13/9/12

ANTACID PRODUCTS

ACID NEUTRALIZE CAPACITY

(ANC)

Dr. Krit Suknuntha

ACID NEUTRALIZE CAPACITY (ANC) ACID NEUTRALIZE CAPACITY USP30

ความสามารถในการสะเทินกรดของยาลดกรด
The acid consumed by the minimum
(mEq of HCl/g of antacid)5 single dose recommended in the
5ยาลดกรด 1 กรัม labeling is not less than 5 mEq and
สามารถสะเทินกรด not less than the number of mEq
ไดกี่ mEq5 calculated by the formula:5
0.55(0.0385A) + 0.8(0.0343M)5

ACID NEUTRALIZE CAPACITY USP30 ACID NEUTRALIZE CAPACITY USP30

Antacil Gel® (Thai Nakorn Patana Co., Ltd.)5 Antacid – HCl Reactions5
Each 15 ml contains:5
Al(OH)3 ; 960 mg5 Al(OH)3 + 3HCl ; ;AlCl3 + 3H2O 5
Mg(OH)2 ; 330 mg5 Mg(OH)3 + 2HCl ; ;MgCl2 + 2H2O 5
Simethicone 60 mg5
Dosage: 1 tablespoonful5
4 - 6 times daily.5

1
 13/9/12

ACID NEUTRALIZE CAPACITY USP30 ACID NEUTRALIZE CAPACITY USP30

Acid neutralize capacity of Al(OH)35
Al(OH)3 + 3HCl ; ; ;AlCl3 + 3H2O 5
Mw = 78 g/mol5
; ; 1 mmol Al(OH)3 Ξ 3 mmol (mEq) HCl5
; ; 78 mg Al(OH)3 Ξ 3 mmol (mEq) HCl 5
; ; 1 mg Al(OH)3 Ξ 3/78 mmol (mEq) HCl 5
; ; 1 mg Al(OH)3 Ξ 0.0385 mmol (mEq) HCl ;5
Acid neutralize capacity of Mg(OH)25
Mg(OH)2 + 2HCl ; ; ;MgCl2 + 2H2O 5
Mw = 58.32 g/mol5
; ; 1 mmol Mg(OH)2 Ξ 2 mmol (mEq) HCl5
; ; 58.32 mg Mg(OH)2 Ξ 2 mmol (mEq) HCl 5
; ; 1 mg Mg(OH)2 Ξ 2/58.32 mmol (mEq) HCl 5
; ; 1 mg Mg(OH)2 Ξ 0.0343 mmol (mEq) HCl ;5

ACID NEUTRALIZE CAPACITY USP30 ACID NEUTRALIZE CAPACITY USP30

Each 15 ml contains:5 Experiment5
Al(OH)3 ; 960 mg5 Acid Neutralize Capacity
Mg(OH)2 ; 330 mg5 = 48.279 mmol (mEq) HCl ??? 5
Acid Neutralize Capacity ANC is not less than 5 mEq and not less than
1 mg Al(OH)3 Ξ 0.0385 mmol (mEq) HCl 5 the number of mEq calculated by the formula:5
1 mg Mg(OH)2 Ξ 0.0343 mmol (mEq) HCl 0.55(0.0385A) + 0.8(0.0343M)5
(0.0385A) + (0.0343M) = *48.279 mmol (mEq) HCl*!
NLT 55% of AL(OH)3 NLT 80% 0f Mg(OH)25

ACID NEUTRALIZE CAPACITY USP30 ACID NEUTRALIZE CAPACITY USP30

Sample preparation5
LAB: Density Determination5
5
5
Add water to 70ml
5
Weight

Weight of antacid
equivalent to 15 ml
10 ml Density = Weight/Volume (Use density) Mix for 1 minute
n=3

2
 13/9/12

ACID NEUTRALIZE CAPACITY USP30 ACID NEUTRALIZE CAPACITY USP30

Sample preparation5 Sample preparation5
5 5
Pipet 30.0 or 60.0 mL of Titrate immediately with
5 1.0 N hydrochloric acid 5 0.5 N NaOH within 5 minutes

30.0 VS 60.0 mL

Mix for 15 minute

After 15 minute
END POINT
Where ANC of the sample is greater than 25 mEq, use 60.0 mL pH = 3.5

ACID NEUTRALIZE CAPACITY USP30 ACID NEUTRALIZE CAPACITY USP30

LAB: Blank5 Blank Sample

1M 20 ml HCl ~15 ml

Titrate with 0.5 N NaOH

Add water Add water
To 70 ml To 70 ml

Add 1.0M HCl

60 ml
pH = 3.5

1.0 M 20ml HCl + 50ml Water END POINT

Titrate with 0.5 N NaOH
pH = 3.5 Titrate immediately with
0.5 N NaOH
within 5 minutes

ACID NEUTRALIZE CAPACITY USP30 ACID NEUTRALIZE CAPACITY USP30

Calculation Calculation
Blank mol of HCl = mol of NaOH Each 15 ml contains:5 Sample = xxx g
1.0 M 20ml HCl Al(OH)3 ; 960 mg5 Density
1 Mg(OH)2 ; 330 mg5
0.5XXX M NaOH Calculate mol of NaOH; (A) Sample = xxx ml
Sample 3x20 ml HCl
è mol of HCl = 3A Al(OH)3 = A? mg5
1.0 M 60ml HCl Mg(OH)2 = M? mg
Antacid A? + M? mg neutralize HCl = 3A-B
mol HCl neutralized = 3A-B 1000 mg neutralize HCl = 3A-B/(A?+M?) x 1000
Calculate mol
3 of NaOH; (B)
0.5XXX M NaOH ANC
2

3
 13/9/12

ACID NEUTRALIZE CAPACITY USP30 ACID NEUTRALIZE CAPACITY USP30

Experiment5
Lab
Acid Neutralize Capacity
1.  Density Determination
= XXX mmol (mEq) HCl5 2.  Blank Titration
ANC is not less than 5 mEq and not less than 3.  Sample Titration

the number of mEq calculated by the formula:5

0.55(0.0385A?) + 0.8(0.0343M?)5

ACID NEUTRALIZE CAPACITY LAB ACID NEUTRALIZE CAPACITY LAB

Density Determination Blank titration
Conc of NaOH = …………………… M
No. Volume (ml) Weight (g)
1. 10 No. Volume of NaOH (ml) Final pH NaOH (mmol)
1.
2. 10
2.
3. 10 3.

Average weight = …………………. g Average NaOH = ......………….. Mol

A
Average HCl = ……..…………Mol
Density = …………………. g/ml
3A = ……………….. Mol

ACID NEUTRALIZE CAPACITY LAB ACID NEUTRALIZE CAPACITY LAB

Sample titration Calculation
No Weight of Volume of pH NaOH HCl Average volume of antacid = ………….……ml
Antacid (g) NaOH (ml) (mmol) consume Contain Al(OH)3 = …………………. mg
(B) (3A-B) Contain Mg(OH)2 = …………………mg
1. Total = …………………. mg
2. Average HCl consume = ……..……………mmol
3. ANC = ………………. mmol (mEq)/g

Average weight of antacid = ………….…..…g Criteria: ANC not less than 5 mEq and not less than5
Average volume of antacid = ………….……ml 0.55(0.0385x………..) + 0.8(0.0343x…………..)5
Average HCl consume = ……..…………….mmol = ………………….5
PASS FAIL