PATHOPHYSIOLOGY

FACTORS

PREDISPOSING FACTORS:
CONTRIBUTING FACTORS:
1. Mutated Hemoglobin
1. Certain Ancestry/Southeast
Genes (Beta chain)
Asian
2. Low Hemoglobin Level
3. Abdominal Swelling
4. Frontal Bossing

 Phosphatidylserine expression DEFORMED RBC

 Coagulation factor expression
 Abnormal ROS production

Hypercoagulability and Hemolysis Ineffective erythropoiesis

platelet dysfunction

Gallstones Anemia
Thromboembolism and
vascular dysfunction
Iron deposition in Cortical
Cutaneous Iron visceral organs thinning
Deposition (Bone marrow
expansion)
Pancreas Bone pain &
Bronze Skin fracture
Extra-
Pituitary medullary
Hepatomegaly
Endocrine Gland erythropoeisis
Dysfunction
Testes & Splenomegaly
Ovaries
Parathyroid &
Thyroid gland
Cirrhosis
Liver
Arrythmias &
Heart failure Heart