CHROMATOGRAPHIC COMMON ADVANTAGES DISADVANTAGES

TECHNIQUES CHARACTERISTICS

Paper Chromatography • The main • Paper • Large quantities of

characteristics of chromatography samples cannot be
paper requires very less applied on paper.
chromatography are quantitative • Complex mixture
the flat bed materials. cannot be separated by
arrangement and • It is cheaper paper chromatography.
the choice of compared to
• Less accurate
heterogeneous other
compared to other
phases. chromatography
techniques.
methods.
• Hassle free
preparation
• More efficient for
polar and water-
soluble
compounds.

Thin Layer • Thin-layer • Faster and better • Results obtained

Chromatography chromatography is separation from the
a technique to • Relatively low experiment are
separate cost difficult to
components of a • High degree of reproduce.
mixture using a thin accuracy and • Applicable for
stationary phase precision soluble mixture
supported by inert • Low solvent components only.
backing. usage on a per- • Not an automatic
sample basis process.

Column • Column • Any types of • Time-consuming

Chromatography Chromatography is mixture can be process for the
a technique used to separated. separation of
absorb solutes of • Wider choice of compounds.
the solution with the mobile phase. • Expensive as
help of a stationary • Automation is higher quantities
phase and possible. of solvents are
separating the • Any quantity of required.
mixture further into mixture can be • Low separation
distinct components separated. power.