®

PENTAVITIN®
Binds to Keratin in skin To keep the moisture balance

Dry skin lacks water in the upper scaly layers, whilst the Function
underlying layers are normally hydrated by the skin’s • PENTAVITIN® is a highly effective moisture regulator that
internal moisturizing mechanism. functions under the driest conditions where traditional
The secret to resolving dry skin is not only having enough moisturizing agents and humectants lose their effective-
moisture, but also having that moisture located where it ness.
can actually resolve a dry skin condition! • PENTAVITIN® has been shown to reduce dryness and
irritation caused by the use of AHAs.
PENTAVITIN®’s composition is similar to that of the
natural carbohydrate complex found in stratum corneum. Cosmetic applications
It is highly substantive to skin, binding itself to keratin • Day and night creams
like a magnet. • Formulations for dry and problem skin, xerotic skin
conditions, UV-exposed and aged skin.
Compound Carbohydrate fraction of PENTAVITIN®
the stratum corneum % % Formulation
Psicose 0.2 3.9 PENTAVITIN® can be processed either warm (<80 °C) or
Mannose 3 4.2 cold, and has to be incorporated into the aqueous phase
Fructose 31.1 26.5 of a cosmetic formulation. PENTAVITIN® is stable in the
Glucose 46.7 57.1 pH-range of 3 to 6.
Galactose 2.1 3.3
Various 14.7 5.0 Suggested concentration
1–5% PENTAVITIN®
Properties
• Extensive studies have examined the binding of INCI name (Actives)
­PENTAVITIN® to the e-amino group of lysine in the keratin, Saccharide Isomerate
leading to a unique substantivity and affinity to skin.
• PENTAVITIN® can only be removed by the natural
process of desquamation.

Active
Sites

PENTAVITIN®
Ecocert approved
Stratum Corneum 100% Natural Origin, 0% Plant Ingredient
Raw material controlled by Ecocert Greenlife according to
Corneocyte the Ecocert Standard for Natural and Organic Cosmetics
Stratum Granulosum

PENTAVITIN®
2% Natural (0% Organic)
Stratum Spinosum 48% Water
50% Derived natural
0% Nature-identical

• PENTAVITIN® regulates and retains moisture in the skin

under any conditions. Complies with the NATRUE Criteria.
 Skin hydration [% increase]
6302 50.00

PENTAVITIN®
40.00

30.00
52212

20.00

10.00

0.00
PENTAVITIN®, Glycerine, PENTAVITIN®, Glycerine,
dry skin dry skin normal skin normal skin

EFFICACY TESTS

1. Moisture Accumulation Test (in-vivo) 3. Chronic Moisturization (in-vivo)

The MAT is a dynamic bioengineering method which In this test it can be shown that PENTAVITIN® has
­provides information about the moisture accumulation favorable moisturizing activity compared to glycerin.
on the surface of the stratum corneum and the retention
capacity of active ingredients, respectively. Skin Hydration (% increase)
((GrössenMuster)) 50.00
+43%
p <0.05

450
Moisture Accumulation (NOVA-Meter units) 40.00
+42% S k in h yd r a tio n
50.0
400 30.00

350
20.00
300

10.00 40.0
Control 250

200 0.00
Glycerin
PENTAVITIN® Glycerin PENTAVITIN® Glycerin
150
dry skin dry skin normal skin normal skin
30.0
PENTAVITIN ®
100
0,0 0,5 1 1,5 2 2,5 3
Time (min)
Compared with glycerin, PENTAVITIN® provided up to
43% more moisturization on dry skin, and up to 42% on
The lower the moisture accumulation on the skin surface, normal skin. 20.0
the better the moisture retention in the skin.
4. Anti-irritation Efficacy (in-vivo)
2. Moisture Regulation Test (in-vitro) In a lactic acid stinging study PENTAVITIN®10.0
proved to be
Test creams containing 1.5% of active ingredient were effective against irritation caused by AHA-containing
­evaluated on their moisture retention efficacy under products.
((GrössenMuster))
­different relative humidities at 37 °C.
Moisture
StingingAccumulation
Score (NOVA-Meter units) 0.0
450
22
Moisture Loss (%) PENTAVITIN,
34 400
21

32 350
20

30 300
19

28 250
Control 18
Control Placebo
26 200
17
Glycerin
Urea 24 150
16
PENTAVITIN ®

0 5 10 15 20 25 30
22 PENTAVITIN ®
100
Time (days)
Glycerin 0,0 0,5 1 1,5 2 2,5 3
20 Time (min)

PENTAVITIN ®
18
15 25 35 45 55 65 75
Relative Humidity (%)

Compared with glycerin and urea, PENTAVITIN® was

shown to exert favorable moisture regulation especially
under low relative humidities.
Copyright © 2009 DSM Nutritional Products AG, CH-4002 Basel, Switzerland. All rights reserved. No part of this brochure may be reproduced, distributed or translated in any form or by any means, or stored
in a database or retrieval system, without the prior written permission of DSM Nutritional Products AG (“DSM”). While making reasonable efforts to ensure that all information in this brochure is accurate and up
to date, DSM makes no representation or warranty of the accuracy, reliability, or completeness of the information. Use of this information shall be at your discretion and risk. Nothing herein relieves you from
carrying out your own suitability determinations and tests and from your obligation to comply with all applicable laws and regulations and to observe all third party rights. The uses and claims for DSM’s products
recommended in the brochure should be adapted to the current local regulatory environment. We disclaim any and all liability in connection with your product or its use.

DSM Nutritional Products Ltd.

P.O. Box 2676
CH-4002 Basel, Switzerland
Phone: +41 61 815 88 88
Fax: +41 61 815 88 80
info.dnp@dsm.com
www.dsmnutritionalproducts.com