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  • Musculoskeletal System 05 Neuromuscular Junction Sliding Filament

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    The document describes the steps in neurotransmitter release at the neuromuscular junction. 1) Acetylcholine is synthesized from choline and acetyl CoA and stored in vesicles. 2) An action potential arrives at the nerve terminal, causing voltage-gated calcium channels to open and calcium to enter the cell. 3) The influx of calcium triggers the fusion of vesicles with the plasma membrane and the release of acetylcholine into the synaptic cleft.

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    Musculoskeletal_System_05_Neuromuscular_Junction_Sliding_Filament

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    The document describes the steps in neurotransmitter release at the neuromuscular junction. 1) Acetylcholine is synthesized from choline and acetyl CoA and stored in vesicles. 2) An action potential arrives at the nerve terminal, causing voltage-gated calcium channels to open and calcium to enter the cell. 3) The influx of calcium triggers the fusion of vesicles with the plasma membrane and the release of acetylcholine into the synaptic cleft.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    5 views1 page

    Musculoskeletal System 05 Neuromuscular Junction Sliding Filament

    Uploaded by

    vkpremiyahoo.com
    The document describes the steps in neurotransmitter release at the neuromuscular junction. 1) Acetylcholine is synthesized from choline and acetyl CoA and stored in vesicles. 2) An action potential arrives at the nerve terminal, causing voltage-gated calcium channels to open and calcium to enter the cell. 3) The influx of calcium triggers the fusion of vesicles with the plasma membrane and the release of acetylcholine into the synaptic cleft.

    Copyright:

    © All Rights Reserved
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    of 1

    +30mV

    Na +
    T.P.
    Choline (diet) +
    -55mV
    R.M.P.
    + + -90mV
    + + +
    + H
    +
    + Synaptobrevin
    + + + +
    Synaptotagmin
    + Acetyl CoA H+
    + Time (ms)
    + SNAP-25 Syntaxin
    Acetyl
    Ca ++
    CoA
    Troponin ACh

    TN-C ACh
    ACh

    sin
    TN-I TN-T

    yo
    om
    op
    Tr
    Na +
    Na +
    Na +
    Na +
    Na +

    1 2 3
    1
    Pi
    ADP ADP ADP
    Pi Pi
    Pi 2 +
    + +
    + + + + + +
    Hydrolysis
    End + + + + T.P. +
    + + +
    of ATP Release K+ + + K + (-55mV) T.P.
    1 2 3
    "Cocked" of Pi Plate + + K +
    + (-55mV) + + +
    + + + + Nicotinic + + + Voltage-+ +
    Potential + + +
    +
    Receptor - 1
    +
    + + +
    Gated Na + + + + + + + + Calsequestrin + + S.R.
    Ca ++ + 2
    + Ca++ Channel
    Ca ++
    + + + + + +
    ATP ATP ATP atp "Energy"
    ADP ADP ADP M-Line S.R. + +
    a H-Zone H-Zone
    r -p-p-p disappears (Sarcoplasm) Z-Discs get Ca ++
    +
    "Detached" Closer to one +
    Power Myofibrils another Ca ++
    6 Stroke 3 + +
    Ca ++
    1 2 3 4 5 1 2 3 + +
    Titin
    ++
    Ca
    ADP ADP
    Ca ++ +
    1 2 3 1 2 3
    + +
    A-Band
    Stays the
    Same
    5
    ADP
    4 I-Band A-Band I-Band I
    -Band
    A-Band I-Band TRIAD
    ATP (Displace) + Ryanodine
    (Add) I-Bands + Receptor
    Anaerobic Decrease Dihydropyridine
    Type 1
    Respiration Rest Contracted Receptor + (RYR-1)
    Neuromuscular Junction +

    | Sliding Filament Theory | Part 3

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