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    Arven Dale Divinagracia
    6 views37 pages
    The document describes the process of DNA replication. It involves the following steps: 1) Unwinding of the DNA double helix by helicase at the origin of replication (OriC). 2) RNA primase synthesizes an RNA primer. 3) DNA polymerase III extends the primer to replicate the leading strand continuously. DNA polymerase I replicates the lagging strand discontinuously. 4) DNA ligase seals the Okazaki fragments on the lagging strand.

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    108 VID

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    The document describes the process of DNA replication. It involves the following steps: 1) Unwinding of the DNA double helix by helicase at the origin of replication (OriC). 2) RNA primase synthesizes an RNA primer. 3) DNA polymerase III extends the primer to replicate the leading strand continuously. DNA polymerase I replicates the lagging strand discontinuously. 4) DNA ligase seals the Okazaki fragments on the lagging strand.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    6 views37 pages

    108 Vid

    Uploaded by

    Arven Dale Divinagracia
    The document describes the process of DNA replication. It involves the following steps: 1) Unwinding of the DNA double helix by helicase at the origin of replication (OriC). 2) RNA primase synthesizes an RNA primer. 3) DNA polymerase III extends the primer to replicate the leading strand continuously. DNA polymerase I replicates the lagging strand discontinuously. 4) DNA ligase seals the Okazaki fragments on the lagging strand.

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    © All Rights Reserved
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    of 37

    5’ 3’

    OriC
    T C A G A

    A G T C T

    3’ 5’
    U U U U U U
    A T C G 5’ 3’
    A A A A A A

    C C C C

    TOPOISOMERASE DNA POL 3 RNA PRIMASE DNA POL 1 LIGASE

    HELICASE
    5’ 3’

    T C A G A
    OriC
    HELICASE

    A G T C T

    3’ 5’
    5’ 3’

    TOPOISOMERASE HELICASE

    3’ 5’
    5’ 3’

    T C A G A
    OriC T C A G A
    OriC
    RNA PRIMASE

    RNA PRIMASE
    A G T C T
    A G T C T

    3’ 5’
    5’ 3’

    T C A G A T
    G
    A
    DNA POL 3

    A G T C T

    3’ 5’
    3’
    5’

    T C A G A

    A G T C T

    DNA POL 3

    A G T C T

    3’ 5’
    3’
    5’

    T C A G A

    A G T C T

    DNA POL 3

    T C A G A

    A G T C T

    3’ 5’
    T C A G A

    A G T C T

    T C A G A
    DNA POL 1
    A G T C T
    T C A G A

    A G T C T

    T C A G A
    DNA POL 1
    A G T C T
    T C A G A
    A G T C T
    LIGASE
    T C A G A
    A G T C T
    α1
    β’

    α2

    ω
    β

    α1 β’

    α2

    ω
    β

    α1 β’

    α2 σ
    ω
    β

    α1 β’

    α2 σ
    ω

    T T G A C G T A T A A T
    A A C T G C A T A T T T

    PROMOTER
    INITIATION
    OPEN COMPLEX
    CLOSE COMPLEX
    ABORTIVIE INITIATION
    CLOSE COMPLEX

    α1 β’

    α2 σ
    ω

    T T G A C G T A T A A T
    A A C T G C A T A T T T
    CLOSE COMPLEX

    β
    T T G A C G T A T A A T

    A A
    α1
    C T G C
    β’ A T A T T T

    α2 σ
    ω
    OPEN COMPLEX

    α1 β’
    α2 σ
    ω
    ABORTIVIE INITIATION

    α1 β’
    α2 σ
    ω
    ABORTIVIE INITIATION

    α1 β’
    α2 σ
    ω
    ELONGATION
    σ

    α1 β’
    α2
    ω
    β

    α1 β’
    α2
    ω
    β

    α1 β’
    α2
    ω
    TERMINATION

    Rho independent
    Rho dependent

    T G C G G G T C G A C T G C C G A T C A G T C G A C C T T T T

    A C G C C C A G C T G A C G G C T A G T C A G C T G G A A A A
    β

    α1 β’
    α2
    ω
    β

    α1 β’ U
    U
    U
    U
    U
    α 2 U
    A
    A
    A
    A
    ω
    A
    A
    β

    α1 β’
    A
    α2 A
    A
    A
    A
    A
    ω

    U
    U
    U
    U
    U
    U
    β

    α1 β’
    α2
    C C C C ω
    β

    α1 β’
    α2
    C C C C
    ω

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