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NOITCUDORTNI
cnacidol is an active ingredient with seboregulating, keratolytic and
antibacterial properties.

Acnacidol is biomimetic to 10-hydroxydecanoic acid, a Royal Jelly omega-

hydroxy acid. 

Royal Jelly possesses significant seboregulating properties due to the action

of two pheromones: 10-hydroxydecanoic and 10-hydroxydecenoic acid.

Vincience Research Center developed a pathway for asymmetrical synthesis

allowing the synthesis of 10-hydroxydecanoic acid, whose properties result
from the presence of acid and alcohol functions at the two extremities of the
molecule:

  


 

Acnacidol also contains sebacic acid and 1,10-decanediol which reinforce the
activity of 10-hydroxydecanoic acid.

  
 

  




Acnacidol aims to re-establish a physiological equilibrium in acne-prone skin:

1) Acnacidol controls hyperseborrhea

2) Acnacidol inhibits bacterial proliferation.


 


 
  


    



   


  
 

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Acnacidol is recommended for oily and acne-prone skin as well as for

oily hair.
ª Acnacidol controls sebum secretion.
ª Acnacidol likewise has antibacterial properties, which helps to limit
the proliferation of bacterial germs, notably P. acnes .

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Antibacterial activity of Acnacidol on ! ,.308

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Molds A. Niger 
  
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inhibited the survival and the development of the majority of the germs tested.
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antimicrobial activity on the totality of the germs tested, compared to the
formulation containing no antibacterial agents and with the formulation
containing an association of two antibacterial agents.

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Name of the company 9LQFLHQFH

Name of the product

 

Code of the product ABG
Title of the study Study of ocular irritation of ACNACIDOL
BG 5%
Director of the study Dr. Nouha DOMLOGE
M. D., Dermatologist
Director of the Laboratory of Toxicology
Center of the study   
655, Route du Pin Montard
BP 212
06904 SOPHIA ANTIPOLIS - FRANCE
Methodology Study of the irritating potential of


 
 active ingredient by the
Neutral Red Release method (NRR Test)
Date of the test 30/03/04
Assay 500 µl
Batch N° ABG 00706
Assessment criteria IC (%)
Results of assessment criteria
Step 1 >50
Step 2 -
% of mortality observed at dilution 50% 30.9
Conclusion:


 
   
   



Date of report 31/03/04

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Acnacidol helps to substantially decrease the sebum secretion rate as well as
the number of hyperactive sebaceous glands. It is therefore recommended for
skin care products for normal and combination skin.



 



  

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1. Maeda T, Kuroda H, Motoyoshi K. Effects of royal jelly and 10-hydroxy

decenoic acid on the sebaceous glands of hamster ear.
 



 
. 98(4):469-75, 1988
2. Jansen T, Plewig G, Kligman AM. Pathophysiology of acne.  

 , Vol 6, 7-17, 1998
3. Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ.
Inflammatory events are involved in acne lesion initiation.   
 . Jul; 121(1):20-7,2003
4. Thiboutot D, Gilliland K, Light J, Lookingbill D. Androgen metabolism in
sebaceous glands from subjects with and without acne.   .
135(9):1041-5, 1999

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