Pasi importanti in siguranta transfuzionala autor: Victoria Hilmagi Cristina Bichis EDITURA MIRTON‘ilu ip sin uri pn ‘etsiNo tp Ate ape neh Aue Megan” Teh a Crt Coc, Coty Manse Dinero Romie SC Kingstone SR Bac © Toate drepturile rezervate autorilor Deserierea CIP Biblitet Naina « Roméinlet ag important sigurania teanseronal Hila, Vitra, chi, Cristina. Timigor: Miro, 2015, Bibiog ISBN 978.973.52.15729 [Blehis,Cristion impart isan mone Cuprins Prete Sere ee 3 he rs opt Sate BOB ‘ener Dah Lor MNS Gene ze 12 ac rig 15 Soman 1. Soemat ABO (1 Asie tc ABO HG — 12a “stem Ra i {Ete pete pacino {2 Atco sea Eo 138ml Rabe 131 Amie tara al. —— 132 Amor shea Ke {2 dteatone deere cient ngs tet Sera uy et Angele cm Da 112 Ante ct Dal tase el 1 ane sc 12 Anerpiteme K Issn NS Lia Amid sea Se 132 Anes tema NS Messina ne ‘i Agel sew oi tena Autor Se Let Lesson E ‘668mm aceportant euranta ranfuconal 17 Feotp RE Kal exis = {ATacom de care depinde mia eo. eg a : aptots2 inunooga yi transinia 2 erode . 22 Ton ince ce privet sntcrp pla 2.3 Tpuiedesoicoranrrotar 3 24 Detejiaeaterplor gua eteiroar ~ 4 25 Dela clare ancrplor equa (A prove dina oe ry a 2.6 Important previ aout In cestre seco atone, Blopafe ne ae copttal3 ‘Examine imanohematologce in vedere transfer Senet Screens ims ne pro tine 32 Munepnenal ect inthcmaloge nn hale eee - oe $22 Algae cil pomtrid docs ose 33 Bape pol tenon 3 31 Pew enna eng 33 Seaton te sa — up angie De Casa deepest 048 ‘up AB ra An ck Oneabeg st xt care emt none pet anf de aac ews prance ope segs petri Ina Wey no Dungen itl ou descent abpopee A, #8Pa imperial tna 24 ec adeno enn es ppd sg cot ee err tance te ‘eto nice sng ame he ae spon sa det tcp ct mae wu een ‘Sed nn hot Soh wp ay ‘pen ended 80a rte pee Be Abia dupa deseoperire factorului Rh, transfusta de slag a sce cy deme hacae peadevento mate eapetick Sir AN0 nue i psp dn hg dos 'semenes pera nut jac ual mporet a pate rer in sep =r ptt in practi for in epingeea rani nostra no conine tn md moral sai ar sngele posed aghtnine snerivoctare ‘Ap to ABO man pases tinge ste ost schinin pn eta grep Lnteneocle ese ‘ell seh proce cna pein pert cn aes ‘ep vv a gina eg Un ne Spe a ‘ci enka dn stn lac n sade ania Fon aang pee det pene pe Fal ppd np mer pe Anca 80 ea pope pcp 1 Impoutea anger rope, ‘hela. Prince grape sanguine tn eal ABO ° r ae os a a a . 1.2 Genetica grupelor sanguine Avutinogende sistemas ABO Ssemal ABO geet bonne (1517.21) ‘Gene semull ABO sunt tut pe ctmzomal eae loss de pe cromonnl 9 exe oapat deo ea A 8 0, Gena eteo gra ‘onsieat ca gen amor, deorece ma celica antigen eect pe pbc edn pe membrana ce iene pan ima 2 Antec grupelrsngune we deol inva embrnark pine raat cre de iat intrasterin. Agena ee no pate eect aun 3? a at ita de dere sng ean i crc nin pena Soba bine ree re cnet eset eect eer etac «patina ch nore Src ee ne nae Sa =f aceasta determin sien satera une glicori SSS get ee aa ncn oad pani mes erin ter cae ep nc ma vc a pune ncaa ae eB oe 1 Golg. Antigenete de grap ABO nnn mr rear pecarre iin timp ce atigenal Beste © D-galactozi eager mec mcg pera seo ‘ng gn ts SL ieceesteers alae epee ta ‘ee terminal glicoproteice sau gicaipiice membrana pout anise A ites cet nara pastes so nano ene ei we cent ye ake spc a bes sein ae ee Seal ea eam cese see ep ee mens ai vith oni ang bel a ine nt ems abr pace ofr mao ah hn atigne de prop sen r= rl maturali Hmni nein ema tel peri et 2 uote a ea au imnogbsne din cde aM 896. Cemalmar pa So ar Anya ‘oa ecru “samen see ahem a fi or nn ne ema Aptian As? aPei portant npn ranonald co ong tira cars mesa eto acu vet de, Tiana eM poste kes gradual dat cu syansarein vt der pn la pure Prin excep log tnd incr ascent expat um gain ce ‘uso contact cu amine de grap ABO anges ttcre stants An ‘icpiam ant sant preven gl persaneleca variate ibe de up A sau B New cui uu de bie canteen de nto an-A yan Bin las co ‘epi eo isa din mame sloimuniate cre pot revel nel etc 1G dela mama care au rer placenta (1) Reamintirea defini (1314) Antigen Antigen exo substan capsbi sh nda formar de ancora propria de 4 se combina nod specie tigre snl ABO apace ah comin 2a af cx aigenal Dla subi Rh pore Aico sunt proeine plasma sinter an sublet apt nod ere una ange ontoraaembinindise in mod spect ca ot De cepl,n ‘ori ants deel dap tweceren enter tle Rh sn cies sae ‘mi Rh (), Acq antconp pot hemola atl oi eal da bola esi a oust. To indi imanocmpetent produ antiory new saptinne ‘sm uobemelzie ft de antigen de grep ABOU, Fenotip ental expr um crater odifcat deo gent ee exprinaca ie caters ‘espectiy n aces psoans. De exemple coicrea pene pent snes stg, ‘ar deine cracteralHhesus pat: Peta care caater dnc ep ng ‘sentip Fetal eritciarcrespundeanigensor membre! eroctar vst on roi ete determina de ose de steme tie pliner Acct gee ada Inteanorguns ontconsderate ca id ie ar uta tae anor natal ‘ain responsi esr liza cellar, neo sever cha fal Cuneo onan ucrur ee important In doc deat de palo scidente manage tanerone incompetent Genotip Genotpul ete un ansambi de gene purtate de comozomicodfcindanumite cattcieallaa act sero pen ce tnstonal lp eon ht 12 html de rap sanguin ABO ices eu sng tea 0 san pe membrana eritrocitelor @ unuia saw a ambel pes ‘Snem ‘0 been share oan Aw pes Se 80 = el mal important sistem de grup sanguin denarece:cind antigenele ce nae gi ec ep apa a a pe thot ind price esl et et sehr ABO op oa rena nase eres ani depo st nC yep se fist Densitatea mare de situs tr atigence de pe membrana i unui mums mare de anicorpi ducind, ta cazal trans ietesentTe! seal Ara ent eden ne MSO A Antigenele A i B sunt det an an deat le scp n-th een (icon produ in bors ™ Hem me incr in noes * on pes ror aw de grap engin (gt ind a en lara cn oe ss peep os Decaenps agen de gop & pe hates aut ‘asain de erp B pe emai tn ser ahtininle@ Niclodt mu ste pene pas en cece Pe hematie 1 aaticorpal (agutinina) corespunzitoa ae Neda undid pen enantio apn ine a "gm phn ica ap Sept De ‘pecinkasd ine pen iaincdtwhpena cree coeecter cutie pe ee apn anton seu pata vec storemte 4-480 theme Oven come mara sa Pee ees ‘eto fs postive cuhematle AA, su B) Sarees ‘abel 13.11 ee eee tl tim ts fr eters Best —F ak = i oo [sane] hens | — st Pig amp aa anton 1.3 Sistema ABO i Hh Antgeel sistema ABO-1h ‘Aaohande hry H so lioeshande parte decal wembranr ae hems inne ello pce 5 end, De serena eet antigen su prezete weet aia seu pe Expresses anigee pe emt eve contol de dot earn dite se chr gee cach enamels namie pvaliransfrare, Amel a pent fancier ua mod ee adam ceea ce nseuo cS preses ‘widened dace expe otic a oud amigne fete Lo- NaI Hh pein doula alice H tb "Rigen ee devin! degen Hua pun oes independent eos ABO. ‘da Hodes acoranses cat adm ofc ap essa fa ol ‘Rohr de bu forind niga Sez lees satin ena 8 seen pcera ara. Antigen cde canta nore steer AB, ecole de ep AB ind antes cea ma ick de sso tee deo O waren ashame Alea © fn st omogt conduc aps age AS Bh ‘relic rot dn sag, co cecorespude ential “Rushton are gna ane on-fnctonl rece tn ate hoot (hh) cermin note Bombay grup sagun nicht A odio Nacional fen niga # porn pe supra hem ube ca ent A, posed dimpate, © ‘lima fue atv gage! complet masa, poste & ttt "als prodor uate maar care ada un resid later formes a ‘send nena cond caipn sh i preent Snel de secre ABH ‘Sitsune Ar He giec in elina woe penoan, Sian He ge sla pemoundor cron independent de grag O, A, 5 AB. Ace subs oul st een ele pin sere de nop ai, ata a preete sale, Dtomenes sunt dtetaten scr tro anlar av sb aie, am, tern nseichistror mucosal val. Sie sertor qi nonseceton tht826 Yamane cel care escort uno ate hb 8 din pesoare seco bei secreor A tn sala abst aigenice At Sebi secrete Bau in sal lo ssa ange Bw 1 Sabie secret! Aa in sl lagu atgenice AB Subcisecetor| Oa in sla ot stan amgenice Site pencice marta carecterl de err corespunde repulo de taser cecark meneiene,ceaterl Se secetar find dependent deo pereche de gne alse Se Soest dominant Se/ Se Se/ ast sector ees: sl st poser ie AR nel "el npr ine alt Reais dnt oc ABO, See “Tani buco roy din ge loco SE na pre se maniete “Ihadetce oso de ah He coin de pea at _genei H cit gia genel Se. ee ema renee Rotate A, A, BAAS. HO. | Fenotipal A, A: ee ‘Ghat dep Sexpin dd pr deat Hp 2 det 3 ‘can in care enzimele sk AHA, eet o clic ico Won ed pe weapon anc Ape ei ‘hel 13.4. Prove sworn 807 hip. stn _guin - Sisternul ABO) icicle bi ALO: AVALATAZ ‘bel. cena pe grape desing popula global (23.17) ONES avn caative le antigenelor Ag 8 2) Yar normale ante A op fe deena cur venison dele potas aps pees 2 ee na de igen orm ecm gr ua gid ston a Awe apt 1) Varia potologice eee cara lever say, sous ent pote sheet senure Peppa eves ABO. Asha ema cv eb grep Amara, eae ap Bc der ate grep. Fenatip Asa x tab Frm stab Ba danse de Bae sunt coma atesa mud dpe Hobs rs disc. niga Apa fat lab Fee at ls coenpt bps cabin pape AH cana ancl Apot apart sdk ge A aug ol peri npstint eceaic bec, «208 ba ron snge et eatin ab mss apie mec ie pate 9 Aste ao cto as com Pe ee ant pops 8) smtp nil abe Suter ener a au rns be ata uso A 8 cae abe nde io eroomath A Awan eon amen: pron ele es eg de eo9O Fae ead pecan es debe A 8a a aad een incest ge Ay a Aon an ree oo ecard ca ni aera ot ts oka ponent mtn jain moe cot de sho cena aia, eer Rincon ant casa A ete mai comune subgrpe de A (rein din prude deg ABauocspse noma Cem ea ncn Arsen A Aces hep teat pine cou He Pt ge hci Imo mt aarp ema mal pine atin Trt ae abe rn abe ale AA, A Ay A Ay aa sme ragrapde de A ar un me di Ge eacica at erat: copie coma stance noite eine.Posing ars nals Lesine {een rice de ein de pce coe oe rexone nod pc ensuite antigene, Cele mal comune lectne utilizate in transfarie sunt: = + ere cin stn em os ‘Dati ioe sie hy ratte eee en Lec racpnc perc heal Oy ceo one gma cohen ones oem aniston deumen ‘bel 131.¥ ene 23) Inca gpd ite rate oo gee ‘nme ere mal ‘cuhematile A, . Statin cpa i ai ph i das pop fe D9) 2 Retin eset el acne cen once ema ar 8 {Noah ate decors ce enena boca tv alin rss ‘bel 13..V1 Dire subrule Ac trl ta (2.9) rbleme cusubgrops A, Fear cn rem predee ca sib A, domes hen A, psf pate aad ol tear aA) pens ator at Ba prob -eeeeck pe pres eo grup sanguin O ast ako unit de age de oem heen no pane ropegsin Osc ind natal aA Fe aca wana eRe one rand ac ena sa ence grep A, sein od erat cheat cup sng oe Am nat tite sete tet anti-A a8) ap tle oo dontr Se grup O cose tes a AB (ih ila res at AB ‘eet pt nce cate oie ene Are dene dent ae [Ravage deserts an-AB) aa otipa ibe nr date deo react eine yeoman ss scares product enh “i Reng A, heat A be de ule oi nu sn apatite de sree et a naTsanants AB detectarea lor ee cel adee fetal nda xo ‘pe noguine snr dicot ne cle? toe (Beth Vincent Son) ries inbmpia cu gop Bh Desc inporan ext grup sngsne Pk eledout meade Per denticaes woo fei A.B sabe tule fs toate eh pos alte, the de are he, stil thor Iglar il te ‘at elect poste caries de asec. ese Sgr ‘hel 13..VIE ‘ebpupede a Bp de opine emt Bth Visco Sinn (23) at Vincent son et DP ci eR ‘Ake eotpr A slike wit cual spec, se pte cae cscs cana defi prin teen et (fe 1 An AW AWA AWB aPo imprint eran ransom Aig ae cn pr eae tts BBW Be, Bo Bw-6, BW-7, BW-8, Bw 9). “ etic A nan! oop AB ee vorb dew rp AB, proven i sea romans ‘postin tip ce pace AB an gee un mney A yon conan ogi rane Feel cu AB fit dexcoper nn at acpi Os ened © B.D tp gear AB cde oer Meare tions oe {Bsc conde are antigen Aa atiges pete de ge Foie At eu ai po aU nen gf (rc normal nantiedr acta ean) sums ‘evn fnaip A, stu 0. i iummicsaned 4 fo eee tar piace As AB, eA Deca icin cA cra rtm de pp AB pag O pec 22-Tetet in ee ya ral at epi ed va de eos omboy eal omy oespunde nl a. ne ele ma xn gene sustenance ena erondent eee de perils rarfane A deer pes pra dain dined BSS Bee {colibri di noes seston a At an Hr, ‘atl ure niece onlge 8 AH El coepune we gra botany ‘stare horsorigot in fami consunguine. ™ a - ‘Grup sngi ape grap ate proan a if de rcpan {EA HintRen tory utente oehemaecerasnate es amb Acs pean ma ot ds tant dec cum neg eyo + ree uated carl ma aceon de pen Sst Hino ete rod gn ncn cart ee het osu de gra Aas 8 pst ona inchs pee ol A ‘Acct enotp ree anid (0) el Bom nun se ‘eri de pret cs saan gpa se Ne pnd enol obey dc ls nctatngropel gine pin Bath Vincent Acct co rap, oe aA Wane on am Hs tute one cas {he Sinn spare gtiarecy hate de A 8) x te hemaer tog Lames Sonia dec atin tae heaton Fete candar tly sulan Hc inprundca eat Ospties pre earache tng Barone ppt 0) “apace ep Bambu. posb detect np ng non-A a8 un 137°C ingot rn nena mado ae 1 feoigl a Bonny saree AB a at ex fe sib at 2 Pad important spran ramfconss cube, Ata omc pp Sem ty See eae seri Ai nade mow At el Pas Bombay a pe reins neat mae ected wfrma ot tun aan ure eft a depeouepesigm ABO ce a ae emt wal pie ppt ABD ec ae enn ee puna giburyeagilo: hen A Spa etl dr emine open nase tecnica ccibpta cna op ello on sng ‘Riannen somone. Bet: He ore se Suen var ae rc ic ple cee ncaa Asters B manda een “ca rl ne wesc else ome ‘ “acest leromen este doar temporar gt dureazi numal pedurata devils ertrocitelor care she aes soto ae rue A, eu diagposti de cance de colon sepia cu epticie ci ronor ane escviae deceit ateraabarulX 1.3.2 Antcorp Sant eerie dou sani erit Eucnp suai steal ABO ce eps an cstcl de nee peru oie ‘reson aompai in ces ier ‘unares aprtiantconpr ep imptsiv stem Ross sa aa vem ino fntmence nec slate lobule ro in sng nator Sx cede nip ete ens ero Antiorpisistemalat ABO e AD Anicorp nati ath A Ham opine 8) ‘Ratep tA at eeptlinptia anno sisters ABO, rt st sam nd ot ree ind ee ile etgnih idl aa fost xpos ove i un igen AB ek li sine atin [Deane ms prepare din sng) i sunt pezen cing angel orespunrtr ete ber see ue amgenlor AB su rene: bacter, plate a ple. Acesen ‘tac nnn sath ant tec ph le Chir ack ce ater ‘eden ctrl et prt nwa nor shim unologice,monite ‘Sng vis isd angen sue ner = ‘Resoele in gro A produc ana aie pesoanle prop 8 produc an np stra es 2Pe impart in nfo 1a atnine andi cu gpa O prod i atcorp at gc ata ta erage ear acpare npc inc lg an din grape ABs posed ‘vcr ntl in steal ABO. La now ast sun abe tinned ont B Acetate fic part din cs de imunogabline gin ea mare propa cu ‘out ies de imanopoline ig ‘Aghia cf at IM hg) eae capable acter cascada compe ‘ment cod reactions altos aca antigens Ast apni fcasngeal Boat oct hemi burro ait in singel paint et motel de las Into) Aces nomen ar lc de empl: n pact de grap Bc pots ad pinnate tanta eu hema de rp care a etgrulA bracts ‘sna recanoyte atigenl A de pe hentia cu coe ‘asc complements rodce ia itrgec) hentai Actives complmentll ates hernia tse ca leraea deem Gobi ers tn pla pls va cpt alae «csr rae 6 Inchsels ses Dec prin igre acer anor staan A at B spas hemator sine !ncompatbi sera ABO, e pat inde o ec de hemor de mate ot falc deere n proposes hear incompatbe Asc natural a umitoar race sei: sant deg ‘uot aps atnere hems in suspen alin sunt wor aha sunt ot pal act °C deck a SPC: se pune cl oil ne ex cat epee pti de atic et a ptin de 30", dat vestie paves Ie ‘umpeataacnpu sant abort ugr deci substan ion de crate 9B ate de Nabors lina substans Witbky penta a neta a ancora rises) sant email: acter agian spare pointe 10 mela 70°C ssi ut de opt mal sun aorp car opr expe abate nmin ten (Enis nee Gove ck agen sate angie nau te ‘er cam ar. calc simul produc desmcaplapersunleeare nu gn emg specc A). ‘ee aos rece nr de 128 se 1256, sun ae mae aparin ral de 36 akc uae ime n "ieicalplishardslor acteriene 2) At antcerp anette natural Antiorp asta elt "st anicorp atu reali ore pel de cae trae ic cnt nc ch ‘eonardm concent etree. Mal important sat Pa Pimpin igarane rmfinl cram soe co gap tg Boba (OH) (MccpianerP nt) seb Ti) Fae ane mee tan ene scoters ecu stage conn ei. an apa ‘Lewis (al-Le anti-Le,ant-M gan ‘ancorp nth opr pect a crete nd oben se ne pec ate pete aan degC rymihC oa 4 0 constituie bolnavul cu maladie drepanocitard ienunizat top OT te cal ele stu fapt, ack necesito transfunie ulterioart, simi inst once esis noone oe ‘burst cng et cone it ce anor ne ae ‘Acesta este un anticorp belt, ia, vcs a psu 8 AB ed eae pen Edi pectoris depp An 25% din ponaaele de grup A. nia ner i Ct crn impugn pent pea Babel opin ingot nce hemo sor in wr tem ditinge she aa erat np iptv ns antigen pret pe lbs roi in sng va unl antigen przeat pe bul eh ign Pet eters ecard one : ms Miter) Secs psde aoesomps ataneoeplani-A jan-B star lsat de pg 2 lloansioep een st nda impoton oan, sof dn sng tn mod norma seen de pe gaballe Antico ima ant, ‘pie rn eur cent de ropsangin A concentra ncrior i concen eestor or sade a peroane snice ps wan cu concentra eros de prup sania Aon 2sPo imgertan sign ean In polo mil, boals Walden, st cei lint conic. Convent car eter cee Inbolile ubimuns, hepa ci cwek ipa oa a amcorplor ABO se ober in ‘munoroprede nani de cell ser emaapueie suspen dig custo depart atria Su const tat sin maul mane prin lime de orgie wanna mca de ae compe a rin ‘munizae maternal a angele A sau B de orgie etal cin naa et de pup © ise imnzecd cel ma recent cot atigea A) Prin hetero trance se prods dicate 4 ac ech sr astoxna ceri ean Caractere serlogie le anticptr man pet namie de cater ope acl tet “sont aticor ec ce au opi teria °C nt antioptinomle ae provoack apinae neil sunt vie ‘tin teal Coombs sont acl de ssn oil tip Wie «pos ptere ena rosa is iz in pees complement ‘st elton este nee 7O°C tin de 1 mite sunt dip IgG tesa places ) Donte iver pero Conventional dost de grep O sant consider ca anor univer. corsage te tramsfaat sprit de oe grp. de singe in grap O confine again,

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De es Poi important i grata anginal secur pte oa Seidel 8) Sh spon oe en HD tm om viv tn) sh Rb-megat (D-negati) ei chemi lind open ern mort i agen ee ea gt ey ot ec ee nea rE cnn ppt pe wo at De a a aun maul epti cae liprese, defini ast eootipurie < en cela! important apts los ines lbs Bsempl de eotpart CDeR ede DEIR ‘Partial trebuie controlat prin biologie molecular. 7 thes de dcr ert er etn moon D ecm ee ovata D pra pt es pons pra eer SS yah pain RAD ponte majorite eacivormomao dpi (LEE ede tn pip! unre) ot dota cami drs porta in nigel D pe xe no pose Fstop. arch able D pri int oar ID ge pane dee war obec ca msl hte ae ales unl bet RAD, banum chee vorba dvs Rh para can praia cae crane oon 2 mo ae act incor rea otpeh RE neta ac ss} ate RB posts uis(2837) 827 aie Ce vrs d o pasta ulsle! RCE Pa ara) eon de sll ce Acs para a aay Chr pe patina Sl der poe dept dss plies. it in dei Bi eta unorndis na econeae csr at 6 Foe, Pe emai ot a tegen xe Ee arent ies D Ace ah de li Wi ae i bane Deu cont dle prileD-.DC™-Ca primo tansies ‘Fe ema sa nope dabei) Festi Rg eee cc wn igen Rh pe hema tol i esta paca ianom meniaare cre da tember de ders pace ea ea antone snr Hy cts rp 9 re pe no agitate cme Ace Peon, dk prio wasn se et uses avr Gc ra (oa un an) eee lr nt gr eg wn dot cng Hema ee Pe sae ta spa i amen Rh conone ence Sema Meee ere sgarl ange clipe ee ates. dete de Ra px condce kaa ema cm 2. enit eee deseverne vrs cao racer «dual de ia x henai i yc pine acl bert. Se bev srt cl eared Rh json er dare 2inrome er Pn an een ato dma La blanca sferoons eda es erp 6) ane orl sei RH (atest Donate bai dat dn punt vedere al Rs D post D paca ab oar aor) ne ett Rh poi se wastrel pales Rb > ta near et neve, ah ein etl x ter anD se ep %Papert grant ransom ett pinot est Coombs nds penta a igo D sh seu D pare fel piml sng Rese (ence ele de danas se Rh ls eft portant aca trol Un slocontel pov ar email ut ecopeie li) de anor del thd at-D este als pont. Duck esta Coombs nec pnt cares Dest po tw gant-C poi sue persue teste super tenis utocontr 14.2. Antionpt seem RE Conaramicoplar i sera ABO, anticop ia inpotria atin stems at Rn un trl i sant de mtd nd (ea esr og air oa ‘our de rep bie Enea ct a ot olin coat cu tetgenl atari ants). “Antigen Decl mamanopen ite antigen de rp sng. de co gl se ea asetransr un bie RE netics hema RE pont Cele antigen F.C pot, de stemene, rovocs pai esc ims cel dee orgie havaizel postrastaioae ne x aber eootle Spe dosti eantiorp ABO, ce sunt i principal gM andcorp Ret doit 1gG. Aor et ma eve ste ant la pesounle Rh net: Denar a cep Rh st seh cel line a FC cea lor vor erate bie ‘etl angoulinc indirect Reale de putin sur acetate de concentra ida depron albumin) est an nod Sabon), de enc rte (i re (EC ete pr eee “Asizorpt Rh or renciona al puternice homoigte Sc cu ematile Ieteroigote Deegan an-Evaeaiona ml puter aera + + geal dab ‘ulemati E+ e+ Acntase ume clea de dbl don “Atigenul Date o ec patric dct ra ehomanigt lt conerst ind ‘elma! iunogen rat de angel E te Seetimest ch proape ate pce ‘RH neat Want cu siege + or rodue ator ants Dee pot pest tin elisa an © a0 e=panee a nigel Dv antes ua spans melo econ ‘spice poate doce eset iano grav, cya inert anand 1 Eoscorplor anti-D jis respectarn stem opto competsias REID ‘in ease de sige (egal de a use sta un subi! RE mega cei RE pont. ‘Avind in vedere fev april anor i emul RH, presen estar co edi ote trate compat ene ec site iene D, Bee "ebule ott pal cb anor an unt mod partir, erie cade bl Iemelices nou eset adc an tra are ent. Gate nie nee npr DEE ae en “Antconpan-D nut soci ca atvaen complement cel mal ep de- 6 Pap portant sigurana racial seat ripe an pet csi ei ne onc Satomi nak ene pee em armen ort thot nei Soden mot a ep maf vc sin os oe opr nen oc we lca a de snca naa frontier gmp oe wero pes ea renee pg ek ‘ae at ne ir Her ne aan earns oo Art hae em A sane a Wl wine wn eo ce ans enn perme inns ps cri ap, ema ho depen emo te Saloons eas ios ne. Camitane de imanar dpi de wnt ter Soe geo apace xen sien cng tens ear nmr ela rm angen: D> © KB C>F>i>-© Bee nara ar ee pn phe ere nit Kel po st nto ror Sedu 98. "cen neon = cae pre Bh pout asic eteo mat mae desta og ori Rhaept a ttedae eel npr (9 dn Kal pot) at tes pa ros Senn ec al eg ch tage al Path Sent ae anu celui era oneness ta clio poe rode sides pte al conic ten icra ico) Pree npr TEA 1.5, Sistema Kell 15: Antigone store Kell Fee eek ote cl mat iqunogen dophsxterul Rens et a stem compl capone Ki) eset eager at-Ke 1 sunt fre ”Pas inger in eo rags Sie Kal te part de op meio xsi ee mt eee denageleatgannat areata Ec pret a nos B38, 31 t mat Ke e ‘vee e288. Te sane a anv sage ec Kl Uma ke) pote ne ue eo Fl dare ss imnnpin indica sbi whl ine sng pnts sani a cw uk Une Kr tr acon ren ca ene alae tn pecs apd ev scp a pus pe ‘nt nie eae fei in psa plo ce ea 998 a seni hse pare puta plat ee spa = prior prsealss Di atealKl eg ct 2g fc pre cap eae ate AerKEL 3 oP REL hp nani tonne ete ae -nispindt. aa A “res ‘itt. Sc al oa ot rc 23) KEL) KEL) Ke (EL 12) on KGL REL} Keke KEL 2) 3% KEL) RELI) Keke EL 12) as 15.2. Ancor sea el ntsc et enor iat esd eco arp ica sean cin evel alma dfn erp Elna al pd dee in aa ston st each sen ani hte co cope) np sents pu ot es “ert eric inert deri tp Ka otpl Rh, pec Indoor est ee de et aca ett to inl ferret doer ange eet ee rat ‘hin ge comp pon ance ep un anya cr Se (Ka) err 2 a pp xi i gene ‘pee RE! Epa ee ngs tara Pec doe tori compatbili find foarte rard. ™ " Pa peri gure rain 1.6 Altessteme de interes niin transfria sanguin ett mele cua de 0 watz sau sain incompa a eb mango eum dee Stee de aie secundaria steal Day (1), isd (0 9 MNS ssi stenl Day Emenee tent daft ditt ancy pola vende ea eum angen poet ml CD AEP om e “acest sistem ase o partcularitate la rasa neagri uate in cove un numa mare de subiecti rie eget seon cvon eis yo) et ree epueetnnet een keen ee ates pc tps oa Fede pds 4 lS TRENT eoimrzcepccdetetgne th dP TR ed we Lace ath sige 1 tbh So eee tes dr cop i anil FY daa ae nary emt one rer ob Dace Ca er sm cmp tej eno ngs Puc a etna Deb pe it noone be 9 Se sa ret grunt te eae a en urea pont pace tani be et aa cat copia ie hereon 78) cn ecco fn on apes ca 8 arp po 0019993 “abe 1.61.2. XI1E ane rapuror Duin rind mir caucacenor fea eis eens 23) Se nary | memyeri | ame | 26 Perper | mewoirray [ame Le BeAr) ewer [ome fe 2 = Wester) | Foote |e 1.612 Antcrp ster Duy “Asp ant Y sant antcorp nan raion ant-F' pot produce accent he mie postr boalt helt eo-saal »ating ses vans tn rida opal de rsh ene 59s enol FY: -L- (Ey) a mae ie oan est ate Deasonene dvi de as near ca fenotip Fy (vb) st eet a infearen soda as ul dine enh pds Protein Dally in egal nasi recep tora Paso ye a sprite hemetr pera itgrarn seta in we in neon elt Fecvea iin nail Fy») pop pap seep ‘ig eaza uel eo gente foarte ect favors supa actin ‘are denn essen nine cu ace parait(9. Chandbrt A lining of bets D {DNA, whch nade the major abit ofthe Duffy Bld gop tem end the repo or the amon vie malar porate) “Ancor steals Dy sunt din ca imunoploblino 1 po mabe dpi {sfcoajtr el entiglbliniindect Nu actionee in etl ens deosese sun degrade de cite ename 1462, istemal Kidd 1621, Anigenl sistema Kid Slt Kd ae in principal 2 le TK apo ks 2; aR rene a tetice ev anh Acetate Kid int normal deve prevent ingle de ‘cordon omble ‘ele out atigne pricpal: XR) (2) sat af imagen a ore tema Day xpeiaatigensor ete determinate doo le codaminante state pe romozam 15,2. Byrd un sister da chia, ‘Sierml Kiddpesit fenoi enin ra: saK12 dat de exer te oe dai en alle serine "ut 3 nop Kd poste K(k? 26% KG boauiki2 2m KG@rbowuiki2 50% ‘abe 1.621.X1 rsa defer Kd a cause gai oi fees 23). BeuKt) | dsoKi) ib OK 12 2% Beaty | NOUKa) er be 2 0% sno aKa) [aw oR) Seb 1a) 2 1622, Amicon stems Ki Ancor sell Ki a acorp nk ant reel unl im! pris inka tone, 0 Pal important tn sipuranta teansfisionsta apo anor ns plan oe 9c ts nts een crt eigen nha a Kl sr er Mt fe ce cole ne Coombs rec: Deere nha de nine et teazptes yn Lis bo acme vey p fl oigies acer wane eeu rth et pt i a eB cert ; te preg at creat artrb Pep ante) gan (KD ou ee oa ederim peso | ida ea debe exirscaar nace postsstrome saa Stems La Ae en ore mire elo wasn eee N. Acesten dau ractilanttetice. Acta Se atot eps mnt er a Feeney hh ap Seopa iar ee ae rs: MS, Ms. NS Ns sre cop dese ei pr apt St ee erat vn deor ese d pst san sa eigen np me state olsen mie Sse aS) “ime ate dot NS. MNSI # MESS MO al une a6 MS, MNS, NS 132 Amcor ste NS ral ae ara qs ut nc ape rt a aan ree Saad npr ton Ae ce mean pn donne mun pot eponeh= sae nc postman bt eer canon cotton us np —— iar alot’ anti-MNS3(S) -periculosts i alm NSE MONS pattie aaking nse arnt 1.6 Stem LEWIS nna el Leo etn se Sel onde pi sanguine encanta ii ee i sci ore snd pe mena hema defn ere Tae posed ga Lev i {ntti tv etn cil sr st ere -substanta Lewis. Dack subiectal este non secretor (ses oa se mumegte Lewis’, ar daca subiectul este secretor (SeiSe su Ses iad nema ei ee ec de i ume pes eer ga mien ce gre Secemi prismh ibl a ach substanta Lewis * este sintetnath (ou ee mi bs Le) tl ev Le Dans eesti it sa ates Le esp errs ee tne ee evi i chore ) bil cor me een wp i 1st. snot np Lee cre at tone! ase Ln eet Inveds fen ono ni Bar inp aie pote ar ‘ron eto et Levi ptt hes ener nlc seco et snl me ety ee bem ot “Anicorp Lewitt dep! tel Sam etl sl cue et WC et noel de momen rm etnies ic so ‘reactioneazi mai bine in testul enzimatic. “pice fees Heats dee hei tl Sra ph i io pr corp anti-Le* se leag eficient de complement. rose ones 1.85, SiemulP Siterl te ace ter en npc nto “Rm ech di oe EES ordi drat itieace sae in tc Phy cna fa pps ash aia non esa soaeet -anti-P stanti-T)*(P.P, Pk, . Peer Pn mange pti seem ABO. 2 nee 1.66. Sitemal Lutheran 1 tnran coprinde 18 tiene, Se ue Lt 0,0. Fa la ut een a eee co 8 cs Opi deci teens Ma ae pie pen pt 1.7. Renotip RH Kel extins 1 ree Rh Ke inp weirs toon Ge Be KL oo eb feat i pb de ain ina etree es seven an cheats prenatal. eee er ce abies primeasc wane angen niece find. angele sin St iam in as an pn xa nti antgbshniindiect ‘pot de efi ep ner ‘leila esl pase rmanlop®) roan tooo ate arf cart anion o emis aos es de roen npr ope Hoge ABO, Se nnd plings deta tid He eh Se pe py oie or ge (uy Rs SOS, Me oe ese pane cared urine eeneeoetee nce rant ti, eu etl st ern oa termi Pe Ot doa de si. even port (bl croc fen ancl h- th Kl ta probe ifr re depnde innunizareaerirocitart Ter eine irene cps even coms clr a nen al ind permanent exo ans rn cen aa nse nae onl pee et nal Pn a nr Pn tg Be sen et gaa eax ae em ‘Areata deel ba sr ere crs iter eon (ors a) Se cca pent nepete HLA en imei eA pe eo cal enanare ABO infin de ange: sustain Beg entigoa poputi Rh pt ip de doar 9), dc vom is imi a 1.8, Fats de a Pring atone zt dct ren Recent dct Ke poss (3% ‘hina erent ect 2X ®Poin an ani Alloimunizres-caractere (4) 1 Concetta anor i aria np ial de stale. Atco ‘nul se eclntca maximum de probeblate din a7-tla 15-42 Tel de ep tar antceporeuln( )wfie dup sere derma. 2) limi pate sven trun mnd explo cid en ings trans ‘Acs ssl se ref placa ce sensible progr lange, {incon ce mat mumerose acarvin contact pin termed mir tas tiidesnge La sebloeiva tots die ism rode anguie compat 2) Alloa te revel acest eles ects memraneagc. snap in dept Gs ne pear ot Wit Sun fort de antcorsanietocta Stcorpimpoetv vlamign em feces (8) popula general: corp an anigene pate vcr imptr uno engee de seven chili a popule (199%): cea event nor mperiva une antigen de ecvena ces >998) i popula panda ocr at amigene rable |) Allomnizarn ete ablrecvent ancorplor inn cee ca nanralde ood sesanguine estat spre sineml HLA lpr enor 5) Alois ee nee ~ ni aes unio Bibliograic hatin mat entree ir a (dja nl iene ton wees ge neg es benign te owen Coot Sep esonlace Dodou Mak ira Madan Yn Csr Deco eo der Asus xe ‘Soin 10 Chin Rai 1050 Tse Cre 9 Be 50208 2 Sa ad ui adhe “Oe ABO Rd tem {itttoe hop fen msc cht Eee og Gnesi astute bg ne Wy ck {Car orn Coma dn Wee {eee gen ap occas Pt iy 08 {Use She Toms nen Rr ey 10 ee 12 tpt Rowe Bh tefoson in Boe, The Wht Bok 0% are 2008 "ens satiate ia ie sa Web Cl Seth Hee on RC Pet nd Whi Cl Antigen a Wi etc Cal ema epic Wir hi, Pn Ed 208-22 1s Rape tion mntunacepe mangan LANDARION Nase Set, “ Cree te cantar La cube, oh Det 18S PES Ea inmate ims FNAB 15 Secs ec ee 2 eee de ct it te ei py mp ie se OUR ion HEURES DEFIANCE ae eet or cn Snemal ADO. Genes poet ae a qynningncent npiicea Str Nr ee 2 eon ABO Peon oer ate sani rou ARO Co et epost ADO ee pote ean FT Hee a nen He ABO BLOOD GRO ss stn, ae Pais 2082 ace pili ncn Rar gg 2 Gomes a rma rbot Freese RE Sse ku oe = "STD ANTIGENS AND ANTIEO einen | 0 13108 | wen agpitinble ouabain a ki ec sean Had L082 ae te a lar eens ars 2 Gon = re ogee, nmin Me 2 en: cage «mn ONE aii PES ic inert cio me Rh eae Yn amie 27 2 ‘es male deere pe ue anion ea Fee ee emma nea teat ee cata an ed ese TERS a een sme opt Te tts alt Oe cing mie ane ec ee 21 i i an cl pies Ha Baw St aie tenants en OO ania fh deiensepaome seer ane ek ce ae cn mc mer ae kta peur en rnd ee Feo ne Bei mc ed ge He ten AS etc 6 on Fe cen ic fans oy es Hod Rr Fee eel poser sca So a8 set ce] ops sng ici he ptgeeite oe ania oct wih Hod pe Rial Boos eg homan Ral ok 6ingrown nls snoniner el icon a Ral ame Mace fess 4o’sappr an tne Shen Boat 8 Taner, Ae DL Op hoa haan ybrcpeshre sn heated! oases cen | tt at sec posi erp, Hace (Fae atin Clana epreton and berry sno lee sea mashes esol. 28, seme 2" Desnay Aloo Bn at a pogo aaa 6p ie se en tetany ons 9) BJ teat Pasa eee amen epee 45'aget Carton sca ago Rh ge Soo 191.73 ‘4 li ht Yi od a al Cat Ge fe stern Neer teyrirriin net oe eee ee ant vy ; se pe ergata ce tas ienomics 1984; 19: 68-74, i r Sarena eee nc meron “9. Saegpal Car Sch WWE Cor eV kin Scant Deed pony pany soto pe tae 50. Tippett P, Lomas-Prancs C, Wallace M. The Rh antigen D> . ner haat etme pnd ca enn ener sgopeson the RAD pebpepide Tan Cn Bl 9.07300 oe mar ene nner = Pscenoes eee acest rg sm alpen ate ase setae eterna any Sia te eats elt eects A Nok. oo TW Aven ND Us W Hughes Jones NG Sennborn HI A mame Sosa ro eee ene a crus ml tnanon RSs late he mtr eee ad sR ert cnn ay = SArcing eelcempnmr rset eee er eee sahind th won mera ey toma agate See se es ee so xin anc yi eas ood 94 1: st D ena Benda Deal Do ‘pion Gae BC eRe Caren, Cle ted segs sen MD ve oa: Re «oe hen op saloon bane nt Oe td ‘ss esstschonarty rer gmap Mpc Bcd RS A “ Pat important igure train “.pmgct Cen Red. CoS Gant econ ahaa ey ay a pnts wa oes 28 Dw RE A “cot ztr Mow Crt PCat ofthe ct at ect en rat ae ciara Seer ensen emterore “cis panei sisters el trace Sree eeceairinn Siren et “ga seguir sat te aanioa renee et era rene ica eh geo cman rie ca Cm mmtaeesinsa Sete eer cero tae sat Een hn ae Sperone an ee es mmm eigen ah “emer cieme ee carne eesti _(Biotiaa cae mon ey ar ace ct "raced ht oactnuminc er EES eenmmoncam mee ante corsa mart ne Oe cn Mal aver Tame MA rane PR, ode Ee ea so Ee acne Segara amt sg aac NG amt een ee nermmemstacamentniene Sacha re er ar ee ahaa "eh eeiteeeeiracaag cm ‘Geant nt aaa ect a sesetcegrnattinatasot onePa inprtan in ogerans ronson ci ices and gram tin AP eset ie. Se 6 274788 tata end? Calla Soncbore i Remi Merson 2 Cate The ‘nd geo Gopi oeg hear sda dese Nal Ae 8 sovDak Werner MMos ie Web Leper ft ag opin raisin Bl ey rcp Bt 13 ‘Garon aba aman eco eopbaris pn geestacesehs Tat ed eves aE 92 1 Rin he prt of poh A pe ts Sei 08 16 Tlen Mh. Chs AR ofthe aman yay Wage oa ttn nn ‘Dreyer Adan Bool os Bs ‘Pat Clg ca, lar dt eel meson Rod Revs 161822. Houta Ce arama WE Cally Tbk A ey ll LI Aco rb spate Pods ar eyo ami apr Ses 8 tt ‘Chun oma Zana Wilms Rat ge AO Cig antl Gn ie aan ey ap enn be so. eseK Mab Khon Sha} Paco ad shel ei of ede ag ety ite edo ol cma rp Modo 5. sey Lc Zh, Nnowt KSain AN Riper gene Hek osciay| ‘ele tds ed in exe slope Semaine cha say [oaths trey wen ch ithe Dual pup angen} en $2 Cua Nie. lj ML Zana Fg og AO. Deen of De atin he sh aot oa cata cn Hoi, Mar Melee Halley Ls 7h Wing, Pepe SC. The Duyn ter hse recur an extn sk 6 92 ‘tg yrs Mau Anat ner MK Sta cote sited wth ak Ru Hed pep angen gcatan ne bum deen | a Che Bane Shak ge Maman tel nema Rh ppp eet ay ied sun ofa ucramlecooe | cham 99220 5 8 eT Ge Lema ete ft mre kan om he immu cet theta rel ht) oie mal 98.2 7 Pe i Sah RLS Hal, Jo Gama, rg A cg an ean eye mnsconotorb sn Soutgee CE, Ch AB ee ES Puck ge arp ft me ye badges inhi andere ame ema Sapte uma kn Nae (ent a 230 ‘Abo Na Yea an Ada Tee Glee Cro Dea cht {At dence he ed cl po 3 my prcp th selon mem ape tetas pan! gyptrin Bod 1988 S87. oh Aa Me, ach , GD Coen Deny. Ra cl metre gy “etn mn ay 61) my gos ec Spy In. Ann D Poo Sf. gw K, Tse MIA Mary AL Thin EE, ai Pao Indra th dpe eel ck thee mir bythe lane psp 8 ‘Pap empoterg te sponte remfeciona aD ov _Mleclar maps ofved cl deformation: hidden astisity and se a eit cigar omaha cane occa rata ei a cP ierB, Rael V, Gane F Mati MG, Bally, ibe B, Cain Y, Carron I. Cansei S ar af the RH los 8 most cases of Rh deficiency. Nature Genet 1996; 13 a ee eset ih wis fe D (RD cep eps 97 set ap A Some ya eee, ihng Feng} hms and aber NOS 2 a em ann et anc Ped 1 7737-0 ciiyeter nian a ce Pape parser Pn TE se ted me pi rn 4 A Reet i Canara 4 30255 inert un amin Capitolul 2 Imunologia gi transfuzia 2. Introducere ‘Aumunians etna din cau cident postransfuronule. Tass proves “ostimulaeaogenc a primitr care nduce modest ans vale nintenstate {cdot Acide imunologis in elie cu tain rant mamersse td rors ‘etal lest depended igen arate declee anszate Tunica trasisonl, sore mize, wee punn stain de ator de ply prin fap cate pit cam tin de 1-2 an Dup acest eroa apar ‘ori de tip pe care pat chine a3 dea dup muni Trecerea de anteap detip p M acele ipi odpm iotdesuna ptr ch acest eee pote area scl de mize estat pine emi mal tot uma easier plansiat egal ete spos de ma lt I fatigene pe cate lecanoae feel mele munizad i yo, ide 2 on ma ope ect rb ele ind ‘tural spose nate rine pis sarc nuit bli cu eon cp ok cease slater de anticorp ‘ul de angen: abu atgene sat et uniare dct ele antigen Decl smaimunogen Alloimesizaresanteirocita ‘Aloimanizeea este un enon cate consi paris de anticrp Intr-n emp caves print aigne dela un abe! din cei spe Alleimanizresamentreitarh eprevnthfabreaen dete orginal peice aio imptrva ntignelor ‘rote primi cei atop one mar alatcorp pen dierent de aso corps betroantinrp “Asset sot anion dts impotv prorir atigne al oraisa “Heronnticop sunt acpi impota antigen provenind de ini dia spec der “erenul d sticon tl se fe eat ancorp ect ei ABO. Ace po 0Pasar ean anit ‘pruning rn de lobule os sa dupe expunere a lobule os ae ‘raining en mage ‘dette bul roan pe membrana orange sine (een se vepisene pe able ro ae pce tagstrat ss le aide corp ore sunt Inept ipotes ul antigen non i” se mus alban oe Mav exist eusanop, cares frmesn cara nor plo tap me arenas mpotrva popiar gbule ok facet seta anticorp inpeire propor bal roi (27) ‘Per spun teste te necear Metiere atc, determina spec ilo te ce met dloc simp 9 neces cunt toric de grup angi Rh iano, recom thn elaborate de mare acute 22, Torin cence privet anticorpi regula + Ptotll ea(41) ‘lobule ro suspend nam seeping epoca urate 4 presen aia lor a une cimper etic negative pur ae mein reefs or de {ent pti sodarca lool ro, Dente tests nr ace caste derek deere Diet de potent orl decane altar cu bub ro medi extra ese de 15 mV Aces potential ui (2) exe determina de mobil Tae eriteclor nae cmp dere Fares sntenple(ee st melee nt) netlizead paral ss cnpu pin urmae pert dato Frlr de ene ‘serial 9 ander Wins, popees de here gti, Pte et) ete reds I aproioaty-7 9 (1-Callogu dy SNBH 20548 SPECTRA BIOLOGIE 151+ ‘on'08) “Iianoglbuinde gc greats molecular | mllon Data, sat mal a ef ‘een petalaes cesar pur, fh de manogloblie IgG accor gee Incl ede 16 00 Dalla, rn amar, ster M sat acral ou comple a amicorp Ig Gruman non apa incompl.Aghias Apinde de mundo de tw antigenic cure unde lens tmnogicbain) de Pe sprafiaplbuleor ot din singe ce xepla 108 ss wr A ep hema A 105 ‘ue pe ohemate 100) 18 00 de suru Kel depo heme el ont + teria punto (41) Sutra imusogabulindr coast dla dou antl dow amar woes cre sor separa dap un vaamentencnasntea parte Fcc din dau agente de Tan gre ook rapt Faber contn ats deeare lantern nies Present ts de ancorp se eg eatin sta pe oak bem om sstind afl o pune mle ine do eto care, eet arma st ape mpreans(1-Cllogu du SNBH 20888 SPECTRA BIOLOGIE 151» A208) 2 Pasi iomportan i siguranja transfusion sn mi tte ce nm me at in cele = Pac eau camper stir mor pie tun. mater ets Bap ‘inn n media sin sunt ot inp pericloy penta tansne. Speicie ee sp recente sn ant RM, (> RB + HS) RS, KEL at Ra PY, Lat MINS, ‘Cs exempt 0 pce ca Rh nega (aren te agen D) poste muna pote eo arp uo ant pia antec ent Ra poate rea ‘te Depend ns Bt Rp) moe 2.4. Detetn antcorplo regular antieritoctar, Detector enteric o aan ilk ef pene preven sl dgoentcaacdenilorpostranfisonae mmarahemolice diagno inca. ‘ii fo mater ‘Screingl deat detectear da pacietlpos antonio tigen de pe lbuee oi print rin ane “Testu peat depres ancorraneivotl este concep pete a preen he- smo pra macs munca ode contest wnsfconle sa ose. Ve Tare sais neces chi sguone 9 tlizaea de coowale de ete sla eine dnp eee aa eee preg ss Pat important guration ere lini rue ancora ee ina eo e nel ace rain de nee tne sede ee "a apni tans hime grave iy ‘tcp reps rebut eect ny hoa cate antigen D) Zomelle mltpare Rh eg 08 care nate Iaieplae srecomands dept acon ep lve si lnpeimal came pcs nasa an de sing a an de rin fnlana yin ad sri. ae al onicopl rea) sant pa, Menara tare allostcorlor ete ‘hau er eau ve penal de sewer, Dac ae vr anor an ih cnet te lc in oaormtatec tel ano. ae orrense estar nace aborts deareela cae rae eral precedent quan congtitc) ponte panel rare pale srl ct al pare Ate lect pio test de Coombs indirect orate inte salted dnp. Tl ntinpr varie ia ani dep de antkorpiconcenrat Tein vt de seco antecedent bt Tenchu ceaticori determine pei etal ensmaiceatior determin, pei etal Combs indie? Riopdom imino cite ape sunt dip gM ‘Nt rnerseed placenta sein pin esta Coombs inde cata amine determin sparta atiorplor de ip Igacompet olan media alison rine Coombs nde testa ctcorpse cla 37°C de HG st ns pent A na In ase nop oer exist ac hema Acs ic beste eatin ance ‘Gapeicter sntcoplor demaararen ntietorete Een gv th neat (nate D) ee dezetantcrp an-D are un is de roles a emicorplat de pig pt tava ares pceatarh “Mauss dectath taint Ge jected uals att pevesizen tain eter Bh “Spano prin roi sagun ju at sips eos dxcone ners eg aac pain per a eet pula unr d nae pina creo rence post spas secunda fno- dpe lone naar agi i impala rans evo, ar pte Sve! Pee Rel ait patentee un atcorp orm un aio pe tds acesteren ea pl chanical deter hr dae se “Tle tee cud webu oldetna eatin considerate alesren wel nt deange pny sexes transi. Dato acest atte ecomandat UTS-urlor it 3sPotro guana nonicinlt spite phir eden dart ola polar na mam al ke "pul de anior: eeu! eps rans antec ‘Dap anti call seul de hemowge) cel ma un in penta de tect llonatcorpi invari dele 3-4-7 re 1-22 dap ia ashe, ‘te important dps aco nglr cu seca cn “Anos semi net rant cose 9c alee dest In 3° pin sel Coon indict (etl ntighbuini incre). efi de senna nc depnde dela pace eae de ev pact entruun pele cre are neva de ten de sine pe temen cr cum ar pene ‘faervente uel un acetal in val, a ete fone importants detect ‘Mloascorpi. a fcemfnepl extn isin ings in ena sec eda pate person acento Bal enfin ce ve nce anf ptt pe Perioud ndlugats ote portant in esr a inne fe fenapal exis apace. In al aceon pace est foarte important determin lator cnc seni, Incercnd gin single ptr fn lena en ‘Deck pce aura! nll un pustngh a al pace un aes de hem hema ale dnstora)precum amcorp cr uot sina een. ‘Sn nportate dessemenes vets cago pace pentru exit bce stimulant aunt pert de ancorp expla Lapse sec est ec co ‘utootcorp cal, penunons a Mjeoplame ne oat ch tarictrpia ec Ete ‘owt important sta deorece rer gi suoamcorpl sub rt de 3 dea (3) Avanaele determine Al (antorpor regular: eeu tench pei itu pele tip depts na 2a inp entices ‘utr alnicorpior imple in cident leat de anf deermnares Ast un amen ore sei pin alae nor panda cu hei homrigt (heat ceau dor dbl de antige, exemple) ees x perme pane, In evden amcor x rasa ator ate Fs) wa ore scarp ia impure niente dn ser R, eat homoxgnt din panel de hema lt In abortor per ptr a erp equa en strctr lr dra dbl engine. Exemp FF 8. Je Taconvelentele determine AL-snt ont de: “anal impli anger pete angen rar preret n popula genes) Pots a ep nee + termine cro woul acest ua tp ag de 5 mine acest ete un lnconenien in male ogee Certs starr anlertoctr ete o az seni pentraa Spit et- ‘cx anor dias impor amigeda de grp sanguin tact fi det Asa 8 ical de hemolasimunsogs prin incomptats dat de sticnp enterica 56 Pal portant tm iguvanga transfusions ect rhentiapose ce ea een MAJOR pute of es mc pte eum aie a cn co mvp Ine na db nom ne spn ps nan ikea inp etal de etre anther eas cde nr esc dl pt aie ct i er hep epee apne ec a rnc ca sara gecetcrd atone non ds de pes etre AD wes iat el ont oe eerie syns ttn dar ne ae sanpamnsnpe ee ae "hemati de panel e pun tn contact ca seul sau plason pacgntuls in conforma an re mips ret anComne , ct hei rou er tn eat cops depen inp reloc ime buk o Titers cnn Sasuin gman Sn at corset sce 657 Sane uring Oe inp atigece: DC 6 KK FY FP. BIE MLN, aa mag de ange per ies D.C 273) 6 iSrevan aa eons anger pb erent ingtve stn: er ne an atl ra pce pe 8 co er asc a reo Com ain eeriitmedecamanet es a neg Alot a trp ene goer ge 9 Bap de dtc: Menicares : settee ete ent x a panel de heat est de grup Os epriie ae cana cent cu angen tir blige cond cel pia 1 emt s