Brief Contents

PREFACE   iv

1 An Introduction to the Human Body 1

2 The Chemical Level of Organization 29

3 The Cellular Level of Organization 63

4 The Tissue Level of Organization 111

5 The Integumentary System 149

AL
6 The Skeletal System: Bone Tissue 177

RI
7 The Skeletal System: The Axial Skeleton 202

TE
8 The Skeletal System: The Appendicular Skeleton 242

9 Joints 269
MA
10 Muscular Tissue 305
D

11 The Muscular System 344

TE

12 Nervous Tissue 419
GH

13 The Spinal Cord and Spinal Nerves 461

14 The Brain and Cranial Nerves 493

RI

15 The Autonomic Nervous System 546

PY

16 Sensory, Motor, and Integrative Systems 569

CO

17 The Special Senses 600

18 The Endocrine System 647

19 The Cardiovascular System: The Blood 696

20 The Cardiovascular System: The Heart 727

21 The Cardiovascular System: Blood Vessels and Hemodynamics 771

22 The Lymphoid (Lymphatic) System and Immunity 846

23 The Respiratory System 891

24 The Digestive System 941

vii
viii  BR IE F CO N TE N TS

25 Metabolism and Nutrition 1000

26 The Urinary System 1042

27 Fluid, Electrolyte, and Acid–­Base Homeostasis 1087

28 The Genital (Reproductive) Systems 1106

29 Development and Inheritance 1160

APPE N D I X A  Measurements A-1

APPE N D I X B   Periodic Table  B-3

APPE N D I X C   Normal Values for Selected Blood Tests  C-4

APPE N D I X D   Normal Values for Selected Urine Tests  D-6

APPE N D I X E   Answers to Critical Thinking Questions  E-8

APPE N D I X F   Medical Eponyms  F-14

GLOSSARY   G-1

INDEX   I-1
 Contents
1 An Introduction to 4 The Tissue Level of
the Human Body 1 Organization 111
1.1 Anatomy and Physiology Defined 2 4.1 Types of Tissues 112
1.2 Levels of Structural Organization and Body 4.2 Cell Junctions 113
Systems 3 4.3 Comparison Between Epithelial and Connective
1.3 Characteristics of the Living Human Tissues 114
Organism 8 4.4 Epithelial Tissue 115
1.4 Homeostasis 9 4.5 Connective Tissue 127
1.5 Basic Anatomical Terminology 14 4.6 Membranes 139
1.6 Aging and Homeostasis 21 4.7 Muscular Tissue 141
1.7 Medical Imaging 22 4.8 Nervous Tissue 143
Chapter Review  26 / Critical Thinking Questions  28 / 4.9 Excitable Cells 143
Answers to Figure Questions  28 4.10 Tissue Repair: Restoring Homeostasis 144
4.11 Aging and Tissues 145
2 The Chemical Level of Chapter Review  146 / Critical Thinking Questions  148 /
Answers to Figure Questions  148
Organization 29
2.1 How Matter Is Organized 30 5 The Integumentary System 149
2.2 Chemical Bonds 34
2.3 Chemical Reactions 37 5.1 Structure of the Skin 150
2.4 Inorganic Compounds and Solutions 40 5.2 Accessory Structures of the Skin 157
2.5 Overview of Organic Compounds 44 5.3 Types of Skin 163
2.6 Carbohydrates 45 5.4 Functions of the Skin 164
2.7 Lipids 47 5.5 Maintaining Homeostasis: Skin Wound
2.8 Proteins 51 Healing 165
2.9 Nucleic Acids 56 5.6 Development of the Integumentary System 167
2.10 Adenosine Triphosphate 58 5.7 Aging and the Integumentary System 169
Chapter Review  59 / Critical Thinking Questions  61 / Chapter Review  175 / Critical Thinking Questions  176 /
Answers to Figure Questions  61 Answers to Figure Questions  176

3 The Cellular Level of 6 The Skeletal System: Bone

Organization 63 Tissue 177
3.1 Parts of a Cell 64 6.1 Functions of Bone and the Skeletal System 178
3.2 The Plasma Membrane 65 6.2 Structure of Bone 178
3.3 Transport Across the Plasma Membrane 68 6.3 Histology of Bone Tissue 180
3.4 Cytoplasm 78 6.4 Blood and Nerve Supply of Bone 184
3.5 Nucleus 89 6.5 Bone Formation 185
3.6 Protein Synthesis 93 6.6 Fracture and Repair of Bone 192
3.7 Cell Division 96 6.7 Bone’s Role in Calcium Homeostasis 195
3.8 Cellular Diversity 104 6.8 Exercise and Bone Tissue 196
3.9 Aging and Cells 104 6.9 Aging and Bone Tissue 197
Chapter Review  107 / Critical Thinking Questions  110 / Chapter Review  199 / Critical Thinking Questions  200 /
Answers to Figure Questions  110 Answers to Figure Questions  201

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x  CO N T E N TS
7 The Skeletal System: The Axial
Skeleton 202
7.1 Divisions of the Skeletal System 203
7.2 Types of Bones 205
7.3 Bone Surface Markings 205
7.4 Skull: An Overview 206
7.5 Cranial Cavity Bones 207
7.6 Facial Bones 216
7.7 Special Features of the Skull 218
7.8 Hyoid Bone 223
7.9 Vertebral Column 223
7.10 Vertebral Regions 226
7.11 Thorax 233
Chapter Review  239 / Critical Thinking Questions  240 /
Answers to Figure Questions  241
8 The Skeletal System: The
Appendicular Skeleton 242
8.1 Pectoral (Shoulder) Girdle 243
8.2 Upper Limb (Extremity) 246
8.3 Pelvic (Hip) Girdle 251
8.4 Greater and Lesser Pelves 253
8.5 Comparison of Female and Male Pelves 255
8.6 Lower Limb (Extremity) 255
8.7 Development of the Skeletal System 263
Chapter Review  267 / Critical Thinking Questions 268 /
Answers to Figure Questions 268
9 Joints 269
9.1 Joint Classification 270
9.2 Fibrous Joints 270
9.3 Cartilaginous Joints 272
9.4 Synovial Joints 272
9.5 Types of Movements at Synovial
Joints 276
9.6 Types of Synovial Joints 281
9.7 Factors Affecting Contact and Range of
Motion at Synovial Joints 284
9.8 Selected Joints of the Body 284
9.9 Temporomandibular Joint 287
9.10 Glenohumeral (Shoulder) Joint 288
9.11 Elbow Joint 292
9.12 Hip Joint 293
9.13 Knee Joint 295
9.14 Aging and Joints 298
9.15 Arthroplasty 299
Chapter Review  302 / Critical Thinking Questions  304 /
Answers to Figure Questions  304
10 Muscular Tissue 305
10.1 Overview of Muscular Tissue 306
10.2 Structure of Skeletal Muscle Tissue 307
10.3 Contraction and Relaxation of Skeletal Muscle
Fibers 316
10.4 Muscle Metabolism 325
10.5 Control of Muscle Tension 328
10.6 Types of Skeletal Muscle Fibers 332
10.7 Exercise and Skeletal Muscle Tissue 333
10.8 Cardiac Muscle Tissue 334
10.9 Smooth Muscle Tissue 335
10.10 Regeneration of Muscular Tissue 337
10.11 Development of Muscle 338
10.12 Aging and Muscular Tissue 339
Chapter Review  341 / Critical Thinking Questions  343 /
Answers to Figure Questions  343
11 The Muscular System 344
11.1 How Skeletal Muscles Produce Movements 345
11.2 How Skeletal Muscles Are Named 351
11.3 Overview of the Principal Skeletal Muscles 353
11.4 Muscles of the Head That Produce Facial
Expressions 353
11.5 Muscles of the Head That Move the Eyeballs
and Upper Eyelids 355
11.6 Muscles That Move the Mandible and Assist in
Mastication and Speech 359
11.7 Muscles of the Head That Move the Tongue and
Assist in Mastication and Speech 359
11.8 Muscles of the Anterior Neck That Assist in
Deglutition and Speech 362
11.9 Muscles of the Neck That Move the Head 364
11.10 Muscles of the Abdomen That Protect Abdominal
Viscera and Move the Vertebral Column 366
11.11 Muscles of the Thorax That Assist in
Breathing 369
11.12 Muscles of the Pelvic Floor That Support the Pelvic
Viscera and Function as Sphincters 372
11.13 Muscles of the Perineum 374
11.14 Muscles of the Thorax That Move the Pectoral
Girdle 375
11.15 Muscles of the Thorax and Shoulder That Move the
Humerus 378
11.16 Muscles of the Arm That Move the Radius and
Ulna 382
11.17 Muscles of the Forearm That Move the Wrist, Hand,
Thumb, and Digits 385
11.18 Muscles of the Palm That Move the Digits—­Intrinsic
Muscles of the Hand 391
11.19 Muscles of the Neck and Back That Move the
Vertebral Column 394

11.20 Muscles of the Gluteal Region That Move the
Femur 398
11.21 Muscles of the Thigh That Move the Femur, Tibia,
and Fibula 404
11.22 Muscles of the Leg That Move the Foot and
Toes 406
11.23 Intrinsic Muscles of the Foot That Move the
Toes 411
Chapter Review  416 / Critical Thinking Questions  418 /
Answers to Figure Questions  418
12 Nervous Tissue 419
12.1 Overview of the Nervous System 420
12.2 Histology of Nervous Tissue 422
12.3 Electrical Signals in Neurons: An Overview 430
12.4 Resting Membrane Potential 434
12.5 Graded Potentials 436
12.6 Action Potentials 438
12.7 Signal Transmission at Synapses 444
12.8 Neurotransmitters 451
12.9 Neural Circuits 454
12.10 Regeneration and Repair of Nervous
Tissue 455
Chapter Review  458 / Critical Thinking Questions  460 /
Answers to Figure Questions  460
13 The Spinal Cord and Spinal
Nerves 461
13.1 Spinal Cord Anatomy 462
13.2 Spinal Nerves 468
13.3 Cervical Plexus 471
13.4 Brachial Plexus 473
13.5 Lumbar Plexus 476
13.6 Sacral and Coccygeal Plexuses 478
13.7 Spinal Cord Physiology 480
Chapter Review  490 / Critical Thinking Questions  491 /
Answers to Figure Questions  491
14 The Brain and Cranial Nerves 493
14.1 Brain Organization, Protection, and Blood
Supply 494
14.2 Cerebrospinal Fluid 497
14.3 The Brainstem and Reticular Formation 502
14.4 The Cerebellum 507
14.5 The Diencephalon 509
14.6 The Cerebrum 512
14.7 Functional Organization of the Cerebral
Cortex 517
14.8 Cranial Nerves: An Overview 524
CONT ENTS  xi
14.9 Olfactory (I) Nerve 524
14.10 Optic (II) Nerve 525
14.11 Oculomotor (III), Trochlear (IV), and
Abducens (VI) Nerves 527
14.12 Trigeminal (V) Nerve 528
14.13 Facial (VII) Nerve 530
14.14 Vestibulocochlear (VIII) Nerve 530
14.15 Glossopharyngeal (IX) Nerve 531
14.16 Vagus (X) Nerve 533
14.17 Accessory (XI) Nerve 535
14.18 Hypoglossal (XII) Nerve 535
14.19 Development of the Nervous System 536
14.20 Aging and the Nervous System 539
Chapter Review  542 / Critical Thinking Questions  545 /
Answers to Figure Questions  545
15 The Autonomic Nervous
System 546
15.1 Comparison of Somatic and Autonomic Nervous
Systems 547
15.2 Anatomy of Autonomic Motor Pathways 549
15.3 ANS Neurotransmitters and Receptors 558
15.4 Physiology of the ANS 560
15.5 Integration and Control of Autonomic
Functions 563
Chapter Review  566 / Critical Thinking Questions  567 /
Answers to Figure Questions  568
16 Sensory, Motor, and Integrative
Systems 569
16.1 Sensation 570
16.2 Somatic Sensations 574
16.3 Somatic Sensory Pathways 580
16.4 Control of Body Movement 584
16.5 Integrative Functions of the
Cerebrum 592
Chapter Review  597 / Critical Thinking Questions  598 /
Answers to Figure Questions  599
17 The Special Senses 600
17.1 Olfaction: Sense of Smell 601
17.2 Gustation: Sense of Taste 604
17.3 Vision: An Overview 607
17.4 Accessory Structures of the Eye 608
17.5 Anatomy of the Eyeball 611
17.6 Physiology of Vision 616
17.7 Hearing 625
17.8 Equilibrium 634
xii  CO N T E N TS
17.9 Development of the Eyes and Ears 639
17.10 Aging and the Special Senses 642
Chapter Review  644 / Critical Thinking Questions  645 /
Answers to Figure Questions  645
18 The Endocrine System 647
18.1 Comparison of Control by the Nervous and
Endocrine Systems 648
18.2 Endocrine Glands 648
18.3 Hormone Activity 650
18.4 Mechanisms of Hormone Action 653
18.5 Control of Hormone Secretion 655
18.6 Hypothalamus and Pituitary Gland 655
18.7 Thyroid Gland 665
18.8 Parathyroid Glands 669
18.9 Suprarenal (Adrenal) Glands 672
18.10 Pancreatic Islets 676
18.11 Ovaries and Testes 681
18.12 Pineal Gland and Thymus 681
18.13 Other Endocrine Tissues and Organs,
Eicosanoids, and Growth Factors 682
18.14 The Stress Response 684
18.15 Development of the Endocrine System 686
18.16 Aging and the Endocrine System 687
Chapter Review  692 / Critical Thinking Questions  695 /
Answers to Figure Questions  695
19 The Cardiovascular System: The
Blood 696
19.1 Functions and Properties of Blood 697
19.2 Formation of Blood Cells 701
19.3 Red Blood Cells 703
19.4 White Blood Cells 707
19.5 Platelets 710
19.6 Stem Cell Transplants from Bone Marrow
and Cord Blood 712
19.7 Hemostasis 713
19.8 Blood Groups and Blood Types 717
Chapter Review  724 / Critical Thinking Questions  726 /
Answers to Figure Questions  726
20 The Cardiovascular System:
The Heart 727
20.1 Anatomy of the Heart 728
20.2 Heart Valves and Circulation of Blood 735
20.3 Cardiac Muscle Tissue and the Cardiac
Conduction System 742
20.4 The Cardiac Cycle 748
20.5 Cardiac Output 752
20.6 Exercise and the Heart 756
20.7 Help for Failing Hearts 757
20.8 Development of the Heart 759
Chapter Review  768 / Critical Thinking Questions  769 /
Answers to Figure Questions  769
21 The Cardiovascular System: Blood
Vessels and Hemodynamics 771
21.1 Structure and Function of Blood Vessels 772
21.2 Capillary Exchange 781
21.3 Hemodynamics: Factors Affecting
Blood Flow 784
21.4 Control of Blood Pressure and
Blood Flow 787
21.5 Checking Circulation 792
21.6 Shock and Homeostasis 793
21.7 Circulatory Routes: Systemic Circulation 796
21.8 The Aorta and Its Branches 798
21.9 Ascending Aorta 801
21.10 The Aortic Arch 802
21.11 Thoracic Aorta 806
21.12 Abdominal Aorta 809
21.13 Arteries of the Pelvis and Lower Limbs 814
21.14 Veins of the Systemic Circulation 817
21.15 Veins of the Head and Neck 819
21.16 Veins of the Upper Limbs 821
21.17 Veins of the Thorax 825
21.18 Veins of the Abdomen and Pelvis 827
21.19 Veins of the Lower Limbs 829
21.20 Circulatory Routes: The Hepatic Portal
Circulation 833
21.21 Circulatory Routes: The Pulmonary
Circulation 834
21.22 Circulatory Routes: The Fetal Circulation 836
21.23 Development of Blood Vessels and Blood 838
21.24 Aging and the Cardiovascular System 839
Chapter Review  842 / Critical Thinking Questions  844 /
Answers to Figure Questions  845
22 The Lymphoid (Lymphatic) System
and Immunity 846
22.1 The Concept of Immunity 847
22.2 Overview of the Lymphoid System 847
22.3 Lymphatic Vessels and Lymph Circulation 849
22.4 Lymphoid Organs and Tissues 851
22.5 Development of Lymphoid Tissues 858
22.6 Innate Immunity 859
22.7 Adaptive Immunity 864

22.8 Cell-Mediated Immunity 870
22.9 Antibody-Mediated Immunity 874
22.10 Self-Recognition and Self-Tolerance 879
22.11 Stress and Immunity 880
22.12 Aging and the Lymphoid System 881
Chapter Review  887 / Critical Thinking Questions  889 /
Answers to Figure Questions  889
23 The Respiratory System 891
23.1 Overview of the Respiratory System 892
23.2 The Upper Respiratory System 894
23.3 The Lower Respiratory System 897
23.4 Pulmonary Ventilation 912
23.5 Lung Volumes and Capacities 917
23.6 Exchange of Oxygen and Carbon Dioxide 918
23.7 Transport of Oxygen and Carbon Dioxide 922
23.8 Control of Breathing 927
23.9 Exercise and the Respiratory System 931
23.10 Development of the Respiratory System 932
23.11 Aging and the Respiratory System 933
Chapter Review  938 / Critical Thinking Questions  940 /
Answers to Figure Questions  940
24 The Digestive System 941
24.1 Overview of the Digestive System 942
24.2 Layers of the Digestive Canal 943
24.3 Neural Innervation of the Digestive Canal 945
24.4 Peritoneum 946
24.5 Mouth 948
24.6 Pharynx 955
24.7 Esophagus 955
24.8 Deglutition 956
24.9 Stomach 958
24.10 Pancreas 964
24.11 Liver and Gallbladder 966
24.12 Small Intestine 971
24.13 Large Intestine 983
24.14 Phases of Digestion 988
24.15 Development of the Digestive System 991
24.16 Aging and the Digestive System 991
Chapter Review  996 / Critical Thinking Questions  998 /
Answers to Figure Questions  998
25 Metabolism and Nutrition 1000
25.1 Metabolic Reactions 1001
25.2 Energy Transfer 1002
25.3 Carbohydrate Metabolism 1003
25.4 Lipid Metabolism 1013
25.5 Protein Metabolism 1017
CONT ENTS  xiii
25.6 Key Molecules at Metabolic Crossroads 1019
25.7 Metabolic Adaptations 1020
25.8 Energy Balance 1025
25.9 Regulation of Body Temperature 1029
25.10 Nutrition 1032
Chapter Review  1039 / Critical Thinking Questions  1041 /
Answers to Figure Questions  1041
26 The Urinary System 1042
26.1 Overview of the Urinary System 1043
26.2 Anatomy of the Kidneys 1044
26.3 The Nephron 1048
26.4 Overview of Renal Physiology 1053
26.5 Glomerular Filtration 1055
26.6 Tubular Reabsorption and Tubular
Secretion 1059
26.7 Production of Dilute and Concentrated
Urine 1067
26.8 Evaluation of Kidney Function 1072
26.9 Urine Transportation, Storage, and
Elimination 1075
26.10 Waste Management in Other Body Systems 1079
26.11 Development of the Urinary System 1079
26.12 Aging and the Urinary System 1080
Chapter Review  1084 / Critical Thinking Questions  1086 /
Answers to Figure Questions  1086
27 Fluid, Electrolyte, and Acid–­Base
Homeostasis 1087
27.1 Fluid Compartments and Fluid Homeostasis 1088
27.2 Electrolytes in Body Fluids 1094
27.3 Acid–­Base Balance 1098
27.4 Aging and Fluid, Electrolyte, and Acid–­Base
Homeostasis 1103
Chapter Review  1104 / Critical Thinking Questions  1105 /
Answers to Figure Questions  1105
28 The Genital (Reproductive)
Systems 1106
28.1 Male Genital (Reproductive) System 1107
28.2 Female Genital (Reproductive) System 1121
28.3 The Female Reproductive Cycle 1137
28.4 The Human Sexual Response 1143
28.5 Birth Control Methods and Abortion 1143
28.6 Development of the Genital Systems 1147
28.7 Aging and the Genital Systems 1149
Chapter Review  1156 / Critical Thinking Questions  1158 /
Answers to Figure Questions  1159
xiv  CO N T E N TS

29 Development and Inheritance 1160 A P P E NDIX A   Measurements  A-1

A P P E NDIX B   Periodic Table  B-3
29.1 Overview of Development 1161 A P P E NDIX C  Normal Values for Selected Blood
29.2 The First Two Weeks of the Embryonic Tests  C-4
Period 1161 A P P E NDIX D  Normal Values for Selected Urine
29.3 The Remaining Weeks of the Embryonic Tests  D-6
Period 1169 A P P E NDIX E  Answers to Critical Thinking
29.4 Fetal Period 1177 Questions  E-8
29.5 Teratogens 1180 A P P E NDIX F   Medical Eponyms  F-14
29.6 Prenatal Diagnostic Tests 1181
GLOSSARY   G-1
29.7 Maternal Changes During Pregnancy 1183
29.8 Exercise and Pregnancy 1186 INDEX   I-1
29.9 Labor 1186
29.10 Adjustments of the Infant at Birth 1188
29.11 The Physiology of Lactation 1189
29.12 Inheritance 1191
Chapter Review  1198 / Critical Thinking Questions  1200 /
Answers to Figure Questions  1200