Gamma Alpha

phosphate phosphate
group group
0 0 0
II II II
o~P-0-P-0-P-0------
1 I I
o- o- o-
Beta
phosphate
OH OH
group
Ribose
.,,,ry
~"'o.V'~A ~

<XC(_)
f\1P

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~

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C,
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C
w
(1) ------------ ·
~ reactants
LL
u,
.c llG < 0
.0
·-
C)

---------------------·~------
products
Reaction Progress
 Activation energy of
~ uncatalyzed reaction

w
...
C)
a,
C:
-t Activati~; en~~gy of
cataryzed reaction
a, - - I

~ reactants
u.
en
.c 6G
.c
·-C)
~-.....
--------------------~-products --
Reaction Progres s 1
 Substrate
Active site

Substrate entering
active site of enzyme

Enzyme/substrate
complex

Enzyme/products
complex

Products

Products leaving
active site of enzyme
 Enzyme changes shape Products
Substrate slightly as substrate binds
Active site
4
¢ ¢
Substrate entering Enzyme/substrate Enzyme/products Products leaving
active site of enzyme complex complex active site of enzyme
 z
,r~
!
0
1.

!
 Allosteric Inhibition Allosteric Activation

Enzyme 1 Enzyme 2

Allosteric
Active---
site Altered - - -
site
active site

7
Inhibitor
Activator

Substrate Substrate

Altered active site Active site

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