peripheral Coils

A Unique Technology of Expansion

AZUR® Peripheral HydroCoil® Embolization System combines a pla-
tinum coil and an expandable hydrogel polymer. The hydrogel coating
expands in the direction of less resistance to fill space when introduced into
the bloodstream1,2.
It offers:

• Unique mechanical occlusion1,2

• Superior volume filling and packing density
- Up to 5.8 times more volume filling than conventional coils for 0.018”
- Up to 4 times more volume filling than conventional coils for 0.035”

Diameter expanded*
AZUR® HydroCoil® Diameter non-expanded
(maximum)
Detachable 0.018” 0.018” 0.032”

Pushable 0.035” 0.023” 0.046”

Pushable 0.018” 0.018” 0.032”

Minimal expansion in 5 minutes, 80% expansion in 20 minutes

Once expanded, the Hydro-

Endothelial formation gel remains soft and confor-
Hydrogel
Cellular mable. It provides a stable
ingrowth This image illustrates the growth and permanent platform
ells
ec of neointima at the neck of an for blood stasis, thrombus
cl
us aneurysm in a rabbit model.
Endothelial m
th ge
n organization and neointima
cell layer oo olla Hydrogel facilitates this process.
Sm th c Artery formation4,9,10.
wi
lumen
The studies performed have
shown that the Hydrogel is
an inert substance that does
Expanding in the direction not contain or produce bio-
of least resistance logics, is not associated
Hydrogel
with any known toxicity,
As this image illustrates,
in-vivo material hypersen-
Hydrogel expands in the direction
sitivity, or interaction with
of the flow–not in the direction
Artery lumen other embolic agents and
of the parent vessel below.
Blood flow will not degrade or break
down5,6,10,13,14.
A Unique Measure of Control
Peripheral HydroCoil® Embolization System

TWO DISTINCT OPTIONS:

AZUR® detachable system is the first

detachable systems for peripheral use that:
Expanding
• Can be detached in less than a second at the push of a button your capabilities
• Features a detachment cycle confirmed by LED light
• Can be retracted and repositioned, reducing risk of migration

AZUR® pushable system:

• Has been specifically designed to be pushed
with a Terumo guide wire

AZUR® detachable and AZUR® pushable

offer the same expanding technology that delivers:
• Permanent mechanical occlusion with less reliance on thrombus
formation
• Superior volume filling, packing density, and occlusion efficacy1,2
• Superior mechanical stability1,2,4,5
• Increased delivery control and long-term durability11,13

With AZUR® HydroCoil®, you can now achieve excellent

occlusion in a wider range of procedures, using the fewest
coils possible.

A Validated Technology
The hydrogel polymer technology featured
Watch this little coil in the AZUR® Peripheral HydroCoil®
Embolization System has been clinically used
for more than 5 years in cerebral aneurysms,
GI bleedings, visceral aneurysms, pulmonary
become AVMs and trauma. It has been analysed
the biggest thing in more than 200 laboratory studies, 20
peer-reviewed articles, 100 oral and poster
presentations that demonstrate:
• Lower vascular recurrence rates versus
in peripheral
platinum and PGLA coils3,4
embolization
• Enhanced reconstruction of the artery wall
versus platinum coils4,5,6
• Increased filling with fewer coils than
previously required1,2
References:

1. Sluzewski M, van Rooij WJ, Slob MJ, Bescós JO, Slump CH, Wijnalda D. Relation between aneurysm volume, packing, and compaction in 145 cerebral aneurysms treated with coils. Radiology. 2004;231(3):653-658.
2. Cloft HJ, Kallmes DF. Aneurysm packing with HydroCoil® Embolic System versus platinum coils: initial clinical experience. AJNR Am J Neuroradiol. 2004;25(1):60-62.
3. DURABLE Multi-center HES Registry (Albany Medical Center, Beaumont Regional Medical Center, Loyola University Medical Center) of 260 aneurysms with 186 follow-ups treated with HydroCoil®. Presented at ABC/WIN. 2006.
4. Plenk H, Killer M, Richling B. Pathophysiologic considerations on HydroCoil®- and platinum coil-occluded retrieved human cerebral aneurysms. Presented at ASITN MicroVention Symposium. 2005.
5. Fujiwara NH, Kallmes DF. Healing response in elastase-induced rabbit aneurysms after embolization with a new platinum coil system. AJNR Am J Neuroradiol. 2002;23(7):1137-1144.
6. Kallmes DF, Fujiwara NH. New expandable hydrogel-platinum coil hybrid device for aneurysm embolization. AJNR Am J Neuradiol. 2002;23(9):1580-1588.
7. Bavinzski G. Talazoglu V. Killer M. et al. Gross and microscopic histopatological findings in aneurysms of the human brain treated with Guglielmi detachable coils. J Neurosurg. 1999;91(2):284293.
8. HEAL Registry. MicroVention, Inc. (197 aneurysms: 128 fallow-up cases: mean follow-up of 14 months).
9. Virmani R. Healing and inflammation in experimental and clinical aneurysms. Presented at WFITN. 2005.
10. Ding YH, Dai D, Lewis DA, Cloft HJ, Kallmes DF. Angiographic and histologic analysis of experimental aneurysms embolized with platinum coils, Matrix, and HydroCoil®. AJNR Am J Neuroradiol. 2005;26(7):1757-1763.
11. Bui Jt, West DL, Pai R, Owens CA. Use of a hydrogel-coated self-expandable coil to salvage a failed transcatheter embolization of a mesentric hemorrhage.
12. Aina R, Olivia VL, Therasse E, et al. Arterial embolotherapy for upper gastrointestonal hemorrhage: outcome assessment.J Vasc Interv Radiol. 2001;12(2):195-200.
13. Fanning NF, Berentai Z, Brennan PR, Thornton J. HydroCoil® as an adjuvant to bare platinum coil treatment of 100 cerebral aneurysms. Neuroradiology 2007;49(2):139-148. Epub 2006 Nov 22.
Peripheral HydroCoil® Embolization System

® ®
AZUR Peripheral HydroCoil Embolization System
Pushable 18 System/Pack of 3 coils Detachable 18 System/Pack of 1 coil
Product Code Loop Diameter Length* Product Code Loop Diameter Length*
45-280202 2 mm 2 cm 45-480202 2 mm 2 cm
45-280302 3 mm 2 cm 45-480204 2 mm 4 cm
45-280304 3 mm 4 cm 45-480302 3 mm 2 cm
45-280402 4 mm 2 cm 45-480305 3 mm 5 cm
45-280404 4 mm 4 cm 45-480310 3 mm 10 cm
45-280406 4 mm 6 cm 45-480405 4 mm 5 cm
45-280504 5 mm 4 cm 45-480410 4 mm 10 cm
45-280506 5 mm 6 cm 45-480415 4 mm 15 cm
45-280510 5 mm 10 cm 45-480420 4 mm 20 cm
45-280606 6 mm 6 cm 45-480610 6 mm 10 cm
45-280610 6 mm 10 cm 45-480615 6 mm 15 cm
45-280614 6 mm 14 cm 45-480620 6 mm 20 cm
45-280810 8 mm 10 cm 45-480810 8 mm 10 cm
45-280814 8 mm 14 cm 45-480815 8 mm 15 cm
45-281014 10 mm 14 cm 45-480820 8 mm 20 cm
45-481010 10 mm 10 cm
Pushable 35 System/Pack of 3 coils 45-481015 10 mm 15 cm
45-481020 10 mm 20 cm
Product Code Loop Diameter Length*
45-481215 12 mm 15 cm
45-250404 4 mm 4 cm 45-481220 12 mm 20 cm
45-250406 4 mm 6 cm 45-481515 15 mm 15 cm
45-250506 5 mm 6 cm 45-481520 15 mm 20 cm
45-250510 5 mm 10 cm 45-481530 15 mm 30 cm
45-250610 6 mm 10 cm 45-482020 20 mm 20 cm
45-250810 8 mm 10 cm 45-482030 20 mm 30 cm
45-250814 8 mm 14 cm
45-251014 10 mm 14 cm
45-251514 15 mm 14 cm
* Length is calculated from the tip of the coil to the point of connexion with the pusher wire when the coil is straight Compatibility
Detachment Controller for Use with Detachable AZUR® HydroCoil® Catheter Guide wire
System/Pack of 5 units Pushable 0.018” PROGREAT 2.4 Fr 0.016” or 0.018”
Pushable 0.035” Glidecath 4 or 5 Fr 0.035” or 0.038”
Product Code Product Description Detachable 0.018” PROGREAT 2.8 Fr 0.016” or 0.018”
45-4001 AZUR Detachment Controller Detachable 0.018” PROGREAT 2.7 Fr included

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